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公开(公告)号：US20190300963A1
公开(公告)日：2019-10-03
申请号：US16192221
申请日：2018-11-15
Applicant: ROSETTA GENOMICS LTD.
Inventor： Zohar Barnett-Itzhaki , Gila Lithwick Yanai , Eti Meiri , Yael Spector , Hila Benjamin , Nir Dromi
IPC: C12Q1/6886 , G16B20/00 , G16B25/00
Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
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公开(公告)号：US20190169690A1
公开(公告)日：2019-06-06
申请号：US16218863
申请日：2018-12-13
Applicant: ROSETTA GENOMICS LTD.
Inventor： Yaron Goren
IPC: C12Q1/6883
Abstract: The invention provides a method of diagnosing Alzheimer's disease (AD) in a subject by determining the level of expression of one or more miRNAs molecules associated with AD, as well as various nucleic acid molecules relating thereto or derived thereof.
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公开(公告)号：US09988690B2
公开(公告)日：2018-06-05
申请号：US15363822
申请日：2016-11-29
Applicant: ROSETTA GENOMICS LTD. , MOR RESEARCH APPLICATIONS
Inventor： Moshe Hoshen , Gila Lithwick Yanai , Ram Eitan
IPC: C12Q1/68 , A61K31/713 , A61K45/00
CPC classification number: C12Q1/6886 , A61K31/713 , A61K45/00 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/16 , C12Q2600/178
Abstract: Described herein are compositions and methods for the prediction of the prognosis of ovarian cancer subjects. The present invention further provides methods for distinguishing between histological subtypes of ovarian cancer tumors, and also methods and compositions for the treatment or prevention of ovarian cancer. Specifically the invention relates to microRNA molecules associated with said methods and compositions, as well as various nucleic acid molecules relating thereto or derived therefrom.
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公开(公告)号：US20180127755A1
公开(公告)日：2018-05-10
申请号：US15813584
申请日：2017-11-15
Applicant: Regulus Therapeutics Inc. , Rosetta Genomics Ltd.
Inventor： C. Frank Bennett , Ayelet Chajut , Christine Esau , Eric Marcusson , Noga Yerushalmi
IPC: C12N15/113 , A61K31/7088 , A61K31/7068 , A61K31/704 , A61K31/407 , A61K31/44 , A61K31/7048 , A61K31/555 , A61K31/4745 , A61K31/513
CPC classification number: C12N15/113 , A61K31/407 , A61K31/44 , A61K31/4745 , A61K31/513 , A61K31/555 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7088 , A61K31/7105 , A61K45/06 , C12N2310/113 , C12N2310/141 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/346 , C12N2310/3525
Abstract: Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
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公开(公告)号：US20170356055A1
公开(公告)日：2017-12-14
申请号：US15625645
申请日：2017-06-16
Applicant: ROSETTA GENOMICS, LTD.
Inventor： Zohar Barnett-Itzhaki , Gila Lithwick Yanai , Eti Meiri , Yael Spector , Hila Benjamin , Nir Dromi
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178 , G16B20/00 , G16B25/00
Abstract: The present invention provides a method for classification of thyroid tumors through the analysis of the expression patterns of specific microRNAs in fine needle aspiration samples. Thyroid tumor classification according to a microRNA expression signature allows optimization of diagnosis and treatment, as well as determination of signature-specific therapy.
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Patent Agency Ranking
公开(公告)号：US09803247B2
公开(公告)日：2017-10-31
申请号：US14284256
申请日：2014-05-21
Inventor： Nitzan Rosenfeld , Shai Rosenwald , Iris Barshack , Dvora Nass
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention provides a process for classification of specific cancers and tumors origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules relating thereto. Classification according to a microRNA expression framework allows optimization of treatment, and determination of specific therapy.
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公开(公告)号：US20170298447A1
公开(公告)日：2017-10-19
申请号：US15586747
申请日：2017-05-04
Applicant: Rosetta Genomics Ltd.
Inventor： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC: C12Q1/68 , A61K38/00 , C12N15/11 , C12N15/113
CPC classification number: C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
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公开(公告)号：US09650680B2
公开(公告)日：2017-05-16
申请号：US14999879
申请日：2016-07-13
Applicant: Rosetta Genomics Ltd.
Inventor： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC: C12N15/11 , C07H21/04 , C12Q1/68 , A61K38/00 , C12N15/113
CPC classification number: C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
Abstract: Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
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公开(公告)号：US09650679B2
公开(公告)日：2017-05-16
申请号：US14756185
申请日：2015-08-13
Applicant: Rosetta Genomics Ltd.
Inventor： Itzhak Bentwich , Amir Avniel , Yael Karov , Ranit Aharonov
IPC: C07H21/04 , C12N15/11 , C12Q1/68 , A61K38/00 , C12N15/113
CPC classification number: C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
Abstract: Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
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公开(公告)号：US20170067106A1
公开(公告)日：2017-03-09
申请号：US15097923
申请日：2016-04-13
Applicant: ROSETTA GENOMICS, LTD.
Inventor： Yaron Goren
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/118 , C12Q2600/158
Abstract: The invention provides a method of diagnosing Alzheimer's disease (AD) in a subject by determining the level of expression of one or more miRNAs molecules associated with AD, as well as various nucleic acid molecules relating thereto or derived thereof.
Abstract translation: 本发明提供了通过测定与AD相关的一种或多种miRNA分子的表达水平以及与其相关或衍生的各种核酸分子来诊断受试者中的阿尔茨海默氏病（AD）的方法。
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