利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

56 条记录 (耗时 0.04 秒)

    Method for identifying compounds which affect synaptogenesis
    48.
    发明申请
    Method for identifying compounds which affect synaptogenesis 有权
    鉴定影响突触发生的化合物的方法

    公开(公告)号：US20030232776A1

    公开(公告)日：2003-12-18

    申请号：US10299957

    申请日：2002-11-18

    申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

    发明人： Paul Worley ,  Richard O'Brien ,  DeSheng Xu ,  Richard L. Huganir

    IPC分类号： A61K048/00 ,  A61K038/17 ,  C12Q001/68 ,  G01N033/53 ,  G01N033/567 ,  A61K039/395

    CPC分类号： G01N33/9406 ,  G01N2510/00

    摘要： A method is provided for identifying a compound which affects the formation of AMPA receptors into aggregates. A method is also provided for identifying a compound which affects the formation of synaptic connections. A method is provided for identifying a compound that modulates immediate early gene expression. A method is further provided for increasing the number of excitory synapses of a neuron, including introducing into the neuron a polynucleotide sequence encoding a Narp operatively linked to a promoter, or a Narp polypeptide, thereby increasing the number of excitory synapses of the neuron. A method is provided for treating a subject with a disorder associated with a decrease in a function or expression of Narp, including administering to the subject a therapeutically effective amount of a compound that augments Narp function or expression. A method is provided for treating a subject with a disorder associated with an increase in a function or expression of Narp, including administering to the subject a therapeutically effective of a compound that inhibits Narp function or expression. A method is provided for treating a patient having or at risk of having a disorder associated with decreased Narp expression. The method includes introducing into a cell of a patient having a disorder associated with decreased Narp expression or function a polynucleotide sequence encoding a Narp polypeptide operatively linked to a promoter. A method is provided for treating a subject having a deficiency in a neuron's immediate early gene responsiveness to a stimulus. The method includes administering a nucleic acid encoding a Narp polypeptide to said subject, wherein the administration results in amelioration of the deficiency.

    摘要翻译： 提供了一种鉴定影响AMPA受体形成聚集体的化合物的方法。 还提供了一种鉴定影响突触连接形成的化合物的方法。 提供了一种鉴定调节立即早期基因表达的化合物的方法。 还提供了一种用于增加神经元的突触突触的数量的方法，包括向神经元引入编码与启动子或Narp多肽有效连接的Narp的多核苷酸序列，从而增加神经元的突触突触的数量。 提供了一种用于治疗与Narp的功能或表达降低相关的障碍的受试者的方法，包括向受试者施用治疗有效量的增强Narp功能或表达的化合物。 提供了一种用于治疗与Narp的功能或表达增加相关的疾病的受试者的方法，包括向受试者施用治疗有效的抑制Narp功能或表达的化合物。 提供了一种治疗患有或具有与降低的Narp表达相关的病症的患者的方法。 所述方法包括向具有与降低的Narp表达相关的病症的患者的细胞中引入编码与启动子有效连接的Narp多肽的多核苷酸序列。 提供了一种用于治疗神经元对刺激的即时早期基因反应性不足的受试者的方法。 该方法包括向所述受试者施用编码Narp多肽的核酸，其中所述给药导致缺乏症的改善。

    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures
    50.
    发明申请
    System and method for magnetic-resonance-guided electrophysiologic and ablation procedures 有权

    公开(公告)号：US20030199755A1

    公开(公告)日：2003-10-23

    申请号：US10424093

    申请日：2003-04-28

    申请人： Johns Hopkins University School Of Medicine

    发明人： Henry R. Halperin ,  Ronald D. Berger ,  Ergin Atalar ,  Elliot R. McVeigh ,  Albert Lardo ,  Hugh Calkins ,  Joao Lima

    IPC分类号： A61B005/05

    CPC分类号： A61B5/055 ,  A61B5/415 ,  A61B5/418 ,  A61B18/1492 ,  A61B90/36 ,  A61B2017/00039 ,  A61B2017/00053 ,  A61B2090/374 ,  G01R33/285 ,  G01R33/34084 ,  G01R33/4808 ,  G01R33/5601

    摘要： A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures is disclosed. The system in its preferred embodiment provides an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures. The invention is particularly applicable to catheter ablation, e.g., ablation of atrial fibrillation. In embodiments which are useful for catheter ablation, the combined electrophysiology and imaging antenna catheter may further include an ablation tip, and such embodiment may be used as an intracardiac device to both deliver energy to selected areas of tissue and visualize the resulting ablation lesions, thereby greatly simplifying production of continuous linear lesions. The invention further includes embodiments useful for guiding electrophysiologic diagnostic and therapeutic procedures other than ablation. Imaging of ablation lesions may be further enhanced by use of MR contrast agents. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or nulllooplessnull type. High-resolution images from the antenna may be combined with low-resolution images from surface coils of the MR scanner to produce a composite image. The invention further provides a system for eliminating the pickup of RE energy in which intracardiac wires are detuned by filtering so that they become very inefficient antennas. An RF filtering system is provided for suppressing the MR imaging signal while not attenuating the RF ablative current. Steering means may be provided for steering the invasive catheter under MR guidance. Other ablative methods can be used such as laser, ultrasound, and low temperatures.