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公开(公告)号：US20210380683A1
公开(公告)日：2021-12-09
申请号：US17046843
申请日：2019-04-12
发明人： Wenhao CHEN , Xian Chang LI
摘要： Disclosed are methods and compositions for inhibiting IRF4 in T-cells, thereby improving transplant outcomes or treating an autoimmune disease such as a myelination disorder. Thus, disclosed are methods to improve a transplant outcome in a recipient of a transplant comprising inhibiting IRF4 in T-cells of the recipient, thereby improving the transplant outcome. In some embodiments, IRF4 can be inhibited by administering an IRF4 inhibitor (e.g., trametinib or anti-IRF4 siRNA), and/or by adoptive transfer of T-cells having IRF4 inhibition. In some embodiments, the T-cells are CD4+ Tcells, and the infiltration thereof into a transplant can be reduced. Also disclosed are methods of treating a subject with a myelination disorder (e.g., multiple sclerosis or encephalomyelitis) comprising inhibiting IRF4.
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公开(公告)号：US20210361167A1
公开(公告)日：2021-11-25
申请号：US17277034
申请日：2019-09-17
申请人： Tatiana WOLFE , Caio C. QUINI , Philip J. HORNER , Matthew K. K. HOGAN , THE METHODIST HOSPITAL SYSTEM
摘要： The exemplified system and method facilitate an objective, non-invasive measurement of myelin quality and integrity in living brains based on isolation of myelin-specific magnetic relaxation constants in k-space. The system uses magnetic resonance (MR) signals to select signatures specific to, or associated with, myelin and its structure and to then encode the selected signatures into an image or model to which the quantitative myelin health information can be co-registered with 2D, 3D visualization, and tractography of the myelin-signal isolated MR information. The system also sets a model for digital hierarchical learning of biomedical signals in MR, and beyond, based on experimental data in which it executes the herein described signal isolation operations.
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公开(公告)号：US20210231686A1
公开(公告)日：2021-07-29
申请号：US17054131
申请日：2019-05-10
发明人： Stanley H. Appel , David R. BEERS
IPC分类号： G01N33/68
摘要： The present disclosure relates generally to methods for the prognosis and management of amyotrophic lateral sclerosis (ALS), as well as associated compositions, kits, solid supports and uses.
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公开(公告)号：US20210154141A1
公开(公告)日：2021-05-27
申请号：US17103347
申请日：2020-11-24
IPC分类号： A61K9/127 , C07K17/02 , A61K38/18 , C07K14/475 , C07K14/54 , A61K47/69 , A61K47/54 , A61P35/00 , A61K31/7016 , A61K38/20
摘要： Disclosed are positively-charged, cytotoxic nanoparticle compositions comprising immune modulators (such as the toll-like receptor (TLR)-4 ligand, monophosphoryl lipid (MPL)-A), and Interleukin (IL)-12)), which exhibit enhanced uptake by mammalian cancer cells, and cause increased cancer cell death and/or an increased release of cancer antigens following direct injection to populations of cancer or tumor cells. Also disclosed are nanoparticle-vectored, immunomodulatory compositions that stimulate antigen presenting immune cells and T cells, and support the development of anti-cancer immunity in mammalian hosts. The disclosed cationic liposomes represent an important advance in the area of cancer immunotherapeutics.
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公开(公告)号：US10913068B2
公开(公告)日：2021-02-09
申请号：US15557957
申请日：2016-03-14
申请人： Nanyang Technological University , Agency for Science, Technology And Research , The Methodist Hospital
发明人： Joseph Sylvester Chang , Geok Soon Lim , Lei Zhang , Zhiping Wang , Ruige Wu , Stephen T. C. Wong , Kemi Cui
IPC分类号： B01L7/00 , C12Q1/686 , A61B5/15 , A61B5/153 , C12Q1/6851
摘要： A testing device is provided. The testing device includes a capturing tool and a microfluidic chip having a plurality of chambers connected in a network, a sample receiving port connected to the network, and a guide structure configured to receive the capturing tool, wherein the capturing tool is configured to capture sample in a distal position from the guide structure and further configured to transfer the captured sample to the sample receiving port in a proximal position from the guide structure.
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公开(公告)号：US20210022848A1
公开(公告)日：2021-01-28
申请号：US17069092
申请日：2020-10-13
摘要： Soft tissue repair grafts are provided for supporting, covering, and/or retaining an implant positioned in the body of a subject. The grafts are particularly suitable for use for pre-pectoral breast reconstruction with a breast implant or tissue expander. The grafts include positional notches for more accurate positioning in a subject. The grafts also include at least one cuff element which is folded to form a reinforced folded edge for suturing the graft more securely to adjacent tissues than previously known grafts. The grafts also include a plurality of arcuate slots which form a plurality of circular patterns arranged concentrically about a focal point, thereby enabling the grafts to expand without tearing and to conform more closely to the implant and/or adjacent body tissues such as the breast pocket, than previously known grafts. Acellular dermal matrices are particularly suitable for making the soft tissue repair grafts.
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公开(公告)号：US10813743B2
公开(公告)日：2020-10-27
申请号：US16125435
申请日：2018-09-07
摘要： Soft tissue repair grafts are provided for supporting, covering, and/or retaining an implant positioned in the body of a subject. The grafts are particularly suitable for use for pre-pectoral breast reconstruction with a breast implant or tissue expander. The grafts include positional notches for more accurate positioning in a subject. The grafts also include at least one cuff element which is folded to form a reinforced folded edge for suturing the graft more securely to adjacent tissues than previously known grafts. The grafts also include a plurality of arcuate slots which form a plurality of circular patterns arranged concentrically about a focal point, thereby enabling the grafts to expand without tearing and to conform more closely to the implant and/or adjacent body tissues such as the breast pocket, than previously known grafts. Acellular dermal matrices are particularly suitable for making the soft tissue repair grafts.
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公开(公告)号：US10736880B2
公开(公告)日：2020-08-11
申请号：US16063312
申请日：2016-12-19
发明人： Jerrie S. Refuerzo , Biana Godin , Monica Longo
IPC分类号： A61K31/405 , A61K38/095 , A61K47/69 , A61K9/00 , A61K9/127 , A61K47/62 , C07K7/16 , A61P15/06 , A61P15/00
摘要： Methods and compositions are provided for treating and preventing preterm labor using liposome encapsulated tocolytic agents, such as indomethacin. In certain aspects, targeted liposomes are provided that allow delivery of tocolytic agents directly to the uterus, such as by targeting to the oxytocin receptor.
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49.发明授权公开(公告)号：US10314811B2
公开(公告)日：2019-06-11
申请号：US15754133
申请日：2016-08-18
发明人： Ren Kong , Hong Zhao , Stephen T. C. Wong
IPC分类号： A61K9/00 , A61P1/12 , A61K31/12 , A61K45/06 , A61K31/121 , A61K31/352 , A61K31/353 , A61K31/4745
摘要： A method for treating diarrhea induced by a chemotherapy agent by administering a carboxylesterase 2 (CES2) inhibitor, i.e., hesperetin, naringenin, or 2′,4′-dihydroxychalcone. Also disclosed is a method for treating cancer by administering a chemotherapy agent together with hesperetin, naringenin, or 2′,4′-dihydroxychalcone. Furthermore, a composition for treating cancer is provided, the composition containing a chemotherapy agent and hesperetin, naringenin, or 2′,4′-dihydroxychalcone.
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公开(公告)号：US20190117572A1
公开(公告)日：2019-04-25
申请号：US15915055
申请日：2018-03-07
发明人： Ennio Tasciotti , Roberto Molinaro
IPC分类号： A61K9/127 , C12N15/113 , A61K51/12 , A61K49/00 , A61K49/18
摘要： Disclosed are methods for designing and manufacturing biomimetic proteolipid nanovesicles using a microfluidic approach, and in particular, a NanoAssemblr®-based platform, which allows for the high-throughput, reproducible, and scalable production of nanoparticles, without affecting their pharmaceutical and biological properties. These nanovesicles, which are composed of synthetic phospholipids and cholesterol, enriched of leukocyte membranes, and surrounding an aqueous core, possess remarkable properties for targeting compounds of interest to particular mammalian cell and tissue types.
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