公开(公告)号：US20060019920A1

公开(公告)日：2006-01-26

申请号：US11179128

申请日：2005-07-11

Applicant: C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

Inventor： C. Bennett ,  Susan Freier ,  Brett Monia ,  Nicholas Dean ,  Hong Zhang ,  Robert McKay ,  Donna Ward ,  William Gaarde ,  Jacqueline Wyatt ,  Andrew Watt ,  Rosanne Crooke ,  Mark Graham ,  Pamela Nero ,  Kenneth Dobie ,  Alexander Borchers ,  Eric Marcusson ,  Mark Roach

IPC: A61K48/00 ,  C07H21/02

CPC classification number: C12N9/1205 ,  Y02P20/582

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.

公开(公告)号：US20050287558A1

公开(公告)日：2005-12-29

申请号：US11124020

申请日：2005-05-05

Applicant: Rosanne Crooke ,  Mark Graham ,  Steven Mah

Inventor： Rosanne Crooke ,  Mark Graham ,  Steven Mah

IPC: A61K48/00 ,  C07H21/04 ,  C12Q1/68

CPC classification number: C12N15/113 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2320/30 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for diagnosis and treatment of diseases and conditions associated with expression of apolipoprotein B are provided.

Abstract translation: 提供了用于调节载脂蛋白B表达的化合物，组合物和方法。该组合物包含靶向编码载脂蛋白B的核酸的寡核苷酸。使用这些化合物调节载脂蛋白B表达并用于诊断和治疗与 提供载脂蛋白B的表达。

公开(公告)号：US20050153924A1

公开(公告)日：2005-07-14

申请号：US11013543

申请日：2004-12-15

Applicant: C. Bennett ,  Brett Monia ,  Susan Murray ,  Madeline Butler ,  Nicholas Dean ,  Rosanne Crooke ,  Mark Graham ,  Hong Zhang ,  Susan Freier ,  Brenda Baker ,  Eric Marcusson ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Andrew Watt

Inventor： C. Bennett ,  Brett Monia ,  Susan Murray ,  Madeline Butler ,  Nicholas Dean ,  Rosanne Crooke ,  Mark Graham ,  Hong Zhang ,  Susan Freier ,  Brenda Baker ,  Eric Marcusson ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Andrew Watt

IPC: A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法 提供了与干扰素γ受体2表达相关的疾病的表达和治疗。

公开(公告)号：US20050043256A1

公开(公告)日：2005-02-24

申请号：US10619253

申请日：2003-07-15

Applicant: Rosanne Crooke ,  Mark Graham

Inventor： Rosanne Crooke ,  Mark Graham

IPC: A61K38/00 ,  A61K45/06 ,  C07H20060101 ,  C12N9/02 ,  C12N15/113 ,  A61K48/00 ,  C07H21/02

CPC classification number: A61K45/06 ,  A61K38/00 ,  C12N9/0083 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y114/19001 ,  Y02P20/582 ,  C12N2310/3525

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.

Abstract translation: 提供反义化合物，组合物和方法用于调节硬脂酰辅酶A去饱和酶的表达。 组合物包含靶向编码硬脂酰辅酶A去饱和酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节硬脂酰辅酶A去饱和酶表达和治疗与硬脂酰辅酶A去饱和酶表达相关的疾病的方法。

公开(公告)号：US06817804B2

公开(公告)日：2004-11-16

申请号：US10068473

申请日：2002-02-06

Applicant: Yann Le Gallo ,  Pascal De Vries ,  Klaus Bruno Wilhelm Blume ,  Charles Berry Hopson ,  Herve Laurandel ,  Simon Blair Dobson ,  Damien Cabanne ,  Mark Graham Lawrie

Inventor： Yann Le Gallo ,  Pascal De Vries ,  Klaus Bruno Wilhelm Blume ,  Charles Berry Hopson ,  Herve Laurandel ,  Simon Blair Dobson ,  Damien Cabanne ,  Mark Graham Lawrie

IPC: B60J504

CPC classification number: F16B5/02 ,  E05F11/382 ,  E05F15/689 ,  E05Y2201/434 ,  E05Y2201/654 ,  E05Y2201/664 ,  E05Y2600/56 ,  E05Y2800/00 ,  E05Y2900/55 ,  Y10T403/44 ,  Y10T403/75

Abstract: An assembly including a first, second and third component and a first and second fixing member, the first, second and third component having respective first, second and third holes, the first hole being a threaded hole, in which the first fixing member cooperates with the second hole and a first threaded portion of the first fixing member engaging the first hole to secure the first component to the second component, the first and second fixing member cooperating with the third hole with the first fixing member engaging the second fixing member to secure the third component to the first component, in which the first component is situated between the second and third component.

Abstract translation: 一种包括第一，第二和第三部件以及第一和第二固定部件的组件，所述第一，第二和第三部件具有相应的第一，第二和第三孔，所述第一孔是螺纹孔，其中所述第一固定部件与 所述第二孔和所述第一固定构件的第一螺纹部分接合所述第一孔以将所述第一构件固定到所述第二构件，所述第一和第二固定构件与所述第三孔协作，所述第一固定构件与所述第二固定构件接合以固定 第一组分的第三组分，其中第一组分位于第二组分和第三组分之间。

公开(公告)号：US06426382B1

公开(公告)日：2002-07-30

申请号：US09720305

申请日：2000-12-21

Applicant: John Farrar ,  Mark Graham ,  Andrew Jackson

Inventor： John Farrar ,  Mark Graham ,  Andrew Jackson

IPC: C08J303

CPC classification number: D21H17/56 ,  B41M5/508 ,  B41M5/5245 ,  C08G73/02 ,  C08G73/0226 ,  C09B23/148 ,  D21H21/30

Abstract: Aqueous solutions of polycationic polymers (PAB) containing quaternary ammonium groups in salt form as heteroatomic chain members or ring members of the polymer, wherein a part of the counter-ions to the quaternary cationic groups are anionic groups of anionic optical brighteners, containing at least one anionic group, are valuable multi-functional agents in papermaking.

Abstract translation: 含有盐形式的季铵基团的聚阳离子聚合物（PAB）的水溶液作为聚合物的杂原子链成员或环成员，其中与季阳离子基团的反离子的一部分为阴离子基团的阴离子荧光增白剂，至少含有 一种阴离子基团是造纸中的有价值的多功能剂。

公开(公告)号：US5913449A

公开(公告)日：1999-06-22

申请号：US716719

申请日：1996-09-16

Applicant: Mark Graham Branch ,  Alan Andrew Baxter

Inventor： Mark Graham Branch ,  Alan Andrew Baxter

IPC: B65D35/12 ,  B65D35/00

CPC classification number: B65D35/12

Abstract: A shoulder piece (31) for assembly to a flexible tube (15) to form a container (40) and which is made from a composition containing high density polyethylene and linear low density polyethylene. The shoulder piece (31) has an annular lip (35) on its external surface (37) for positioning proximate an end (46) of a respective tube (15) to be assembled to the shoulder piece 31.

Abstract translation: 一种用于组装到柔性管（15）以形成容器（40）并且由含有高密度聚乙烯和线性低密度聚乙烯的组合物制成的肩部件（31）。 肩部件（31）在其外表面（37）上具有环形唇缘（35），用于邻近待组装到肩部件31的相应管子（15）的端部（46）定位。

公开(公告)号：US08752543B2

公开(公告)日：2014-06-17

申请号：US10577977

申请日：2004-11-02

Applicant: Michael Birsha Davies ,  Mark Graham Hedley ,  Margot Jean Jones

Inventor： Michael Birsha Davies ,  Mark Graham Hedley ,  Margot Jean Jones

IPC: A61M11/00

CPC classification number: A61M15/0001 ,  A61M15/009 ,  A61M15/08 ,  B05B11/0037 ,  B05B11/0038 ,  B05B11/3052 ,  B05B11/3056 ,  B05B11/3059 ,  B65D83/16 ,  B65D83/201 ,  B65D83/386

Abstract: A fluid dispensing device for dispensing a fluid having a viscosity of from 10 to 2000 mPas at 25° C., the dispensing device having at least one finger-operable lever pivotably moveable into the housing transversely with respect to the longitudinal axis of the fluid discharge device, to apply a force to an actuating member connected to the neck of a container, the device having a pre-load to prevent pivoting until a pre-determined force is applied, wherein the actuating member and the lever have surfaces which slidingly interact, wherein the pre-load is formed by one of the surfaces of the actuating member or the lever having a dual-gradient profile.

Abstract translation: 一种流体分配装置，用于在25℃下分配粘度为10至2000mPas的流体，所述分配装置具有至少一个手指可操作的杠杆，其可相对于流体排放物的纵向轴线可横向移动到壳体中 装置，以向连接到容器的颈部的致动构件施加力，所述装置具有预加载力以防止枢转直到施加预定力，其中所述致动构件和所述杆具有滑动相互作用的表面， 其中所述预载荷由所述致动构件的所述表面中的一个或具有双梯度轮廓的所述杠杆形成。

公开(公告)号：US20130278881A1

公开(公告)日：2013-10-24

申请号：US13919740

申请日：2013-06-17

Applicant: William Kokonaski ,  Yongping Wang ,  Ronald D. Blum ,  Mark Graham ,  Claudio Dalla Longa ,  Sambo S. He ,  Christian Krutzik

Inventor： William Kokonaski ,  Yongping Wang ,  Ronald D. Blum ,  Mark Graham ,  Claudio Dalla Longa ,  Sambo S. He ,  Christian Krutzik

IPC: G02C11/00

CPC classification number: G02C11/10 ,  G02C5/14 ,  G02C5/22 ,  G02C7/083 ,  G02C7/101 ,  H02J7/0044 ,  H02J7/025 ,  H02J50/10

Abstract: Aspects of the present invention provide electronics for controlling and synchronizing operation of electro-active lenses regardless of frame type, size or style. The controlling electronics can be contained within one or more electronic modules positioned within the frame temples and can be removable and reprogrammable and can include inductive charge regions. Conductive links between electronic modules and/or between left and right Sides of the electro active spectacles can include left and right upper and lower rim portions of the frame, the bridge, conductive layers of the electro-active lenses, the upper and lower grooves of the electro-active lenses, and/or wires embedded within any portion of the frame. Aspects of the present invention also provide chargers for recharging electro-active spectacles of any size, shape or style using adjustable inductive charging cradles to inductively charge electro-active spectacles of the present invention.

Abstract translation: 本发明的方面提供用于控制和同步电活动透镜的操作的电子装置，而不管框架类型，尺寸或风格如何。 控制电子设备可以被包含在位于框架镜腿内的一个或多个电子模块内，并且可以是可拆卸和可重新编程的并且可以包括感应电荷区域。 电动模组之间和/或电动眼镜左右两侧之间的导电连接可以包括框架的左上和下右边缘部分，桥梁，电活性透镜的导电层，上下凹槽 电活性透镜和/或嵌入在框架的任何部分内的电线。 本发明的方面还提供充电器，用于使用可调节的感应充电支架对任何尺寸，形状或风格的电活动眼镜进行充电，以感应地对本发明的电活动眼镜进行充电。

公开(公告)号：US20130221825A1

公开(公告)日：2013-08-29

申请号：US13403611

申请日：2012-02-23

Applicant: Arturo J. Bonomie ,  Daniel Mark Graham ,  Mark J. Blahnik ,  Sean Petersen

Inventor： Arturo J. Bonomie ,  Daniel Mark Graham ,  Mark J. Blahnik ,  Sean Petersen

IPC: F25D23/02 ,  H01H9/00 ,  E05D11/10 ,  E05F1/12 ,  E05F3/20

CPC classification number: E05D3/14 ,  E05D7/00 ,  E05D11/08 ,  E05F1/1261 ,  E05F3/20 ,  E05F3/227 ,  F25D23/02 ,  F25D23/028 ,  F25D2323/024 ,  H01H3/162 ,  H01H9/00 ,  H01H21/02 ,  Y10T16/2771 ,  Y10T16/304 ,  Y10T16/522 ,  Y10T16/5383 ,  Y10T16/5385 ,  Y10T16/53864 ,  Y10T16/5387 ,  Y10T16/547 ,  Y10T16/5476 ,  Y10T16/551 ,  Y10T16/61

Abstract: A hinge including a device bracket, a door bracket, a first arm, a second arm, and a closure device is provided. The first arm mounts to the device bracket at a first pin and to the door bracket at a second pin. The second arm mounts to the device bracket at a third pin and to the door bracket at a fourth pin. The third pin is closer to an axis of rotation of a door than the first pin when the door is in a closed position. The closure device includes a closure device body mounted to move with the second arm, a rod mounted within the closure device body, a spring, a spring retainer mounted to the rod, and a nut mounting the rod to the device bracket. The spring is mounted between the spring retainer and the closure device body to exert a force on the second arm.

Abstract translation: 提供一种包括装置支架，门支架，第一臂，第二臂和闭合装置的铰链。 第一个臂在第一个引脚安装到设备支架，并在第二个引脚上安装到门支架。 第二个臂在第三个引脚安装在设备托架上，并在第四个引脚上安装到门托架上。 当门处于关闭位置时，第三销更靠近门的旋转轴线而不是第一销。 闭合装置包括安装成与第二臂移动的封闭装置主体，安装在封闭装置主体内的杆，弹簧，安装到杆的弹簧保持器和将杆安装到装置支架上的螺母。 弹簧安装在弹簧保持器和封闭装置本体之间，以在第二臂上施加力。