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公开(公告)号：US09190258B2
公开(公告)日：2015-11-17
申请号：US14445551
申请日：2014-07-29
申请人： The Charles Stark Draper Laboratory, Inc. , Johns Hopkins University School of Medicine , Mini-Mass Counseling
发明人： Theresa Evans-Nguyen , Di Wang , Friso Van Amerom
CPC分类号： H01J49/427 , H01J49/0031 , H01J49/022 , H01J49/424 , H01J49/429
摘要： The present disclosure discusses a system and method for continuous operation of an ion trap mass spectrometer. The described system does not introduce ions into the ion trap in distinct trapping phase, rather the described system continuously injects ions into the ion trap while continuously scanning out the ions. The system and method described herein achieves a much higher duty cycle and cycle rate when compared to standard mass spectrometer devices.
摘要翻译： 本公开内容讨论了用于离子阱质谱仪的连续操作的系统和方法。 所描述的系统不会在不同的俘获阶段将离子引入离子阱，而是所描述的系统在连续扫描离子的同时将离子连续地注入到离子阱中。 与标准质谱仪器件相比，本文所述的系统和方法实现了更高的占空比和循环速率。
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公开(公告)号：US20150034820A1
公开(公告)日：2015-02-05
申请号：US14445551
申请日：2014-07-29
申请人： The Charles Stark Draper Laboratory, Inc. , Johns Hopkins University School of Medicine , Mini-Mass Counseling
发明人： Theresa Evans-Nguyen , Di Wang , Friso Van Amerom
CPC分类号： H01J49/427 , H01J49/0031 , H01J49/022 , H01J49/424 , H01J49/429
摘要： The present disclosure discusses a system and method for continuous operation of an ion trap mass spectrometer. The described system does not introduce ions into the ion trap in distinct trapping phase, rather the described system continuously injects ions into the ion trap while continuously scanning out the ions. The system and method described herein achieves a much higher duty cycle and cycle rate when compared to standard mass spectrometer devices.
摘要翻译： 本公开内容讨论了用于离子阱质谱仪的连续操作的系统和方法。 所描述的系统不会在不同的俘获阶段将离子引入离子阱，而是所描述的系统在连续扫描离子的同时将离子连续地注入到离子阱中。 与标准质谱仪器件相比，本文所述的系统和方法实现了更高的占空比和循环速率。
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公开(公告)号：US20140243795A1
公开(公告)日：2014-08-28
申请号：US14268723
申请日：2014-05-02
发明人： Signe Erickson Varner , Eugene de Juan, JR. , Aaron Christopher Barnes , Terry Harrison Shelley , Michael J. Cooney
IPC分类号： A61F9/00
CPC分类号： A61F9/0017 , A61F2250/0067 , A61F2250/0068 , A61M31/002 , A61M39/0208 , A61M2039/0205 , A61M2205/04 , A61M2210/0612
摘要： A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.
摘要翻译： 允许药剂持续释放的输送装置，特别用于将治疗剂持续释放到有限的进入区域，例如眼睛和内耳的后室。 输送装置是微创的，可再填充的并且可以容易地固定到治疗区域。 递送装置包括中空体，其中在其近端具有用于插入药剂的入口端口，用于容纳药剂的储存器和用于将药剂从储存器持续递送至患者的输送机构。
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公开(公告)号：US20030203885A1
公开(公告)日：2003-10-30
申请号：US10441857
申请日：2003-05-19
IPC分类号： A61K031/58
CPC分类号： A61K31/4355 , Y10S435/962 , Y10T436/141111
摘要： The present invention sterol-modified hedgehog polypeptides and functional fragments thereof Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. In one aspect of the invention, the method provides a means for affecting cholesterol biosynthesis or transport in a cell comprising contacting a cell with an effective amount of a compound that affects hedgehog, thereby affecting cholesterol biosynthesis or transport. The effect may be inhibition or stimulation of cholesterol biosynthesis or transport.
摘要翻译： 本发明固醇修饰的刺猬蛋白多肽及其功能片段描述了基于对刺猬蛋白的胆固醇修饰的抑制影响刺猬蛋白活性的组合物的方法。 在本发明的一个方面，该方法提供了影响细胞中胆固醇生物合成或转运的方法，包括使细胞与有效量的影响刺猬蛋白的化合物接触，从而影响胆固醇生物合成或转运。 该作用可能是抑制或刺激胆固醇生物合成或运输。
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公开(公告)号：US20030074680A1
公开(公告)日：2003-04-17
申请号：US09872856
申请日：2001-06-01
发明人： Se-Jin Lee , Alexandra C. McPherron
IPC分类号： A01K067/027 , A23L001/31
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2267/02 , A01K2267/03 , A01K2267/0318 , A01K2267/035 , A01K2267/0362 , A61K38/00 , A61K48/00 , C07K14/475 , C07K14/495 , C07K16/22 , C07K2319/00
摘要： A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity of growth differentiation factor-8 (GDF-8) chromosomally integrated into the germ cells of the animal is disclosed. Also disclosed are methods for making such animals, and methods of treating animals, including humans, with antibodies or antisense directed to GDF-8. The animals so treated are characterized by increased muscle tissue and bone content.
摘要翻译： 选自以下的物种的转基因非人动物：具有转基因的鸟，牛，绵羊和猪，导致染色体整合的生长分化因子-8（GDF-8）的产生和/或活性的产生和/或活性 公开了动物的生殖细胞。 还公开了制备这种动物的方法，以及用针对GDF-8的抗体或反义治疗包括人在内的动物的方法。 如此治疗的动物的特征在于肌肉组织和骨含量增加。
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公开(公告)号：US20020197608A1
公开(公告)日：2002-12-26
申请号：US09863806
申请日：2001-05-22
发明人： David Sidransky
IPC分类号： C12Q001/68
CPC分类号： C07K14/4703 , A61B10/0051 , C07K14/82 , C12Q1/6827 , C12Q1/6886 , C12Q2600/156
摘要： Methods for detection of a cell proliferative disorder, such as cancer, are provided utilizing analysis of target mutant nucleic acids in saliva specimens are described. The presence of target mutant nucleic acids is indicative of a neoplastic disorder of the lung or the head and neck.
摘要翻译： 描述了通过唾液标本中靶突变体核酸的分析来提供用于检测细胞增殖性病症（例如癌症）的方法。 靶突变体核酸的存在表明肺或头颈部的肿瘤性疾病。
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公开(公告)号：US20020188105A1
公开(公告)日：2002-12-12
申请号：US10024809
申请日：2001-12-19
发明人： Nancy L. Craig
IPC分类号： C12N009/16 , C12N015/74 , C12P021/02 , C07K014/705
摘要： The invention is specifically directed to efficient, random, simple insertion of a transposon or derivative transposable element into DNA in vivo or in vitro. The invention is particularly directed to mutations in ATP-utilizing regulatory transposition proteins that permit insertion with less target-site specificity than wild-type. The invention encompasses gain-of-function mutations in TnsC, an ATP-utilizing regulatory transposition protein that activates the bacterial transposon Tn7. Such mutations enable the insertion of a Tn7 transposon or derivative transposable element in a non-specific manner into a given DNA segment. Insertion can be effected in plasmid and cosmid libraries, cDNA libraries, PCR products, bacterial artificial chromosomes, yeast artificial chromosomes, mammalian artificial chromosomes, genomic DNAs, and the like. Such insertion is useful in DNA sequencing methods, for genetic analysis by insertional mutagenesis, and alteration of gene expression by insertion of a given genetic sequence.
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8.发明申请Monoclonal antibodies against leukocyte adhesion receptor beta-chain, methods of producing these antibodies and use therefore 失效针对白细胞粘附受体β链的单克隆抗体，因此产生这些抗体的方法公开(公告)号：US20010014325A1
公开(公告)日：2001-08-16
申请号：US09761209
申请日：2001-01-16
发明人： James E. Hildreth
IPC分类号： A61K039/395 , G01N033/53 , G01N033/537 , G01N033/543
CPC分类号： C07K16/2845 , A61K38/00
摘要： Monoclonal antibodies and method for ameliorating an immune response disorder. The monoclonal antibodies are specific for an epitope present on the leukocyte adhesion receptor null-chain.
摘要翻译： 用于改善免疫应答障碍的单克隆抗体和方法。 单克隆抗体对存在于白细胞粘附受体β链上的表位是特异性的。
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公开(公告)号：US20230101480A1
公开(公告)日：2023-03-30
申请号：US17947661
申请日：2022-09-19
发明人： Esen K. Akpek , Gopalan V. Balaji , Jose J. de la Cruz , Theodore C. Fleck , Genevieve M. Gurczenski , Thomas B. Schmiedel
摘要： Methods, apparatuses, and systems for monitoring health of corneal tissue are disclosed. The system includes a corneal measurement device configured to measure a first state of health indicator that is tissue thickness or volume of a region of the corneal tissue during a first period of time and a second state of health indicator that is tissue thickness or volume of the region during a second period of time after the first period of time. The system further includes a processing unit configured to receive the first and second state of health indicators from the corneal measurement device and generate a health map of the region based on the first and second state of health indicators, the health map indicative of a change between the first and second state of health indicators as measured from the first period of time to the second period of time in the region of the cornea.
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公开(公告)号：US20220273768A1
公开(公告)日：2022-09-01
申请号：US17747905
申请日：2022-05-18
摘要： The present disclosure generally relates to compositions and methods of treating opioid-induced respiratory depression in a subject in need thereof, the method comprising administering leptin.
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