公开(公告)号：US10238668B2

公开(公告)日：2019-03-26

申请号：US15207694

申请日：2016-07-12

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Carlos Ramon Plata Salaman ,  Nicolas Tesson

IPC: A61K31/135 ,  A61K31/635 ,  C07C217/24 ,  C07D231/12 ,  A61K31/192 ,  C07C59/64 ,  C07C217/74 ,  A61K45/06

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

公开(公告)号：US09952218B2

公开(公告)日：2018-04-24

申请号：US14426235

申请日：2013-09-06

Applicant: LABORATORIOS DEL DR. ESTEVE S.A. ,  FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA

Inventor： Julián Miguel Blanco Arbués ,  Jorge Carrillo Molina

IPC: G01N33/577 ,  C07K14/005 ,  G01N33/569 ,  C07K16/10 ,  C12N7/00

CPC classification number: G01N33/56988 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30 ,  C12N7/00 ,  C12N2740/16122 ,  G01N2333/162

Abstract: The present invention relates to an in vitro method for determining HIV neutralizing antibodies in a sample. It further relates to a fusion protein to be used in said method and a nucleic acid encoding said fusion protein.

公开(公告)号：US09902711B2

公开(公告)日：2018-02-27

申请号：US15106398

申请日：2014-12-19

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Félix Cuevas-Cordobés ,  Carmen Almansa-Rosales ,  Monica Garcia Lopez ,  Eva Maria Ayet Galcera ,  Maria Teresa Serafini Cabanes

IPC: C07D401/06 ,  C07D401/14

CPC classification number: C07D401/06 ,  C07D401/14

Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

公开(公告)号：US09611229B2

公开(公告)日：2017-04-04

申请号：US14759280

申请日：2014-01-07

Applicant: LABORATORIOS DEL DR. ESTEVE S.A.

Inventor： Antoni Torrens-Jover ,  Ute Christmann ,  Josè-Luis Diaz-Fernández ,  Carmen Almansa-Rosales

IPC: C07D249/04 ,  C07D249/06 ,  C07D295/185 ,  C07F7/10 ,  C07D401/12

CPC classification number: C07D249/04 ,  C07D249/06 ,  C07D295/185 ,  C07D401/12 ,  C07F7/10

Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.

公开(公告)号：US09279132B2

公开(公告)日：2016-03-08

申请号：US14531200

申请日：2014-11-03

Applicant: LABORATORIOS DEL DR. ESTEVE, S. A. ,  UNIVERSIDAD AUTONOMA DE BARCELONA

Inventor： Fátima Bosch Tubert ,  Éduard Ayuso López ,  Albert Ruzo Matías

IPC: C12N15/52 ,  C12N15/86 ,  C12N9/14 ,  A61K48/00 ,  C12N15/864

CPC classification number: C12N15/86 ,  A61K48/00 ,  A61K48/0066 ,  C12N9/14 ,  C12N15/52 ,  C12N15/8645 ,  C12N2750/14143 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2840/105

Abstract: The present invention provides new sequences, gene constructions, vectors and pharmaceutical compositions for the treatment of diseases and specially, for the treatment of mucopolysaccharidoses.

公开(公告)号：US09012440B2

公开(公告)日：2015-04-21

申请号：US14066127

申请日：2013-10-29

Applicant: Laboratorios del Dr. Esteve, S.A.

Inventor： Carlos Ramon Plata Salaman ,  Nicolas Tesson

IPC: A01N43/00 ,  A61K31/33 ,  A01N33/00 ,  A61K31/13 ,  A61K31/16 ,  A61K31/192 ,  A61K31/135 ,  C07C59/64 ,  C07C217/74 ,  A61K31/137 ,  A61K31/635

CPC classification number: A61K31/635 ,  A61K9/16 ,  A61K31/135 ,  A61K31/137 ,  A61K31/192 ,  A61K45/06 ,  C07B2200/13 ,  C07C59/64 ,  C07C217/74 ,  C07C2601/14 ,  C07D231/12 ,  A61K2300/00

Abstract: The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.

Abstract translation: 本发明涉及选自NSAIDs / coxibs的曲马多和共晶体形成剂的共晶体，其制备方法及其作为药物的用途或药物制剂，特别是用于治疗疼痛。

公开(公告)号：US08877753B2

公开(公告)日：2014-11-04

申请号：US12988951

申请日：2009-04-24

Applicant: Helmut Heinrich Buschmann ,  Jose Miguel Vela Hernandez ,  Daniel Zamanillo-Castanedo

Inventor： Helmut Heinrich Buschmann ,  Jose Miguel Vela Hernandez ,  Daniel Zamanillo-Castanedo

IPC: A61K31/4152 ,  A61K31/4155 ,  A61K31/485 ,  A61K31/5377 ,  A61P25/36 ,  C07D231/22 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K45/06

CPC classification number: C07D231/22 ,  A61K31/4152 ,  A61K31/4155 ,  A61K31/485 ,  A61K31/5377 ,  A61K45/06 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04 ,  A61K2300/00

Abstract: The invention relates to the use of a group of sigma receptor ligands of formula (I) for the potentiation of the analgesic effect of opioids and opiates and at the same time for decreasing the dependency induced by them.

Abstract translation: 本发明涉及一组式（I）的σ受体配体用于增强阿片样物质和阿片剂的镇痛作用，同时降低它们引起的依赖性。

公开(公告)号：US20140024622A1

公开(公告)日：2014-01-23

申请号：US14036828

申请日：2013-09-25

Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.

Inventor： Enrique PORTILLO SALIDO ,  Sebastia VIDELA CES

IPC: A61K31/635 ,  A61K31/137

CPC classification number: A61K31/635 ,  A61K31/135 ,  A61K31/137 ,  A61K31/415 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.

Abstract translation: 本发明涉及包含曲马多和塞来昔布的药物组合物及其作为药物或止痛剂的用途，更具体地涉及用炎症组分治疗严重至中度疼痛。

公开(公告)号：US20130324535A1

公开(公告)日：2013-12-05

申请号：US13991282

申请日：2011-12-02

Applicant: Daniel Zamanillo-Castanedo ,  José Miguel Vela-Hernández ,  Carlos Plata-Salaman

Inventor： Daniel Zamanillo-Castanedo ,  José Miguel Vela-Hernández ,  Carlos Plata-Salaman

IPC: C07D231/22 ,  A61K31/5377 ,  A61K31/485

Abstract: The invention refers to the use of a sigma ligand, particularly a sigma ligand of formula (I) to prevent and/or treat pain associated to bone cancer.

Abstract translation: 本发明涉及使用Sigma配体，特别是式（I）的Sigma配体来预防和/或治疗与骨癌相关的疼痛。

公开(公告)号：US08470867B2

公开(公告)日：2013-06-25

申请号：US12703112

申请日：2010-02-09

Applicant: Christian Laggner ,  María Rosa Cuberes-Altisent ,  Joerg Holenz ,  Juana María Berrocal-Romero ,  Maria Montserrat Contijoch-Llobet

Inventor： Christian Laggner ,  María Rosa Cuberes-Altisent ,  Joerg Holenz ,  Juana María Berrocal-Romero ,  Maria Montserrat Contijoch-Llobet

IPC: C07D231/22

CPC classification number: C07D471/04 ,  C07D231/22 ,  C07D401/12 ,  C07D403/12

Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.

Abstract translation: 本发明涉及具有对σ受体的药理学活性的式（I）化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/或预防其中σ受体 参与。