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公开(公告)号：US12138118B2
公开(公告)日：2024-11-12
申请号：US17507280
申请日：2021-10-21
Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SORBONNE UNIVERSITÉ , UNIVERSITÉ PARIS CITÉ , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
Inventor： Jean-Luc Gennisson , Mickaël Tanter , Thomas Deffieux , Mathieu Pernot
Abstract: The invention concerns a multi-sensor brain detecting apparatus, the detecting apparatus being adapted to obtain two different physical values of a brain of a subject, the detecting apparatus comprising: a set of sensors comprising an ultrasound transducer adapted to produce ultrasound waves, a frame with a position with relation to the brain known with a stereotaxic precision, the frame being adapted to hold a sensor that can be positioned at a specific location by a user of the detecting apparatus without using a tool.
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42.发明公开公开(公告)号：US20240354955A1
公开(公告)日：2024-10-24
申请号：US18701112
申请日：2022-10-14
Inventor： Jean-Charles AUREGAN , Catherine BOSSER , Manon BACHY
CPC classification number: G06T7/0014 , A61B5/442 , G06T7/62 , G06T2207/20081 , G06T2207/30088
Abstract: A non-invasive method for determining a characteristic length representative of a quality of collagenic organs of a patient, includes acquisition of at least one image of a cutaneous replica of a portion of the skin surface of the patient, the cutaneous replica being obtained from a skin patching device applied on the portion of the skin surface; processing of the acquired image in order to obtain a processed image, said processed image being formed by a plurality of geometrical shapes; extraction of a plurality of features from the plurality of geometrical shapes; determination of the characteristic length representative of the quality of the collagenic organs of the patient based on the extracted features.
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公开(公告)号：US12038569B2
公开(公告)日：2024-07-16
申请号：US17273255
申请日：2019-09-04
Applicant: Sorbonne Université , Centre National de la Recherche Scientifique , École Normale Supérieure de Paris
Inventor： Sylvain Gigan , Thomas Juffmann , Andrés De Los Ríos Sommer
CPC classification number: G02B21/14 , G02B21/365
Abstract: A device for phase microscopy is disclosed that comprises a spatial light modulator and a connecting means adapted to fix the spatial light modulator onto a phase microscope. The phase microscope comprises a light path comprising at least a sample area, a light device for lighting said sample area, and an imaging device for capturing a phase image of said sample area. The phase image is a 2D matrix of pixels. The spatial light modulator is positioned in the light path in a conjugated plane of the sample area. The device also comprises a command of the spatial light modulator connected to the imaging device and adapted to measure the phase shift of a plurality of pixels of the phase image and to command the spatial light modulator in order to subtract the measured phase shifts.
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公开(公告)号：US11905330B1
公开(公告)日：2024-02-20
申请号：US17935261
申请日：2022-09-26
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP) , UNIVERSITÉ PARIS CITÉ , SORBONNE UNIVERSITÉ
Inventor： Guido Kroemer , José Manuel Bravo San Pedro
IPC: A61K39/395 , C07K16/18 , C07K16/28 , A61P3/04 , A61K39/00
CPC classification number: C07K16/286 , A61P3/04 , A61K2039/505 , A61K2039/545
Abstract: Autophagy is typically activated by starvation, allowing cells and organisms to mobilize their energy reserves. It is known that pharmacological modulation of autophagy represents a therapeutic potential. Here the inventors report that a protein that is released from cells in an unconventional, autophagy-dependent manner, namely, diazepam binding inhibitor (DBI), regulates autophagy. In particular, the inventors demonstrate that DBI inhibits autophagy and that the supply of recombinant DBI to mice enhanced glycolysis, enhanced lipogenesis, and inhibited fatty acid oxidation. The inventors show that neutralisation of DBI by a monoclonal antibody and an active immunization by means of an immunogenic DBI derivative eliciting autoantibodies induce autophagy and lead to metabolic changes that increase starvation-induced weight loss, reduce food intake upon refeeding, and reduce weight gain in response to hypercaloric diets. Accordingly, the present invention relates to methods and pharmaceutical compositions for modulating autophagy based on the modulation of the activity or expression of DBI.
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公开(公告)号：US11857254B2
公开(公告)日：2024-01-02
申请号：US17044029
申请日：2019-03-28
Applicant: Essilor International , Sorbonne Université
Inventor： Rémy Allard , Daphné Silvestre
CPC classification number: A61B3/0025 , A61B3/0041 , A61B3/022 , A61B3/032 , A61B3/066 , G16H30/40 , G16H50/30
Abstract: The invention relates to a method for characterizing a visual system of a subject using measures of the sensitivity to contrast, the visual system comprising visual signal processing elements each having an impact on the sensitivity to contrast, wherein a visual test where visual patterns having different spatiotemporal frequencies and with varying luminance levels and with varying levels of visual degradation of the visual patterns are shown to a subject to measure the sensitivity to contrast of said subject, is performed, wherein a predetermined response model of a visual system is preestablished on the basis of a determination of the visual signal processing element that predominantly limits the sensitivity to contrast for each value of luminance and spatiotemporal frequency, said predetermined response model relating the visual signal processing elements predominantly limiting the sensitivity to contrast to the luminances and to the spatiotemporal frequencies, wherein at least one of the visual signal processing elements is selected in order to be investigated, wherein at least one visual test is performed on the visual system of the subject, said visual test being optimized according to said at least one selected visual signal processing element, during the optimized visual test, the variations of the luminance levels and of spatiotemporal frequencies being limited within a range of luminance and a range of spatiotemporal frequency where the predetermined response model locates the visual signal processing element as predominant in limiting the sensitivity to contrast.
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Patent Agency Ranking
公开(公告)号：US20230420084A1
公开(公告)日：2023-12-28
申请号：US18022805
申请日：2021-08-25
Applicant: Sanofi , Ecole Normale Supérieure , Sorbonne Université , Centre National de la Recherche Scientifique
Inventor： Maxime Langevin
Abstract: A computer-implemented method of generating a molecule includes sequentially processing, by a memory network, each token in a token string representation of a molecular scaffold to generate a molecule, wherein the token string representation comprises a plurality of tokens representing predefined structures of the molecular scaffold and one or more tokens representing open positions of the molecular scaffold, and wherein the memory network encodes a sequential probability distribution on the tokens using an internal state of the memory network. The method further includes outputting, from the memory network, a token string representation of the generated molecule. Sequentially processing each token in the token string representation of the molecular scaffold includes determining whether or not a current token being processed is a token representing an open position of the molecule.
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公开(公告)号：US20230400402A1
公开(公告)日：2023-12-14
申请号：US18250514
申请日：2020-10-29
Inventor： Sinan HALIYO , Stéphane RÉGNIER , Edison GERENA
CPC classification number: G01N15/1434 , G02B21/32 , G02B21/0088
Abstract: The present invention relates to a device for determining the position of a plurality of objects that are simultaneously trapped by a single laser beam, characterized in that the device comprises:—a laser source for emitting a laser beam, an actuation system for a three-dimensional deflecting of the laser beam between several trapping points,—a microscope objective for focusing the laser beam coming from the actuation system on the trapping points,—a sample chamber including the objects to be trapped on the trapping points,—a light source for lighten the sample chamber, and—a camera for determining the position of each of the trapped objects, said camera being located between the laser source and the actuation system, so that the light emitted by the light source passes successively through the sample chamber, the microscope objective, the actuation system and the camera.
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48.发明公开公开(公告)号：US20230253118A1
公开(公告)日：2023-08-10
申请号：US18004710
申请日：2021-07-12
Inventor： Delphine SAUCE , Martin LARSEN
CPC classification number: G16H50/30 , G01N33/5308
Abstract: An in vitro method of classifying a subject suspected to suffer from an acute event including the steps of: determining neopterin concentration in a biological sample obtained from the subject, comparing the concentration with a predetermined reference neopterin concentration, and assigning the subject to a risk group based on the comparison of the neopterin concentration with the predetermined reference neopterin concentration.
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49.发明公开公开(公告)号：US20230142731A1
公开(公告)日：2023-05-11
申请号：US17862622
申请日：2022-07-12
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , GENETHON , SORBONNE UNIVERSITÉ , UNIVERSITÉ DE PARIS , SPARK THERAPEUTICS, INC.
Inventor： Sébastien LACROIX-DESMAZES , Federico MINGOZZI , Jordan DIMITROV , Christian LEBORGNE , Sean ARMOUR
IPC: A61K48/00 , C12N9/24 , C12N15/113 , C12N15/86 , A61K38/48 , C12N9/64 , C12N15/861
CPC classification number: A61K48/005 , C12N9/2402 , C12N15/113 , C12N15/86 , A61K38/4873 , C12N9/6475 , C12N15/861 , C12N2310/11 , C12N2310/141 , C12N2750/14143 , C12Y302/01 , C12Y304/22 , C12Y304/2201 , G01N33/6854
Abstract: Disclosed herein are methods for treating patients that may develop or already have pre-existing gene therapy neutralizing antibodies by administering a protease that cleaves peptide bonds present in immunoglobulins or by administering a glycosidase that cleaves carbohydrate residues present on immunoglobulins, or other similar enzymatic cleavage of immunoglobulins in vivo. Also disclosed are methods for utilizing IdeS and other immunoglobulin G-degrading enzyme polypeptides for gene therapy treatment of a disease in a patient in need thereof.
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公开(公告)号：US11643449B2
公开(公告)日：2023-05-09
申请号：US16759975
申请日：2018-11-02
Applicant: SORBONNE UNIVERSITÉ , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Inventor： Xavier Nicol , Oriol Ros Torres
CPC classification number: C07K14/4728 , A61K38/00 , C07K2319/02 , C07K2319/60
Abstract: The disclosure pertains to the field of molecular means capable of binding calcium, in particular peptides which are calcium chelators, appropriate for use in vitro or in vivo and preferably capable of targeting specific cellular compartments. Polypeptide comprising a first calcium-binding domain, a peptide linker and a second calcium binding domain, wherein the first and second binding domains are linked through the peptide linker, and wherein: the first calcium-binding domain and the second calcium binding domain each comprise at least one calcium-binding site derived from a EF-hand motif; and, the first calcium-binding domain and the second calcium binding domain differ in at least one calcium-binding site.
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