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公开(公告)号：US06692960B2
公开(公告)日：2004-02-17
申请号：US09967669
申请日：2001-09-28
申请人： C. Frank Bennett , Susan M. Freier
发明人： C. Frank Bennett , Susan M. Freier
IPC分类号： C07H2104
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/01091 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of sphingosine-1-phosphate lyase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding sphingosine-1-phosphate lyase. Methods of using these compounds for modulation of sphingosine-1-phosphate lyase expression and for treatment of diseases associated with expression of sphingosine-1-phosphate lyase are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节鞘氨醇-1-磷酸裂解酶的表达。 组合物包含靶向编码鞘氨醇-1-磷酸裂解酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节鞘氨醇-1-磷酸裂解酶表达和治疗与鞘氨醇-1-磷酸裂合酶表达相关的疾病的方法。
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42.发明授权Antisense modulation of phospholipase A2, group VI (Ca2+-independent) expression 有权磷脂酶A2，VI（Ca2 + - 独立）表达的反义调节公开(公告)号：US06410325B1
公开(公告)日：2002-06-25
申请号：US09851896
申请日：2001-05-09
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01004 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Phospholipase A2, group VI (Ca2+-independent). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Phospholipase A2, group VI (Ca2+-independent). Methods of using these compounds for modulation of Phospholipase A2, group VI (Ca2+-independent) expression and for treatment of diseases associated with expression of Phospholipase A2, group VI (Ca2+-independent) are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节磷脂酶A2，VI（Ca 2+独立）的表达。 组合物包含靶向编码磷脂酶A2，组VI（Ca 2+独立）的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节磷脂酶A2，VI（Ca2 + - 独立）表达和治疗与磷脂酶A2，VI（Ca2 + - 独立型）表达相关的疾病的方法。
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公开(公告)号：US20140005252A1
公开(公告)日：2014-01-02
申请号：US13988296
申请日：2011-11-17
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/323 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing alpha-synuclein mRNA and protein expression. Also disclosed herein are methods for treating, preventing, and ameliorating neurodegenerative diseases in an individual in need thereof.
摘要翻译： 本文公开了用于降低α-突触核蛋白mRNA和蛋白质表达的反义化合物和方法。 本文还公开了在有需要的个体中治疗，预防和改善神经变性疾病的方法。
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公开(公告)号：US20130046008A1
公开(公告)日：2013-02-21
申请号：US13577622
申请日：2011-02-08
申请人： C. Frank Bennett , Michael Hayden , Susan M. Freier , Sarah Greenlee , Jeffrey Carroll , Simon Warby , Eric E. Swayze
发明人： C. Frank Bennett , Michael Hayden , Susan M. Freier , Sarah Greenlee , Jeffrey Carroll , Simon Warby , Eric E. Swayze
IPC分类号： A61K31/7088 , A61P25/28 , A61K31/7115 , A61K31/7125 , C12N5/071 , A61K31/712
CPC分类号： C12Q1/6883 , C12N15/113 , C12N2310/11 , C12N2320/34 , C12Q1/6811 , C12Q1/6897 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2525/207 , C12Q2535/131 , C12Q2539/107 , C12Q2521/327 , C12Q2525/121 , C12Q2525/185
摘要： Disclosed herein are antisense compounds and methods for selectively reducing expression of an allelic variant of a huntingtin gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate Huntington's Disease (HD).
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公开(公告)号：US20130046007A1
公开(公告)日：2013-02-21
申请号：US13577616
申请日：2011-02-08
IPC分类号： C12N15/113 , A61K31/7088 , A61P25/28 , A61P25/00 , A61P25/16 , A61P11/00 , A61P1/16 , A61P11/06 , A61P29/00 , A61P27/12 , A61P3/10 , A61P9/10 , A61P27/02 , A61P9/12 , A61P3/04 , A61P25/24 , A61P35/00 , C12N5/07
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/34
摘要： Disclosed herein are antisense compounds and methods for selectively of reducing expression of an allelic variant of a gene containing a single nucleotide polymorphism (SNP). Such methods, compounds, and composition are useful to treat, prevent, or ameliorate diseases, including neurodegenerative, such as Huntington's Disease (HD).
摘要翻译： 本文公开了用于选择性降低含有单核苷酸多态性（SNP）的基因的等位变体的表达的反义化合物和方法。 这些方法，化合物和组合物可用于治疗，预防或改善疾病，包括神经变性如亨廷顿病（HD）。
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公开(公告)号：US20120157514A1
公开(公告)日：2012-06-21
申请号：US13412307
申请日：2012-03-05
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： A61K31/712 , C12Q1/68 , A61P37/00 , C12N5/07
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
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公开(公告)号：US20120149757A1
公开(公告)日：2012-06-14
申请号：US13264353
申请日：2010-04-13
CPC分类号： C07H21/00
摘要： Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
摘要翻译： 本文公开了用于调节细胞，组织或动物中SMN2mRNA的剪接的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症（包括脊髓性肌肉萎缩）的药物中的用途。
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公开(公告)号：US08106025B2
公开(公告)日：2012-01-31
申请号：US12346940
申请日：2008-12-31
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
摘要翻译： 提供化合物，组合物和方法用于调节小非编码RNA的表达和功能。 组合物包含靶向小的非编码RNA的寡聚化合物。 还提供了使用这些化合物调节小非编码RNA以及这些RNA的下游靶标以及用于诊断和治疗与小非编码RNA相关的疾病的方法。
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公开(公告)号：US20090298174A1
公开(公告)日：2009-12-03
申请号：US12345780
申请日：2008-12-30
申请人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
发明人： Christine Esau , Bridget Lollo , C. Frank Bennett , Susan M. Freier , Richard H. Griffey , Brenda F. Baker , Timothy A. Vickers , Eric G. Marcusson , Erich Koller , Eric E. Swayze , Ravi Jain , Balkrishen Bhat , Eigen Peralta
IPC分类号： C12N5/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2310/113 , C12N2310/14 , C12N2310/141 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3515 , C12N2320/11 , C12N2320/30 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
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50.发明授权Compositions and methods for the treatment of severe acute respiratory syndrome (SARS) 有权治疗严重急性呼吸综合征（SARS）的组合物和方法公开(公告)号：US07339051B2
公开(公告)日：2008-03-04
申请号：US10831901
申请日：2004-04-26
申请人： Stanley T. Crooke , David J. Ecker , Rangarajan Sampath , Susan M. Freier , Christian Massire , Steven A. Hofstadler , Kristin Sannes Lowery , Eric E. Swayze , Brenda F. Baker , C. Frank Bennett
发明人： Stanley T. Crooke , David J. Ecker , Rangarajan Sampath , Susan M. Freier , Christian Massire , Steven A. Hofstadler , Kristin Sannes Lowery , Eric E. Swayze , Brenda F. Baker , C. Frank Bennett
CPC分类号： C12N15/1131 , C07K16/10 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： The present invention provides design and synthesis of oligomeric compounds and compositions that can be administered to reduce the activity of SARS virus in vivo or in vitro, to prevent or treat SARS virus-associated disease, to detect AARS virus, and to diagnose SARS virus-associated diseases.
摘要翻译： 本发明提供可以施用以降低SARS病毒在体内或体外的活性，预防或治疗SARS病毒相关疾病，检测AARS病毒和诊断SARS病毒的寡聚化合物和组合物的设计和合成， 相关疾病
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