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公开(公告)号：US20220163820A1
公开(公告)日：2022-05-26
申请号：US17650266
申请日：2022-02-08
Applicant: ACUCELA INC.
Inventor： Philip M. BUSCEMI , Ryo KUBOTA
Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.
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公开(公告)号：US20210311326A1
公开(公告)日：2021-10-07
申请号：US17250507
申请日：2019-07-26
Applicant: ACUCELA INC.
Inventor： Beat WYSS , Jean-Noël FEHR , Glenn NORONHA , Karim HAROUD , Julien SAUVET , Hans BERNHARD , Christian OGGENFUSS , Amitava GUPTA , Ryo KUBOTA
Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.
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公开(公告)号：US20210171435A1
公开(公告)日：2021-06-10
申请号：US16934715
申请日：2020-07-21
Applicant: Acucela Inc.
Inventor： Claes Olof BAVIK , Susan Hayes HENRY , Ryo KUBOTA , Vladimir A. KUKSA
IPC: C07C215/08 , C07C323/32 , A61K31/35 , A61K31/138 , A61K45/06 , C07C211/27 , A61K31/765 , C07C217/20 , C07D309/06 , A61K31/137
Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.
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44.发明申请公开(公告)号：US20180271363A1
公开(公告)日：2018-09-27
申请号：US15996329
申请日：2018-06-01
Applicant: Acucela Inc.
Inventor： Lukas SCHEIBLER , Matthias PFISTER , Urban SCHNELL , Stefan TROLLER , Ryo KUBOTA
CPC classification number: A61B3/102 , A61B3/0008 , A61B3/0025 , A61B3/10 , A61B3/1005 , A61B3/1225 , A61B5/0013 , A61B2505/07 , A61B2560/0425 , A61B2560/0431 , A61B2560/0456 , A61B2576/00 , G01B9/02
Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.
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公开(公告)号：US20250076682A1
公开(公告)日：2025-03-06
申请号：US18952067
申请日：2024-11-19
Applicant: ACUCELA INC.
Inventor： Beat WYSS , Jean-Noel FEHR , Glenn NORONHA , Karim HAROUD , Julien SAUVET , Hans BERNHARD , Christian OGGENFUSS , Amitava GUPTA , Ryo KUBOTA
Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.
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Patent Agency Ranking
公开(公告)号：US20240385467A1
公开(公告)日：2024-11-21
申请号：US18786135
申请日：2024-07-26
Applicant: ACUCELA INC.
Inventor： Philip M. BUSCEMI , Ryo KUBOTA
Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.
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公开(公告)号：US20240252835A1
公开(公告)日：2024-08-01
申请号：US18632487
申请日：2024-04-11
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Karim HAROUD , Beat WYSS , Hans BERNHARD , Jean-Noel FEHR , Patrizia WEBER , Moritz HAEBERLI , Amitava GUPTA
CPC classification number: A61N5/0622 , G02B27/0172 , G02B27/30 , A61N2005/063 , A61N2005/0648 , A61N2005/0652 , A61N2005/0663 , G02B2027/0178
Abstract: A device to stimulate the retina comprises one or more light sources coupled to one or more optical elements. The one or more optical elements is configured to illuminate the retina with one or more images at a location away from a fovea of a wearer. In some embodiments, each of the one or more images comprises a depth of focus and a spatial resolution. The one or more images can be formed at a distance anterior to the retina, at a distance posterior to the retina or on the retina. In some embodiments, the depth of focus is less than the distance, and the spatial resolution greater than a spatial resolution of the retina at the location.
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48.发明公开公开(公告)号：US20240108216A1
公开(公告)日：2024-04-04
申请号：US18525549
申请日：2023-11-30
Applicant: ACUCELA INC.
Inventor： Lukas SCHEIBLER , Matthias PFISTER , Urban SCHNELL , Stefan TROLLER , Ryo KUBOTA
CPC classification number: A61B3/102 , A61B3/0008 , A61B3/0025 , A61B3/10 , A61B3/1005 , A61B3/1225 , A61B5/0013 , G01B9/02 , A61B2505/07 , A61B2560/0425 , A61B2560/0431 , A61B2560/0456 , A61B2576/00
Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.
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公开(公告)号：US20230363640A1
公开(公告)日：2023-11-16
申请号：US18317549
申请日：2023-05-15
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Stephan WYDER , Philip M. BUSCEMI , Matthias PFISTER , Alexander HOLZER
IPC: A61B3/10 , G01B9/02004 , G01B9/02091 , A61B3/12
CPC classification number: A61B3/102 , G01B9/02004 , G01B9/02091 , A61B3/1225
Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. The scan pattern is a continuous pattern that includes a plurality of lobes. The measurement beam may be caused to move on the retina by the motion of a mirror that intercepts and redirects the measurement beam. The mirror position may be altered by the application of a drive signal to one or more actuators that respond to the drive signal by rotating the mirror about an axis or axes.
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公开(公告)号：US20230284897A1
公开(公告)日：2023-09-14
申请号：US18005888
申请日：2021-09-30
Applicant: ACUCELA INC.
Inventor： Ryo KUBOTA , Philip M. BUSCEMI
CPC classification number: A61B3/103 , A61B3/14 , A61B3/0025 , A61B3/1015 , A61B3/135 , A61B3/102
Abstract: Embodiments of the present disclosure are directed to systems, apparatuses and methods for prediction, diagnosis, planning and monitoring for myopia and myopic progression. In some embodiments, one or more refractive properties of the eye is determined for each of a plurality of retinal locations of the eye. The plurality of locations may comprise a central region, such as a fovea of the eye, or non-foveal region such as a peripheral region or a region of the macula outside the fovea. Measuring the refractive properties of the eye for the plurality of locations may be helpful in diagnosing myopia and other ocular conditions by providing the refractive properties of the eye for locations away from the fovea, such as the peripheral retina.
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