公开(公告)号：US20220290183A1

公开(公告)日：2022-09-15

申请号：US17753284

申请日：2020-08-28

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Rafael DAVALOS ,  Amrinder NAIN

IPC: C12N15/87 ,  C12N13/00

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to methods for modifying cells such as, for example, changing shape, cell force, and/or modifying structural integrity of the cells. In a further aspect, the disclosure relates to controlling membrane permeability in cells by applying an electric current, where the cells are in contact with a polymeric nanofiber array and wherein direction and voltage of the electric current can be modified to induce the desired cellular response. In some aspects, the method results in higher survivability for cells during electroporation, greater permeability to molecules and/or drugs of different sizes, and greater transfection efficiencies for rare primary cells.

公开(公告)号：US20220216612A1

公开(公告)日：2022-07-07

申请号：US17607513

申请日：2020-07-08

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Ali Hosseini-Fahraji ,  Majid Manteghi

IPC: H01Q9/28 ,  H01Q1/36 ,  H01Q21/10

Abstract: Disclosed are various embodiments of a coaxial collinear antenna. In one embodiment, the coaxial collinear antenna includes a first segment and a second segment of a coaxial cable. The second segment comprises a second inner conductor and a second outer conductor. The first inner conductor of the first segment is coupled to the second outer conductor of the second segment. The first outer conductor of the first segment is coupled to the second inner conductor of the second segment. Further, a first wire mesh is attached to the first outer conductor of the first segment, and a second wire mesh is attached to the second outer conductor of the second segment. Additionally, the coaxial collinear antenna includes an end-fed port that is situated at a distal end of the coaxial collinear antenna.

公开(公告)号：US11368103B2

公开(公告)日：2022-06-21

申请号：US15931795

申请日：2020-05-14

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Jun Wang ,  Rolando Burgos ,  Dushan Boroyevich

IPC: H02M7/483 ,  H02M1/08

Abstract: Aspects of hybrid-current-mode switching-cycle control are described. In one embodiment, a peak current mode is selected to control a switching power cell. The switching power cell is in an arm of a phase leg of a modular multilevel converter. The phase leg includes an upper arm and a lower arm, and the switching power cell includes a capacitor and at least one switch. At least one switch control signal switches the switching power cell according to a peak current mode based on at least one arm current boundary crossing identified for the arm.

公开(公告)号：US11334807B1

公开(公告)日：2022-05-17

申请号：US16017904

申请日：2018-06-25

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Timothy James O'Shea ,  Kiran Karra ,  T. Charles Clancy

IPC: G06N5/04 ,  G06N3/02 ,  H04B17/309 ,  H04B17/391 ,  G06N20/00

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learning estimation networks in a communications system. One of the methods includes: processing first information with ground truth information to generate a first RF signal by altering the first information by channel impairment having at least one channel effect, using a receiver to process the first RF signal to generate second information, training a machine-learning estimation network based on a network architecture, the second information, and the ground truth information, receiving by the receiver a second RF signal transmitted through a communication channel including the at least one channel effect, inferring by the trained estimation network the receiver to estimate an offset of the second RF signal caused by the at least one channel effect, and correcting the offset of the RF signal with the estimated offset to obtain a recovered RF signal.

公开(公告)号：US11307266B2

公开(公告)日：2022-04-19

申请号：US17006058

申请日：2020-08-28

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Yuliang Cao ,  Minh Ngo ,  Dong Dong ,  Rolando Burgos

IPC: G01R31/62 ,  G01R33/12 ,  G01R31/72

Abstract: Various examples of a high frequency, inductor and transformer core loss characterization and measurement method and system for arbitrary waveforms are disclosed herein. A system and method for determining core loss of a magnetic core can include generating a waveform to excite a first test circuit which comprises an excitation circuit, a circuit under test (CUT) comprising the magnetic core, and an inductance circuit having an inductor connected in parallel to the CUT. The method includes measuring a first current, when the first test circuit is excited. The method includes disconnecting the CUT from the first test circuit to form a second test circuit. The method includes generating the waveform to excite the second test circuit, and measuring a second current, when the second test circuit is excited. The power loss for the magnetic core is calculated based on an input voltage and the first and second measured current.

公开(公告)号：US11290022B2

公开(公告)日：2022-03-29

申请号：US17008893

申请日：2020-09-01

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Yuliang Cao ,  Minh Ngo ,  Ning Yan ,  Dong Dong ,  Rolando Burgos

IPC: H02M3/335 ,  H02M7/5387 ,  H02M1/00

Abstract: Aspects of bidirectional architectures with partial energy processing in resonant direct current (DC)-to-DC converters are described. In one embodiment, an alternating circuit (AC)-to-DC circuit generates an AC voltage from a DC voltage. A voltage of the AC voltage is transformed into a majority AC voltage of a majority power path and at least one minority AC voltage of the minority power paths. The majority AC voltage is rectified into a majority DC voltage and a minority AC voltage is rectified into a minority DC voltage. The majority power path and the minority power path are combined as a combined DC voltage.

公开(公告)号：US11272979B2

公开(公告)日：2022-03-15

申请号：US16152743

申请日：2018-10-05

Applicant: Virginia Tech Intellectual Properties Inc.

Inventor： Paulo A. Garcia ,  Christopher B. Arena ,  Michael B. Sano ,  Rafael V. Davalos

IPC: A61B18/14 ,  C12N13/00 ,  A61B34/10 ,  A61B18/00 ,  A61B34/00 ,  A61B90/00

Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.

公开(公告)号：US20210393312A1

公开(公告)日：2021-12-23

申请号：US17277662

申请日：2019-09-18

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Natalie White

IPC: A61B18/12

Abstract: Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

公开(公告)号：US11180489B2

公开(公告)日：2021-11-23

申请号：US16089939

申请日：2017-03-29

Applicant: University of Virginia Patent Foundation ,  Virginia Tech Intellectual Properties, Inc.

Inventor： Steven Brandon Thorpe ,  Webster L. Santos ,  Kevin R. Lynch

IPC: C07D403/14 ,  C07D403/04 ,  C07D413/14 ,  C07D413/04

Abstract: Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides prodrugs of compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both, according to formula (I) as described herein. Formula I compounds are useful in the treatment of a range of diseases wherein increasing the level of sphingosine-1-phosphate in blood is medically indicated. The invention also provides pharmaceutical compositions of Formula I compounds.

公开(公告)号：US20210351401A1

公开(公告)日：2021-11-11

申请号：US17273718

申请日：2019-09-06

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Guoliang LIU ,  Tianyu LIU

IPC: H01M4/36 ,  H01M4/86 ,  H01M4/88 ,  H01M4/96 ,  H01M4/04 ,  H01M4/133 ,  H01M4/1393 ,  H01M4/583 ,  H01G11/24 ,  H01G11/40 ,  H01G11/26 ,  H01G11/86

Abstract: Porous carbon fiber electrode materials are provided having fast electron and ion transport. The porous carbon fiber electrodes include uniform mesoscale pores that are partially filled with a metal oxide layer. With large mass loadings of metal oxide, porous carbon fiber electrodes described herein can outperform conventional metal oxide electrodes at similar loadings. In various aspects, electrode materials are provided having (i) a porous carbon fiber support with a plurality of mesoscale pores having an internal surface and an average pore width of about 2 mm to about 200 mm; and (ii) a metal oxide layer on at least the internal surface of the mesoscale pores. Methods of making the porous carbon fiber electrode materials are also provided. Using a microphase-separation of block copolymers, the methods can provide porous carbon fiber supports with interconnected and uniform mesoscale pores that can be deposited with a metal oxide layer.