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    COMPOSITE PARTICLE, CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING, AND PHOTOACOUSTIC IMAGING METHOD
    45.
    发明申请
    COMPOSITE PARTICLE, CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING, AND PHOTOACOUSTIC IMAGING METHOD 审中-公开
    复合颗粒，摄影成像对比剂和光电成像方法

    公开(公告)号：US20120165646A1

    公开(公告)日：2012-06-28

    申请号：US13328802

    申请日：2011-12-16

    申请人： Fumio Yamauchi ,  Satoshi Ogawa ,  Kengo Kanazaki ,  Tatsuki Fukui ,  Sachiko Inoue

    发明人： Fumio Yamauchi ,  Satoshi Ogawa ,  Kengo Kanazaki ,  Tatsuki Fukui ,  Sachiko Inoue

    IPC分类号： A61B5/05 ,  A61K49/00 ,  G01N33/53 ,  C07K16/00

    CPC分类号： A61K49/225 ,  A61B5/0095 ,  A61B8/481

    摘要： Regarding a composite particle in the related art, an antibody and a dye are bound to the surface of the particle. Therefore, it is not possible to bind both the antibody and the dye high in number. Accordingly, the present invention provides a composite particle, wherein a large acoustic wave can be emitted and both the antibody and the dye can be bound high in number. A composite particle including a core particle, a dye bound to the above described core particle, and an antibody, wherein the above described antibody is bound to the above described dye, is suitable for use.

    摘要翻译： 关于现有技术的复合粒子，抗体和染料与粒子的表面结合。 因此，不能将抗体和数量高的染料结合。 因此，本发明提供一种复合颗粒，其中可以发射大的声波，并且抗体和染料都可以结合数量高。 包含核心颗粒，与上述核心颗粒结合的染料和其中上述抗体与上述染料结合的抗体的复合颗粒适合使用。

    CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING AND PHOTOACOUSTIC IMAGING METHOD USING THE SAME
    48.
    发明申请
    CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING AND PHOTOACOUSTIC IMAGING METHOD USING THE SAME 审中-公开
    用于摄影成像的对比剂和使用其的光电成像方法

    公开(公告)号：US20110117023A1

    公开(公告)日：2011-05-19

    申请号：US13014345

    申请日：2011-01-26

    申请人： Fumio Yamauchi ,  Satoshi Ogawa ,  Kengo Kanazaki ,  Sachiko Inoue ,  Tatsuki Fukui ,  Masato Minami ,  Mayuko Kishi

    发明人： Fumio Yamauchi ,  Satoshi Ogawa ,  Kengo Kanazaki ,  Sachiko Inoue ,  Tatsuki Fukui ,  Masato Minami ,  Mayuko Kishi

    IPC分类号： A61K49/00 ,  C07K16/00 ,  C07K2/00 ,  G01N33/53 ,  C12Q1/02

    CPC分类号： A61K41/00 ,  A61K47/6855 ,  A61K49/225 ,  A61K49/226 ,  Y10T428/2982

    摘要： It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP-((L)l-(P)m)n  (Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.

    摘要翻译： 旨在提供一种新颖的光声成像造影剂，其具有高度能够结合靶分子并产生高光声信号。 本发明提供了由式1表示的光声成像造影剂：MNP - （（L）1-（P）m）n（式1）（其中MNP表示含有氧化铁颗粒的颗粒; L表示连接分子 ; P表示配体分子; l表示0或1; m和n表示1或更大的整数），光声成像用造影剂包括：含有吸收近红外区域的光的氧化铁粒子的粒子 ; 和固定在含有氧化铁颗粒的颗粒上的至少一种或多种配体分子，其中配体分子的固定密度等于或高于靶分子的细胞表面密度。