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公开(公告)号：US12022848B2
公开(公告)日：2024-07-02
申请号：US18185195
申请日：2023-03-16
Applicant: COVERCRESS INC. , BOARD OF TRUSTEES OF ILLINOIS STATE UNIVERSITY , REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Tim Ulmasov , Gary Hartnell , John C. Sedbrook , Michael David Marks , Ratan Chopra , Maliheh Esfahanian
IPC: A23K10/30 , A23K20/158
CPC classification number: A23K10/30 , A23K20/158
Abstract: Pennycress seed, seed lots, and seed meal having reduced fiber content and improved suitability for use in producing animal feed are provided.
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公开(公告)号：US20240192140A1
公开(公告)日：2024-06-13
申请号：US18536537
申请日：2023-12-12
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Peter K. Kang , Sang Hyun Lee , Cara M. Santelli , Shreya Srivastava
CPC classification number: G01N21/8803 , C02F3/347 , C12M23/16 , C12M29/14 , C12N1/14 , G01N21/64 , C02F2101/32
Abstract: A bio-enhanced remediation model system generally includes a microfluidic device, a fluid source in fluid communication with the microfluidic device, and an imager in visual communication with a portion of the microfluidic device. Generally, the microfluidic device includes a main flow channel having an inlet, an outlet, and a main flow channel width; one or more microfluidic beds in fluid communication with the main flow channel, at least one microfluidic bed having a plurality of structures that define secondary channels, at least a portion of the secondary channels having a width narrower than the main flow channel width; an aqueous phase dispersed within at least a portion of the main flow channel; and a non-aqueous phase liquid (NAPL) dispersed within at least a portion of the secondary channels.
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公开(公告)号：US20240173411A1
公开(公告)日：2024-05-30
申请号：US18547748
申请日：2022-02-04
Applicant: H. Lee Moffitt Cancer Center and Research Institute, Inc. , REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Marco L. Davila , Brian Betts
IPC: A61K39/00 , A61K39/395 , C07K16/28
CPC classification number: A61K39/464411 , A61K39/3955 , A61K39/4611 , A61K39/4613 , A61K39/4631 , A61K39/464412 , A61K39/464417 , A61K39/464426 , A61K39/464429 , C07K16/2803 , C07K2317/622
Abstract: Disclosed herein are methods of providing an anti-tumor immunity in a subject with a CD83-expressing cancer that involves adoptive transfer of the immune effector cells engineered to express chimeric antigen receptor (CAR) polypeptides that selectively bind CD83-expressing cancers. Also disclosed herein are dual-CAR systems to increase safety and/or efficacy of the CAR-T cells.
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公开(公告)号：US20240165251A1
公开(公告)日：2024-05-23
申请号：US18228550
申请日：2023-07-31
Applicant: Seagen Inc. , Regents of the University of Minnesota
Inventor： Kung-Pern WANG , Alyson SMITH , Christopher Scott NEUMANN , Shyra J. GARDAI , David FERGUSON
IPC: A61K47/68 , A61P35/00 , C07D471/04 , C07H15/203 , C07K16/28
CPC classification number: A61K47/6803 , A61K47/6849 , A61P35/00 , C07D471/04 , C07H15/203 , C07K16/2866
Abstract: The present disclosure provides, inter alia, antibody drug conjugates that are useful in treating various diseases such as cancer. The antibody drug conjugates can be configured to elicit tumor site-specific responses, including tumor microenvironment immunostimulation, while limiting off-target and systemic effects. In certain embodiments disclosed herein, the antibody drug conjugates are configured to release payloads following internalization by immune, cancer, or tumor associated cells.
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公开(公告)号：US20240162891A1
公开(公告)日：2024-05-16
申请号：US18392208
申请日：2023-12-21
Applicant: Regents of the University of Minnesota
Inventor： Hyung-il Kim , William Moy , Hao Lo
Abstract: A fully connected ring oscillator circuit includes a plurality of first ring oscillator loops, a plurality of second ring oscillator loops, a plurality of ring oscillators and a plurality of coupled ring oscillators. Each first ring oscillator loop extends along a first axis. Each second ring oscillator loop extends along a second axis that is transverse to the first axis and intersects each of the first ring oscillator loops. Each ring oscillator includes one of the first ring oscillator loops connected to one of the second ring oscillator loops. Each coupled ring oscillator includes two of the ring oscillators that are connected to each other through a programmable weighted coupling block.
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Patent Agency Ranking
公开(公告)号：US20240156342A1
公开(公告)日：2024-05-16
申请号：US18372439
申请日：2023-09-25
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Robert Vince , Swati Sudhakar More
IPC: A61B3/12 , A61B3/14 , A61B5/00 , A61K38/06 , G01J3/00 , G01J3/28 , G01J3/40 , G01N21/25 , G01N21/31 , G01N33/50
CPC classification number: A61B3/12 , A61B3/14 , A61B5/4848 , A61K38/063 , G01J3/00 , G01J3/28 , G01J3/40 , G01N21/25 , G01N21/31 , G01N33/5038
Abstract: Described herein is the use of a visible near infrared (VNIR) hyperspectral imaging system as a non-invasive diagnostic tool for early detection of Alzheimer's disease (AD). Also described herein is the use of a VNIR hyperspectral imaging system in high throughput screening of potential therapeutics against AD.
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47.发明公开公开(公告)号：US20240148962A1
公开(公告)日：2024-05-09
申请号：US18548814
申请日：2022-03-04
Inventor： Demetris Yannopoulos , Dionysios Foustoukos
CPC classification number: A61M5/141 , A61K33/00 , A61M5/36 , A61M2202/0007 , A61M2202/0476 , A61M2210/02 , A61M2210/1042 , A61M2210/12
Abstract: An example system includes a fluid delivery device configured to deliver gas nanobubbles to a target site of a patient from a solution comprising a fluid, supersaturated with a. gas, wherein the fluid delivery' device defines a flow channel configured to flow the solution through the flow channel such that the gas in the supersaturated fluid forms gas nanobubbles as the solution flows through the flow channel towards the target site, and wherein the gas nanobubbles remain in the fluid at least until delivery' to the target site.
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公开(公告)号：US11979290B2
公开(公告)日：2024-05-07
申请号：US18055233
申请日：2022-11-14
Inventor： Bo Han , Vijay Gopalakrishnan , Muhammad Bilal Anwer , Zhi-Li Zhang , Yang Zhang
IPC: H04L41/0893 , G06F9/455 , G06F9/50 , H04L12/24 , H04L12/715 , H04L15/16 , H04L45/64 , H04L61/256
CPC classification number: H04L41/0893 , G06F9/45558 , G06F9/5077 , H04L45/64 , H04L61/256 , G06F2009/45595
Abstract: Systems and methods are disclosed for parallelizing service function chains. A method comprises receiving a sequential service function chain comprising a plurality of network functions, receiving a plurality of operations, determining at least two network functions are capable of being parallelized, aggregating operations of the plurality of operations associated with the at least two network functions into a network function segment, determining whether another network function is capable of being parallelized with the network function segment, based on the determining: aggregating an operation associated with the another network function into the network function segment when the another network function is capable of being parallelized with the network function segment, or pushing the network function segment as a completed segment of a hybrid service function chain when the another network function is not capable of being parallelized with the network function segment, and implementing the hybrid service function chain.
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公开(公告)号：US11946935B2
公开(公告)日：2024-04-02
申请号：US17411524
申请日：2021-08-25
Applicant: Regents of the University of Minnesota
Inventor： Nurten Saydam , Okay Saydam
IPC: G01N33/574 , G01N33/50
CPC classification number: G01N33/57488 , G01N33/5091 , G01N2333/515 , G01N2333/71 , G01N2333/96466
Abstract: Methods and diagnostic compositions for detecting and monitoring meningiomas.
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公开(公告)号：US20240099997A1
公开(公告)日：2024-03-28
申请号：US18237360
申请日：2023-08-23
Applicant: Regents of the University of Minnesota
Inventor： Ambika Bhagi-Damodaran , Leonardo Rander Asse, Jr. , Sourav Chatterjee
IPC: A61K31/15 , A01N33/26 , A01N43/40 , A01N43/78 , A01N43/84 , A01N43/90 , A61K31/428 , A61K31/4365 , A61K31/439 , A61K31/445 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P31/06
CPC classification number: A61K31/15 , A01N33/26 , A01N43/40 , A01N43/78 , A01N43/84 , A01N43/90 , A61K31/428 , A61K31/4365 , A61K31/439 , A61K31/445 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61P31/06
Abstract: Disclosed herein are methods to inhibit a metalloprotein and methods to treat diseases and crop infections with a compound of formula I:
X-L-Y I
or a salt thereof. Also disclosed are novel compounds of formula I or a salt thereof and compositions comprising a compound of formula I.
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