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    FORCE SENSING DEVICE, MEDICAL ENDODEVICE AND PROCESS OF USING SUCH ENDODEVICE
    42.
    发明申请
    FORCE SENSING DEVICE, MEDICAL ENDODEVICE AND PROCESS OF USING SUCH ENDODEVICE 有权

    公开(公告)号：US20210267709A1

    公开(公告)日：2021-09-02

    申请号：US17254737

    申请日：2019-06-21

    Applicant: UNIVERSITÄT BASEL

    Inventor： Georg RAUTER ,  Ivan SUSIC

    IPC: A61B90/00 ,  A61B1/00 ,  A61B1/05

    Abstract: A force sensing device is disclosed that includes a housing tip, a plurality of sensors stationarily spaced from each other, and a spring element connecting the housing tip to the sensors such that moving the housing tip and the sensor relative to each other causes a resilient deformation of the spring element. The spring element is configured to arrange the housing tip in a zero position relative to the sensors by a spring force of the spring element. The force sensing device is also equipped with a spring tensioning structure configured to adapt the spring force of the spring element.

    Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
    43.
    发明授权
    Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids 有权

    公开(公告)号：US11091591B2

    公开(公告)日：2021-08-17

    申请号：US15760398

    申请日：2016-09-14

    Applicant: UNIVERSITÄT BASEL

    Inventor： Ruben Herrendorff ,  Beat Ernst ,  Andreas Steck ,  Hélène Pfister ,  Giulio Navarra

    IPC: C07H15/12 ,  C08G69/48 ,  A61P25/00

    Abstract: The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II). The compounds of formula (I) are defined as: wherein RI1 is Z or wherein RI2 is H, SO3H, or wherein RI3 is H or wherein RI4 is H or wherein RI5 and RI6 are independently H or wherein RI7 is H or and compounds of formula (II) are defined as: wherein RII1 is Z or wherein RII2 is Z or wherein Z is —N(Ra)—A—B—CH2—(CH2)q—SH, wherein Ra is H, C1-C4-alky, C1-C4alkoxy, CH2C6H5, CH2CH2C6H5, OCH2C6H5, or OCH2CH2C6H5; A is C1-C7-alkylene, C1-C7-alkoxy, C1-C4-alkyl—(OCH2CH2)pO—C1-C4-alkyl, or C1-C7-alkoxy-Rb, wherein Rb is an optionally substituted aryl or an optionally substituted heteroaryl, and wherein p is 0 to 6, preferably p is 1, 2 or 3, and further preferably p is 1; B is NHC(O), S or CH2; q is 0 to 6, preferably q is 1, 2, 3 or 4, and further preferably q is 1 or 2.

    Sample holder for holding a sample for use with an atomic force microscope
    45.
    发明授权
    Sample holder for holding a sample for use with an atomic force microscope 有权

    公开(公告)号：US10823756B2

    公开(公告)日：2020-11-03

    申请号：US14910704

    申请日：2014-08-06

    Applicant: UNIVERSITÄT BASEL

    Inventor： Marko Loparic

    IPC: G01Q30/20

    Abstract: The invention relates to a sample holder (1) for holding a sample, particularly for use with an atomic force microscope. According to the invention, the sample holder (1) comprises: preferably a flexible support (10) having an upper side (10a) and a lower side (10b) facing away from said upper side (10a), a first and a second holding member (100, 200), wherein each holding member (100, 200) comprises a first section (101, 201) that is preferably connected to the upper side (10a) of the flexible support (10), as well as an opposing second section (102, 202) forming a tip (103, 203) of the respective holding member (100, 200), such that the holding members (100, 200) are each movable from a first position, in which the tips (103, 203) are positioned adjacent to one another, into a second position, in which the tips (103, 203) are further apart from each other than in said first positions and are separated by a gap (G) for receiving at least a portion of the sample (S) to be held, and wherein said tips (103, 203) are designed to penetrate the sample (S) or to press against it so as to hold it when the sample (S) is received by said gap (G) and the holding members (100, 200) are moved back from the second positions into the first positions.

    MR1 RESTRICTED T CELL RECEPTORS FOR CANCER IMMUNOTHERAPY
    46.
    发明申请
    MR1 RESTRICTED T CELL RECEPTORS FOR CANCER IMMUNOTHERAPY 审中-公开

    公开(公告)号：US20190389926A1

    公开(公告)日：2019-12-26

    申请号：US16563987

    申请日：2019-09-09

    Applicant: UNIVERSITÄT BASEL

    Inventor： Gennaro DE LIBERO ,  Marco LEPORE ,  Lucia MORI

    IPC: C07K14/725 ,  C12N5/0783 ,  G01N1/30 ,  G01N33/569 ,  C12N5/09 ,  C12N15/85 ,  A61P35/00 ,  A61K35/17

    Abstract: The invention relates to a method of isolating a T cell that expresses a T cell receptor capable of binding specifically to an antigen presented by a cancer cell in association with an MR1 molecule. The method comprises the steps of (a) providing a preparation of T cells, (b) contacting the preparation with cancer cells expressing MR1 protein; (c) isolating a T cell that is specifically reactive to said cancer cells.The invention further relates to a method of preparing a T cell preparation expressing select MR1 recognizing T cell receptors from transgene expression vectors, the use of such T cell preparations in treatment of cancer, and to collections of MR1 reactive T cell receptor encoding nucleic acids and cells.

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