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    Preparation of phosphoric acid derivatives and intermediates
    41.
    发明授权
    Preparation of phosphoric acid derivatives and intermediates 失效
    磷酸衍生物和中间体的制备

    公开(公告)号：US5010193A

    公开(公告)日：1991-04-23

    申请号：US282712

    申请日：1988-12-09

    Applicant: Fritz Maurer ,  Reinhard Lantzsch ,  Helmut Fiege ,  Albert Schnatterer

    Inventor： Fritz Maurer ,  Reinhard Lantzsch ,  Helmut Fiege ,  Albert Schnatterer

    IPC: C07D239/06 ,  C07D239/10 ,  C07D239/14 ,  C07D239/36 ,  C07D239/46 ,  C07D239/47 ,  C07D239/52 ,  C07F9/6512

    CPC classification number: C07D239/06 ,  C07D239/14 ,  C07D239/36 ,  C07D239/46 ,  C07F9/65125

    Abstract: A process for the preparation of a compound of the formula ##STR1## in which R is hydrogen, alkoxy, alkylamino, dialkylamino or an optionally substituted radical from the group consisting of alkyl, cycloalkyl, aralkyl and aryl,R.sup.1 is an optionally substituted radical from the group consisting of alkyl, alkoxy, alkylthio, mono- or dialkylamino and phenyl,R.sup.2 is optionally substituted alkyl, andY is oxygen or sulphur,comprising(a1) reacting a compound of the formula ##STR2## with ##STR3## or withR.sup.5 COOHin whichR.sup.5 is R except for hydrogen, or equivalent, to produce ##STR4## oxidizing that compound or its salt to ##STR5## and phosphorylating. Several of the intermediates are new.

    Abstract translation: 制备式（I）化合物的方法，其中R是氢，烷氧基，烷基氨基，二烷基氨基或任选取代的基团，其由烷基，环烷基，芳烷基和芳基组成的组中，R 1是任选的 取代基由烷基，烷氧基，烷硫基，一烷基或二烷基氨基和苯基组成的组中，R 2为任选取代的烷基，Y为氧或硫，包括（a1）使式（IIa）化合物与 （III）或其中R5为R的R5 COOH，或氢等价物，以产生氧化该化合物或其盐至（V）并进行磷酸化的（VIa）（Ⅳa）。 几个中间体是新的。

    Process for the preparation of benzothiazepinone derivatives
    42.
    发明授权
    Process for the preparation of benzothiazepinone derivatives 失效
    苯并噻吖啶酮衍生物的制备方法

    公开(公告)号：US4948886A

    公开(公告)日：1990-08-14

    申请号：US293265

    申请日：1989-01-04

    Applicant: Franz-Josef Mais ,  Helmut Fiege

    Inventor： Franz-Josef Mais ,  Helmut Fiege

    IPC: C07C17/12 ,  C07D281/10 ,  C07D281/16

    CPC classification number: C07C17/12 ,  C07D281/10

    Abstract: Benzothiazepinone derivatives can be prepared by alkaline hydrolysis of benzothiazoles to give o-amino-thiophenols, isolation thereof by acidification and further reaction with acrylic acids. In this connection, the acidification is carried out using a mineral acid, after which the o-amino-thiophenol is extracted using a water-insoluble solvent and is reacted in this extract with an acrylic acid.

    Abstract translation: 可以通过苯并噻唑碱性水解制备苯并噻吖啶酮衍生物，得到邻氨基苯硫酚，通过酸化进行分离，并进一步与丙烯酸反应。 就此而言，使用无机酸进行酸化，然后使用水不溶性溶剂萃取邻氨基苯硫酚，并在该萃取液中与丙烯酸反应。

    Process are the preparation of p-hydroxy-benzaldehydes
    43.
    发明授权
    Process are the preparation of p-hydroxy-benzaldehydes 失效
    方法是制备对羟基苯甲醛

    公开(公告)号：US4929766A

    公开(公告)日：1990-05-29

    申请号：US311481

    申请日：1989-02-16

    Applicant: Albert Schnatterer ,  Helmut Fiege

    Inventor： Albert Schnatterer ,  Helmut Fiege

    IPC: B01J31/22 ,  C07B61/00 ,  C07C45/00 ,  C07C45/36 ,  C07C47/565 ,  C07C67/00

    CPC classification number: C07C45/36

    Abstract: p-Hydroxy-benzaldehydes can be obtained by oxidation of the corresponding p-cresols with oxygen in the presence of basic substances in a solvent, the reaction being carried out in the additional presence of a chelate complex of iron and/or manganese. If desired, the reaction can be carried out in the presence of further metal salts.

    Abstract translation: 对 - 羟基 - 苯甲醛可以通过在溶剂中碱性物质存在下用氧气氧化相应的对甲酚来获得，该反应在额外存在铁和/或锰螯合物的情况下进行。 如果需要，反应可以在其它金属盐的存在下进行。

    Preparation of 2-alkyl- and 2-aryl-thiomethylphenols
    45.
    发明授权
    Preparation of 2-alkyl- and 2-aryl-thiomethylphenols 失效
    2-烷基 - 和2-芳基 - 硫代甲基苯酚的制备

    公开(公告)号：US4304940A

    公开(公告)日：1981-12-08

    申请号：US181593

    申请日：1980-08-27

    Applicant: Karlfried Wedemeyer ,  Helmut Fiege

    Inventor： Karlfried Wedemeyer ,  Helmut Fiege

    IPC: C07B61/00 ,  B01J21/00 ,  B01J21/02 ,  B01J21/10 ,  B01J23/00 ,  B01J23/02 ,  B01J23/06 ,  B01J23/34 ,  B01J23/36 ,  B01J23/70 ,  C07C20060101 ,  C07C67/00 ,  C07C313/00 ,  C07C323/16 ,  C07C148/00

    CPC classification number: C07C323/00

    Abstract: In the preparation of a 1-alkyl- and 2-aryl-thio-methylphenol of the formula ##STR1## in which R.sup.1 is, or the radicals R.sup.1 are, in the 3-, 5- and/or 6-positions relative to the hydroxyl group and each independently is a hydrogen or halogen atom, or an alkyl, cycloalkyl, aryl, aralkyl or alkoxy group,n is 1, 2, or 3, andR.sup.2 is an optionally substituted alkyl group having 1 to 12 carbon atoms, an optionally substituted cycloalkyl group having 3 to 6 carbon atoms, an optionally substituted phenyl radical or an optionally substituted aralkyl radical,by reacting a phenol of the formula ##STR2## with formaldehyde or an formaldehyde producing compound and with a mercaptan or a thiophenol of the formulaR.sup.2 --S--H.the improvement which comprises effecting the reaction at a temperature of about 90.degree. to 220.degree. C. in the presence of at least one compound of lithium, magnesium, calcium, strontium, barium, zinc, cadmium, lead, manganese, cobalt, nickel, cooper, iron, chromium and aluminum as a catalyst. The products are obtained in high yield and selectivity.

    Abstract translation: 在制备其中R 1为或基团R 1为在相对于C 1 -C 6烷基的3-，5-和/或6-位的式“IMAGE”的1-烷基 - 和2-芳基 - 硫代 - 甲基苯酚 羟基，并且各自独立地为氢或卤素原子，或烷基，环烷基，芳基，芳烷基或烷氧基，n为1,2或3，并且R 2为任选取代的具有1至12个碳原子的烷基， 任选取代的具有3至6个碳原子的环烷基，任选取代的苯基或任选取代的芳烷基，通过使式IMA的苯酚与甲醛或产生甲醛的化合物和式（I）的硫醇或苯硫酚反应， R2-SH。 包括在至少一种锂，镁，钙，锶，钡，锌，镉，铅，锰，钴，镍等的化合物的存在下在约90℃至220℃的温度下进行反应的改进。 铜，铬和铝作为催化剂。 以高产率和选择性获得产品。

    Process for the continuous preparation of di-tertiary butylcresols
    47.
    发明授权
    Process for the continuous preparation of di-tertiary butylcresols 失效
    连续制备二叔丁基甲酚的方法

    公开(公告)号：US4144400A

    公开(公告)日：1979-03-13

    申请号：US748073

    申请日：1976-12-06

    Applicant: Helmut Fiege ,  Josef Haydn ,  Johann Renner ,  Karlfried Wedemeyer

    Inventor： Helmut Fiege ,  Josef Haydn ,  Johann Renner ,  Karlfried Wedemeyer

    IPC: C07C27/00 ,  C07C37/14 ,  C07C39/06 ,  C07C67/00

    CPC classification number: C07C37/14

    Abstract: A process for the continuous preparation of a ditertiary butylcresol wherein m- or p-cresol is reacted with isobutene at elevated temperature using H.sub.2 SO.sub.4 as catalyst wherein the process is carried out stepwise by introducing stepwise into a reaction mixture comprising substantially all of the cresol to be reacted with isobutene. The total amount of isobutene introduced is introduced such that less isobutene is charged in a last stage of the process than in the first stage thereof. Thereafter the catalyst is deactivated.

    Abstract translation: 连续制备二叔丁基甲酚的方法，其中使用H 2 SO 4作为催化剂，在高温下使异丙烯与异丁烯反应，其中该步骤通过逐步引入含有基本上所有甲酚的反应混合物来逐步进行 与异丁烯反应。 导入的异丁烯的总量被引入，使得在该方法的最后阶段比在第一阶段中加入较少的异丁烯。 此后催化剂失活。

    Process for preparing 4,6-diamino-resorcinol dihydrochloride
    48.
    发明授权
    Process for preparing 4,6-diamino-resorcinol dihydrochloride 失效
    制备4,6-二氨基间苯二酚二盐酸盐的方法

    公开(公告)号：US6093852A

    公开(公告)日：2000-07-25

    申请号：US180972

    申请日：1998-11-17

    Applicant: Horst Behre ,  Helmut Fiege ,  Heinz Ulrich Blank ,  Wolfgang Eymann

    Inventor： Horst Behre ,  Helmut Fiege ,  Heinz Ulrich Blank ,  Wolfgang Eymann

    IPC: B01J23/44 ,  C07B61/00 ,  C07C213/02 ,  C07C215/80 ,  C07C209/00

    CPC classification number: C07C213/02

    Abstract: The invention concerns 4,6-diamino-resorcinol which is prepared in the form of its dihydrochloride by catalytic hydrogenation of 1,3-benzyloxy-4,6-dinitrobenzene on a noble metal contact in a two-phase mixture of dilute aqueous hydrochloric acid and an organic solvent which is not miscible with dilute aqueous hydrochloric acid. This process is carried out at a pressure of between 1 and 200 bar and a temperature of between 0 and 200.degree. C.

    Abstract translation: PCT No.PCT / EP97 / 02409 Sec。 371日期：1998年11月17日 102（e）1998年11月17日PCT PCT 1997年5月12日PCT公布。 出版物WO97 / 44311 日期1997年11月27日本发明涉及通过在二相混合物中贵金属接触上的1,3-苄氧基-4,6-二硝基苯的催化氢化制备其二盐酸盐形式的4,6-二氨基间苯二酚 的稀盐酸水溶液和与稀盐酸水溶液不混溶的有机溶剂。 该方法在1至200巴之间的压力和0至200℃的温度下进行。

    Process for preparing di-C.sub.1 - C.sub.4 -alkyl 5-nitro-isophthalates
    49.
    发明授权
    Process for preparing di-C.sub.1 - C.sub.4 -alkyl 5-nitro-isophthalates 失效
    制备5-硝基 - 间苯二甲酸二-C1-4-烷基酯的方法

    公开(公告)号：US6002041A

    公开(公告)日：1999-12-14

    申请号：US73485

    申请日：1998-05-06

    Applicant: Gunter Rauchschwalbe ,  Bernhard Beitzke ,  Helmut Fiege

    Inventor： Gunter Rauchschwalbe ,  Bernhard Beitzke ,  Helmut Fiege

    IPC: C07C205/57 ,  C07C205/00

    CPC classification number: C07C201/12

    Abstract: Particularly pure di-C.sub.1 -C.sub.4 -alkyl 5-nitro-isophthalates are obtained in good yield and in a simple process by dissolving 5-nitro-isophthalic acid in a mixture of a C.sub.1 -C.sub.4 -alkyl alcohol and a solvent which is miscible or only partially miscible with water, heating in the presence of a strong acid, thus forming a second, aqueous phase, crystallizing out, after the esterification reaction has ended, the di-C.sub.1 -C.sub.4 -alkyl 5-nitro-isophthalate formed from the organic phase by cooling and removing the aqueous phase before or after the di-C.sub.1 -C.sub.4 -alkyl 5-nitro-isophthalate is separated off.

    Abstract translation: 通过将5-硝基间苯二甲酸溶解在C1-C4烷基醇和可混溶的溶剂的混合物中，以良好的产率和简单的方法得到特别纯的5-硝基 - 间苯二甲酸二 - 仅在水中部分混溶，在强酸存在下加热，从而形成第二个水相，在酯化反应结束后结晶出由有机物形成的5-硝基间苯二甲酸二C1-C4烷基酯 在分离出5-硝基间苯二甲酸二-C 1 -C 4烷基酯之前或之后，通过冷却和除去水相来进行相。

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