公开(公告)号：US4766075A

公开(公告)日：1988-08-23

申请号：US483052

申请日：1983-04-07

Applicant: David V. Goeddel ,  William J. Kohr ,  Diane Pennica ,  Gordon A. Vehar

Inventor： David V. Goeddel ,  William J. Kohr ,  Diane Pennica ,  Gordon A. Vehar

IPC: A61K38/00 ,  C12N9/06 ,  C12N9/72 ,  C12N15/71 ,  C12N5/00 ,  C07H17/00 ,  C12N1/00 ,  C12N1/20 ,  C12N9/48 ,  C12N15/00

CPC classification number: C12N9/003 ,  C12N15/71 ,  C12N9/6459 ,  C12Y304/21069 ,  A61K38/00 ,  Y10S930/26

Abstract: Human tissue phasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.

Abstract translation: 使用重组DNA技术以有用的量产生人体组织phasminogen激活剂（t-PA）。 因此，所公开的发明使得能够生产没有其天然细胞环境中通常相关的污染物的t-PA。 还公开了可用于其生产的方法，表达载体和各种宿主细胞。

公开(公告)号：US20090010936A1

公开(公告)日：2009-01-08

申请号：US11932861

申请日：2007-10-31

Applicant: Diane Pennica ,  Victoria Smith ,  William I. Wood

Inventor： Diane Pennica ,  Victoria Smith ,  William I. Wood

IPC: A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/04 ,  A61P31/00

CPC classification number: C12N15/1034 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/47 ,  C07K2319/00 ,  C12N15/85 ,  G01N33/574 ,  A61K2300/00

Abstract: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及与Stra6，鼠视黄酸反应性蛋白质以及编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07396533B2

公开(公告)日：2008-07-08

申请号：US10628770

申请日：2003-07-28

Applicant: Arnold J. Levine ,  Diane Pennica

Inventor： Arnold J. Levine ,  Diane Pennica

IPC: A61K39/385 ,  C12N9/14 ,  C07K14/435

CPC classification number: G01N33/57484 ,  C07K14/47 ,  C07K2317/24 ,  C07K2319/02 ,  G01N33/68

Abstract: DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

Abstract translation: 提供DNA，其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

公开(公告)号：US20070274995A1

公开(公告)日：2007-11-29

申请号：US11537537

申请日：2006-09-29

Applicant: David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

Inventor： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

IPC: A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C12N1/21 ,  C12N1/18 ,  C12N5/06 ,  C07K16/30 ,  C07K14/82

CPC classification number: C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2333/52 ,  G01N2500/00

Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

Abstract translation: 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，被扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

公开(公告)号：US07258983B2

公开(公告)日：2007-08-21

申请号：US10895545

申请日：2004-07-21

Applicant: David Botstein ,  Audrey Goddard ,  David A. Lawrence ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

Inventor： David Botstein ,  Audrey Goddard ,  David A. Lawrence ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

IPC: C12Q1/68 ,  C07H21/02 ,  C07H21/04

CPC classification number: C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2333/52 ,  G01N2500/00

Abstract: The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

Abstract translation: 本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的复合和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，被扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

公开(公告)号：US20070160618A1

公开(公告)日：2007-07-12

申请号：US11535254

申请日：2006-09-26

Applicant: David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

Inventor： David Botstein ,  Audrey Goddard ,  David Lawrence ,  Diane Pennica ,  Margaret Roy ,  William Wood

IPC: A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC classification number: C12Q1/6886 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/52 ,  C07K16/18 ,  C07K16/24 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N2333/52 ,  G01N2500/00

Abstract: The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.

公开(公告)号：US20070041964A1

公开(公告)日：2007-02-22

申请号：US11488375

申请日：2006-07-17

Applicant: David Botstein ,  Robert Cohen ,  Audrey Goddard ,  Austin Gurney ,  Kenneth Hillan ,  David Lawrence ,  Arnold Levine ,  Diane Pennica ,  Margaret Roy ,  William Wood

Inventor： David Botstein ,  Robert Cohen ,  Audrey Goddard ,  Austin Gurney ,  Kenneth Hillan ,  David Lawrence ,  Arnold Levine ,  Diane Pennica ,  Margaret Roy ,  William Wood

IPC: A61K39/395 ,  C07K16/40 ,  C07K16/42

CPC classification number: C07K14/47 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/74 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

Abstract translation: 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

公开(公告)号：US20070025998A1

公开(公告)日：2007-02-01

申请号：US11458237

申请日：2006-07-18

Applicant: Diane Pennica ,  Paul Polakis ,  Wayne Szeto ,  David Tice

Inventor： Diane Pennica ,  Paul Polakis ,  Wayne Szeto ,  David Tice

IPC: A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  A61K39/00 ,  A61K31/07 ,  A61K31/203

CPC classification number: C12N15/1034 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/47 ,  C07K2319/00 ,  C12N15/85 ,  G01N33/574 ,  A61K2300/00

Abstract: The invention concerns the identification of tumor antigens the expression of which is selectively upregulated by retinoid treatment. The invention further concerns improved methods of cancer treatment and, in particular, methods enhancing the efficacy of the treatment of cancers characterized by aberrant Wnt signaling by administration of retinoic acid or other retinoids.

Abstract translation: 本发明涉及通过类视色素治疗选择性上调其表达的肿瘤抗原的鉴定。 本发明还涉及改进的癌症治疗方法，特别是通过给予视黄酸或其它类视色素来提高癌症治疗特征的异常Wnt信号传导的功效的方法。

公开(公告)号：US07101850B2

公开(公告)日：2006-09-05

申请号：US10112267

申请日：2002-03-27

Applicant: Arnold J. Levine ,  Diane Pennica

Inventor： Arnold J. Levine ,  Diane Pennica

IPC: A61K38/00

CPC classification number: C07K14/47 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/74 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

公开(公告)号：US07091178B2

公开(公告)日：2006-08-15

申请号：US10659549

申请日：2003-09-10

Applicant: Diane Pennica

Inventor： Diane Pennica

IPC: C07K14/00

CPC classification number: C07K14/47 ,  Y10S977/775 ,  Y10S977/924

Abstract: A member of the guanylate-binding protein family, designated GBP-4, is provided. Also provided are isolated nucleic acid encoding GBP-4, vectors and host cells containing such nucleic acid molecule, and a method for producing the GBP-4 recombinantly.