公开(公告)号：US3194802A

公开(公告)日：1965-07-13

申请号：US25681563

申请日：1963-02-07

Applicant: AMERICAN HOME PROD

Inventor： ALBURN HARVEY E ,  GRANT NORMAN H ,  FLETCHER RD HORACE

IPC: C07D499/00 ,  C07D499/74

CPC classification number: C07D499/00

公开(公告)号：US3886186A

公开(公告)日：1975-05-27

申请号：US39308773

申请日：1973-08-30

Applicant: AMERICAN HOME PROD

Inventor： DVONCH WILLIAM ,  ALBURN HARVEY E

IPC: C07D493/04 ,  C07D5/32

CPC classification number: C07D493/04

Abstract: The 2- and 5-nitrate esters of 1,4:3,6-dianhydro-D-glucitol are prepared by nitrating 1,4:3,6-dianhydro-D-glucitol. The mononitrates so produced are separated and converted by standard procedures to derivatives in which an alkyl, benzoyl, cycloalkyl, carbamoyl, sulfamoyl, or benzoyl radical is substituted on the hydroxyl group. The derivatives possess cardiovascular activity.

Abstract translation: 通过硝化1,4：3,6-二脱氢-D-葡萄糖醇制备1,4：3,6-二脱氢-D-葡萄糖醇的2-和5-硝酸酯。 如此制备的单硝酸酯通过标准方法分离并转化成衍生物，其中烷基，苯甲酰基，环烷基，氨基甲酰基，氨磺酰基或苯甲酰基被羟基取代。 衍生物具有心血管活性。

公开(公告)号：US3704312A

公开(公告)日：1972-11-28

申请号：US3704312D

申请日：1970-10-30

Applicant: AMERICAN HOME PROD

Inventor： RUSSELL PETER B ,  FLETCHER HORACE ,  ALBURN HARVEY E

IPC: C07D235/24 ,  C07C101/04

CPC classification number: C07D235/24

Abstract: THE COMPOUNDS ARE BIALICYCLIC AMINO ACIDS WHICH ARE USEFUL AS ANTI-INFLAMMATORY AGENTS IN WARMBLOODED ANIMALS. THE COMPOUNDS ARE ALSO USEFUL, WHEN THEIR AMINO GROUPS ARE PROPERLY BLOCKED, FOR REACTING WITH 6-AMINOPENICILLANIC ACID, OR DERIVATIVES THEREOF, TO PREPARE PENICILLINS HAVING ANTIBIOTIC ACTIVITY, OR AS INTERMEDIATES IN THE PREPARATION OF THEIR CORRESPONDING N-CARBOXYANHYDRIDES WHICH MAY BE REACTED DIRECTLY WITH 6-AMINOPENICILLANIC ACID, OR DERIVATIVES THEREOF, TO PREPARE SAID PENICILLINS.

公开(公告)号：US3703542A

公开(公告)日：1972-11-21

申请号：US3703542D

申请日：1969-11-05

Applicant: AMERICAN HOME PROD

Inventor： ALBURN HARVEY E ,  CLARK DONALD E ,  GRANT NORMAN H ,  LAPIDUS MILTON

IPC: C07C103/30 ,  A61K27/00

Abstract: THE COMPOUNDS ARE HYDROXAMIC ACIDS OF ALICYCLIC AMINO ACIDS, AND ESTERS OF SAID COMPOUNDS, ALL OF WHICH HAVE VALUABLE PHARMACODYNAMIC PROPERTIES IN THAT THEY RELIEVE HYPERGLYCEMIA IN WARM-BLOODED AMINALS.

公开(公告)号：US3600426A

公开(公告)日：1971-08-17

申请号：US3600426D

申请日：1968-09-30

Applicant: AMERICAN HOME PROD

Inventor： GRANT NORMAN H ,  ALBURN HARVEY E

IPC: A61K31/24 ,  B23K9/28 ,  C07C101/36 ,  C07C101/44 ,  C07C125/06

CPC classification number: A61K31/24 ,  B23K9/28

Abstract: 1-AMINOCYCLOPENTANECARBOXYLIC ACID ESTERS OPTIONALLY MONO-SUBSTITUTED ON THE AMINO GROUP WITH ALKYL, ARYL, ARYLALKYL OR ARYLALKOXYCARBONYL (I) ARE PROVIDED BY REACTING THE CORRESPONDING 1-AMINOCYCLOPENTYLACYL COMPOUND (II) WITH A REAGENT (III) CAPABLE OF PROVIDING THE ESTER LINKAGE. COMPOUNDS (I) ARE PHARMACOLOGICALLY ACTIVE IN WARM BLOODED LOWER ANIMALS AS ANTI-INFLAMMATORY AND ANTI-IMMUNE AGENTS.

公开(公告)号：US3591574A

公开(公告)日：1971-07-06

申请号：US3591574D

申请日：1968-05-29

Applicant: AMERICAN HOME PROD

Inventor： FENICHEL RICHARD L ,  GRANT NORMAN H ,  ALBURN HARVEY E

IPC: C07K14/575 ,  A61K38/28 ,  C07K1/06 ,  C07K14/62 ,  C07K14/625 ,  C07K16/00 ,  C07C103/52

CPC classification number: C07K14/625 ,  C07K1/063

Abstract: ACYL-SUBSTITUTED-INSULINS, PARTICULARLY PHENYL- AND SUBSTITUTED-PEHNYLGLYCYL-INSULINS, ESPECIALLY N-PHENYLGLYCYLINSULIN, N-P-METHYLPHENYLGLYCYL-INSULIN AND N-P-CHLOROPHENYLGLYCYL-INSULIN (1), ARE PREPARED BY TREATING INSULIN WITH AN ACYLATING AGENT, ESPECIALLY THE CORRESPONDING NCHLOROFORMYL-N-PHENYL OR SUBSTITUTED-PHENYLGLYCIN (II). THE NEW COMPOUNDS (I) HAVE HYPOGLYCEMIC ACTIVITY AND ARE USEFUL TO TREAT DIABETES, ESPECIALLY IN SUBJECTS WHO ARE INSULIN FAST.

公开(公告)号：US3558602A

公开(公告)日：1971-01-26

申请号：US3558602D

申请日：1968-11-20

Applicant: AMERICAN HOME PROD

Inventor： ALBURN HARVEY E ,  GRANT NORMAN H

IPC: C07D499/80 ,  A61K31/43 ,  A61P31/04 ,  C07D235/02 ,  C07D499/00 ,  C07D499/74 ,  C07D99/16

CPC classification number: C07D235/02 ,  C07D499/00

Abstract: THIS IS CONCERNED WITH 6-(1-AMINOCYCLOPENTENE-1CARBOXAMIDO)PENICILLANIC ACIDS AND 6-(4-OXO-1,3-DIAZASPIROL(4LNONEN - 3 - YL)PENICILLANIC ACIDS HAVING POTENT ACTIVITY AGAINST GRAM-NEGATIVE AND GRAM-POSITIVE MICROORGANISMS.

公开(公告)号：US3542776A

公开(公告)日：1970-11-24

申请号：US3542776D

申请日：1967-10-25

Applicant: AMERICAN HOME PROD

Inventor： DVONCH WILLIAM ,  ALBURN HARVEY E

IPC: C07D413/14 ,  C07D473/00 ,  C07D87/24

CPC classification number: C07D413/14 ,  C07D473/00

公开(公告)号：US3522250A

公开(公告)日：1970-07-28

申请号：US3522250D

申请日：1968-10-15

Applicant: AMERICAN HOME PROD

Inventor： KERWIN RICHARD M ,  DVONCH WILLIAM ,  ALBURN HARVEY E

IPC: C07D501/18 ,  C07D501/26 ,  C07D99/24

CPC classification number: C07D501/18 ,  C07D501/26 ,  Y10S435/849

公开(公告)号：US3504020A

公开(公告)日：1970-03-31

申请号：US3504020D

申请日：1967-10-04

Applicant: AMERICAN HOME PROD

Inventor： LAPIDUS MILTON ,  GRANT NORMAN H ,  ROSENTHALE MARVIN E ,  ALBURN HARVEY E

IPC: C07C405/00 ,  C07C159/00 ,  A61K27/00 ,  C07C59/18

CPC classification number: C07C405/00