公开(公告)号：US20060034838A1

公开(公告)日：2006-02-16

申请号：US11250411

申请日：2005-10-17

申请人： Kenya Shitara ,  Mikito Ito ,  Nobuo Hanai ,  Yoko Kawada ,  Kazuyasu Nakamura ,  Masabumi Shibuya

发明人： Kenya Shitara ,  Mikito Ito ,  Nobuo Hanai ,  Yoko Kawada ,  Kazuyasu Nakamura ,  Masabumi Shibuya

IPC分类号： A61K39/395

CPC分类号： G01N33/57407 ,  A61K38/00 ,  C07K16/2803 ,  C07K16/2863 ,  C07K2317/24 ,  C12N2799/026 ,  G01N33/6863 ,  G01N33/6893 ,  G01N33/74

摘要： The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1. It also provides a means for the diagnosis or treatment of diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.

公开(公告)号：US20060029663A1

公开(公告)日：2006-02-09

申请号：US10515204

申请日：2004-07-16

申请人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Tsuneaki Tottori

发明人： Akihiro Uchida ,  Yasuhiro Ishikawa ,  Yasuhiko Ueno ,  Kiichiro Kaji ,  Tsuneaki Tottori

IPC分类号： A61K31/522 ,  A61K9/20

CPC分类号： A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/522 ,  C07D473/04

摘要： (wherein R1, R2 and R3 may be the same or different and each represents a hydrogen atom, lower alkyl, lower alkenyl or lower alkynyl; and R4 represents cycloalkyl, —(CH2)n—R5 or the above formula (II)) The present invention provides a solid formulation comprising a xanthine derivative represented by the above formula (I) or a pharmaceutically acceptable salt thereof, and microcrystalline cellulose, which possesses excellent pharmaceutical properties, for example, in hardness, disintegration property, dissolution property, stability or the like.

摘要翻译： （其中R 1，R 2和R 3）可以相同或不同，并且各自表示氢原子，低级烷基，低级烯基或 低级炔基; R 4表示环烷基， - （CH 2）n - R 5 - 或上式 （II））本发明提供包含由上述式（I）表示的黄嘌呤衍生物或其药学上可接受的盐和微晶纤维素的固体制剂，其具有优异的药物性质，例如硬度，崩解性，溶解性 财产，稳定性等。

公开(公告)号：US06986890B1

公开(公告)日：2006-01-17

申请号：US09453718

申请日：1999-12-03

申请人： Kenya Shitara ,  Mikito Ito ,  Nobuo Hanai ,  Yoko Kawada ,  Kazuyasu Nakamura ,  Masabumi Shibuya

发明人： Kenya Shitara ,  Mikito Ito ,  Nobuo Hanai ,  Yoko Kawada ,  Kazuyasu Nakamura ,  Masabumi Shibuya

IPC分类号： A61K39/395

CPC分类号： G01N33/57407 ,  A61K38/00 ,  C07K16/2803 ,  C07K16/2863 ,  C07K2317/24 ,  C12N2799/026 ,  G01N33/6863 ,  G01N33/6893 ,  G01N33/74

摘要： The present invention provides an antibody or peptide which immunologically reacts with human VEGF receptor Flt-1 and cells in which human VEGF receptor Flt-1 is expressed on the cell surface and an antibody or peptide which inhibits binding of human VEGF to human VEGF receptor Flt-1. It also provides a means for the diagnosis or treatment of diseases in which their morbid states progress by abnormal angiogenesis, such as proliferation or metastasis of solid tumors, arthritis in rheumatoid arthritis, diabetic retinopathy, retinopathy of prematurity, psoriasis, and the like.

公开(公告)号：US06982266B2

公开(公告)日：2006-01-03

申请号：US10344736

申请日：2001-08-17

申请人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

发明人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

IPC分类号： A01K31/675 ,  A01K31/517 ,  C07D43/02 ,  C07D239/72

CPC分类号： C07D239/94 ,  A61K31/517 ,  C07D401/12 ,  C07D403/12

摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及用于预防或治疗细胞增殖性疾病如动脉硬化的方法 ，血管重构，癌症和肾小球硬化症。

公开(公告)号：US20050287138A1

公开(公告)日：2005-12-29

申请号：US10959310

申请日：2004-10-07

申请人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

发明人： Shigeru Iida ,  Mitsuo Satoh ,  Miho Urakubo ,  Masako Wakitani ,  Kazuhisa Uchida ,  Rinpei Niwa ,  Kenya Shitara

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2866 ,  C07K2317/41 ,  C07K2317/732

摘要： The present invention provides an antibody composition comprising an antibody molecule which specifically binds to human CC chemokine receptor 4 (CCR4) and has complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chains; a transformant which produces the antibody composition; a process for producing the antibody composition; and a pharmaceutical composition comprising the antibody composition.

摘要翻译： 本发明提供一种抗体组合物，其包含特异性结合人类CC趋化因子受体4（CCR4）的抗体分子，并且在Fc区具有复合型N-糖苷连接的糖链，其中复合型N-糖苷连接的糖链 在糖链的还原端具有岩藻糖不与N-乙酰葡糖胺结合的结构; 产生抗体组成的转化体; 制备抗体组合物的方法; 和包含该抗体组合物的药物组合物。

公开(公告)号：US06974597B2

公开(公告)日：2005-12-13

申请号：US09890217

申请日：2000-11-29

申请人： Shigenori Ohta ,  Chiaki Saitoh ,  Hiroaki Iwasaki ,  Aki Morita

发明人： Shigenori Ohta ,  Chiaki Saitoh ,  Hiroaki Iwasaki ,  Aki Morita

IPC分类号： A23L27/00 ,  A23L23/00 ,  A23L27/21 ,  A23L27/40 ,  A23L27/50 ,  A23L2/00 ,  A23L1/237 ,  A22L1/227

CPC分类号： A23L23/00 ,  A23L27/21 ,  A23L27/40 ,  A23L27/50

摘要： The present invention relates to a method of enhancing the salty taste of a food or beverage containing salt which comprises adding an acidic peptide or a peptide obtained by subjecting a protein to hydrolysis and deamidation to the food or beverage, a salty taste enhancer comprising the peptide as an active ingredient, a salty taste seasoning agent comprising the peptide and salt, and a food or beverage comprising the salty taste enhancer or the salty taste seasoning agent.

摘要翻译： 本发明涉及一种增加含有食品或饮料的咸味的方法，该方法包括加入通过使蛋白质对食品或饮料进行水解和脱酰胺而获得的酸性肽或肽，包含该肽的咸味增强剂 作为活性成分，包含肽和盐的咸味调味剂和包含咸味增强剂或咸味调味剂的食品或饮料。

公开(公告)号：US06965024B2

公开(公告)日：2005-11-15

申请号：US10265713

申请日：2002-10-08

申请人： Kenya Shitara ,  Nobuo Hanai ,  Mamoru Hasegawa ,  Hiromasa Miyaji ,  Yoshihisa Kuwana

发明人： Kenya Shitara ,  Nobuo Hanai ,  Mamoru Hasegawa ,  Hiromasa Miyaji ,  Yoshihisa Kuwana

IPC分类号： A61K36/00 ,  A61K38/00 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/30 ,  C07K16/32 ,  C07K16/46 ,  C07K19/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12N15/13 ,  C12N15/62 ,  C12P21/08 ,  C12R1/91 ,  C07H21/04

CPC分类号： C07K16/3084 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/462 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/02

摘要： A humanized chimera antibody, a pharmaceutical composition comprising a humanized chimera antibody and a pharmaceutically acceptable carrier, and a method of treating cancer which comprises administering to a patient a pharmaceutically acceptable amount of said humanized chimera antibody, are disclosed.

摘要翻译： 人源化嵌合体抗体，包含人源化嵌合体抗体和药学上可接受的载体的药物组合物，以及治疗癌症的方法，其包括向患者施用药学上可接受量的所述人源化嵌合体抗体。

公开(公告)号：US06956039B2

公开(公告)日：2005-10-18

申请号：US10344737

申请日：2001-08-17

申请人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

发明人： Anjali Pandey ,  Robert M. Scarborough ,  Kenji Matsuno ,  Michio Ichimura ,  Yuji Nomoto ,  Shinichi Ide ,  Eiji Tsukuda ,  Junko Sasaki ,  Shoji Oda

IPC分类号： A61P35/00 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D487/00

CPC分类号： C07D401/12 ,  C07D239/94 ,  C07D403/12

摘要： The present invention relates to nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also related to a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases. In a particular aspect the present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of a PDGF receptor to hinder abnormal cell growth and cell wandering, and a method for preventing or treating cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

摘要翻译： 本发明涉及对抑制这种激酶活性的激酶磷酸化具有抑制活性的含氮杂环化合物及其药学上可接受的盐。 本发明还涉及通过抑制激酶的磷酸化来抑制哺乳动物的激酶和治疗疾病状态的方法。 在一个特定方面，本发明提供了抑制PDGF受体的磷酸化以阻止异常细胞生长和细胞游动的含氮杂环化合物及其药学上可接受的盐，以及预防或治疗细胞增殖性疾病如动脉硬化，血管 重建，癌症和肾小球硬化症。

公开(公告)号：US06953785B2

公开(公告)日：2005-10-11

申请号：US10258454

申请日：2001-04-24

申请人： Yoji Ino ,  Nobuyoshi Amishiro ,  Mayumi Miyata ,  Tsutomu Agatsuma ,  Kozue Muramatsu ,  Takeshi Takahashi ,  Shiro Akinaga ,  Chikara Murakata

发明人： Yoji Ino ,  Nobuyoshi Amishiro ,  Mayumi Miyata ,  Tsutomu Agatsuma ,  Kozue Muramatsu ,  Takeshi Takahashi ,  Shiro Akinaga ,  Chikara Murakata

IPC分类号： A61P5/24 ,  A61P5/32 ,  A61P13/08 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07J41/00 ,  C07J43/00 ,  A61K31/56 ,  A61K31/58 ,  C07J3/00 ,  C07J17/00

CPC分类号： C07J43/00 ,  C07J41/00

摘要： Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I): {wherein R1 and R2 are the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; R3 represents a hydrogen atom etc.; R4 represents a hydrogen atom etc.; R5 represents a hydrogen atom etc.; R6 represents a cyano group, an amino group, COR53 (wherein R53 represents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.

摘要翻译： 提供了类固醇硫酸酯酶抑制剂，其包含作为活性成分的由式（I）表示的雌-1,3,5（10） - 三烯衍生物：其中R 1和R 2 > 2相同或不同，表示氢原子，低级烷基等。 R 3表示氢原子等; R 4表示氢原子等; R 5表示氢原子等; R 6表示氰基，氨基，COR 53（其中R 53表示取代的低级烷基等），取代的 或未取代的芳基，取代或未取代的杂环基等）或其药学上可接受的盐。

公开(公告)号：US20050216958A1

公开(公告)日：2005-09-29

申请号：US11127173

申请日：2005-05-12

申请人： Naoko Yamane ,  Mitsuo Satoh ,  Katsuhiro Mori ,  Kazuya Yamano

发明人： Naoko Yamane ,  Mitsuo Satoh ,  Katsuhiro Mori ,  Kazuya Yamano

IPC分类号： A61P9/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  C07K16/28 ,  C07K16/30 ,  C12N9/10 ,  C12P21/08 ,  A01K67/027 ,  A01H1/00 ,  C12N5/04 ,  C12N5/06 ,  C12N15/82

CPC分类号： C07K16/3084 ,  A01K2217/075 ,  C07K16/2866 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/732 ,  C12N9/1051 ,  C12N2510/00 ,  C12Y204/01068

摘要： A cell in which genome is modified so as to have a more decreased or deleted activity of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain than its parent cell, and a process for producing an antibody composition using the cell.

摘要翻译： 其中基因组被修饰以具有与糖链修饰相关的酶的更多减少或缺失的活性的细胞，其中岩藻糖的1位通过α通过还原末端结合到N-乙酰氨基葡萄糖的6-位上 在其复合N-糖苷连接的糖链中比其亲本细胞，以及使用该细胞产生抗体组合物的方法。