公开(公告)号：US20120184576A1

公开(公告)日：2012-07-19

申请号：US13262040

申请日：2010-03-31

Applicant: Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

Inventor： Santosh Kumar Srivastava ,  Ashok Kumar Agrawal ,  Subhash Chandra Singh ,  Vinay Kumar Khanna ,  Janardan Singh ,  Chandeshwar Nath ,  Madan Mohan Gupta ,  Shikha Gupta ,  Ram Kishor Verma ,  Anirban Pal ,  Duyaneshwar Umrao Bawankule ,  Dharmendra Saikia ,  Anil Kumar Gupta ,  Anupam Maurya ,  Suman Preet Singh Khanuja

IPC: A61K31/4375 ,  C07D455/00 ,  A61P25/18 ,  A61K31/475

CPC classification number: A61K36/24

Abstract: The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-derαethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkabids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R. tetraphylla and in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS). 1. R1=R2=OMe R3=β-H (Isoreserpiline) 2. R1=R2=OMe R3=β-H (Reserpiline) ″3. R1=OMe R2=HR3=β-H (11-Demethoxy reserpiline) ″4.R1=H R2=OMe R3=β-H (10-Demethoxy reserpiline) ″5. R1=R2=H R3=α-H (Tetrahydroalstonine) *7. R1=OMe R2=H R3=α-H (10-Methoxytetrahudroalstonine).

Abstract translation: 本发明涉及生物活性提取物，其部分和化合物从萝卜（Rauwolfia tetraphylla）分离。 基于动物模型的体内验证和针对抗精神病活性的多巴胺能D2，胆碱能（毒蕈碱）和血清素能（5HT2A）受体的比例结合亲和力，提取物和级分可用于治疗精神病。 本发明涉及式1和2的叶生物碱中的新型抗精神病活性，命名为四氢奥斯汀，10-甲氧基四氢奥斯汀，异丙基苯胺，10-脱乙氧基去甲苯胺，11-去甲氧基甲苯吡胺，储存蛋白和α-育亨宾。 本发明还涉及获得抗精神病药提取物以及分离来自罗非草（Rauwolfia tetraphylla）的叶子的式1和2的烷烃的方法。 本发明特别涉及在四氢叶酸甲酯的MeOH提取物，乙酸乙酯和氯仿级分中以及在分离的化合物α-育亨宾，储存器中和以1:1.5比例混合的10-脱甲氧基对苯二胺和11-脱甲氧基苯甲苯胺中的显着的抗精神病活性，用于治疗 精神病没有任何额外的锥体症状（EPS）。 R1 = R2 = OMe R3 =＆bgr; -H（Isoreserpiline）2.R1 = R2 = OMe R3 =＆bgr; -H（Reserpiline）“3。 R1 = OMe R2 = HR3 =＆bgr; -H（11-甲氧基乙酰胺）“4.R1 = H R2 = OMe R3 =＆bgr; -H（10-甲氧基乙胺） R1 = R2 = H R3 =α-H（四氢奥斯汀）* 7。 R1 = OMe R2 = H R3 =α-H（10-甲氧基四胡司汀）。

公开(公告)号：US20120096553A1

公开(公告)日：2012-04-19

申请号：US12907721

申请日：2010-10-19

Applicant: Manoj Kumar Srivastava ,  William Andrews Walker ,  Eric Alexander Olson

Inventor： Manoj Kumar Srivastava ,  William Andrews Walker ,  Eric Alexander Olson

IPC: G06F21/00 ,  G06F15/16

CPC classification number: G06Q10/107 ,  G06F15/16 ,  G06F21/00 ,  G06F21/56 ,  H04L51/12 ,  H04L51/32 ,  H04L63/1425 ,  H04L63/1441

Abstract: Methods and systems for detecting social engineering attacks comprise: extracting one or more non-semantic data items from an incoming email; determining whether the one or more non-semantic data items match information stored in a data store of previously collected information; performing behavioral analysis on the one or more non-semantic data items; analyzing semantic data associated with the email to determine whether the non-semantic data matches one or more patterns associated with malicious emails; and based on the determining, performing, and analyzing, identifying the email as potentially malicious or non-malicious. The system also includes processes for collecting relevant information for storage within the data store and processes for harvesting information from detected social engineering attacks for entry into the data store and seeding of the collection processes.

Abstract translation: 用于检测社会工程攻击的方法和系统包括：从传入的电子邮件中提取一个或多个非语义数据项; 确定所述一个或多个非语义数据项是否与先前收集的信息的数据存储中存储的信息相匹配; 对一个或多个非语义数据项执行行为分析; 分析与所述电子邮件相关联的语义数据，以确定所述非语义数据是否匹配与恶意电子邮件相关联的一个或多个模式; 并且基于确定，执行和分析，将该电子邮件识别为潜在的恶意或非恶意的。 该系统还包括用于收集用于在数据存储器内存储的相关信息的过程，以及用于从检测到的社会工程攻击中收集信息的过程，以进入数据存储和收集流程。

公开(公告)号：US08156082B2

公开(公告)日：2012-04-10

申请号：US11756925

申请日：2007-06-01

Applicant: Ajay Kumar Srivastava ,  Raj K. Rathee ,  Yanhong Wang

Inventor： Ajay Kumar Srivastava ,  Raj K. Rathee ,  Yanhong Wang

IPC: G06F17/30

CPC classification number: G06F17/30575

Abstract: System and methods for temporary data management in shared disk cluster configurations is described. In one embodiment, a method for managing temporary data storage comprises: creating a global temporary database accessible to all nodes of the cluster on shared storage; creating a local temporary database accessible to only a single node (owner node) of the cluster; providing failure recovery for the global temporary database without providing failure recovery for the local temporary database, so that changes to the global temporary database are transactionally recovered upon failure of a node; binding an application or database login to the local temporary database on the owner node for providing the application with local temporary storage when connected to the owner node; and storing temporary data used by the application or database login in the local temporary database without requiring use of write ahead logging for transactional recovery of the temporary data.

Abstract translation: 描述了共享磁盘集群配置中临时数据管理的系统和方法。 在一个实施例中，一种用于管理临时数据存储的方法包括：创建可在所述共享存储器上的所述集群的所有节点访问的全局临时数据库; 创建仅可以访问集群的单个节点（所有者节点）的本地临时数据库; 为全局临时数据库提供故障恢复，而不会为本地临时数据库提供故障恢复，以便在节点故障时事务性地恢复对全局临时数据库的更改; 将应用程序或数据库登录绑定到所有者节点上的本地临时数据库，以在连接到所有者节点时向应用程序提供本地临时存储; 以及将应用程序或数据库登录使用的临时数据存储在本地临时数据库中，而不需要使用写入提前日志来进行临时数据的事务恢复。

公开(公告)号：US07844580B2

公开(公告)日：2010-11-30

申请号：US11891962

申请日：2007-08-14

Applicant: Piyush Kumar Srivastava ,  Madhusudhana Honnuduke Srinivasa Murthy

Inventor： Piyush Kumar Srivastava ,  Madhusudhana Honnuduke Srinivasa Murthy

IPC: G06F17/30

CPC classification number: G06F17/30575 ,  G06F17/30215 ,  Y10S707/99945 ,  Y10S707/99953

Abstract: Methods and systems for efficient file replication are provided. In some embodiments, one or more coarse signatures for blocks in a base file are compared with those coarse signatures for blocks of a revised file, until a match is found. A fine signature is then generated for the matching block of the revised file and compared to a fine signature of the base file. Thus, fine signatures are not computed unless a coarse signature match has been found, thereby minimizing unneeded time-consuming fine signature calculations. Methods are also provided for determining whether to initiate a delta file generation algorithm, or whether to utilize a more efficient replication method, based upon system and/or file parameters. In accordance with additional embodiments, the lengths of valid data on physical blocks are obtained from physical block mappings for the files, and these lengths and mappings are utilized for delta file generation, to minimize unnecessary signature computations.

Abstract translation: 提供了有效文件复制的方法和系统。 在一些实施例中，将用于基本文件中的块的一个或多个粗略签名与用于修改文件的块的那些粗略签名进行比较，直到找到匹配。 然后为修改后的文件的匹配块生成精细签名，并与基本文件的精细签名进行比较。 因此，除非已经找到粗略的签名匹配，否则不会计算精细签名，从而最小化不需要的耗时的精细签名计算。 还提供了用于基于系统和/或文件参数来确定是否启动增量文件生成算法或者是否利用更有效的复制方法的方法。 根据另外的实施例，从文件的物理块映射获得物理块上的有效数据的长度，并且这些长度和映射用于增量文件生成，以最小化不必要的签名计算。

公开(公告)号：US07807712B2

公开(公告)日：2010-10-05

申请号：US11018923

申请日：2004-12-22

Applicant: Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

Inventor： Ram Pratap ,  Mavurapu Satyanarayana ,  Chandeshwar Nath ,  Ram Raghubir ,  Anju Puri ,  Ramesh Chander ,  Priti Tiwari ,  Brajendra Kumar Tripathi ,  Arvind Kumar Srivastava

IPC: A61K31/36 ,  A61K31/427 ,  A61K31/085 ,  C07D317/06 ,  C07C49/105 ,  C07C49/11 ,  A61P3/10 ,  A61P9/10

CPC classification number: C07D295/092 ,  C07D277/34 ,  C07D317/54 ,  C07D417/12

Abstract: The present invention provides appropriately substituted chalcones, such as, for example, represented by the structural formula as shown herein below Wherein R1, R2 and R3 are selected from the group consisting of H, OH, O-alkyl, O-phenyl and O-substituted phenyl; B represents Ar—Z—O or RO; where Z is an alkane having up to 5 carbon atoms; R is substituted propanol amino, wherein substituted amino groups are selected from the group consisting of t-butyl, n-butyl, i-butyl, i-propyl, 4-phenyl piperazine-1-yl, 4-(2-methoxyphenyl)-piperazin-1-yl and 3,4-dimethoxy phenethyl; and Ar is thiazolidine-dione methylene phenoxy. The compounds prepared have been demonstrated to exhibit significant antidiabetic effect in various animal models indicating potential for further exploitation.

Abstract translation: 本发明提供适当取代的查尔酮，例如由如下文所示的结构式表示，其中R1，R2和R3选自H，OH，O-烷基，O-苯基和O- 取代的苯基; B表示Ar-Z-O或RO; 其中Z是具有至多5个碳原子的烷烃; R是取代的丙醇氨基，其中取代的氨基选自叔丁基，正丁基，异丁基，异丙基，4-苯基哌嗪-1-基，4-（2-甲氧基苯基） - 哌嗪-1-基和3,4-二甲氧基苯乙基; Ar是噻唑烷二酮亚甲基苯氧基。 已经证明所制备的化合物在各种动物模型中表现出显着的抗糖尿病作用，表明有可能进一步开发。

公开(公告)号：US07779318B2

公开(公告)日：2010-08-17

申请号：US11318347

申请日：2005-12-23

Applicant: Danish Hasan Syed ,  Vishal Kumar Srivastava

Inventor： Danish Hasan Syed ,  Vishal Kumar Srivastava

IPC: G01R31/28 ,  G06F11/00

CPC classification number: G01R31/31855 ,  G01R31/318519 ,  H03K19/17728 ,  H03K19/17736 ,  H03K19/17748 ,  H03K19/17764 ,  H03K19/17772

Abstract: A self test structure for interconnect and logic element testing in programmable devices including a plurality of logic elements; an interconnect structure for connecting the logic elements; SRAM based configuration latches for configuring the interconnect structure; test configuration circuitry for configuring any desired set of logic elements, interconnect structure and configuration latches during reset state that links the logic elements and interconnect structure to form a complete path between the interface points of the programmable logic device to enable testing of the desired elements in the complete path.

Abstract translation: 一种用于在包括多个逻辑元件的可编程设备中进行互连和逻辑元件测试的自检结构; 用于连接逻辑元件的互连结构; 用于配置互连结构的基于SRAM的配置锁存器; 测试配置电路，用于在复位状态期间配置任何期望的逻辑元件集，互连结构和配置锁存器，所述复位状态链接逻辑元件和互连结构，以在可编程逻辑器件的接口点之间形成完整的路径，以使得能够测试所需的元件 完整的路径。

公开(公告)号：US20100077840A1

公开(公告)日：2010-04-01

申请号：US12459193

申请日：2009-06-26

Applicant: Arvind Kumar Srivastava ,  Vinayak P. Dravid

Inventor： Arvind Kumar Srivastava ,  Vinayak P. Dravid

IPC: G01N21/00 ,  G01N27/00 ,  G01J3/00

CPC classification number: G01N27/305 ,  G01N33/0034

Abstract: A light-assisted sensor and method of light-assisted sensing of gaseous species involves contacting a gaseous medium with a material selected to adsorb on its surface one or more gaseous species of interest and illuminating the surface of the material from a source to induce a change of an electrical property, such as conductivity, of the material in the presence of the one or more gaseous species. The change in the electrical property of the material is measured and can be used to identify and quantify the gaseous species of interest in the gaseous medium.

Abstract translation: 光辅助传感器和光辅助感测气态物质的方法包括使气体介质与选定成在其表面上吸附一种或多种感兴趣的气体物质的材料接触，并从源发射材料的表面以引起变化 具有在一种或多种气态物质存在下的材料的电性质，例如导电性。 测量材料的电性能的变化，并且可用于鉴定和量化气态介质中感兴趣的气态物质。

公开(公告)号：US20100056785A1

公开(公告)日：2010-03-04

申请号：US12595663

申请日：2008-04-10

Applicant: Om Dutt Tyagi ,  Tushar Kumar Srivastava ,  Vellanki Siva Ram Prasad ,  Dnyandev Ragho Rane ,  Bandi Naga Durga Rao ,  Daggula Srinivas Reddy

Inventor： Om Dutt Tyagi ,  Tushar Kumar Srivastava ,  Vellanki Siva Ram Prasad ,  Dnyandev Ragho Rane ,  Bandi Naga Durga Rao ,  Daggula Srinivas Reddy

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Present invention relates to an improved process for the preparation of Zopiclone and its enantiomerically enriched isomer (Eszopiclone). 6-(5-Chloropyridin-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]pyrazine is reacted with 1-chloro-carbonyl-4-methylpiperazine in the presence of alkali earth metal carbonates, hydroxides or oxides in a solvent medium to give Zopiclone. It is reacted with optically active acid in a mixture of water and water miscible organic solvent followed by work up to give Eszopiclone. The present invention also relates to process for the conversion of (R) or (S) Zopiclone to 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydro-pyrrolo-[3,4-b]-pyrazine of the intermediate which can be converted to racemic Zopiclone.

Abstract translation: 本发明涉及一种改良的佐匹克隆及其对映体富集异构体（依佐替普）的制备方法。 6-（5-氯吡啶-2-基）-5-羟基-7-氧代-5,6-二氢吡咯并[3,4-b]吡嗪在碱存在下与1-氯 - 羰基-4-甲基哌嗪反应 土壤金属碳酸盐，氢氧化物或氧化物在溶剂介质中给予佐匹克隆。 将其与光学活性酸在水和水混溶性有机溶剂的混合物中反应，随后加工得到依佐替普。 本发明还涉及将（R）或（S）佐匹克隆转化为6-（5-氯吡啶-2-基）-5-羟基-7-氧代-5,6-二氢 - 吡咯并[3 ，4-b] - 吡嗪，其可以转化为外消旋佐匹克隆。

公开(公告)号：US07658954B2

公开(公告)日：2010-02-09

申请号：US11025757

申请日：2004-12-29

Applicant: Palpu Pushpangadan ,  Ajay Kumar Singh Rawat ,  Chandana Venkateshwara Rao ,  Sharad Kumar Srivastava ,  Sayyada Khatton

Inventor： Palpu Pushpangadan ,  Ajay Kumar Singh Rawat ,  Chandana Venkateshwara Rao ,  Sharad Kumar Srivastava ,  Sayyada Khatton

IPC: A61K36/00 ,  A61K9/00 ,  A61K47/00

CPC classification number: A61K36/29 ,  A61K36/19 ,  A61K36/24 ,  A61K36/59 ,  A61K36/906 ,  Y02A50/385 ,  Y02A50/40 ,  A61K2300/00

Abstract: The present invention relates to a synergistic antipyretic formulation comprising extracts of plants Berberis aristata , Tinospora cordifolia , Alstonia scholaris, Andrographis paniculata and Hedychium spicatum , optionally along with pharmaceutically acceptable additives; its use in treating fever, and lastly, a process for the preparation said synergistic antipyretic formulation.

Abstract translation: 本发明涉及一种协同解热制剂，其包含植物小檗，Tinospora cordifolia，Alstonia scholaris，Andrographis paniculata和Hedychium spicatum的任选连同药学上可接受的添加剂的提取物; 其用于治疗发烧，最后是制备所述协同解热制剂的方法。

公开(公告)号：US20070212745A1

公开(公告)日：2007-09-13

申请号：US11531032

申请日：2006-09-12

Applicant: Neelam Singh Sangwan ,  Sidharth Kumar Misra ,  Suman Preet Singh Khanuja ,  Advadesh Kumar Srivastava ,  Rajender Singh Sangwan

Inventor： Neelam Singh Sangwan ,  Sidharth Kumar Misra ,  Suman Preet Singh Khanuja ,  Advadesh Kumar Srivastava ,  Rajender Singh Sangwan

IPC: C12Q1/34 ,  C12N9/24

CPC classification number: C12Q1/34 ,  C12N9/2445 ,  C12Y302/01021

Abstract: The present invention provides a novel beta glucosidase and a process for extraction of a beta-glucosidase from Rauvolfia serpentine useful for the cleaving of beta-1,4 linkage of PNPG and to convert other gluco-conjugates such as strictosidine and raucaffricine into their corresponding aglycon such as vomilenine, commercially through immobilizing the enzyme. The β glucosidase enzyme has shown maximum activity in the acid pH range, with high optimum temperature using PNPG as substrate. The crude enzyme, when stored at 4° C., was quite stable for 6 days with 50% loss of activity. The enzyme was activated in presence of FeSO4 in the assay mixture.

Abstract translation: 本发明提供了一种新颖的β-葡糖苷酶和从Rauvolfia蛇纹石中提取β-葡糖苷酶的方法，其可用于切割PNPG的β-1,4键并将其它葡糖共轭物如斯曲霉素和草酸转化成其相应的糖苷配基 如维生素E，通过固定酶进行商业化。 β-葡萄糖苷酶在酸性pH范围内显示出最大的活性，使用PNPG作为底物具有最高的最佳温度。 当粗酶在4℃下储存时，相当稳定6天，活性降低50％。 该酶在测定混合物中在FeSO 4的存在下活化。