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132 条记录 (耗时 0.025 秒)

    Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
    41.
    发明授权
    Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity 有权
    取代的苯乙胺具有5-羟色胺能和/或去甲肾上腺素能活性

    公开(公告)号：US07456317B2

    公开(公告)日：2008-11-25

    申请号：US11565451

    申请日：2006-11-30

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： C07C211/00 ,  A01N33/02 ,  A61K31/135

    CPC分类号： A61K31/137 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C65/21 ,  C07C217/74 ,  C07C235/34 ,  C07C255/37 ,  C07C2601/14

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。

    PREPARATION AND UTILITY OF SUBSTITUTED ERYTHROMYCIN ANALOGS
    44.
    发明申请
    PREPARATION AND UTILITY OF SUBSTITUTED ERYTHROMYCIN ANALOGS 审中-公开
    取代的红霉素类似物的制备和应用

    公开(公告)号：US20070281894A1

    公开(公告)日：2007-12-06

    申请号：US11756319

    申请日：2007-05-31

    申请人： Thomas G. GANT ,  Sepehr Sarshar

    发明人： Thomas G. GANT ,  Sepehr Sarshar

    IPC分类号： C07H17/08 ,  A61K31/7052

    CPC分类号： C07H17/08

    摘要： The present disclosure is directed to novel macrolide antibiotics of Formula 1 and pharmaceutically acceptable salts and prodrugs thereof; and the chemical syntheses and medical uses of these novel macrolide antibiotics for the treatment and/or management of infections caused by various aerobic and anaerobic gram-positive and gram-negative microorganisms as well as various mycobacteria.

    摘要翻译： 本公开涉及式1的新型大环内酯类抗生素及其药学上可接受的盐和前药; 以及这些新型大环内酯类抗生素的化学合成和医疗用途，用于治疗和/或治疗由各种需氧和厌氧革兰氏阳性和革兰氏阴性微生物以及各种分枝杆菌引起的感染。

    PH sensitive prodrugs of 2,6-Diisopropylphenol
    45.
    发明授权
    PH sensitive prodrugs of 2,6-Diisopropylphenol 有权
    2,6-二异丙基苯酚的PH敏感前药

    公开(公告)号：US07250412B2

    公开(公告)日：2007-07-31

    申请号：US10514303

    申请日：2004-03-15

    申请人： Subramanian Marappan ,  Cris Davenport ,  Sepehr Sarshar

    发明人： Subramanian Marappan ,  Cris Davenport ,  Sepehr Sarshar

    IPC分类号： A61K31/54 ,  A61K31/165 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4164 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/505 ,  A61K31/495 ,  A61K31/53 ,  A61K31/5375

    CPC分类号： C07D295/18

    摘要： The present invention is directed to water-soluble derivatives of 2,6-diisopropylphenol (Propofol). The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol. Pharmaceutical compositions comprising these compounds, methods of induction and maintenance of anesthesia or sedation as well as methods of treating neurodegenerative diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

    摘要翻译： 本发明涉及2,6-二异丙基苯酚（Propofol）的水溶性衍生物。 该化合物作为2,6-二异丙基苯酚的前体药物，并快速代谢到丙泊酚，从而提供了不溶于水的2,6-二异丙基苯酚的替代物。 还公开了包含这些化合物的药物组合物，诱导和维持麻醉或镇静的方法以及利用包含这些化合物的药物组合物治疗神经变性疾病的方法及其制备方法。

    Inhibitors of the gastric H+, K+-atpase with enhanced therapeutic properties
    46.
    发明申请
    Inhibitors of the gastric H+, K+-atpase with enhanced therapeutic properties 有权
    抑制胃H +，K + -atpase具有增强的治疗性能

    公开(公告)号：US20070082929A1

    公开(公告)日：2007-04-12

    申请号：US11544407

    申请日：2006-10-04

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/4439 ,  C07D403/02

    CPC分类号： C07D401/12

    摘要： Chemical syntheses and medical uses of novel inhibitors of the gastric H+, K+-ATPase for the treatment and/or management of duodenal ulcers, heartburn, acid reflux, other conditions mediated by gastric acid secretion and/or psoriasis are described.

    摘要翻译： 用于治疗和/或治疗十二指肠溃疡，胃灼热，酸反流，其他条件的胃H +，K + + ATP酶的新型抑制剂的化学合成和医学用途 由胃酸分泌和/或牛皮癣介导。

    SUBSTITUTED PHENYLPIPERIDINES WITH SEROTONINERGIC ACTIVITY AND ENHANCED THERAPEUTIC PROPERTIES
    47.
    发明申请
    SUBSTITUTED PHENYLPIPERIDINES WITH SEROTONINERGIC ACTIVITY AND ENHANCED THERAPEUTIC PROPERTIES 审中-公开
    具有丝氨酸活性和增强治疗性质的替代苯基哌啶

    公开(公告)号：US20110130424A1

    公开(公告)日：2011-06-02

    申请号：US12916894

    申请日：2010-11-01

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/4525 ,  C07D401/12 ,  A61P25/00 ,  A61P29/00 ,  A61P3/10 ,  A61P13/00 ,  A61P3/04 ,  A61P9/00 ,  A61P15/10

    CPC分类号： C07D405/12

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。

    SUBSTITUTED PDE5 INHIBITORS
    48.
    发明申请
    SUBSTITUTED PDE5 INHIBITORS 审中-公开
    取代PDE5抑制剂

    公开(公告)号：US20100234388A1

    公开(公告)日：2010-09-16

    申请号：US12303720

    申请日：2007-06-08

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/4985 ,  C07D471/14 ,  A61P9/12 ,  A61P15/00 ,  C12N9/99

    CPC分类号： C07D471/14 ,  C07B2200/05

    摘要： Provided herein are substituted PDE5 inhibitors of Formula (1), and processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and/or management of hypertension, erectile dysfunction, and/or the inability to maintain improved erectile function. The compounds are deuterated tadalafil derivatives.

    摘要翻译： 本文提供了式（1）的取代的PDE5抑制剂及其制备方法及其药物组合物。 还提供了它们用于治疗和/或治疗高血压，勃起功能障碍和/或不能维持改善的勃起功能的方法。 化合物是氘化的他达拉非衍生物。

    PREPARATION AND UTILITY OF HMG-COA REDUCTASE INHIBITORS
    50.
    发明申请
    PREPARATION AND UTILITY OF HMG-COA REDUCTASE INHIBITORS 审中-公开
    HMG-COA还原抑制剂的制备和应用

    公开(公告)号：US20100137244A1

    公开(公告)日：2010-06-03

    申请号：US12373228

    申请日：2007-07-12

    申请人： Thomas G. Gant ,  Sepehr Sarshar

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/695 ,  C07D309/10 ,  C07F7/02 ,  A61P3/00 ,  A61P9/00 ,  A61P25/16 ,  A61P25/28 ,  A61P35/00

    CPC分类号： C07D309/30

    摘要： Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of hypercholesterolemia, dyslipidemia, coronary artery disease, atherosclerosis, metabolic syndrome, a hyperproliferative disease such as colorectal cancer, prostate cancer, and melanoma, a neurodegenerative disease such as cerebral ischemia, Alzheimer's disease, and Parkinson's disease are described.

    摘要翻译： 3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶和异构体的非对映异构体混合物，其各自的非对映异构体，药学上可接受的盐，溶剂合物或前药的新型调节剂的化学合成和医学用途，其化学合成和 用于治疗和/或治疗高胆固醇血症，血脂异常，冠状动脉疾病，动脉粥样硬化，代谢综合征，过度增殖性疾病如结肠直肠癌，前列腺癌和黑素瘤的医学用途，神经变性疾病如脑缺血，阿尔茨海默病 ，帕金森氏病。