公开(公告)号：US20060019326A1

公开(公告)日：2006-01-26

申请号：US11183115

申请日：2005-07-15

Applicant: Joseph Vacanti ,  Robert Rubin ,  Wing Cheung

Inventor： Joseph Vacanti ,  Robert Rubin ,  Wing Cheung

IPC: C12Q1/34 ,  C12Q1/42

CPC classification number: C12Q1/48 ,  B33Y80/00 ,  C12Q1/00 ,  C12Q1/18 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/44 ,  G01N33/5038 ,  G01N33/5088

Abstract: The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects, new uses) of existing drugs. Preferably, evaluation is carried out in three-dimensional tissue-engineered systems, wherein drug toxicity, metabolism, interaction and/or efficacy can be determined.

Abstract translation: 本发明一般涉及组织工程，药物发现和药物开发领域的组合。 它更具体地提供了用于测试实验药物的功效和安全性，定义实验药物的代谢途径和表征现有药物的性质（例如副作用，新用途）的新方法和材料。 优选地，在三维组织工程系统中进行评价，其中可以确定药物毒性，代谢，相互作用和/或功效。

公开(公告)号：US06747002B2

公开(公告)日：2004-06-08

申请号：US09569612

申请日：2000-05-10

Applicant: Wing Cheung ,  David Gibson ,  Christine Cote ,  Els Vercammen

Inventor： Wing Cheung ,  David Gibson ,  Christine Cote ,  Els Vercammen

IPC: A61K3819

CPC classification number: G06F19/3437 ,  A61K38/00 ,  A61K38/1816 ,  G06F19/00 ,  G06F19/704 ,  G16H50/50 ,  A61K38/14 ,  A61K33/24 ,  A61K31/70 ,  A61K31/505 ,  A61K31/475 ,  A61K31/28 ,  A61K2300/00

Abstract: The present invention relates to systems and methods for obtaining optimized EPO dosage regimens for a desired pharmacodynamic/pharmacokinetic response. The system includes choosing one or more EPO dosage regimens, then using a PK/PD model to determine the pharmacodynamic/pharmacokinetic profile of one or more EPO dosage regimens, and finally selecting one of the EPO dosage regimens for administration to achieve the desired pharmacodynamic/pharmacodynamic response based on the EPO profile.

公开(公告)号：US06604709B1

公开(公告)日：2003-08-12

申请号：US10078859

申请日：2002-02-20

Applicant: Mark E. Wentland ,  Wing Cheung ,  Kevin Shimasaki

Inventor： Mark E. Wentland ,  Wing Cheung ,  Kevin Shimasaki

IPC: B64D1102

CPC classification number: B64D11/02 ,  B64D11/00

Abstract: An expandable, modular, multi-mode lavatory for aircraft featuring its multi-mode use as a lavatory, shower and accommodations for handicapped persons. The invention comprises a primary structure with a volume that expands into adjacently located unused space, such as an aircraft's main entry cross-aisleway. Deployable walls and doors are used to create a partitioned environment. A false bottom shower pan cover provides structural support for wheelchairs while also being removable to reveal a modular shower pan for bathing.

Abstract translation: 用于飞机的可扩展的，模块化的多模式洗手间，其多模式用作洗手间，淋浴和残疾人的住宿。 本发明包括具有扩展成相邻位置的未使用空间的体积的主要结构，例如飞行器的主入口横走道。 可部署的墙壁和门用于创建分区环境。 假底淋浴盘盖为轮椅提供结构支撑，同时也可移动，以露出用于沐浴的模块化淋浴盘。

公开(公告)号：US06466997B1

公开(公告)日：2002-10-15

申请号：US09332836

申请日：1999-06-14

Applicant: Theodore L. Ross ,  Douglas M. Washabaugh ,  Peter J. Roman ,  Wing Cheung ,  Koichi Tanaka ,  Shinichi Mizuguchi ,  Robert E. Thomas

Inventor： Theodore L. Ross ,  Douglas M. Washabaugh ,  Peter J. Roman ,  Wing Cheung ,  Koichi Tanaka ,  Shinichi Mizuguchi ,  Robert E. Thomas

IPC: G06F500

CPC classification number: G06F13/387 ,  H04L2012/5616 ,  H04L2012/5658

Abstract: A method and system for requesting an interrupt from a host system to service an adapter connected to the host system and a data interface. Data packets, including one or more data cells, are transferred between the data interface and the host system. The host system includes a host memory that includes a plurality of memory slots to store data packets transferred between the data interface and the host system. It is determined when a transfer of data has resulted in an occurrence of an interrupt event. An interrupt event occurs when the transfer of data includes a transfer of a data cell between the data interface and the host system and the data cell is defined to be an end of a data packet. In response to the occurrence of an interrupt event, it is determined whether to generate an interrupt request to the host system. This step of determining includes determining whether a predetermined interval of time has elapsed since the host system last processed an interrupt request or determining whether a predetermined number of interrupt events have occurred since the host system last processed an interrupt request. If the predetermined interval of time has elapsed or the predetermined number of events has occurred, respectively, the interrupt request from the adapter to the host system is generated.

Abstract translation: 一种用于从主机系统请求中断来服务连接到主机系统的适配器和数据接口的方法和系统。 包括一个或多个数据单元的数据包在数据接口和主机系统之间传输。 主机系统包括主机存储器，其包括多个存储器插槽以存储在数据接口和主机系统之间传送的数据包。 确定何时传输数据导致发生中断事件。 当数据传输包括在数据接口和主机系统之间的数据信元的传送并且数据信元被定义为数据包的结尾时，发生中断事件。 响应于中断事件的发生，确定是否向主机系统生成中断请求。 该确定步骤包括确定从主机系统最后一次处理中断请求以来是否已经过去了预定的时间间隔，或者确定从主机系统最后一次处理中断请求以来是否发生了预定数量的中断事件。 如果预定的时间间隔已经过去或预定的事件数量分别发生，则从适配器向主机系统产生中断请求。

公开(公告)号：US06337851B1

公开(公告)日：2002-01-08

申请号：US09629727

申请日：2000-07-31

Applicant: Anna Charny ,  Wing Cheung ,  Peter Roman ,  Robert Thomas

Inventor： Anna Charny ,  Wing Cheung ,  Peter Roman ,  Robert Thomas

IPC: H04L100

CPC classification number: H04L12/5602 ,  H04L2012/5616 ,  H04L2012/5619 ,  H04L2012/5679 ,  H04Q11/0478

Abstract: A method of scheduling a plurality of data flows in a shared resource in a computer system, each of the data flows containing a plurality of data cells including the steps of providing a scheduler in the shared resource, initializing the scheduler to receive the plurality of data flows, receiving a first data flow in the scheduler, said first data flow having a first flow rate, receiving a second data flow in the scheduler, said second data flow having a second flow rate, scheduling, by the scheduler, the first data flow and the second data flow such that the first flow rate and the second flow rate are less than an available bandwidth in the shared resource and a relative error is minimized between an actual scheduling time and an ideal scheduling time on a per cell basis, and repeating the steps of receiving and scheduling.

Abstract translation: 一种在计算机系统中的共享资源中调度多个数据流的方法，每个数据流包含多个数据单元，包括以下步骤：在共享资源中提供调度器，初始化调度器以接收多个数据 流，在调度器中接收第一数据流，所述第一数据流具有第一流速，接收调度器中的第二数据流，所述第二数据流具有第二流速，由调度器调度第一数据流 以及第二数据流，使得第一流量和第二流量小于共享资源中的可用带宽，并且在每个小区的基础上在实际调度时间和理想调度时间之间将相对误差最小化，并重复 接收和调度的步骤。

公开(公告)号：US06212567B1

公开(公告)日：2001-04-03

申请号：US08712778

申请日：1996-09-12

Applicant: Robert E. Thomas ,  Douglas M. Washabaugh ,  Peter J. Roman ,  Wing Cheung

Inventor： Robert E. Thomas ,  Douglas M. Washabaugh ,  Peter J. Roman ,  Wing Cheung

IPC: G06F1516

CPC classification number: H04L12/5601 ,  H04L2012/5625 ,  H04L2012/5635 ,  H04L2012/5651 ,  H04L2012/5652 ,  H04L2012/5658 ,  H04L2012/5667

Abstract: A mechanism for mitigating the rate at which status reports associated with raw cell data transfers occur during receive operations in a network node is presented. The network node has an adapter for coupling a network and a host system, the host system including a host memory. The adapter operates to reassemble cell data received from the network and store the reassembled cell data in the host memory. A raw report holdoff counter is programmed to count a number corresponding to a preselected rx raw report holdoff value. If a raw cell data transfer request to be processed is detected, rx raw report information necessary to creating an rx raw cell status report is copied to a temporary storage area. When the data is transferred to the host system, the raw report holdoff counter is modified by one. When the modified counter has expired, the rx raw report information is written to a report queue in host memory.

Abstract translation: 呈现一种用于减轻在网络节点的接收操作期间发生与原始小区数据传输相关联的状态报告的速率的机制。 网络节点具有用于耦合网络和主机系统的适配器，主机系统包括主机存储器。 适配器操作以重新组合从网络接收的小区数据，并将重新组装的小区数据存储在主机存储器中。 原始报告缓存计数器被编程为对与预选的rx原始报告缓存值相对应的数字进行计数。 如果检测到要处理的原始小区数据传输请求，则将生成rx原始小区状态报告所需的rx原始报告信息复制到临时存储区域。 当数据传输到主机系统时，原始报告缓存计数器被修改为1。 当修改的计数器已经过期时，rx原始报告信息被写入主机存储器中的报告队列。

公开(公告)号：US6167394A

公开(公告)日：2000-12-26

申请号：US75727

申请日：1998-05-11

Applicant: Edward Wing Cheung Leung ,  Andrew Fu

Inventor： Edward Wing Cheung Leung ,  Andrew Fu

IPC: G06F17/30

CPC classification number: G06F17/30643 ,  G06F17/30241 ,  Y10S707/99933

Abstract: A computer-based document management system that utilizes a geographic interface and allows any interested party to view individually selected location-specific documents which are stored in a particular geographic location from anywhere in the world is disclosed. Examples of the site-specific documents include, for example, MSDS information. Access to this electronically stored information may be had via any suitable medium such as, for example, the internet, the world wide web, an intranet, or a local area network.

Abstract translation: 公开了一种基于计算机的文档管理系统，其利用地理接口并允许任何感兴趣的方式从世界上任何地方查看存储在特定地理位置的单独选择的位置特定文档。 特定于站点的文档的示例包括例如MSDS信息。 可以经由诸如互联网，万维网，内联网或局域网的任何合适的介质访问该电子存储的信息。

公开(公告)号：US08446914B2

公开(公告)日：2013-05-21

申请号：US13092864

申请日：2011-04-22

Applicant: Joseph Juh-En Cheng ,  Wing Cheung ,  John Michael Terry ,  Suresh Vobbilisetty ,  Surya P. Varanasi ,  Parviz Ghalambor

Inventor： Joseph Juh-En Cheng ,  Wing Cheung ,  John Michael Terry ,  Suresh Vobbilisetty ,  Surya P. Varanasi ,  Parviz Ghalambor

IPC: H04L12/56

CPC classification number: H04L45/66 ,  H04L12/4625 ,  H04L12/4633 ,  H04L45/00 ,  H04L45/245 ,  H04L49/70 ,  Y02D50/30

Abstract: One embodiment of the present invention provides a switch. The switch includes a forwarding mechanism and a control mechanism. During operation, the forwarding mechanism forwards frames based on their Ethernet headers. The control mechanism operates the switch in conjunction with a separate physical switch as a single logical switch and assigns a virtual switch identifier to the logical switch, wherein the virtual switch identifier is associated with a link aggregation group.

公开(公告)号：US08173361B2

公开(公告)日：2012-05-08

申请号：US12707469

申请日：2010-02-17

Applicant: Joseph P. Vacanti ,  Robert Rubin ,  Wing Cheung ,  Jeffrey T. Borenstein

Inventor： Joseph P. Vacanti ,  Robert Rubin ,  Wing Cheung ,  Jeffrey T. Borenstein

IPC: C12Q1/00

CPC classification number: C12Q1/48 ,  B33Y80/00 ,  C12Q1/00 ,  C12Q1/18 ,  C12Q1/26 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q1/44 ,  G01N33/5038 ,  G01N33/5088

Abstract: A method for detecting one or more metabolites of a test agent in a tissue including: A) incubating a test agent and an enzyme within a three-dimensional structure comprising a first mold or polymer scaffold, a semi-permeable membrane, and a second mold or polymer scaffold, wherein the semi-permeable membrane is disposed between the first and second molds or polymer scaffolds, and wherein the first mold or polymer scaffold has microchannels that form a fluidic branching network that mimics the forces and transport of natural vasculatures and wherein the second mold or polymer scaffold comprises cells; B) forming an enzyme-substrate complex between the enzyme and the test agent; and C) detecting one or more metabolites of the test agent.

Abstract translation: 一种用于检测组织中测试剂的一种或多种代谢物的方法，包括：A）将测试试剂和酶在三维结构内孵育，所述三维结构包括第一模具或聚合物支架，半透膜和第二模具 或聚合物支架，其中所述半透膜设置在所述第一和第二模具或聚合物支架之间，并且其中所述第一模具或聚合物支架具有微通道，所述微通道形成模拟天然脉管系统的力和运输的流体分支网络，并且其中 第二模具或聚合物支架包括细胞; B）在酶和试验剂之间形成酶 - 底物复合物; 和C）检测试剂的一种或多种代谢物。

公开(公告)号：US20110299414A1

公开(公告)日：2011-12-08

申请号：US13048817

申请日：2011-03-15

Applicant: Shunjia Yu ,  Anoop Ghanwani ,  Phanidhar Koganti ,  John Michael Terry ,  Wing Cheung ,  Joseph Juh-En Cheng ,  Surya P. Varanasi

Inventor： Shunjia Yu ,  Anoop Ghanwani ,  Phanidhar Koganti ,  John Michael Terry ,  Wing Cheung ,  Joseph Juh-En Cheng ,  Surya P. Varanasi

IPC: H04L12/26

CPC classification number: H04L47/2491 ,  H04L12/4641 ,  H04L45/00 ,  H04L45/66

Abstract: Systems and techniques for processing and/or forwarding packets are described. An ingress switch can use a QoS mapping mechanism to map a first set of Quality of Service (QoS) bits in a packet received from a customer to a second set of QoS bits for use in a Transparent Interconnection of Lots of Links (TRILL) packet which encapsulates the packet. The first set of QoS bits can be different from the second set of QoS bits. The TRILL packet can be processed and/or forwarded in the network based on the second set of QoS bits. At the egress switch, the TRILL packet can be decapsulated and the original packet with the original QoS bits (or QoS bits that are different from the original QoS bits) can be forwarded to the customer's network. In this manner, some embodiments of the present invention can preserve the QoS bits across a TRILL network.

Abstract translation: 描述用于处理和/或转发分组的系统和技术。 入口交换机可以使用QoS映射机制来将从客户端接收的分组中的第一组服务质量（QoS）比特映射到第二组QoS比特，以用于多个链路（TRILL）分组的透明互连 它封装了数据包。 第一组QoS位可以与第二组QoS位不同。 TRILL分组可以基于第二组QoS比特在网络中被处理和/或转发。 在出口交换机上，可以对TRILL数据包进行解封装，将原始QoS位（或不同于原始QoS位的QoS位）的原始数据包转发到客户的网络。 以这种方式，本发明的一些实施例可以保持跨TRILL网络的QoS比特。