公开(公告)号：US20210230597A1

公开(公告)日：2021-07-29

申请号：US17227483

申请日：2021-04-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Orna ISSLER

IPC: C12N15/113 ,  C12N15/11 ,  C12Q1/6883

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.

公开(公告)号：US11047855B2

公开(公告)日：2021-06-29

申请号：US15555258

申请日：2016-02-29

Applicant: IMMUNARRAY LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rachel Sorek ,  Keren Jakobi ,  Pennina Safer ,  Anat Reiner-Benaim ,  Irun R. Cohen

IPC: G01N33/564 ,  G01N33/68 ,  G16B40/00

Abstract: Methods and kits for diagnosing or monitoring systemic lupus erythematosus (SLE) in a subject are provided. Particularly, provided is a specific antibody reactivity profile useful in diagnosing or monitoring SLE in a subject.

公开(公告)号：US11035858B2

公开(公告)日：2021-06-15

申请号：US16082296

申请日：2017-03-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yifat Merbl ,  Hila Wolf-Levy ,  Yishai Levin ,  Bareket Dassa

IPC: G01N33/00 ,  G01N33/573 ,  C12Q1/37 ,  G01N33/50

Abstract: A method of isolating barrel-like proteases is disclosed. The method comprising isolating barrel-like proteases from a biological sample containing the barrel-like proteases under conditions that maintain the content of the barrel-like protease-processed peptides in the barrel-like proteases upon isolation. A method of isolating barrel-like protease-processed peptides and a method of identifying barrel-like protease-processed peptides are also disclosed.

公开(公告)号：US11028127B2

公开(公告)日：2021-06-08

申请号：US16704010

申请日：2019-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Moshe Oren ,  Varda Rotter ,  Perry Tal

IPC: C07K14/00 ,  C07K14/47 ,  C07K7/06 ,  A61K38/16 ,  A61K38/08 ,  C07K7/08 ,  A61K38/00

Abstract: The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.

公开(公告)号：US20210115092A1

公开(公告)日：2021-04-22

申请号：US17254932

申请日：2019-06-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef SHAUL ,  Nina REUVEN

IPC: C07K14/005 ,  C12N9/22 ,  C12N7/00 ,  C12N15/11 ,  A61K38/46 ,  A61K31/7088 ,  C12N15/90

Abstract: A recombinant system for improving genome editing via homologous recombination is disclosed. The system comprising a first nucleic acid sequence encoding a DNA editing agent having a double strand DNA cutting activity and a second nucleic acid sequence encoding a polypeptide capable of increasing homologous recombination in a target cell.

公开(公告)号：US20210049883A1

公开(公告)日：2021-02-18

申请号：US16964799

申请日：2019-01-24

Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Ben NASSI ,  Adi SHAMIR ,  Yuval ELOVICI

IPC: G08B13/196 ,  G06F21/83 ,  G06F21/62

Abstract: A system and method for identifying if a drone is illegitimately video streaming a location, object or person. An interceptor intercepts radio transmissions and identifies if a radio transmission is an FPV video transmission. A watermarker is used for emitting a periodic physical stimulus at a given frequency for a given duration. The system then verifies if there is a correlation between the video transmission and the periodic physical stimulus; and issues a privacy invasion attack notification if such a correlation is determined between the video transmission and the periodic physical stimulus.

公开(公告)号：US20200382100A1

公开(公告)日：2020-12-03

申请号：US16473630

申请日：2017-12-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.

Inventor： Reshef TENNE ,  Ernesto JOSELEVICH ,  Yiftach DIVON ,  Roi LEVI ,  Assaf YAAKOBOVITZ ,  Dan YUDILEVICH

IPC: H03H9/24 ,  H03H9/02 ,  B82B1/00

Abstract: This invention provides electromechanical resonators based on metal chalcogenide nanotubes. The invention further provides methods of fabrication of electromechanical resonators and methods of use of such electromechanical resonators.

公开(公告)号：US10849985B2

公开(公告)日：2020-12-01

申请号：US15573550

申请日：2016-05-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Valery Krizhanovsky ,  Yossi Ovadya

IPC: A61K47/68 ,  A61P35/00 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113

Abstract: A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.

公开(公告)号：US20200368322A1

公开(公告)日：2020-11-26

申请号：US16986473

申请日：2020-08-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Benjamin GEIGER ,  Eran ELINAV ,  Inna GROSHEVA

IPC: A61K38/20 ,  A61K38/19 ,  A61K38/18 ,  A61K38/08

Abstract: A method of treating a disease associated with intestinal barrier dysfunction in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which downregulates the amount of glucose in intestinal cells, with the proviso that the disease is not Diabetes or obesity. Other agents for treating diseases associated with intestinal barrier dysfunction are also disclosed.

公开(公告)号：US10829561B2

公开(公告)日：2020-11-10

申请号：US15961928

申请日：2018-04-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18 ,  A61K39/00 ,  A61P35/00

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.