公开(公告)号：US20100311792A1

公开(公告)日：2010-12-09

申请号：US12599608

申请日：2008-09-26

Applicant: Bin Shao ,  Jiangchao Yao

Inventor： Bin Shao ,  Jiangchao Yao

IPC: A61K31/4468 ,  C07D211/58 ,  C07D401/04 ,  C07D401/06 ,  C07D405/12 ,  A61K31/4545 ,  A61K31/454 ,  A61K31/453 ,  A61P29/00 ,  A61P25/18 ,  A61P25/28 ,  A61P25/24 ,  A61P25/22 ,  A61P9/06 ,  A61P9/12 ,  G01N33/53

CPC classification number: C07D211/58 ,  C07D401/04

Abstract: The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, R3, Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula I to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

Abstract translation: 本发明涉及式（I）的氮杂环丁烷基，吡咯烷基，哌啶基和六氢氮杂卟啉化合物及其药学上可接受的盐，前药或溶剂化物，其中R1，R2，R3，Z和q如说明书所述定义。 本发明还涉及使用式I化合物来治疗对阻断钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US07678809B2

公开(公告)日：2010-03-16

申请号：US11494826

申请日：2006-07-28

Applicant: Donald Kyle ,  Richard R. Goehring ,  Bin Shao

Inventor： Donald Kyle ,  Richard R. Goehring ,  Bin Shao

IPC: A61K31/44

CPC classification number: C07D401/04

Abstract: Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.

Abstract translation: 公开了式（I）的化合物，其中A，R 1，R 2，R 3，R 4和X 1如本文所公开。 该化合物对ORL1受体具有亲和力，可用于治疗慢性和急性疼痛。

公开(公告)号：US20090298878A1

公开(公告)日：2009-12-03

申请号：US12373328

申请日：2007-07-12

Applicant: Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

Inventor： Akira Matsumura ,  Hidenori Mikamiyama ,  Naoki Tsuno ,  Donald J. Kyle ,  Bin Shao ,  Jiangchao Yao

IPC: A61K31/445 ,  C07D211/98 ,  G01N23/00 ,  C07D401/12

CPC classification number: C07D211/72 ,  C07D211/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04

Abstract: The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

Abstract translation: 本发明涉及式（I）的肟化合物及其药学上可接受的盐，前药或溶剂化物，其中X是氢，任选取代的芳基，任选取代的杂芳基等; Y是CO，SO2，CR3R4等; Z是任选取代的低级烷基，任选取代的芳基等; W是任选取代的低级亚烷基或任选取代的低级亚烯基，R 3和R 4各自独立地是氢，低级烷基等; p是0,1或2，q是0,1或2.本发明还涉及使用式I化合物来治疗，预防或改善对阻断钙通道有响应的病症，特别是N型 钙通道。 本发明的化合物特别适用于治疗疼痛。

公开(公告)号：US20090220640A1

公开(公告)日：2009-09-03

申请号：US12271229

申请日：2008-11-14

Applicant: Xinde Xu ,  Bin Shao ,  Di Zhou ,  Chunbo Chen ,  Yimin Hong

Inventor： Xinde Xu ,  Bin Shao ,  Di Zhou ,  Chunbo Chen ,  Yimin Hong

IPC: A23K1/18 ,  A23K1/16

CPC classification number: A23K50/75 ,  A23K20/179 ,  A23L2/58 ,  A23L5/43 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/044 ,  A23V2200/324 ,  A23V2250/211 ,  A23V2250/702

Abstract: The present invention provides a method of supplementing animals with carotenoids by drinking water, comprising the following steps of: (1) making yellow and/or red pigments into the microencapsulated dry powders or beadlets; (2) mixing the aforementioned microencapsulated dry powders or beadlets in a certain proportion and dissolving them in water to prepare for a pigment solution; (3) administering the prepared pigment solution to animals by drinking. The method of supplementing the carotenoids according to the present invention has the advantages of easy absorption, economical dosages of pigments, high efficiency of coloration, stable coloration and small effects on the process of pigments in comparison with conventional methods currently.

Abstract translation: 本发明提供了一种通过饮用水补充动物类胡萝卜素的方法，包括以下步骤：（1）将黄色和/或红色颜料制成微囊化的干粉或珠粒; （2）将上述微囊化干燥粉末或珠粒以一定比例混合并将其溶解在水中以制备颜料溶液; （3）通过饮用将制备的颜料溶液给予动物。 根据本发明的补充类胡萝卜素的方法具有吸收容易，颜料的经济剂量，着色效率高，着色稳定，对颜料工艺的影响小于目前常规方法。

公开(公告)号：US07570116B2

公开(公告)日：2009-08-04

申请号：US11801653

申请日：2007-05-10

Applicant: Olli Haila ,  Song Qin ,  Bin Shao

Inventor： Olli Haila ,  Song Qin ,  Bin Shao

IPC: H03F3/18

CPC classification number: H03F3/3001

Abstract: An output stage, comprising a first transistor operable to pull a voltage at an output node towards a first voltage, and a rechargeable energy store having a potential difference between first and second terminals wherein the rechargeable energy store is arranged to be controllably connected between the output node and a second voltage supply such that the voltage at the output node can be driven to a voltage outside of a range defined between the first and second voltages.

Abstract translation: 输出级，包括可操作以将输出节点处的电压拉向第一电压的第一晶体管，以及具有第一和第二端子之间的电势差的可再充电能量存储器，其中可再充电能量存储器被布置成可控地连接在输出端 节点和第二电压供应，使得输出节点处的电压可以被驱动到在第一和第二电压之间限定的范围之外的电压。

公开(公告)号：US20080278234A1

公开(公告)日：2008-11-13

申请号：US11801653

申请日：2007-05-10

Applicant: Olli Haila ,  Song Qin ,  Bin Shao

Inventor： Olli Haila ,  Song Qin ,  Bin Shao

IPC: H03F3/26

CPC classification number: H03F3/3001

Abstract: An output stage, comprising a first transistor operable to pull a voltage at an output node towards a first voltage, and a rechargeable energy store having a potential difference between first and second terminals wherein the rechargeable energy store is arranged to be controllably connected between the output node and a second voltage supply such that the voltage at the output node can be driven to a voltage outside of a range defined between the first and second voltages.

Abstract translation: 输出级，包括可操作以将输出节点处的电压拉向第一电压的第一晶体管，以及在第一和第二端子之间具有电位差的可再充电能量存储器，其中可再充电能量存储器被布置成可控地连接在输出端 节点和第二电压供应，使得输出节点处的电压可以被驱动到在第一和第二电压之间限定的范围之外的电压。

公开(公告)号：US20080214827A1

公开(公告)日：2008-09-04

申请号：US10585485

申请日：2005-02-02

Applicant: R. Richard Goehring ,  John Whitehead ,  Bin Shao

Inventor： R. Richard Goehring ,  John Whitehead ,  Bin Shao

IPC: C07D401/04

CPC classification number: C07D471/10 ,  C07D401/04

Abstract: Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

Abstract translation: 在某些实施方案中公开了合成式（V）化合物及其盐的方法。

公开(公告)号：US09656959B2

公开(公告)日：2017-05-23

申请号：US13996082

申请日：2011-12-21

Applicant: Chiyou Ni ,  Minnie Park ,  Bin Shao ,  Laykea Tafesse ,  Jiangchao Yao ,  Mark A. Youngman ,  Xiaoming Zhou

Inventor： Chiyou Ni ,  Minnie Park ,  Bin Shao ,  Laykea Tafesse ,  Jiangchao Yao ,  Mark A. Youngman ,  Xiaoming Zhou

IPC: C07D213/75 ,  C07D401/02 ,  C07D401/12 ,  C07D401/14 ,  C07D213/76 ,  C07D213/81 ,  C07D413/12

CPC classification number: C07D213/75 ,  C07D213/76 ,  C07D213/81 ,  C07D401/02 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12

Abstract: The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

公开(公告)号：US09622497B2

公开(公告)日：2017-04-18

申请号：US13997273

申请日：2011-01-30

Applicant: Xinde Xu ,  Bin Shao ,  Xuejun Lao

Inventor： Xinde Xu ,  Bin Shao ,  Xuejun Lao

IPC: A23D9/007 ,  A61K9/10 ,  A61K31/015 ,  A61K47/44 ,  A23K20/179 ,  A23K20/158

CPC classification number: A23D9/007 ,  A23K20/158 ,  A23K20/179 ,  A61K9/10 ,  A61K31/015 ,  A61K47/44

Abstract: A carotenoid oil suspension and preparation method thereof are provided. The method includes the following steps: a) mixing carotenoid with organic solvent, heating the mixture to dissolve the carotenoid sufficiently to obtain carotenoid solution; b) introducing the carotenoid solution obtained in step a) into a vegetable oil solution stirred in high speed by spraying, meanwhile recovering the organic solvent generated during spraying under vacuum condition, then, simultaneously completing recycling and spraying, thereafter, obtaining carotenoid oil suspension; wherein, the carotenoid oil suspension comprises a carotenoid crystal with an average particle size of less than 5 μm. The method is applicable in industrial scale with continuous operation and increased efficiency without additional carotenoid crystal grinding processes, and decreases the degradation of carotenoid during the preparation process of carotenoid oil suspension.

公开(公告)号：US08981667B2

公开(公告)日：2015-03-17

申请号：US13548624

申请日：2012-07-13

Applicant: Bin Shao ,  Kenji Tomiyoshi

Inventor： Bin Shao ,  Kenji Tomiyoshi

IPC: G05F1/00 ,  H05B37/02 ,  H05B39/04 ,  H05B41/36 ,  H05B33/08 ,  G05F1/46

CPC classification number: H05B33/0842 ,  G05F1/46 ,  H05B33/0824

Abstract: The present disclosure proposes a fully integrated accurate LED output current controlling circuit and method, which can be seamlessly combined with true PWM dimming. The current controlling circuit has an auto zero function in the light-emitting diode driver to eliminate offsets caused by the system, process variations, parasitic effects, dimming and so on in an LED driver application, and thus is capable of controlling the LED current with high accuracy. Moreover, the driver of the present disclosure does not require the use of external components such as an external resistor to regulate current accuracy.

Abstract translation: 本公开提出了一种完全集成的准确的LED输出电流控制电路和方法，其可以与真实的PWM调光无缝组合。 电流控制电路在发光二极管驱动器中具有自动调零功能，以消除LED驱动器应用中由系统引起的偏移，工艺变化，寄生效应，调光等，从而能够控制LED电流 高准确率。 此外，本公开的驱动器不需要使用诸如外部电阻器的外部组件来调节电流精度。