公开(公告)号：US20210090872A1

公开(公告)日：2021-03-25

申请号：US17025430

申请日：2020-09-18

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Bazargan

IPC: H01J49/10 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

公开(公告)号：US20210074533A1

公开(公告)日：2021-03-11

申请号：US16920887

申请日：2020-07-06

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Samad Bazargan ,  Hamid Badiei

IPC: H01J49/00 ,  H01J49/04

Abstract: Certain embodiments described herein are directed to methods and systems of detecting two or more analytes present in a single system such as a nanoparticle or nanostructure. In some examples, the methods and systems can estimate data gaps and fit intensity curves to obtained detection values so the amount of the two or more analytes present in the single system can be quantified.

公开(公告)号：US10796895B2

公开(公告)日：2020-10-06

申请号：US16551056

申请日：2019-08-26

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Hamid Badiei ,  Serguei Savtchenko ,  Samad Bazargan

IPC: H01J49/00 ,  H01J49/10 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16

Abstract: Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

公开(公告)号：US10651020B2

公开(公告)日：2020-05-12

申请号：US15715523

申请日：2017-09-26

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Tak Shun Cheung ,  Chui Ha Cindy Wong

IPC: H01J49/42 ,  H01J1/02 ,  H01J49/02 ,  H01G4/012 ,  H01G4/10 ,  H01G4/008 ,  H01G4/38 ,  H01G4/30 ,  H01G4/12 ,  H01J49/06

Abstract: Certain configurations of a stable capacitor are described which comprise electrodes produced from materials comprising a selected coefficient of thermal expansion to enhance stability. The electrodes can be spaced from each other through one of more dielectric layers or portions thereof. In some instances, the electrodes comprise integral materials and do not include any thin films. The capacitors can be used, for example, in feedback circuits, radio frequency generators and other devices used with mass filters and/or mass spectrometry devices.

公开(公告)号：US20190355566A1

公开(公告)日：2019-11-21

申请号：US15983590

申请日：2018-05-18

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Anna Kornilova ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/14 ,  G01N27/62 ,  H01J27/20

Abstract: Certain configurations of ionization sources are described. In some examples, an ionization source comprises an ionization block, an electron source, an electron collector, an ion repeller and at least one electrode configured to provide an electric field when a voltage is provided to the at least one electrode. Systems and methods using the ionization source are also described.

公开(公告)号：US20190355563A1

公开(公告)日：2019-11-21

申请号：US16383629

申请日：2019-04-14

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Tak Shun Cheung ,  Chui Ha Cindy Wong ,  Hamid Badiei ,  William Fisher

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/10

Abstract: Certain configurations of systems and methods that can detect inorganic ions and organic ions in a sample are described. In some configurations, the system may comprise one, two, three or more mass spectrometer cores. In some instances, the mass spectrometer cores can utilize common components such as gas controllers, processors, power supplies and vacuum pumps. In certain configurations, the systems can be designed to detect both inorganic and organic analytes comprising a mass from about three atomic mass units, four atomic mass units or five atomic mass units up to a mass of about two thousand atomic mass units.

公开(公告)号：US20190244799A1

公开(公告)日：2019-08-08

申请号：US16209130

申请日：2018-12-04

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Chady Stephan ,  Ruth Merrifield

IPC: H01J49/10 ,  H01J49/04 ,  G01N30/72 ,  H01J49/16

CPC classification number: H01J49/107 ,  G01N30/7273 ,  H01J49/045 ,  H01J49/049 ,  H01J49/167

Abstract: Certain configurations of systems comprising a cell analyzer and a mass spectrometer are described. In some embodiments, the system can be used to determine both a cell phenotype or cellular response and an amount of at least one elemental species in the cell. The phenotype or other cellular characteristic and elemental content of each cell in a cell population can be determined and correlated.

公开(公告)号：US20190189417A1

公开(公告)日：2019-06-20

申请号：US16147683

申请日：2018-09-29

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Heather Gamble ,  Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/14 ,  H01J49/04 ,  G01N30/72

CPC classification number: H01J49/147 ,  G01N30/7206 ,  H01J27/205 ,  H01J49/0422 ,  H01J49/145

Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.

公开(公告)号：US10262850B2

公开(公告)日：2019-04-16

申请号：US15845419

申请日：2017-12-18

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Tak Shun Cheung ,  Chui Ha Cindy Wong ,  Hamid Badiei ,  William Fisher

IPC: H01J49/26 ,  H01J49/00 ,  H01J49/42 ,  H01J49/10

Abstract: Certain configurations of systems and methods that can detect inorganic ions and organic ions in a sample are described. In some configurations, the system may comprise one, two, three or more mass spectrometer cores. In some instances, the mass spectrometer cores can utilize common components such as gas controllers, processors, power supplies and vacuum pumps. In certain configurations, the systems can be designed to detect both inorganic and organic analytes comprising a mass from about three atomic mass units, four atomic mass units or five atomic mass units up to a mass of about two thousand atomic mass units.

公开(公告)号：US20180332697A1

公开(公告)日：2018-11-15

申请号：US15948078

申请日：2018-04-09

Applicant: PERKINELMER HEALTH SCIENCES CANADA, INC.

Inventor： Samad Bazargan ,  Brian Chan ,  Serguei Savtchenko ,  Hamid Badiei

IPC: H05H1/28 ,  H05H1/30

CPC classification number: H05H1/28 ,  G01J3/42 ,  G01N21/73 ,  H01J49/105 ,  H05H1/46 ,  H05H2001/4667 ,  H05H2001/4675

Abstract: Certain configurations of a torch are described which can be used to sustain a plasma using lower powers and lower cooling gas flow rates. In some examples, the torch may comprise an inner tube of variable diameter along a longitudinal length with a selected gap between outer surfaces of a terminal end or third section of the inner tube and inner surfaces of the outer tube. The terminal end length and/or gap distance can be selected to sustain a concentric plasma using the torch and one or more induction devices. Methods and systems using the torch are also described.