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公开(公告)号：US09610148B2
公开(公告)日：2017-04-04
申请号：US14460113
申请日：2014-08-14
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Michael Prencipe , Suman Chopra , Joseph Thomas Norris , Adolfo Serrano
IPC: A45D34/00 , A45D34/04 , A61K8/00 , A61K8/22 , A61Q11/00 , A61C19/06 , A46B9/02 , A46B11/00 , A46B17/04 , A61C3/00 , A61K8/81
CPC classification number: A61C19/066 , A46B9/005 , A46B9/021 , A46B9/025 , A46B11/0024 , A46B11/0027 , A46B17/04 , A46B2200/10 , A46B2200/1046 , A46B2200/20 , A61C1/0092 , A61C3/005 , A61C17/0202 , A61C19/063 , A61K8/22 , A61K8/8147 , A61K2800/87 , A61K2800/92 , A61Q11/00
Abstract: The method of the present invention is directed to the storage and dispensing of a peroxide containing tooth whitening composition. During storage and subsequent use the composition in the storage chamber must be maintained segregated from the applicator surface. This is accomplished by delivering the peroxide containing tooth whitening composition from the storage chamber through a delivery channel having a length and a cross-sectional diameter sufficient to preclude the migration of moisture and the enzyme catalase from the application surface to the storage chamber. The composition is applied to teeth by means of bristles, a sponge surface or fibrillated surface. This applicator can be used with both aqueous and non-aqueous peroxide containing tooth whitening compositions.
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公开(公告)号：US20170049680A1
公开(公告)日：2017-02-23
申请号：US15344504
申请日：2016-11-04
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Lynette A. Zaidel , Guisheng Pan , Suman K. Chopra , Prakasarao Mandadi , Michael Prencipe
CPC classification number: A61K8/8176 , A61K8/0208 , A61K8/22 , A61K8/24 , A61K8/49 , A61K8/817 , A61K8/891 , A61K8/90 , A61K2800/805 , A61Q11/00 , A61Q11/02
Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
Abstract translation: 口腔护理组合物，其包含：（a）包含过氧化物组分和N-乙烯基杂环聚合物（例如聚-N-乙烯基聚内酰胺或聚-N-乙烯基 - 聚酰亚胺）的过氧化物络合物; （b）增白剂（例如过氧化氢）; 和（c）口头可接受的承运人。 在一个实施方案中，载体包括成膜材料。 还提供了用于制备口腔护理组合物的方法，其包括：（a）将增白剂，硅氧烷粘合剂和载体流体混合以形成均匀的混合物; （b）向所述均匀混合物中加入过氧化物络合物，其中所述络合物包含过氧化氢和N-乙烯基杂环聚合物; 和（c）在真空下混合。
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公开(公告)号：US20170049671A1
公开(公告)日：2017-02-23
申请号：US15307782
申请日：2014-04-30
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Michael Prencipe , Steven Wade Fisher
IPC: A61K8/27 , A61K8/362 , A61K8/25 , A61K8/46 , A61K8/34 , A61K8/73 , A61K8/24 , A61Q11/00 , A61K8/81
CPC classification number: A61K8/27 , A61K8/0241 , A61K8/24 , A61K8/25 , A61K8/345 , A61K8/362 , A61K8/463 , A61K8/731 , A61K8/8164 , A61K2800/28 , A61K2800/412 , A61K2800/92 , A61Q11/00
Abstract: An oral care composition comprising (a) a silica abrasive having an average particle size of no greater than the diameter of a dentin tubule, or, alternatively 8 microns or less; (b) zinc citrate, (c) a bioadhesive agent, and (d) an anticalculus agent. The oral care composition can reduce or inhibit biofilm formation and/or dentinal hypersensitivity in an oral cavity.
Abstract translation: 一种口腔护理组合物，其包含（a）平均粒度不大于牙本质小管的直径的二氧化硅磨料，或者8微米或更小的; （b）柠檬酸锌，（c）生物粘附剂，和（d）防牙垢剂。 口腔护理组合物可以减少或抑制口腔中的生物膜形成和/或牙质超敏反应。
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公开(公告)号：US09566230B2
公开(公告)日：2017-02-14
申请号：US14338319
申请日：2014-07-22
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Michael Prencipe , Suman K. Chopra , Michael Collins
IPC: A61Q11/00 , A61K8/22 , A61K8/89 , A61K8/25 , A61K6/00 , A61C19/06 , A61K8/81 , A61K8/891 , A61K8/895
CPC classification number: A61K8/89 , A61C19/066 , A61K8/22 , A61K8/8176 , A61K8/891 , A61K8/895 , A61Q11/00
Abstract: A tooth whitening system comprising a dental tray having a surface operable to confront a tooth surface, and a tooth whitening composition comprising a whitening agent and a hydrophobic polymer carrier. The tooth whitening composition is preferably substantially non-water soluble. A tooth whitening kit is also provided using a dental tray and the tooth whitening composition comprising a whitening composition and a hydrophobic polymer carrier.
Abstract translation: 一种牙齿美白系统，其包括具有可操作以面对牙齿表面的表面的牙托盘，和包含增白剂和疏水性聚合物载体的牙齿增白组合物。 牙齿美白组合物优选基本上是非水溶性的。 还使用牙科托盘和含有美白组合物和疏水性聚合物载体的牙齿增白组合物来提供牙齿美白试剂盒。
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公开(公告)号：US20170007529A1
公开(公告)日：2017-01-12
申请号：US15270450
申请日：2016-09-20
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Andre Morgan , Marilou Joziak , Michael Prencipe
CPC classification number: A61K8/86 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/362 , A61K8/368 , A61K8/463 , A61K8/49 , A61K8/81 , A61K2800/54 , A61Q11/00
Abstract: Disclosed herein are compositions comprising a fluoride ion source, a poly(propylene oxide)/poly(ethylene oxide) copolymer, and optionally a sparingly soluble acid; and methods of using and of making the same.
Abstract translation: 本文公开了包含氟离子源，聚（环氧丙烷）/聚（环氧乙烷）共聚物和任选的微溶酸的组合物; 以及使用和制作相同的方法。
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Patent Agency Ranking
公开(公告)号：US09532932B2
公开(公告)日：2017-01-03
申请号：US14147826
申请日：2014-01-06
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Michael Prencipe , Andre Morgan , Venda Porter Maloney
CPC classification number: A61K8/27 , A61K8/0245 , A61K8/19 , A61K8/29 , A61K8/44 , A61K8/731 , A61K2800/412 , A61K2800/5922 , A61K2800/594 , A61K2800/624 , A61Q11/00
Abstract: Disclosed are oral care compositions, for example dentifrice compositions, comprising an oral care composition comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and at least one amino acid capable of chelating the metal oxide. The composition may comprise a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.
Abstract translation: 公开了口腔护理组合物，例如洁牙剂组合物，其包含口腔护理组合物，其包含口腔可接受的载体，平均粒度不大于牙本质小管的金属氧化物颗粒和能够螯合金属氧化物的至少一种氨基酸。 组合物可以包含用于将金属氧化物颗粒粘附在牙本质小管中的聚合物粘附材料。 金属氧化物颗粒的中值粒径为5微米以下，可以含有氧化锌。
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公开(公告)号：US20160178527A1
公开(公告)日：2016-06-23
申请号：US14580510
申请日：2014-12-23
Applicant: Colgate-Palmolive Company
Inventor： Stanislav Jaracz , Ravi Subramanyam , Michael Prencipe
IPC: G01N21/78
CPC classification number: G01N21/78 , A61K8/466 , A61K2800/45 , A61Q11/00 , G01N21/77 , G01N21/79 , G01N33/20
Abstract: A method of measuring the relative rates of release of a target metal ion from two or more samples includes: (i) providing at least two aliquots of a solution including an indicator, the indicator having a colour; (ii) dispersing a sample into each aliquot; and (iii) during step (ii), monitoring the colour of the indicator in situ to determine the rates of release of the target metal ions from the samples relative to one another. Each sample comprises at least one source of the target metal ion. The indicator comprises zincon. The samples are oral care compositions selected from a toothpaste, a tooth gel, and a tooth powder. The target metal ion is selected from the stannous and zinc (II).
Abstract translation: 测量来自两个或更多个样品的靶金属离子的相对释放速率的方法包括：（i）提供包含指示剂的溶液的至少两个等分试样，所述指示剂具有颜色; （ii）将样品分散到每个等分试样中; 和（iii）在步骤（ii）期间，在现场监测指示剂的颜色以确定目标金属离子从样品相对于彼此的释放速率。 每个样品包含至少一种目标金属离子源。 指标包括zincon。 样品是选自牙膏，牙胶和牙粉的口腔护理组合物。 目标金属离子选自亚锡和锌（II）。
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公开(公告)号：US20150335539A1
公开(公告)日：2015-11-26
申请号：US14654512
申请日：2012-12-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Michael Prencipe , Xiao Yi Huang , Yuan Hui Xie
CPC classification number: A61K8/24 , A61K8/19 , A61K8/21 , A61K8/27 , A61K8/365 , A61K2800/30 , A61Q11/00
Abstract: The present invention relates to an oral care composition with a high water content which has improved robustness towards microbial challenge. The oral care composition includes compositions comprising from 0.125 wt % to 0.75 wt % of a water soluble source of stannous ions, wherein the composition comprises at least 50 wt % water and wherein the source of stannous ions is selected from the group consisting of stannous chloride, stannous pyrophosphate, stannous formate, stannous acetate, stannous gluconate, stannous lactate, stannous tartrate, stannous oxalate, stannous malonate, stannous citrate, stannous ethylene glyoxide, and mixtures thereof.
Abstract translation: 本发明涉及具有高水含量的口腔护理组合物，其具有改善的对微生物攻击的鲁棒性。 口腔护理组合物包括包含0.125重量％至0.75重量％的水溶性亚锡离子源的组合物，其中所述组合物包含至少50重量％的水，并且其中所述亚锡离子源选自氯化亚锡 ，焦磷酸亚锡，甲酸亚锡，乙酸亚锡，葡萄糖酸亚锡，乳酸亚锡，酒石酸亚锡，草酸亚锡，丙二酸亚锡，柠檬酸亚锡，亚乙基亚乙基氧化物及其混合物。
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公开(公告)号：US20150202129A1
公开(公告)日：2015-07-23
申请号：US14676767
申请日：2015-04-01
Applicant: Colgate-Palmolive Company
Inventor： Michael Prencipe
CPC classification number: A61K8/27 , A61K8/0241 , A61K8/21 , A61K8/24 , A61K8/25 , A61K8/33 , A61K8/416 , A61K8/42 , A61K8/43 , A61K8/49 , A61K8/4926 , A61K8/4953 , A61K8/4973 , A61K8/55 , A61K8/58 , A61K8/64 , A61K2800/412 , A61Q11/00
Abstract: The invention includes a dentifrice composition that comprises a zinc ion source, a polyphosphate ion source, an anethole, and a silica. The silica has a mean particle size of about 5 to about 12 microns, an Einlehner hardness of about 1 to about 20, and an oil absorption of about 40 to less than about 100 cc/100 g. The composition contains zinc ions and polyphosphate ions in a weight ratio of about 0.1:1 to about 10:1 and has a RDA value of about 100 to about 200 and a PCR value of about 75 to about 110. Related methods are also included.
Abstract translation: 本发明包括含有锌离子源，多磷酸盐离子源，茴香脑和二氧化硅的洁齿剂组合物。 二氧化硅具有约5至约12微米的平均粒度，约1至约20的爱因纳硬度，以及约40至小于约100cc / 100g的吸油量。 该组合物含有约0.1:1至约10:1的重量比的锌离子和多磷酸根离子，并且RDA值为约100至约200，PCR值为约75至约110.相关方法也包括在内。
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公开(公告)号：US20150157542A1
公开(公告)日：2015-06-11
申请号：US14527829
申请日：2014-10-30
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： Lyndsay Schaeffer-Korbylo , Andre Michelle Morgan , Davide Miksa , Laurence Du-Thumm , Michael Prencipe , Evangelia Arvanitidou , Gregory Szewczyk
CPC classification number: A61K8/34 , A01N49/00 , A61K8/19 , A61K8/21 , A61K8/33 , A61K8/342 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/4926 , A61K8/97 , A61K2800/92 , A61Q11/00 , A01N31/08 , A01N31/16 , A01N43/40 , A01N59/16 , A01N65/00 , A01N2300/00 , A01N65/08
Abstract: Disclosed are oral care compositions and the use of such oral care compositions for treating conditions caused by biofilm formation. Also disclosed are methods for inhibiting biofilm formation and/or degrading biofilm. The oral care composition includes a sesquiterpenoid and an antimicrobial agent, in which the sesquiterpenoid and the antimicrobial agent are present in an amount effective to inhibit and/or degrade a biofilm in the oral cavity.
Abstract translation: 公开了口腔护理组合物和这种口腔护理组合物用于治疗由生物膜形成引起的病症的用途。 还公开了抑制生物膜形成和/或降解生物膜的方法。 口腔护理组合物包括倍半萜和抗微生物剂，其中倍半萜烯和抗微生物剂以有效抑制和/或降解口腔中生物膜的量存在。
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