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公开(公告)号:US20130109701A1
公开(公告)日:2013-05-02
申请号:US13808639
申请日:2011-07-04
IPC分类号: C07C311/04 , C07D231/12 , A61K31/415 , C07D237/08 , A61K31/50 , A61K45/06 , A61K31/451 , A61K31/277 , C07D241/04 , A61K31/495 , C07D271/06 , A61K31/4245 , A61K31/18 , C07D211/22
CPC分类号: C07C311/04 , A61K31/18 , A61K31/277 , A61K31/415 , A61K31/4245 , A61K31/451 , A61K31/495 , A61K31/50 , A61K45/06 , C07C311/51 , C07D211/22 , C07D231/12 , C07D237/08 , C07D241/04 , C07D271/06
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfon-amide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中X,Ar 1,R 1,R 2,R 3,R 4和R 5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US20120010183A1
公开(公告)日:2012-01-12
申请号:US13179587
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
发明人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
IPC分类号: A61K31/44 , C07D401/04 , C07D215/20 , C07D405/12 , C07D231/56 , A61P29/00 , A61K31/506 , A61K31/47 , A61K31/4427 , A61K31/416 , A61K31/4545 , A61K31/4439 , C07D213/69 , C07D401/12
CPC分类号: C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Het1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中Het1,X,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US08592629B2
公开(公告)日:2013-11-26
申请号:US13179587
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
发明人: Andrew Simon Bell , Alan Daniel Brown , Marcel John De Groot , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Nigel Alan Swain , Steven Matthieu Gaulier
IPC分类号: C07C303/00 , A61K31/18
CPC分类号: C07D213/69 , C07D213/63 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/74 , C07D213/85 , C07D215/20 , C07D231/56 , C07D239/47 , C07D401/04 , C07D405/12 , C07D487/04
摘要: This invention relates to sulfonamide derivative of formula (I), to their use in medicine, to compositions containing them, to processes for their preparation, and to intermediates used in such processes. These compounds are inhibitors of Nav1.7.
摘要翻译: 本发明涉及式(I)的磺酰胺衍生物,其在药物中的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 这些化合物是Nav1.7的抑制剂。
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公开(公告)号:US20120010182A1
公开(公告)日:2012-01-12
申请号:US13178534
申请日:2011-07-08
申请人: Alan Daniel Brown , Marcel John De Groot , Brian Edward Marron , David James Rawson , Thomas Ryckmans , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West
发明人: Alan Daniel Brown , Marcel John De Groot , Brian Edward Marron , David James Rawson , Thomas Ryckmans , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Christopher William West
IPC分类号: A61K31/501 , C07D403/12 , A61K31/427 , C07D417/14 , A61P25/00 , A61K31/4439 , A61K31/496 , A61K31/506 , C07D401/14 , C07D417/12 , C07D401/12
CPC分类号: C07D237/20 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12 , C07D417/14 , A61K2300/00
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceutically acceptable salts thereof, wherein Z1, Ra, Rb, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐,其中Z 1,R a,R b,R 1,R 2,R 3,R 4和R 5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US09096500B2
公开(公告)日:2015-08-04
申请号:US13808639
申请日:2011-07-04
IPC分类号: C07C311/04 , A61K31/18 , C07C311/51 , C07D231/12 , A61K31/277 , A61K31/415 , A61K31/4245 , A61K31/451 , A61K31/495 , A61K31/50 , A61K45/06 , C07D211/22 , C07D237/08 , C07D241/04 , C07D271/06
CPC分类号: C07C311/04 , A61K31/18 , A61K31/277 , A61K31/415 , A61K31/4245 , A61K31/451 , A61K31/495 , A61K31/50 , A61K45/06 , C07C311/51 , C07D211/22 , C07D231/12 , C07D237/08 , C07D241/04 , C07D271/06
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein X, Ar1, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中X,Ar1,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US20130116285A1
公开(公告)日:2013-05-09
申请号:US13808658
申请日:2011-07-06
申请人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
发明人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Manuel Perez-Pacheco , David James Rawson , Robert Ian Storer , Nigel Alan Swain
IPC分类号: A61K31/444 , A61K31/4418 , A61K45/06 , A61K31/4164 , C07C311/13 , A61K31/18 , C07D233/64 , C07D213/64 , C07D401/12
CPC分类号: A61K31/444 , A61K31/18 , A61K31/4164 , A61K31/4418 , A61K45/06 , C07C311/13 , C07C311/51 , C07D213/64 , C07D213/65 , C07D213/69 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D401/12
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I):(I) or a pharmaceutically acceptable salt thereof, wherein Z, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式10(I):(I)的新型磺酰胺Nav1.7抑制剂或其药学上可接受的盐,其中Z,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US20120010207A1
公开(公告)日:2012-01-12
申请号:US13179585
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
发明人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
IPC分类号: A61K31/18 , C07D231/12 , C07D233/64 , A61P29/00 , A61K31/415 , A61K31/4164 , A61K31/50 , A61K31/277 , C07C311/51 , C07D237/08
CPC分类号: C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description.Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中Ar1,X,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US08685977B2
公开(公告)日:2014-04-01
申请号:US13179585
申请日:2011-07-11
申请人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
发明人: Andrew Simon Bell , Alan Daniel Brown , Russell Andrew Lewthwaite , Ian Roger Marsh , David Simon Millan , Manuel Perez Pacheco , David James Rawson , Nunzio Sciammetta , Robert Ian Storer , Paul Anthony Stupple , Nigel Alan Swain , Marcel John De Groot
IPC分类号: A01N43/58 , A61K31/50 , A01N43/40 , A61K31/435 , A01N43/56 , A61K31/415 , A01N43/36 , A61K31/40
CPC分类号: C07C311/51 , C07C2601/02 , C07D231/12 , C07D233/60 , C07D237/08
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): or a pharmaceutically acceptable salt thereof, wherein Ar1, X, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医学上的用途,含有它们的组合物,其制备方法以及在这些方法中使用的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:或其药学上可接受的盐,其中Ar1,X,R1,R2,R3,R4和R5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病,特别是疼痛。
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公开(公告)号:US20130109708A1
公开(公告)日:2013-05-02
申请号:US13808653
申请日:2011-07-04
IPC分类号: C07D213/69 , C07D213/30 , C07D213/65 , C07D471/04 , A61K45/06 , A61K31/472 , C07D217/02 , A61K31/505 , C07D239/34 , A61K31/44 , A61K31/437
CPC分类号: C07D213/69 , A61K31/437 , A61K31/44 , A61K31/472 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/64 , C07D213/65 , C07D217/02 , C07D217/24 , C07D239/34 , C07D471/04
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to 5 compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I):10 X NH O S O O R1 R2 R5 R4 R3 Het1 (I) or a pharmaceutically acceptable salt thereof, wherein X, Het1, R1, R2, R3, R4 and R5 are as defined in the description. 15 Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医药中的用途,含有它们的5种组合物,其制备方法和用于此类方法的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:10X NH OSOO R1 R2 R5 R4 R3 Het1(I)或其药学上可接受的盐,其中X,Het1,R1,R2,R3, R4和R5如说明书中所定义。 15 Nav 1.7抑制剂可用于治疗各种各样的疾病,特别是疼痛。
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公开(公告)号:US09102621B2
公开(公告)日:2015-08-11
申请号:US13808653
申请日:2011-07-04
IPC分类号: C07D213/24 , C07D311/04 , A61K31/44 , A61K31/18 , C07D213/69 , C07D213/30 , C07D213/64 , C07D213/65 , C07D217/24 , C07D471/04 , A61K31/437 , A61K31/472 , A61K31/505 , A61K45/06 , C07D217/02 , C07D239/34
CPC分类号: C07D213/69 , A61K31/437 , A61K31/44 , A61K31/472 , A61K31/505 , A61K45/06 , C07D213/30 , C07D213/64 , C07D213/65 , C07D217/02 , C07D217/24 , C07D239/34 , C07D471/04
摘要: The invention relates to sulfonamide derivatives, to their use in medicine, to 5 compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula (I): 10 X NH O S O O R1 R2 R5 R4 R3 Het1 (I) or a pharmaceutically acceptable salt thereof, wherein X, Het1, R1, R2, R3, R4 and R5 are as defined in the description. 15 Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译: 本发明涉及磺酰胺衍生物,其在医药中的用途,含有它们的5种组合物,其制备方法和用于此类方法的中间体。 更具体地,本发明涉及式(I)的新的磺酰胺Nav1.7抑制剂:10X NH OSOO R1 R2 R5 R4 R3 Het1(I)或其药学上可接受的盐,其中X,Het1,R1,R2,R3, R4和R5如说明书中所定义。 15 Nav 1.7抑制剂可用于治疗各种各样的疾病,特别是疼痛。
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