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    Metalloproteinase ADAM 22
    42.
    发明申请
    Metalloproteinase ADAM 22 审中-公开
    金属蛋白酶ADAM 22

    公开(公告)号：US20050221376A1

    公开(公告)日：2005-10-06

    申请号：US11142737

    申请日：2005-06-02

    Applicant: Paul Young ,  Steven Ruben

    Inventor： Paul Young ,  Steven Ruben

    IPC: A61K38/00 ,  C07H21/04 ,  C12N9/64 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6883

    CPC classification number: C12N9/6489 ,  A61K38/00 ,  C12Q1/6883

    Abstract: The present invention relates to a novel metalloproteinase protein called ADAM 22. In particular, isolated nucleic acid molecules are provided encoding the human ADAM 22 proteins. ADAM 22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ADAM 22 activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of this metalloproteinase.

    Abstract translation: 本发明涉及称为ADAM22的新型金属蛋白酶蛋白质。特别地，提供编码人ADAM22蛋白质的分离的核酸分子。 还提供了ADAM22多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定ADAM22活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及其特征在于该金属蛋白酶的过量或不足产生的其它病症。

    Interleukin 17 receptor-like protein
    44.
    发明申请
    Interleukin 17 receptor-like protein 审中-公开
    白介素17受体样蛋白

    公开(公告)号：US20050181372A9

    公开(公告)日：2005-08-18

    申请号：US10645702

    申请日：2003-08-22

    Applicant: Yanggu Shi ,  Steven Ruben

    Inventor： Yanggu Shi ,  Steven Ruben

    IPC: A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C12Q1/68 ,  C07H21/04

    CPC classification number: C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

    Abstract: The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

    Abstract translation: 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

    Antibodies that immunospecifically bind to TRAIL receptors
    45.
    发明申请
    Antibodies that immunospecifically bind to TRAIL receptors 有权
    免疫特异性结合TRAIL受体的抗体

    公开(公告)号：US20050129699A1

    公开(公告)日：2005-06-16

    申请号：US10986047

    申请日：2004-11-12

    Applicant: Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

    Inventor： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

    IPC: A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

    CPC classification number: A61K39/395 ,  A61K31/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/622 ,  A61K2300/00

    Abstract: The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4i. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    Abstract translation: 本发明涉及免疫特异性结合TRAIL受体TR4i的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。

    Human G-protein coupled receptors
    46.
    发明申请
    Human G-protein coupled receptors 审中-公开
    人类G蛋白偶联受体

    公开(公告)号：US20050123961A1

    公开(公告)日：2005-06-09

    申请号：US10968990

    申请日：2004-10-21

    Applicant: Yi Li ,  Steven Ruben

    Inventor： Yi Li ,  Steven Ruben

    IPC: C12N15/09 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/74

    CPC classification number: C07K14/705

    Abstract: Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a mutation in the nucleic acid sequence of each of the G-protein coupled receptors.

    Abstract translation: 公开了两种人G-蛋白偶联受体多肽和编码每种这样的多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽鉴定这种多肽的拮抗剂和激动剂的方法。 还公开了用于检测每个G蛋白偶联受体的核酸序列中的突变的诊断方法。

    FRUIT PEELER
    47.
    发明申请
    FRUIT PEELER 失效
    水果皮

    公开(公告)号：US20050066529A1

    公开(公告)日：2005-03-31

    申请号：US10674310

    申请日：2003-09-30

    Applicant: Steven Ruben

    Inventor： Steven Ruben

    IPC: A47J17/02 ,  A47J43/28

    CPC classification number: A47J17/02

    Abstract: A hand utensil for peeling and pitting a fruit, such as a mango, has a spoon-shaped bowl through which a plurality of elongated generally parallel slots laterally extend in a lower region of the concave surface between the proximal end and the distal end of the bowl. In addition, a series of arcuate ridges project from the concave surface of the bowl, wherein each arcuate ridge has a radius of curvature extending from a center point on a longitudinal axis defined by the bowl.

    Abstract translation: 用于剥离和点蚀水果（如芒果）的手工具具有勺形碗，多个细长的大致平行的狭槽通过该勺形碗横向延伸在凹形表面的下端区域中， 碗。 此外，一系列弧形凸起从碗的凹面突出，其中每个弧形脊具有从由碗定义的纵向轴线上的中心点延伸的曲率半径。

    Human oncogene induced secreted protein I
    50.
    发明申请
    Human oncogene induced secreted protein I 失效
    人类致癌基因诱导分泌蛋白I

    公开(公告)号：US20050003437A1

    公开(公告)日：2005-01-06

    申请号：US10909386

    申请日：2004-08-03

    Applicant: Henrik Olsen ,  Steven Ruben

    Inventor： Henrik Olsen ,  Steven Ruben

    IPC: A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/64

    CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    Abstract: The present invention relates to a novel protein, the Human Oncogene Induced Secreted Protein I (“HOIPS I”) protein. In particular, isolated nucleic acid molecules are provided encoding the human HOIPS I protein. HOIPS I polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for detecting abnormal cell proliferation and differentiation disorders and therapeutic methods for treating the same.

    Abstract translation: 本发明涉及一种新的蛋白质，即人癌基因诱导的分泌蛋白I（“HOIPS I”）蛋白质。 特别地，提供编码人HOIPS I蛋白的分离的核酸分子。 还提供HOIPS I多肽，载体，宿主细胞和用于制备其的重组方法。 还提供了用于检测异常细胞增殖和分化障碍的诊断方法及其治疗方法。

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