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公开(公告)号：US11267853B2
公开(公告)日：2022-03-08
申请号：US16775046
申请日：2020-01-28
Inventor： Yana K. Reshetnyak , Oleg A. Andreev , Anna Moshnikova , Donald M. Engelman
Abstract: The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP®).
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公开(公告)号：US11229710B2
公开(公告)日：2022-01-25
申请号：US15810830
申请日：2017-11-13
Inventor： Yana K. Reshetnyak , Oleg A. Andreev , Donald M. Engelman
IPC: A61K47/64 , A61K38/04 , A61K41/00 , A61K49/00 , A61K49/08 , A61K49/14 , A61K51/08 , A61K38/12 , C07K7/06 , C07K14/00 , A61K33/24 , A61K48/00 , G01N33/574 , A61K47/54 , A61K33/242 , A61K33/243 , A61K9/127 , C07K14/705 , A61K33/244
Abstract: An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
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公开(公告)号：US20210269304A1
公开(公告)日：2021-09-02
申请号：US17188985
申请日：2021-03-01
Applicant: University of Rhode Island Board of Trustees
Inventor： Jason Rodger DWYER , Y.M. Nuwan D. Y. BANDARA , Brian SHEETZ
IPC: B81C1/00
Abstract: The present invention provides a simple method for ablating a protective thin film on a bulk surface and roughening the underlying bulk. In an embodiment, silicon nitride thin films, which are useful as etch-stop masks in micro- and nano-fabrication, is removed from a silicon wafer's surface using a hand-held “flameless” Tesla-coil lighter. Vias created by a spatially localized electron beam from the lighter allow a practitioner to perform micro- and nano-fabrication without the conventional steps of needing a photoresist and photolithography. Patterning could be achieved with a hard mask or rastering of the spatially confined discharge, offering—with low barriers to rapid use—particular capabilities that might otherwise be out of reach to researchers without access to conventional, instrumentation-intensive micro- and nano-fabrication workflows.
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公开(公告)号：US20200323882A1
公开(公告)日：2020-10-15
申请号：US16818527
申请日：2020-03-13
Inventor： Yana K. Reshetnyak , David Wolfsohn , Anna Moshnikova , Oleg A. Andreev , Donald M. Engelman
IPC: A61K31/573 , A61K47/64 , A61K47/34 , A61K9/00 , A61P35/00 , A61P17/00 , A61P19/02 , A61P37/02 , A61P11/00
Abstract: The invention features a composition comprising a corticosteroid and a pHLIP® peptide. pHLIP® peptides target corticosteroids to cell surface acidity in inflamed and fibrotic tissues, where they translocate corticosteroids across plasma membranes into the cytoplasms of cells, thereby suppressing inflammation in the targeted tissues while avoiding the side effects resulting from non-targeted administration.
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45.发明申请公开(公告)号：US20200292495A1
公开(公告)日：2020-09-17
申请号：US16804787
申请日：2020-02-28
Applicant: University of Rhode Island Board of Trustees
Inventor： Jimmie Oxley , James L. Smith , Alexander Yevdokimov , Gerald Kagan
Abstract: The present disclosure describes an improved sample preparation technique and adapter device for the removal of trace materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The adapter device and technique aids the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release corner or tip is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray pointed at or positioned within the inlet of the detection instrument.
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Patent Agency Ranking
公开(公告)号：US12049433B2
公开(公告)日：2024-07-30
申请号：US17203325
申请日：2021-03-16
Applicant: University of Rhode Island Board of Trustees
Inventor： Jimmie Oxley , James L. Smith , Taylor Busby , Athina Kominia
Abstract: A plasticized pyrotechnic material can be easily portioned and formed or molded into a desired shape and burns at a high temperature (>2000° C.) but does not detonate. The plasticized pyrotechnic material may preferably include a combination of about 70-99% by weight of a pyrotechnic composition and about 1-30% by weight of a plasticizer composition comprising various low to mid molecular weight polyisobutylenes. The pyrotechnic material comprises inorganic oxidizers (e.g. metal oxides, oxohalide salts, nitrates, nitrites, chlorates/perchlorates) and metal or metal oxides powders mixed intimately. The plasticizer may include a small amount of a fluoropolymer, such as polytetrafluoroethylene (PTFE) and may also include up to 1-2% by weight of a processed oil, such as a mineral oil or motor oil. Some embodiments may also include a biocide precursor molecule.
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公开(公告)号：US12029793B2
公开(公告)日：2024-07-09
申请号：US16774966
申请日：2020-01-28
Inventor： Yana K. Reshetnyak , Oleg A. Andreev , Anna Moshnikova , Donald M. Engelman
IPC: A61K47/64 , A61K9/00 , A61K31/4745 , A61K31/5386 , A61K31/7036 , A61K38/12 , A61K47/60 , A61P35/00
CPC classification number: A61K47/6425 , A61K9/0014 , A61K9/0034 , A61K31/4745 , A61K31/5386 , A61K31/7036 , A61K38/12 , A61K47/60 , A61K47/6415 , A61P35/00
Abstract: The invention features a composition comprising a potent cytotoxic compound and a pH low insertion peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. The pH low insertion peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
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公开(公告)号：US20240156998A1
公开(公告)日：2024-05-16
申请号：US18353822
申请日：2023-07-17
Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER , UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES , PHLIP, INC.
Inventor： Jason S. Lewis , Dustin DEMOIN , Yana K. RESHETNYAK , Oleg A. ANDREEV , Nerissa VIOLA-VILLEGAS
CPC classification number: A61K51/088 , A61K47/545 , A61K47/547 , A61K47/64 , A61K49/0056 , A61K49/085 , A61K49/124
Abstract: The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
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公开(公告)号：US20240042063A1
公开(公告)日：2024-02-08
申请号：US18331904
申请日：2023-06-08
Inventor： Yana K. RESHETNYAK , Oleg A. ANDREEV , Donald M. ENGELMAN
CPC classification number: A61K49/0056 , G01N33/84 , C07K7/06 , A61K47/65 , A61K47/42 , A61B5/0071 , A61K47/64 , C07K14/00 , G01N2033/0003
Abstract: Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided.
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50.发明公开公开(公告)号：US20230144468A1
公开(公告)日：2023-05-11
申请号：US18056845
申请日：2022-11-18
Applicant: University of Rhode Island Board of Trustees
Inventor： Jimmie Oxley , James L. Smith , Robert Ichiyama , Gerald Kagan
IPC: A62D3/33 , A62D3/02 , C08L101/08
CPC classification number: A62D3/33 , A62D3/02 , C08L101/08 , A62D2101/06
Abstract: The present disclosure describes a unique, two-part, water-soluble polymer matrix material and a method of application that immobilizes a wide variety of loose powder or crystalline hazardous materials and renders them “safe” or at least “safer” for handling and transport. The polymer matrix material is a two-part polymer material comprising a liquid cross-linking polymer and a cross-linking agent, initiator, or biocide contained in a solution. The cross-linking agent functions to cross-link the polymer and cause it to harden in place.
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