Abstract:
The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/ kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.
Abstract:
A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.
Abstract:
A method for recursively estimating at least one parameter of a first oscillating component represented by one or more sampled noisy input signal waveforms, the method comprising, recursively generating from the one or more sampled noisy input signals an estimate of a Z-transform component corresponding to the first oscillating component, forming, from the estimated Z-transform component, one or more signals providing an indication of one or more of a frequency and an amplitude of the Z-transform component; and estimating, from the one or more signals, one or more of a frequency, a relative phase and an amplitude parameter of the first oscillating component.
Abstract:
An electric machine comprising: a) a first means for providing a first magneto motive force comprising a first set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic in said first set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subsets of said first set of magneto motive force space harmonics comprises a dominant undesirable harmonic; and b) a second means for providing a second magneto motive force comprising a second set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic of said second set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subset of said second set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subset of said second set of magneto motive force space harmonics comprises a dominant undesirable harmonic; wherein the net effect of said first and second means provides a resultant magneto motive force comprising a resultant set of magneto motive force space harmonics comprising odd and even harmonic subsets, each harmonic of said resultant set of magneto motive force space harmonics having a respective amplitude, wherein one of said odd or even subsets of said resultant set of magneto motive force space harmonics comprises a dominant working harmonic and the other of said odd or even subsets of said resultant set of magneto motive force space harmonics comprises a dominant undesirable harmonic, wherein the amplitude of the dominant undesirable harmonic of the resultant set of magneto motive force space harmonics is at least reduced relative to the amplitudes of the dominant undesirable harmonics of the first and second sets of harmonics.
Abstract:
The invention provides a method for producing an electrospun scaffold, comprising electrospinning a polymer or co-polymer onto a template comprising a conductive collector having a three dimensional pattern thereon, wherein said electrospun polymer or co-polymer preferentially deposits onto said three dimensional pattern.
Abstract:
The present invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.
Abstract:
Methods of treatment and prophylaxis of various diseases and disorders, and in particular diseases and disorders of lipid and bone metabolism, involving the administration of prenyl transferase (farnesyl pyrophosphate synthase) and/or isopentenyl pyrophosphate isomerase inhibitor compounds are disclosed.
Abstract:
The present invention relates to polymer conjugates. More specifically, the present invention relates to polymer conjugates capable of binding to fungi, to compositions comprising these conjugates and to the use of these conjugates for detecting the presence of fungi in a sample such as, for example, a biological sample. The present invention also provides for the use of said polymer conjugates in the treatment of a fungal infection.