Fuel cell stack
    42.
    发明授权
    Fuel cell stack 失效
    燃料电池堆

    公开(公告)号:US08435693B2

    公开(公告)日:2013-05-07

    申请号:US12950957

    申请日:2010-11-19

    IPC分类号: H01M2/38

    摘要: A fuel cell stack configured to alleviate pressure and decrease the flow rate of at least one of a fuel and an oxidant is disclosed. The fuel cell stack includes a membrane-electrode assembly, an anode separator, a cathode separator and a filing member. The membrane-electrode assembly may include an electrolyte membrane, an anode formed on a first surface of the electrolyte membrane, and a cathode formed on a second surface of the electrolyte membrane. The anode separator may include a fuel channel, a fuel inlet manifold in fluid communication with the fuel channel, and a fuel outlet manifold in fluid communication with the fuel channel. The cathode separator may include an oxidant channel, an oxidant inlet manifold in fluid communication with the oxidant channel, and an oxidant outlet manifold in fluid communication with the oxidant channel. The filling member may be positioned within at least one of the fuel inlet manifold and the oxidant inlet manifold.

    摘要翻译: 公开了一种构造成减轻压力并降低燃料和氧化剂中的至少一种的流量的燃料电池堆。 燃料电池堆包括膜 - 电极组件,阳极分离器,阴极分离器和归档构件。 膜 - 电极组件可以包括电解质膜,形成在电解质膜的第一表面上的阳极和形成在电解质膜的第二表面上的阴极。 阳极分离器可以包括燃料通道,与燃料通道流体连通的燃料入口歧管以及与燃料通道流体连通的燃料出口歧管。 阴极分离器可以包括氧化剂通道,与氧化剂通道流体连通的氧化剂入口歧管和与氧化剂通道流体连通的氧化剂出口歧管。 填充构件可以位于燃料入口歧管和氧化剂入口歧管中的至少一个内。

    Benzothiophene compounds
    48.
    发明授权
    Benzothiophene compounds 失效
    苯并噻吩化合物

    公开(公告)号:US5728724A

    公开(公告)日:1998-03-17

    申请号:US692666

    申请日:1996-08-06

    CPC分类号: C07D333/56

    摘要: The present invention relates to compounds of formula I ##STR1## wherein R.sup.1 is --H, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOC.sub.6 H.sub.5, --OCO(C.sub.1 -C.sub.6 alkyl), or --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl); R.sup.2 is 1-naphthyl, 2-naphthyl, 2-thienyl, 3-thienyl, benzothienyl, or --CH.sub.2 C.sub.6 H.sub.5 ; any of which may be optionally substituted with 1-3 substituents independently selected from the group halo, --OH, --O(C.sub.1 -C.sub.4 alkyl), --OCOC.sub.6 H.sub.5, --OCO(C.sub.1 -C.sub.6 alkyl), or --OSO.sub.2 (C.sub.4 -C.sub.6 alkyl); X is --CH.sub.2 --, --CO--, or --CH(OH)--; n is 2 or 3; and R.sup.3 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino; or a pharmaceutically acceptable salt thereof. The present invention further relates to pharmaceutical compositions containing compounds of formula I, and the use of such compounds, for alleviating the symptoms of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. The compounds of the present invention also are useful for inhibiting uterine fibroid disease and endometriosis in women and aortal smooth muscle cell proliferation, particularly restenosis, in humans.

    摘要翻译: 本发明涉及式Ⅰ化合物其中R 1是-H,-OH,-O(C 1 -C 4烷基),-OCOC 6 H 5,-OCO(C 1 -C 6烷基)或-OSO 2(C 4 -C 6 烷基); R2是1-萘基,2-萘基,2-噻吩基,3-噻吩基,苯并噻吩基或-CH2C6H5; 其中任何一个可以任选被1-3个独立地选自卤素,-OH,-O(C 1 -C 4烷基),-OCOC 6 H 5,-OCO(C 1 -C 6烷基)或-OSO 2(C 4 -C 6 烷基); X是-CH 2 - , - CO-或-CH(OH) - ; n为2或3; 并且R 3是1-哌啶基,1-吡咯烷基,甲基-1-吡咯烷基,二甲基-1-吡咯烷基,4-吗啉代,二甲基氨基,二乙基氨基或1-六亚甲基亚氨基; 或其药学上可接受的盐。 本发明还涉及包含式I化合物的药物组合物,以及这些化合物用于缓解绝经后综合征,特别是骨质疏松症,心血管相关病理状况和雌激素依赖性癌症的症状的用途。 本发明的化合物还可用于抑制妇女子宫肌瘤和子宫内膜异位症以及主动脉平滑肌细胞增殖,特别是人类的再狭窄。