利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

73 条记录 (耗时 0.043 秒)

    2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, and their salts useful in the treatment of brain injury
    42.
    发明授权
    2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, and their salts useful in the treatment of brain injury 失效
    2,3-二氢-5-（3-氧代-2-环己烯-1-基）-2-苯并呋喃羧酸及其盐可用于治疗脑损伤

    公开(公告)号：US4654365A

    公开(公告)日：1987-03-31

    申请号：US780144

    申请日：1985-09-26

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07D307/85 ,  A61K31/34

    CPC分类号： C07D307/85

    摘要： The invention relates to novel substituted 2,3-dihydro-5-(3-oxo-2-cyclohexen-1-yl)-2-benzofurancarboxylic acids, their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代的2,3-二氢-5-（3-氧代-2-环己烯-1-基）-2-苯并呋喃羧酸及其衍生物及其盐。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。

    Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-dione s for treatment of grey matter edema
    43.
    发明授权
    Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-dione s for treatment of grey matter edema 失效
    取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮用于治疗灰质水肿

    公开(公告)号：US4605664A

    公开(公告)日：1986-08-12

    申请号：US605743

    申请日：1984-05-01

    申请人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    发明人： Edward J. Cragoe, Jr. ,  Otto W. Woltersdorf, Jr.

    IPC分类号： C07D207/44 ,  C07D207/456 ,  C07D409/10 ,  A61K31/40

    CPC分类号： C07D207/456 ,  C07D409/10

    摘要： The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

    摘要翻译： 本发明涉及新的取代-3-（2,3-二氢-1H-茚-5-基）-4-羟基-1H-吡咯-2,5-二酮，其类似物及其盐。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防脑部损伤以及头部创伤，中风（特别是缺血性），呼吸暂停，心跳骤停，雷叶综合征，脑血栓形成，脑栓塞，脑出血，脑肿瘤，脑脊髓炎 ，脊髓损伤，脑积水，术后脑损伤创伤，由于脑部感染引起的水肿和各种脑震荡。