公开(公告)号：US12105093B2

公开(公告)日：2024-10-01

申请号：US17386234

申请日：2021-07-27

Applicant: University of Washington ,  Washington State University

Inventor： Bhagwat Prasad ,  Kenneth E. Thummel ,  Abdul Basit Shaikh ,  Allan E. Rettie

IPC: G01N33/68

CPC classification number: G01N33/6848

Abstract: Methods of LC-MS/MS quantification of γ-carboxylated proteins in plasma, serum, or blood, including dried blood spots, are disclosed. The methods can be used to determine patient-specific dosing of anticoagulant drugs and diagnosis of liver diseases, such as hepatocellular carcinoma.

公开(公告)号：US20240260568A1

公开(公告)日：2024-08-08

申请号：US18565073

申请日：2022-05-26

Applicant: University of Washington

Inventor： Dayong Gao ,  Shaohang Hao ,  Ye Jin ,  Ruidong Ma ,  Shen Zen ,  Zhiquan Shu ,  Ziyuan Wang ,  Ming Chen

IPC: A01N1/02 ,  H05B6/64 ,  H05B6/68 ,  H05B6/80

CPC classification number: A01N1/0284 ,  A01N1/0294 ,  H05B6/6452 ,  H05B6/6491 ,  H05B6/68 ,  H05B6/688 ,  H05B6/80

Abstract: An example method for rewarming a cryopreserved material includes identifying a parameter indicating a state of a container enclosing a single-mode electromagnetic field. The method further includes maintaining the single-mode electromagnetic field by adjusting, based on the parameter, a frequency and/or a power of the electromagnetic waves.

公开(公告)号：US20240252484A1

公开(公告)日：2024-08-01

申请号：US18461812

申请日：2023-09-06

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Robert A. STEINER ,  Charles CHAVKIN ,  Donald K. CLIFTON ,  Susan REED ,  Victor NAVARRO

IPC: A61K31/485 ,  A61K31/40 ,  A61K31/439 ,  A61K31/47 ,  A61K45/06

CPC classification number: A61K31/485 ,  A61K31/40 ,  A61K31/439 ,  A61K31/47 ,  A61K45/06

Abstract: The present disclosure is generally directed to compositions and methods for treating or limiting development of vasomotor symptoms in a subject.

公开(公告)号：US20240217835A1

公开(公告)日：2024-07-04

申请号：US18558087

申请日：2022-04-29

Applicant: Kevin LEE ,  Vincent HOLMBERG ,  University of Washington

Inventor： Alexander Bard ,  Kevin Guesang Lee ,  Greg Felsted ,  Vincent Holmberg ,  Peter Pauzauskie

IPC: C01F17/36 ,  H01M4/58

CPC classification number: C01F17/36 ,  H01M4/582 ,  C01P2002/01 ,  C01P2002/72 ,  C01P2002/86 ,  C01P2004/04 ,  C01P2004/38 ,  C01P2006/12 ,  C01P2006/16 ,  C01P2006/40

Abstract: Systems, devices, materials, and methods including nanostructured gels are provided. A nanostructured gel includes a primary crystalline phase including cubic sodium yttrium fluoride, a secondary crystalline phase including cubic yttrium fluoride, and an amorphous phase including sodium ions and yttrium fluoride.

公开(公告)号：US20240215142A1

公开(公告)日：2024-06-27

申请号：US18553839

申请日：2022-06-02

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Ravi Sankar Vaddi ,  Igor V. Novosselov ,  Alexander V. Mamishev

IPC: H05H1/24 ,  B64C23/00 ,  F15D1/00 ,  F15D1/12

CPC classification number: H05H1/2439 ,  B64C23/005 ,  F15D1/0075 ,  F15D1/12

Abstract: Dielectric barrier discharge plasma actuators are described. In one embodiment, a fluid flow actuator includes: a dielectric sheet; and a first electrode of a dielectric barrier discharge-direct current augmented (DBD-DCA) actuator disposed on a first face of the dielectric sheet. The first electrode is exposed to a surrounding fluid. The fluid actuator also includes a second electrode of the DBD-DCA actuator disposed on a second face of the dielectric sheet. The second face of the dielectric sheet is opposite from the first face of the dielectric sheet. The first electrode and the second electrode are configured for receiving an alternating current (AC) voltage configured to locally ionize the fluid and to generate ions. A third electrode located downstream from the first electrode and the second electrode. The third electrode is configured for receiving a direct current (DC) voltage configured to accelerate the ions.

公开(公告)号：US20240209925A1

公开(公告)日：2024-06-27

申请号：US18557643

申请日：2022-04-28

Applicant: University of Washington

Inventor： Jeffrey Lipton

IPC: F16H21/04

CPC classification number: F16H21/04

Abstract: The present disclosure provides a mechanical linkage device including a ground link comprising an inverse center linked to one end of the ground link. The mechanical linkage device further includes a movement link connecting the ground link to a control point. The mechanical linkage device further includes two or more linkages having a first link of the two or more linkages including a first end linked to the control point and a second link of the two or more linkages including second end linked to an end point. The end point, the control point, and the inverse center of the ground link remain co-linear. The control point and the end point have an inverse relationship such that movement of the control point is inversely translated to the end point. The ground link, the movement link, and at least one of the two or more linkages do not all he in a plane throughout an entire range of motion of the mechanical linkage device.

公开(公告)号：US20240207376A1

公开(公告)日：2024-06-27

申请号：US18513879

申请日：2023-11-20

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin SIEGEL ,  David BAKER ,  Sydney Rin Anna GORDON ,  Ingrid Swanson PULTZ ,  Elizabeth Joy STANLEY ,  Sarah Jane WOLF

IPC: A61K38/48 ,  C12N9/52

CPC classification number: A61K38/482 ,  A61K38/48 ,  C12N9/52 ,  C12Y304/21

Abstract: The invention provides compositions and methods for treating celiac sprue.

公开(公告)号：US20240189481A1

公开(公告)日：2024-06-13

申请号：US18553941

申请日：2022-04-06

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Charles E. MURRY ,  Michael REGNIER ,  Hans REINECKE ,  Xiulan YANG ,  Dasom YOO

IPC: A61L27/38 ,  A61K35/34 ,  A61L27/52 ,  A61P9/00

CPC classification number: A61L27/3826 ,  A61K35/34 ,  A61L27/52 ,  A61P9/00 ,  A61L2400/06 ,  A61L2430/20

Abstract: Described herein are compositions and methods relating to the improvement of cardiac function. Various embodiments relate to transplant compositions comprising cardiomyocytes which are engineered to be non-contractile, and to methods of using such cardiomyocytes or transplant compositions to improve cardiac function, e.g., by administering them to cardiac tissue.

公开(公告)号：US20240182922A1

公开(公告)日：2024-06-06

申请号：US18283929

申请日：2022-03-25

Applicant: CORNELL UNIVERSITY ,  UNIVERSITY OF WASHINGTON

Inventor： Shaoyi JIANG ,  Zhefan YUAN ,  Sijin LUOZHONG ,  Wenchao GU ,  Ruoxin LI ,  Bowen LI

IPC: C12N15/86 ,  A61K47/69 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61K47/6901 ,  A61K48/0041 ,  A61K48/0083 ,  C12N2750/14143 ,  C12N2750/14145

Abstract: Compositions and methods for modified viral vectors which mitigate the immunogenicity of viral vectors, enabling multiple administrations of viral-based gene delivery viral vectors are described herein. The viral vectors advantageously possess low immunogenicity and comprise at least one immunosuppressive moiety. Also described herein are methods for introducing genetic material into a cell. Additionally, described herein are methods for preparing a modified viral vector. Lastly, described herein are methods for treating a subject, the method comprising administering to a subject a modified viral vector composition as described above.

公开(公告)号：US20240158774A1

公开(公告)日：2024-05-16

申请号：US18357617

申请日：2023-07-24

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Justin Bloomfield SIEGEL ,  David BAKER ,  Ingrid Swanson PULTZ

IPC: C12N9/52 ,  C12N9/64

CPC classification number: C12N9/52 ,  C12N9/64 ,  C12N9/6489 ,  A61K38/00

Abstract: The invention provides compositions and methods for treating celiac sprue.