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135 条记录 (耗时 0.079 秒)

    Polymorphic form of a [1,2,4]triazole[4,3-A] pyridine derivative inflammatory diseases
    45.
    发明授权
    Polymorphic form of a [1,2,4]triazole[4,3-A] pyridine derivative inflammatory diseases 有权
    [1,2,4]三唑[4,3-A]吡啶衍生物炎症性疾病的多形态

    公开(公告)号：US08222273B2

    公开(公告)日：2012-07-17

    申请号：US12865889

    申请日：2009-01-28

    申请人： Kenneth John Butcher

    发明人： Kenneth John Butcher

    IPC分类号： A61K31/437 ,  C07D471/07

    CPC分类号： C07D471/04

    摘要： The present invention relates to a polymorphic form B of Λ/-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-N-{2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea (I) as de-fined herein. This polymorph is useful in the treatment of various conditions, particularly in the treatment of inflammatory conditions such as chronic obstructive pulmonary disease.

    摘要翻译： 本发明涉及Λ/ - [3-叔丁基-1-（3-氯-4-羟基苯基）-1H-吡唑-5-基] -N- {2 - [（3- 苯基} [1,2,4]三唑并[4,3-a]吡啶-6-基）硫烷基]苄基}脲（I）。 该多晶型物可用于治疗各种病症，特别是治疗炎症性疾病如慢性阻塞性肺疾病。

    Method and apparatus for filling a container
    46.
    发明授权
    Method and apparatus for filling a container 有权
    填充容器的方法和装置

    公开(公告)号：US08201590B2

    公开(公告)日：2012-06-19

    申请号：US10581668

    申请日：2004-08-04

    申请人： Peter John Houzego

    发明人： Peter John Houzego

    IPC分类号： B65B1/14

    CPC分类号： B65B1/08 ,  B65B1/22

    摘要： A method and apparatus for filling with powder (4) a container (8) having an open end, including positioning an outlet of a hopper (2) containing powder above the open end of the container (8), mechanically agitating the hopper so as to cause powder (4) to be transferred from the hopper to the container and mechanically agitating the container, wherein the steps of mechanically agitating are conducted by at least a predetermined amount sufficient to ensure that the container is filled with powder at a predetermined density.

    摘要翻译： 一种用于填充粉末的方法和装置（4）具有开口端的容器（8），包括将容纳器（8）的开口端上方含有粉末的料斗（2）的出口定位，机械搅拌料斗，以便 使粉末（4）从料斗转移到容器中并机械搅拌容器，其中机械搅拌的步骤至少以足以确保容器以预定密度填充粉末的预定量进行。

    Antibody Purification Process By Precipitation
    48.
    发明申请
    Antibody Purification Process By Precipitation 审中-公开
    抗体纯化过程通过沉淀

    公开(公告)号：US20100204455A1

    公开(公告)日：2010-08-12

    申请号：US12670733

    申请日：2008-07-18

    申请人： David Paul Gervais ,  Katherine Anne Pfeiffer

    发明人： David Paul Gervais ,  Katherine Anne Pfeiffer

    IPC分类号： C07K16/18 ,  C07K16/00

    CPC分类号： C07K1/30 ,  C07K16/00

    摘要： The present invention relates to a method of purification of antibodies. An object of the present invention is to provide a method for the isolation of antibodies from a solution containing one or more antibodies, comprising the steps of precipitating the antibody and washing the solid precipitate with washing buffer. Preferably, the antibody is precipitated by using a PEG solution or sodium phosphate.

    摘要翻译： 本发明涉及一种纯化抗体的方法。 本发明的目的是提供一种从含有一种或多种抗体的溶液中分离抗体的方法，其包括沉淀抗体并用洗涤缓冲液洗涤固体沉淀物的步骤。 优选地，通过使用PEG溶液或磷酸钠沉淀抗体。

    Purine derivatives
    49.
    发明授权
    Purine derivatives 失效
    嘌呤衍生物

    公开(公告)号：US07642350B2

    公开(公告)日：2010-01-05

    申请号：US11417982

    申请日：2006-05-03

    申请人： David Pryde

    发明人： David Pryde

    IPC分类号： C07D473/34 ,  A61K31/522 ,  A61P31/20 ,  A61P31/14

    CPC分类号： C07D473/34 ,  C07D519/00

    摘要： This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use.The present invention provides compounds of formula (I) wherein R1, R2, R3, R9, R9a and Y are defined in the description. More particularly, the present invention relates to the use of purine derivatives in the treatment of a variety of viral infections and immune or inflammatory disorders, including those in which the modulation, in particular agonism, of Toll-Like Receptors (TLRs) is implicated. Accordingly, the compounds of the invention are useful in the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infections, inflammatory diseases such as asthma and arthritis, and cancer.

    摘要翻译： 本发明涉及嘌呤衍生物，其制备方法，含有它们的组合物及其用途。 本发明提供式（I）化合物，其中R1，R2，R3，R9，R9a和Y在说明书中定义。 更具体地说，本发明涉及嘌呤衍生物在治疗各种病毒感染和免疫或炎性疾病中的用途，包括涉及Toll样受体（TLR）的调节特别是激动作用的那些。 因此，本发明的化合物可用于治疗感染性疾病如肝炎（例如HCV，HBV），遗传相关病毒感染，炎性疾病如哮喘和关节炎以及癌症。