公开(公告)号：US20230227688A1

公开(公告)日：2023-07-20

申请号：US18114947

申请日：2023-02-27

Applicant: Agency for Science, Technology and Research

Inventor： Xu Li ,  Yu Zhang ,  Ming Yan Tan ,  Siew Yee Wong ,  Xi Kui Zhang

IPC: C09D133/14 ,  C08F2/18 ,  C08F292/00 ,  C08F2/44 ,  C08K3/34 ,  C08K9/04 ,  C08K5/5425 ,  C08F220/18 ,  C08K5/14

CPC classification number: C09D133/14 ,  C08F2/18 ,  C08F292/00 ,  C08F2/44 ,  C08K3/346 ,  C08K9/04 ,  C08K5/5425 ,  C08F220/1808 ,  C08K5/14 ,  C08F220/1806

Abstract: A method of synthesizing a polymeric clay composition for coating. A clay-polyacrylate composite is produced, where the clay-polyacrylate composite includes one or more layers of clay intercalated with polyacrylate, where the one or more layers of clay include at least one organosilane coupling agent including an acrylate moiety, where the at least one organosilane coupling agent is attached to a surface of the one or more layers of clay and the polyacrylate is covalently attached to the organosilane coupling agent, and where the polyacrylate consists of a first acrylate monomer and a second acrylate monomer having different solubility, where the first acrylate monomer is a hydrophilic acrylate monomer including a hydroxyl (—OH) group and the second acrylate monomer is a hydrophobic acrylate monomer which repels water. Furthermore, the clay-polyacrylate composite is mixed with a solution including a polymer to form the polymeric clay composition.

公开(公告)号：US11702425B2

公开(公告)日：2023-07-18

申请号：US17265175

申请日：2019-07-23

Applicant: Agency for Science, Technology and Research

Inventor： Vikrant Arun Adsool

IPC: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

CPC classification number: C07D491/08 ,  C07D215/233 ,  C07D401/12 ,  C07D451/06 ,  C07D451/14

Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.

公开(公告)号：US11690380B2

公开(公告)日：2023-07-04

申请号：US16686111

申请日：2019-11-16

Applicant: International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Willy Chin ,  James L. Hedrick ,  Nor Lizawati Ibrahim ,  Ashlynn L. Z. Lee ,  Robert J. Ono ,  Qingxing Xu ,  Yi Yan Yang

IPC: A01N47/44 ,  C08G64/42 ,  C08G18/38 ,  C08G64/02 ,  C08G18/48 ,  C08G18/66 ,  C08G18/73 ,  C08G18/75 ,  C08G64/30

CPC classification number: A01N47/44 ,  C08G18/3819 ,  C08G18/3831 ,  C08G18/4833 ,  C08G18/6681 ,  C08G18/73 ,  C08G18/755 ,  C08G64/0241 ,  C08G64/30 ,  C08G64/42 ,  A01N47/44 ,  A01N25/10

Abstract: Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.

公开(公告)号：US20230201345A1

公开(公告)日：2023-06-29

申请号：US18058699

申请日：2022-11-23

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-I Wang ,  Hsueh Ling Janice Oh ,  Siok Ping Yeo

IPC: A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  C07K14/705 ,  G01N33/53 ,  G01N33/574

CPC classification number: A61K39/3955 ,  C07K16/2827 ,  A61K39/395 ,  A61K45/06 ,  C07K14/70532 ,  G01N33/53 ,  G01N33/57484 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/21 ,  A61K2039/505

Abstract: Anti-PD-L1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.

公开(公告)号：US20230184762A1

公开(公告)日：2023-06-15

申请号：US17596950

申请日：2020-06-26

Applicant: Agency for Science, Technology and Research

Inventor： Florent Ginhoux ,  Charles Antoine Dutertre

IPC: G01N33/569

CPC classification number: G01N33/56972 ,  G01N2333/70596 ,  G01N2800/7095

Abstract: There is provided a method of identifying pro-inflammatory dendritic cells, the method comprising: determining an expression of CD5, CD14 and/or CD163 in cells, wherein CD5−, CD14+ and/or GD163+ cells are identified as pro-inflammatory dendritic cells. Also disclosed is a method of characterising inflammation and/or inflammatory disease in a subject, the method comprising: determining a proportion of CD5−, CD14+ and/or GD163+ dendritic cells in the subject's sample, wherein the proportion positively correlates with the level of inflammation and/or the severity of inflammatory disease in the subject.

公开(公告)号：US20230181782A1

公开(公告)日：2023-06-15

申请号：US17925914

申请日：2021-04-15

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  OTSAW DIGITAL PTE. LTD.

Inventor： Ting Ming LING ,  Thanh Quang TRAN ,  Ronnie Jin Wah TEO

IPC: A61L2/24 ,  A61L2/10

CPC classification number: A61L2/24 ,  A61L2/10 ,  A61L2202/11 ,  A61L2202/16 ,  A61L2202/14

Abstract: Disclosed is an apparatus for disinfection comprising a cylindrical housing; a plurality of ultra-violet light emitting diode (UV-LED) modules disposed on the circumference of the cylindrical housing, each UV-LED module comprising a heat sink; and a heat dissipation module disposed along the central axis of the cylindrical housing, the heat dissipation module arranged in thermal contact with the heat sink of each of the plurality of UV-LED modules; wherein each of the plurality of UV-LED modules is pivotably mounted onto the circumference.

公开(公告)号：US11670078B2

公开(公告)日：2023-06-06

申请号：US17598800

申请日：2020-03-27

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Wei Xiong ,  Wenyu Chen ,  Jierong Cheng ,  Jia Du

IPC: G06V20/00 ,  G06T7/277 ,  G06F18/20 ,  G06V10/44 ,  G06V10/32

CPC classification number: G06V20/00 ,  G06F18/295 ,  G06T7/277 ,  G06V10/32 ,  G06V10/457 ,  G06T2207/10016

Abstract: This disclosure relates to method and system for visual inspection of rotating components. The method includes representing rotation cycles of a rotating component as spatial features based on video or image frames, ascertaining and/or evolving Hidden Markov Model (HMM) chains for the cycles, ascertaining a count of the rotating component in the frames and/or labelling the frames with ascertained states of the HMM chains.

公开(公告)号：US11629333B2

公开(公告)日：2023-04-18

申请号：US16484427

申请日：2018-02-08

Applicant: Agency for Science, Technology and Research

Inventor： Shu Wang ,  Wei Xia Ang ,  Jieming Zeng

IPC: C12N5/0783 ,  A61P35/00 ,  A61K35/17 ,  C07K14/435 ,  C07K14/725 ,  C07K14/705 ,  C07K16/28 ,  C12N15/85

Abstract: The present invention relates to a method of generating γδ T cells having at least one down-regulated co-inhibitory receptor, the method comprising the steps of: (a) culturing a population of cells comprising γδ T cells with a phosphoantigen to expand the γδ T cells; and (b) culturing the expanded γδ T cells with artificial antigen-presenting cells expressing a Fc receptor, and an anti-CD3 antibody. The present invention also relates to γδ T cells generated according to a method of the present invention, as well as methods of treatment and medical uses thereof.

公开(公告)号：US11623202B2

公开(公告)日：2023-04-11

申请号：US16614191

申请日：2018-05-15

Applicant: Agency for Science, Technology and Research

Inventor： Xu Li ,  Chin Chong Ray Yap ,  Jiating He ,  Siew Yee Wong

IPC: B01J20/20 ,  B01J20/02 ,  B01J20/22 ,  B01J20/28 ,  B01J20/30

Abstract: A method of forming one or more composite structures is provided wherein one or more carbon structures is formed from a carbon source via a hydrothermal process. Said carbon source is a biomass material including glucose and glucosamine hydrochloride. In particular, the method further comprises introducing a seeding additive of potassium or phosphate salt, preferably monopotassium phosphate to the carbon source. The method includes introducing iron onto the carbon structures to form the one or more composite structures including carbon and iron.

公开(公告)号：US11617367B2

公开(公告)日：2023-04-04

申请号：US17215700

申请日：2021-03-29

Applicant: International Business Machines Corporation ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： James L. Hedrick ,  Mareva B. Fevre ,  Nathaniel H. Park ,  Victoria A. Piunova ,  Yi Yan Yang ,  Pang Kern Jeremy Tan

IPC: A01N25/10 ,  A01N37/26 ,  A01N43/50 ,  A01N47/44 ,  C07C279/10 ,  C08L79/02 ,  C08G69/26 ,  C08G73/02 ,  C08L101/00 ,  A61Q17/00

Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.