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    Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
    42.
    发明授权
    Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators 有权
    识别特异性激活人T2R受体的苦配体和相关测定法，用于鉴定人类苦味调节剂

    公开(公告)号：US07883856B2

    公开(公告)日：2011-02-08

    申请号：US11766974

    申请日：2007-06-22

    Applicant: Xiaodong Li ,  Hong Xu ,  Qing Li ,  Huixian Tang ,  Alexey Pronin

    Inventor： Xiaodong Li ,  Hong Xu ,  Qing Li ,  Huixian Tang ,  Alexey Pronin

    IPC: G01N33/566 ,  C07K14/705

    CPC classification number: G01N33/566 ,  G01N33/5008 ,  G01N33/5023 ,  G01N2500/00 ,  G01N2500/10

    Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands and related compounds. These compounds may be used as additives and/or removed from foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste. Also T2R ligands may be used as therapeutics to treat and modulate T2R associated gastrointestinal and metabolic functions as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.

    Abstract translation: 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味化合物的反应的发现。 此外，本发明还涉及特异性hT2R9等位基因的发现及其在具有相同配体配体的功能测定中的不同活性。 本发明还涉及这些T2R受体在用于鉴定通过特定的苦配体和相关化合物调节这些味觉受体的活化的配体的测定中的用途。 这些化合物可以用作添加剂和/或从食品，饮料，化妆品和药物中去除，以便改变（阻断）T2R相关的苦味。 也可以使用T2R配体作为治疗和调节T2R相关胃肠和代谢功能以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病，克罗恩病，乳糜泻等的治疗剂。

    POLYMERIZATION PROCESS FOR PREPARING MONODISPERSAL ORGANIC/INORGANIC COMPOSITE NANO-MICROSPHERE
    43.
    发明申请
    POLYMERIZATION PROCESS FOR PREPARING MONODISPERSAL ORGANIC/INORGANIC COMPOSITE NANO-MICROSPHERE 有权
    单组分有机/无机复合纳米微球的制备工艺

    公开(公告)号：US20100292388A1

    公开(公告)日：2010-11-18

    申请号：US12160802

    申请日：2007-01-11

    Applicant: Longlan Cui ,  Hong Xu ,  Hongchen Gu

    Inventor： Longlan Cui ,  Hong Xu ,  Hongchen Gu

    IPC: C08J3/07

    CPC classification number: C08F2/22

    Abstract: Polymerization process for preparing mono-disperse organic/inorganic nanocomposite microspheres in the field of nano technology is disclosed. The process comprises preparing of two different miniemulsion systems of A with inorganic nanoparticles and B with polymeric monomers in advance; adding water-soluble initiator into miniemulsion A, stirring till complete dissolution finally, heating the mixed system to a given temperature for isothermal reaction. The grain size of the as-prepared superparamagnetic Fe3O4/polystyrene using to present invention is homogeneous and controllable, and the magnetic particles content is controllable.

    Abstract translation: 公开了在纳米技术领域制备单分散有机/无机纳米复合微球的聚合方法。 该方法包括预先制备具有无机纳米颗粒和B的两种不同的细乳液体系和聚合单体; 将水溶性引发剂加入到细乳液A中，搅拌至最终完全溶解，将混合体系加热至给定温度进行等温反应。 使用本发明的制备的超顺磁性Fe 3 O 4 /聚苯乙烯的粒径是均匀的和可控的，并且磁性颗粒含量是可控的。

    Identification of bitter receptors for hydrolyzed soy protein
    44.
    发明授权
    Identification of bitter receptors for hydrolyzed soy protein 有权
    鉴定水解大豆蛋白的苦味受体

    公开(公告)号：US07794959B2

    公开(公告)日：2010-09-14

    申请号：US12053855

    申请日：2008-03-24

    Applicant: Xiaodong Li ,  Hong Xu ,  Lan Zhang ,  Hanghui Liu ,  Keping Wu

    Inventor： Xiaodong Li ,  Hong Xu ,  Lan Zhang ,  Hanghui Liu ,  Keping Wu

    IPC: G01N33/567 ,  C07K14/705

    CPC classification number: C12Q1/6895 ,  G01N33/5008 ,  G01N33/566 ,  G01N2500/00

    Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1 or hT2R67 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.

    Abstract translation: 本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解大豆蛋白衍生物质中的特定苦味化合物的反应的发现。 本发明还涉及这些T2R受体在用于鉴定通过水解大豆蛋白材料及其衍生物和相关化合物中存在的特定苦味配体调节这些味觉受体的活化的配体的测定中的用途。 这些化合物可以用作添加剂和/或从大豆基食品，饮料，化妆品和药物中去除，以便改变（阻断）水解大豆蛋白材料中存在的苦配子引起的与T2R相关的苦味。 此外，这些T2R配体可能被用作治疗和调节hT2R1或hT2R67相关的胃肠道和代谢功能如血清胆固醇水平以及治疗胃肠道和代谢疾病如饮食失调，食物感觉，食物吸收，肥胖，糖尿病， 克罗恩病，乳糜泻等。

    Method and system for providing a circle of trust on a network
    45.
    发明授权
    Method and system for providing a circle of trust on a network 有权
    在网络上提供信任圈的方法和系统

    公开(公告)号：US07716469B2

    公开(公告)日：2010-05-11

    申请号：US10627019

    申请日：2003-07-25

    Applicant: Bhavna Bhatnagar ,  Ping Luo ,  Qingwen Cheng ,  Shivaram Bhat ,  Hong Xu ,  Wei Sun ,  Aravindan Ranganathan

    Inventor： Bhavna Bhatnagar ,  Ping Luo ,  Qingwen Cheng ,  Shivaram Bhat ,  Hong Xu ,  Wei Sun ,  Aravindan Ranganathan

    IPC: H04L29/06 ,  H04L9/32 ,  G06F7/04

    CPC classification number: H04L63/0815 ,  H04L9/3263 ,  H04L63/0823

    Abstract: Embodiments of the present invention provide a circle of trust on a network. The circle of trust is configured by exchanging credential of a first and a second affiliated entity. The credentials of the first affiliated entity is stored in a trusted partner list of the second affiliated entity. The credentials of the second affiliated entity is stored in a trusted partner list of the first affiliated entity. Thereafter, a circle of trust session may be provided when a client device initiates use of a resource on a relying party device by providing an authentication assertion reference. The identity of the issuing party of the authentication is determined as a function of the authentication assertion reference. The relying party sends an authentication query containing its credential to the issuing party. The issuing party determines if the relying party is a trusted entity based upon whether the relying party's credential is contained in the trusted partner list of the issuing party.

    Abstract translation: 本发明的实施例提供了一种网络上的信任圈。 通过交换第一个和第二个附属实体的凭证来配置信任圈。 第一个关联实体的凭证存储在第二个关联实体的可信合作伙伴列表中。 第二个关联实体的凭证存储在第一个关联实体的可信赖的合作伙伴列表中。 此后，当客户端设备通过提供认证断言引用来在依赖方设备上启动资源的使用时，可以提供一个信任圈。 认证的发行方的身份被确定为认证断言参考的函数。 依赖方向发卡方发送包含其凭据的认证查询。 发行方基于信任方的凭证是否包含在发行方的受信任的合作伙伴列表中来确定依赖方是否是可信赖的实体。

    THEME-BASED INSTANT MESSAGING COMMUNICATIONS
    46.
    发明申请
    THEME-BASED INSTANT MESSAGING COMMUNICATIONS 审中-公开
    基于主题的即时消息通信

    公开(公告)号：US20090248824A1

    公开(公告)日：2009-10-01

    申请号：US12414705

    申请日：2009-03-31

    Applicant: Steven Francis Best ,  Yue Ma ,  Su Ying Rui ,  Hong Xu ,  Zhi Yu Yue

    Inventor： Steven Francis Best ,  Yue Ma ,  Su Ying Rui ,  Hong Xu ,  Zhi Yu Yue

    IPC: G06F15/16

    CPC classification number: H04L51/04

    Abstract: Instant messaging communications are controlled using themes. A theme is a definition of properties and features of a specific instance of an instant messaging communications environment. Themes are stored at a server computer and may be requested by users of a client computer. Themes may be made available to users based on enterprise policies established by the owner of the server computer. Once downloaded to the client computer, a theme may be personalized by the user of the client computer provided personalization is consistent with the enterprise policy. Inheritance techniques may be used to provide personalized themes that remain consistent with enterprise policy while extending functions not defined in the enterprise policy. A user may select different themes manually. Alternatively, theme selection may be automated based on system detection of events such as time of day, user location, availability of network connections and the like. Changes in a downloaded theme may be returned to and stored by the server for future use by the user of the client computer.

    Abstract translation: 使用主题控制即时通讯。 主题是即时消息通信环境的特定实例的属性和特征的定义。 主题存储在服务器计算机中，可能由客户端计算机的用户请求。 可以基于由服务器计算机的所有者建立的企业策略向用户提供主题。 一旦下载到客户端计算机，主题可能会由客户端计算机的用户个性化提供个性化与企业策略一致。 继承技术可用于提供与企业策略保持一致的个性化主题，同时扩展未在企业策略中定义的功能。 用户可以手动选择不同的主题。 或者，主题选择可以基于诸如时间，用户位置，网络连接的可用性等事件的系统检测而自动化。 下载的主题中的更改可能返回到服务器并由客户端计算机的用户将来使用。

    HETEROMERIC TASTE RECEPTORS
    47.
    发明申请
    HETEROMERIC TASTE RECEPTORS 有权
    异体吸收受体

    公开(公告)号：US20090221798A1

    公开(公告)日：2009-09-03

    申请号：US12270857

    申请日：2008-11-14

    Applicant: Mark Zoller ,  Xiaodong Li ,  Lena Staszewski ,  Shawn O'Connell ,  Sergey Zozulya ,  Jon Elliot Adler ,  Hong Xu ,  Fernando Echeverri

    Inventor： Mark Zoller ,  Xiaodong Li ,  Lena Staszewski ,  Shawn O'Connell ,  Sergey Zozulya ,  Jon Elliot Adler ,  Hong Xu ,  Fernando Echeverri

    IPC: C07K14/00

    CPC classification number: G01N33/5008 ,  A01K2217/05 ,  C07K14/705 ,  G01N33/5041 ,  G01N33/566 ,  G01N2333/726

    Abstract: Heteromeric taste receptors are provided. These receptors comprise a first polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R2 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R2 polypeptide or a different GPCR; and a second polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R3 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R3 polypeptide or that of a different GPCR.

    Abstract translation: 提供异味味觉受体。 这些受体包含第一多肽，其包含细胞外和跨膜结构域，其中跨膜结构域与特异性T1R2多肽的跨膜结构域至少95％相同，并且细胞外结构域与特异性T1R2的相应胞外结构域至少95％相同 多肽或不同的GPCR; 和包含细胞外和跨膜结构域的第二多肽，其中所述跨膜结构域与特异性T1R3多肽的跨膜结构域至少95％相同，并且细胞外结构域与特异性T1R3多肽的相应细胞外结构域至少95％相同，或 不同的GPCR。

    HUMAN T2R RECEPTORS FOR RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS
    50.
    发明申请
    HUMAN T2R RECEPTORS FOR RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS 有权
    人类T2R受体的RANITIDINE，STRYCHNINE和DENATONIUM及相关测定用于鉴定人体双歧杆菌调味剂

    公开(公告)号：US20090087866A1

    公开(公告)日：2009-04-02

    申请号：US12166980

    申请日：2008-07-02

    Applicant: Xiaodong LI ,  Hong Xu ,  Huixian Tang ,  Qing Li

    Inventor： Xiaodong LI ,  Hong Xu ,  Huixian Tang ,  Qing Li

    IPC: G01N33/567

    CPC classification number: G01N33/74 ,  G01N33/566 ,  G01N2333/726 ,  G01N2500/02

    Abstract: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter ligands, i.e., acetaminophen, ranitidine, strychnine and denatonium. The present invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors and which may be used as additives in foods, beverages and medicinals for modifying (blocking) T2R-associated bitter taste.

    Abstract translation: 本发明涉及T2R味觉受体家族中的特定人味受体对特定苦味配体即对乙酰氨基酚，雷尼替丁，士的宁和丹那铵的反应的发现。 本发明还涉及这些受体在用于鉴定调节这些味觉受体的活化的配体的测定中的用途，并且其可用作用于改变（阻断）T2R相关苦味的食品，饮料和药物中的添加剂。

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