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    METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES
    43.
    发明公开
    METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES 审中-公开

    公开(公告)号：US20230233549A1

    公开(公告)日：2023-07-27

    申请号：US18184364

    申请日：2023-03-15

    Applicant: Academia Sinica

    Inventor： Rong-Jie CHEIN ,  Pan-Chyr YANG ,  Chi-Huey WONG ,  Ming-Shiu LIN ,  Ting-Jen CHENG ,  Ting-Hung Rachel CHOU

    IPC: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

    CPC classification number: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

    Abstract: Provided herein are compounds of Formula (I). The disclosure provides new compounds, compositions, and methods for treating, delaying, and/or preventing the adverse effects of proliferative diseases, such as cancers including, for example, lung cancer, breast cancer, ovarian cancer, prostate cancer, head cancer, neck cancer, head and neck cancer, or leukemia (e.g., cancer resistant to treatment by one or more microtubule-targeting agents (e.g., cancer resistant to multiple drugs associated with P-glycoprotein (P-gp) overexpression)). Provided are methods of inhibiting polymerization of a cancer cell microtubule in a subject in need thereof or a cell, tissue, or biological sample, binding β-tubulin, inhibiting microtubule assembly and, inducing apoptosis in a cancer cell resistant to multiple drugs in a tissue, biological sample, or subject. Also provided in the present disclosure are pharmaceutical compositions, kits, and methods of using the compounds for treating any of the target diseases described herein.

    NOVEL GLYCAN CONJUGATES AND METHODS OF USE THEREOF
    45.
    发明申请
    NOVEL GLYCAN CONJUGATES AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20200078452A1

    公开(公告)日：2020-03-12

    申请号：US16502844

    申请日：2019-07-03

    Applicant: ACADEMIA SINICA

    Inventor： Chi-Huey WONG ,  Chung-Yi WU

    IPC: A61K39/00 ,  C07K16/30 ,  C07H15/04 ,  C08B37/00 ,  C07H5/02 ,  C07H5/06 ,  A61K31/715 ,  C07H5/04 ,  A61K31/7028 ,  C07H15/26 ,  C07K16/44

    Abstract: The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

    GLYCAN ARRAYS FOR HIGH THROUGHPUT SCREENING OF VIRUSES
    46.
    发明申请
    GLYCAN ARRAYS FOR HIGH THROUGHPUT SCREENING OF VIRUSES 审中-公开

    公开(公告)号：US20190391149A1

    公开(公告)日：2019-12-26

    申请号：US16458986

    申请日：2019-07-01

    Applicant: ACADEMIA SINICA

    Inventor： Chi-Huey WONG ,  Chung-Yi WU ,  Chi-Hui LIANG ,  An-Suei YANG

    IPC: G01N33/569 ,  G01N33/543 ,  G01N33/53

    Abstract: Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed.

    ALKYNYL SUGAR ANALOGS FOR LABELING AND VISUALIZATION OF GLYCOCONJUGATES IN CELLS
    49.
    发明申请
    ALKYNYL SUGAR ANALOGS FOR LABELING AND VISUALIZATION OF GLYCOCONJUGATES IN CELLS 审中-公开

    公开(公告)号：US20180106780A1

    公开(公告)日：2018-04-19

    申请号：US15729317

    申请日：2017-10-10

    Applicant: Academia Sinica

    Inventor： Chi-Huey WONG ,  Tsui-Ling HSU ,  Sarah R. Hanson ,  Masaaki SAWA

    IPC: G01N33/50 ,  G01N33/533

    CPC classification number: G01N33/5005 ,  G01N33/5008 ,  G01N33/533 ,  G01N2400/00

    Abstract: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.

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