公开(公告)号：US20080176816A1

公开(公告)日：2008-07-24

申请号：US11999637

申请日：2007-12-06

Applicant: Yijuang Chern ,  Yun-Lian Lin ,  Nai-Kuei Huang ,  Jung-Hsing Lin ,  Jim-Min Fang ,  Chia-I Lin

Inventor： Yijuang Chern ,  Yun-Lian Lin ,  Nai-Kuei Huang ,  Jung-Hsing Lin ,  Jim-Min Fang ,  Chia-I Lin

IPC: C07H19/16 ,  A61K31/7076 ,  A61P25/00

CPC classification number: A61K36/8988 ,  A61K31/7076

Abstract: This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.

Abstract translation: 本文件描述了与天麻属相关的化合物，提取物和药物组合物，以及治疗具有代谢紊乱或医学病症如亨廷顿病，三核苷酸重复疾病或异常血糖水平的受试者的方法。

公开(公告)号：US07396656B2

公开(公告)日：2008-07-08

申请号：US11649176

申请日：2007-01-03

Applicant: Han-Jia Lin ,  Yee-Hsiung Chen

Inventor： Han-Jia Lin ,  Yee-Hsiung Chen

IPC: C12Q1/48 ,  C12N9/00 ,  C12N9/10 ,  C07K1/00

CPC classification number: C12N9/104 ,  C07K1/1075 ,  C12P21/00

Abstract: A method of cross-linking a peptide to form a homopolymer of the peptide, to immobilize the peptide on a solid phase and to enhance antigenicity of the peptide is disclosed. The method comprises the steps of preparing a fusion peptide by incorporating a cross-linking segment including a tetrapeptide sequence Q-X-K-(S/T) (SEQ ID NO: 15) into the peptide and cross-linking the peptide by a glutaminase.

Abstract translation: 公开了将肽交联以形成肽的均聚物的方法，以将肽固定在固相上并增强肽的抗原性。 该方法包括通过将包含四肽序列Q-X-K-（S / T）（SEQ ID NO：15）的交联链段并入肽中并通过谷氨酰胺酶交联肽来制备融合肽的步骤。

公开(公告)号：US20080152666A1

公开(公告)日：2008-06-26

申请号：US11949125

申请日：2007-12-03

Applicant: Shu-Mei Liang ,  Jei-Ming Peng ,  Chi-Ming Liang

Inventor： Shu-Mei Liang ,  Jei-Ming Peng ,  Chi-Ming Liang

IPC: A61K39/12 ,  A61K31/7088 ,  A61P35/00 ,  A61P37/04

CPC classification number: C07K14/005 ,  A61K31/7088 ,  A61K38/162 ,  A61K39/00 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/523 ,  C07K1/1136 ,  C12N2770/32122 ,  C12N2770/32133

Abstract: An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.

公开(公告)号：US20080145846A1

公开(公告)日：2008-06-19

申请号：US11747674

申请日：2007-05-11

Applicant: Yuan-Tsong Chen ,  Shuen-lu Hung ,  Chih-Lung Shen ,  Chi-Feng Chang ,  Hsin-Yu Lin ,  Wei-Hsuan Chen

Inventor： Yuan-Tsong Chen ,  Shuen-lu Hung ,  Chih-Lung Shen ,  Chi-Feng Chang ,  Hsin-Yu Lin ,  Wei-Hsuan Chen

IPC: C12Q1/68 ,  C12Q1/02

CPC classification number: C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/142 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172 ,  Y10T436/143333

Abstract: This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, or hypersensitivity syndrome) based on the presence or absence of a genetic marker (e.g., HLA-B*1502, HLA-B*5801, or HLA-B*4601).

Abstract translation: 本发明涉及确定某些HLA等位基因如HLA-B * 1502或HLA-B * 5801的存在的方法以及用于实施该方法的试剂盒。 还公开了一种基于遗传标记（例如HLA-B）的存在或不存在来评估患者是否处于发展不良药物反应（例如，史蒂文斯 - 约翰逊综合征，中毒性表皮坏死松解症或超敏反应综合征）的风险中的方法 * 1502，HLA-B * 5801或HLA-B * 4601）。

公开(公告)号：US07351434B2

公开(公告)日：2008-04-01

申请号：US11400064

申请日：2006-04-07

Applicant: Yijuang Chern ,  Yun-Lian Lin ,  Nai-Kuei Huang

Inventor： Yijuang Chern ,  Yun-Lian Lin ,  Nai-Kuei Huang

IPC: A01N65/00

CPC classification number: A61K36/8988 ,  A61K31/421 ,  A61K31/426 ,  A61K31/454 ,  A61K31/496 ,  A61K31/497 ,  A61K31/498 ,  A61K31/517 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/70

Abstract: This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.

Abstract translation: 本文件描述了与天麻属相关的化合物，提取物和药物组合物，以及治疗具有代谢紊乱或医学病症如亨廷顿病，三核苷酸重复疾病或异常血糖水平的受试者的方法。

公开(公告)号：US07348471B2

公开(公告)日：2008-03-25

申请号：US10819371

申请日：2004-04-05

Applicant: Su-May Yu ,  Chwan-Yang Hong

Inventor： Su-May Yu ,  Chwan-Yang Hong

IPC: A01H1/00 ,  C07H21/04 ,  C12N15/00

CPC classification number: C12N15/8234 ,  C12N15/8257

Abstract: A nucleic acid containing a glutelin gene promoter. Disclosed are transformed plant cells and transgenic plants containing a nucleic acid that includes the promoter operably linked to a sequence encoding heterologous protein. Also disclosed are methods of making the transformed plant cells and transgenic plants and methods for expressing a polypeptide.

Abstract translation: 含有谷蛋白基因启动子的核酸。 公开了转化的植物细胞和含有核酸的转基因植物，所述核酸包括可操作地连接到编码异源蛋白质的序列的启动子。 还公开了制备转化的植物细胞和转基因植物的方法以及用于表达多肽的方法。

公开(公告)号：US20080063664A1

公开(公告)日：2008-03-13

申请号：US11515843

申请日：2006-09-05

Applicant: Pei-Wen Hsiao ,  Ning-Sun Yang ,  Chang-Jen Huang ,  En-Hau Lin

Inventor： Pei-Wen Hsiao ,  Ning-Sun Yang ,  Chang-Jen Huang ,  En-Hau Lin

IPC: A61K39/215 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The present invention provides a method utilizing mammalian expression system for generating virus-like particles (VLPs) of mammalian-hosted viruses, particularly SARS-CoV. The method of the present invention involves expression of viral structural proteins in Vero cells and thereby obtaining recombinant VLPs in the culture medium. SARS-VLPs generated by the method of the present invention are highly immunogenic and can elicit not only humoral but also cellular immune responses in a mammal.

Abstract translation: 本发明提供了利用哺乳动物表达系统产生哺乳动物宿主病毒特别是SARS-CoV的病毒样颗粒（VLPs）的方法。 本发明的方法涉及在Vero细胞中表达病毒结构蛋白，从而在培养基中获得重组VLP。 通过本发明的方法产生的SARS-VLP是高度免疫原性的，并且不仅可引起哺乳动物的体液，而且可引发细胞免疫应答。

公开(公告)号：US07320791B2

公开(公告)日：2008-01-22

申请号：US10620091

申请日：2003-07-15

Applicant: Steve Roffler ,  Tian-Lu Cheng ,  Pin-Yi Wu

Inventor： Steve Roffler ,  Tian-Lu Cheng ,  Pin-Yi Wu

IPC: A61K39/00

CPC classification number: G01N33/5308 ,  A61K2039/505 ,  C07K16/44 ,  G01N2430/60

Abstract: A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the clearance of a polyethylene glycol containing compound from the blood circulation in the human body thereby reducing the toxicity associated with the polyethylene glycol containing conjugate. The antibody is particularly useful in cancer therapy where the therapeutic agent is selectively delivered to the tumor by increasing the tumor/blood ratio of the polyethylene glycol containing compound.

Abstract translation: 公开了一种新的抗聚乙二醇单克隆抗体及其制备方法。 这样的抗体可以用于体外测定聚乙二醇浓度，或加速来自人体血液循环的含聚乙二醇的化合物的清除，从而降低与含聚乙二醇的缀合物相关的毒性。 抗体特别可用于癌症治疗，其中治疗剂通过增加含聚乙二醇的化合物的肿瘤/血液比选择性递送至肿瘤。

公开(公告)号：US20070298426A1

公开(公告)日：2007-12-27

申请号：US11757860

申请日：2007-06-04

Applicant: Yuan-Tsong Chen ,  Chih-Lung Shen ,  Chi-Feng Chang ,  Ming Ta Lee ,  Jen-Chi Hsu ,  Liang-Suei Lu ,  Ming-Shen Wen

Inventor： Yuan-Tsong Chen ,  Chih-Lung Shen ,  Chi-Feng Chang ,  Ming Ta Lee ,  Jen-Chi Hsu ,  Liang-Suei Lu ,  Ming-Shen Wen

IPC: C12Q1/68 ,  A61K31/366

CPC classification number: C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

Abstract: This invention relates to predicting a patient's warfarin dose based on the nucleotide at position −1639 of the VKORC1 gene and the genotype of the CYP2C9 gene in that patient. The warfarin dose so predicted can be further adjusted according to the patient's non-genetic factors, e.g., age, body surface area, medical conditions, and use or non-use of certain drugs.

Abstract translation: 本发明涉及基于VKORC1基因位置-1639处的核苷酸和该患者中CYP2C9基因的基因型来预测患者的华法林剂量。 如此预测的华法林剂量可以根据患者的非遗传因素进一步调整，例如年龄，体表面积，医疗条件以及某些药物的使用或不使用。

公开(公告)号：US07291768B2

公开(公告)日：2007-11-06

申请号：US10630636

申请日：2003-07-30

Applicant: Su-May Yu

Inventor： Su-May Yu

IPC: C12N15/29 ,  C12N15/82 ,  C12N15/87 ,  A01H5/00

CPC classification number: C12N15/8217 ,  C07K14/415

Abstract: A pure polypeptide containing an amino acid sequence at least 70% identical to SEQ ID NO:7, 8, or 9. The polypeptide regulates expression of a gene in a cell. Also disclosed is an isolated nucleic acid characterized in that it hybridizes under stringent conditions to SEQ ID NO:1, 2, or 3, or a complementary sequence thereof. Also within the scope of the invention are a transformed cell or a transgenic plant containing such a nucleic acid and a method of identifying a compound that modulates the activity of the polypeptide.

Abstract translation: 含有与SEQ ID NO：7,8或9至少70％相同的氨基酸序列的纯多肽。该多肽调节基因在细胞中的表达。 还公开了分离的核酸，其特征在于其在严格条件下与SEQ ID NO：1,2或3或其互补序列杂交。 也在本发明的范围内的是含有这种核酸的转化细胞或转基因植物以及鉴定调节多肽活性的化合物的方法。