公开(公告)号：US20210101978A1

公开(公告)日：2021-04-08

申请号：US17107302

申请日：2020-11-30

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL

IPC: C07K16/28 ,  A61K39/395 ,  C07K14/725 ,  C07K14/705 ,  C07K16/24

Abstract: The present disclosure is related to compositions that include polynucleotides encoding chimeric receptors, methods of delivering polynucleotides encoding chimeric receptors to immune cells, and methods of using immune cells encoding chimeric receptors to treat or prevent cancer.

公开(公告)号：US20210079074A1

公开(公告)日：2021-03-18

申请号：US16943123

申请日：2020-07-30

Applicant: Alector LLC

Inventor： Jeonghoon SUN ,  Wei-Hsien HO ,  Muhammad A. ALHAWAGRI ,  Philip Ling KONG ,  Herve RHINN ,  Hua LONG ,  Karpagam SRINIVASAN ,  Ananya MITRA ,  Daniel P. BERMINGHAM ,  Klaus-Dieter HEGER ,  Santiago Viveros SALAZAR ,  Francesca CIGNARELLA ,  Ilaria TASSI ,  Tina SCHWABE ,  Angie Grace YEE ,  Arnon ROSENTHAL

IPC: C07K16/18

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, humanized antibodies and antibody fragments, that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20210040200A1

公开(公告)日：2021-02-11

申请号：US16965676

申请日：2019-01-31

Applicant: Alector LLC

Inventor： Philip KONG ,  Herve RHINN ,  Tina SCHWABE ,  Angie YEE ,  Ilaria TASSI ,  Muhammad Abbas ALHAWAGRI ,  Arnon ROSENTHAL

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MS4A4A polypeptide, e.g., a mammalian MS4A4A or human MS4A4A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20200024348A1

公开(公告)日：2020-01-23

申请号：US16510773

申请日：2019-07-12

Applicant: Alector LLC

Inventor： Tina SCHWABE ,  Michael KURNELLAS ,  Arnon ROSENTHAL ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20190062427A1

公开(公告)日：2019-02-28

申请号：US15772010

申请日：2016-10-28

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Kate MONROE ,  Seung-Joo LEE

IPC: C07K16/28 ,  A61P29/00 ,  A61P35/00 ,  A61P25/00 ,  A61P31/04 ,  A61K39/395 ,  A61K45/06

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Siglec-9 protein, e.g., human Siglec-9 or a mammalian Siglec-9, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20180160661A1

公开(公告)日：2018-06-14

申请号：US15836089

申请日：2017-12-08

Applicant: ALECTOR LLC

Inventor： Arnon ROSENTHAL ,  Seung-Joo LEE

IPC: A01K67/027 ,  C12N15/85

CPC classification number: A01K67/0276 ,  A01K67/0275 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/07 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  C07K14/7056 ,  C07K14/70596 ,  C12N15/8509

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.

公开(公告)号：US20240329054A1

公开(公告)日：2024-10-03

申请号：US18656427

申请日：2024-05-06

Applicant: Alector LLC

Inventor： Robert PAUL ,  Michael F. WARD ,  Felix Leejia YEH ,  Yijie LIAO ,  Herve RHINN ,  Arnon ROSENTHAL

IPC: G01N33/68

CPC classification number: G01N33/6854 ,  G01N33/6896 ,  G01N2333/70503 ,  G01N2800/2821 ,  G01N2800/52

Abstract: The present disclosure relates generally to biomarkers of activity and/or therapeutic efficacy of anti-CD33 antibodies for the treatment of a disease or injury in an individual, as well as methods related thereto.

公开(公告)号：US20240294650A1

公开(公告)日：2024-09-05

申请号：US17995189

申请日：2021-03-30

Applicant: Alector LLC

Inventor： Michael KURNELLAS ,  Santiago Viveros SALAZAR ,  Marina ROELL ,  Angie Grace YEE ,  Seung-Joo LEE ,  Tina SCHWABE ,  Maxime CHAPON ,  William Francis ESTACIO ,  Arnon ROSENTHAL

IPC: C07K16/28 ,  G01N33/573

CPC classification number: C07K16/2863 ,  G01N33/573 ,  C07K2317/33 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/9121

Abstract: The present disclosure is generally directed to antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g. a mammalian MerTK or human MerTK, and use of such compositions in preventing, reducing risk, or treating a disease or disorder an individual in need thereof.

公开(公告)号：US20240287204A1

公开(公告)日：2024-08-29

申请号：US18392569

申请日：2023-12-21

Applicant: ALECTOR LLC

Inventor： Seung-Joo LEE ,  Spencer Liang ,  Angie YEE ,  Marina ROELL ,  Arnon ROSENTHAL

IPC: C07K16/40 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/40 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/507 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MerTK polypeptide, e.g., a mammalian MerTK or human MerTK, and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20230183341A1

公开(公告)日：2023-06-15

申请号：US17916728

申请日：2021-04-02

Applicant: Alector LLC

Inventor： Robert PAUL ,  Michael F. WARD ,  Hua LONG ,  Omer Rizwan SIDDIQUI ,  Arnon ROSENTHAL ,  Felix Leejia YEH ,  Sam JACKSON

IPC: C07K16/28 ,  A61P25/28

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61K2039/505

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a TREM2 protein, e.g., human TREM2, for use in treating and/or delaying progression of a disease or injury in an individual in need thereof.