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公开(公告)号：US20170114368A1
公开(公告)日：2017-04-27
申请号：US15259848
申请日：2016-09-08
Applicant: California Institute of Technology
Inventor： David Baltimore , Matthew Porteus
IPC: C12N15/90
CPC classification number: C12N15/907 , A61K48/00 , C07K2319/00 , C07K2319/09 , C07K2319/43 , C07K2319/81 , C12N9/22 , C12N2800/80 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/203
Abstract: Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivating a target gene or other chromosomal DNA. In one aspect, this disclosure relates to methods and compositions for gene targeting with high efficiency in a cell. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases.
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42.发明申请公开(公告)号：US20130295615A1
公开(公告)日：2013-11-07
申请号：US13749319
申请日：2013-01-24
Inventor： Carlos Lois-Caballe , David Baltimore , Xiao-Feng Qin , Irvin S.Y. Chen , Dong Sung An
IPC: C12N15/113
CPC classification number: C12N15/1132 , A61K48/00 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N15/63 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2330/30 , C12N2740/16043 , C12N2740/16045 , C12N2760/20122 , C12N2799/027 , C12N2810/609 , C12N2830/003 , C12N2830/008 , C12N2830/48 , C12N2840/203
Abstract: In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.
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公开(公告)号：US20240125793A1
公开(公告)日：2024-04-18
申请号：US18493253
申请日：2023-10-24
Applicant: The Board of Trustees of the Leland Stanford Junior University , CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Michael Edward Birnbaum , Juan Luis Mendoza , Michael Thomas Bethune , David Baltimore , Kenan Christopher Garcia
CPC classification number: G01N33/6845 , C07K14/00 , G01N2333/7051 , G01N2333/70539
Abstract: Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.
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公开(公告)号：US11125755B2
公开(公告)日：2021-09-21
申请号：US17011899
申请日：2020-09-03
Applicant: The Board of Trustees of the Leland Stanford Junior University , CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Michael Edward Birnbaum , Juan Luis Mendoza , Michael Thomas Bethune , David Baltimore , Kenan Christopher Garcia
Abstract: Compositions and methods are provided for the identification of peptide sequences that are ligands for a T cell receptor (TCR) of interest, in a given MHC context.
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公开(公告)号：US20190201443A1
公开(公告)日：2019-07-04
申请号：US16122562
申请日：2018-09-05
Applicant: California Institute of Technology
Inventor： Alok V Joglekar , Michael T Leonard , Michael T Bethune , David Baltimore
IPC: A61K35/17 , C07K14/725 , C12N5/0783 , A61P37/00
CPC classification number: A61K35/17 , A61K48/00 , A61P37/00 , C07K14/705 , C07K14/7051 , C07K14/70539 , C07K2319/03 , C07K2319/70 , C12N5/0636 , C40B40/02 , G01N33/566 , G01N33/68 , G01N2333/7051
Abstract: Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more antigen presenting domains comprise a binding fragment of a major histocompatibility complex (MHC) molecule. Various immunological functions of the SABRs are also described.
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Patent Agency Ranking
公开(公告)号：US10006053B2
公开(公告)日：2018-06-26
申请号：US15259848
申请日：2016-09-08
Applicant: California Institute of Technology
Inventor： David Baltimore , Matthew Porteus
IPC: C12N15/90
CPC classification number: C12N15/907 , A61K48/00 , C07K2319/00 , C07K2319/09 , C07K2319/43 , C07K2319/81 , C12N9/22 , C12N2800/80 , C12N2830/00 , C12N2830/002 , C12N2830/15 , C12N2830/48 , C12N2830/60 , C12N2830/90 , C12N2840/203
Abstract: Gene targeting is a technique to introduce genetic change into one or more specific locations in the genome of a cell. For example, gene targeting can introduce genetic change by modifying, repairing, attenuating or inactivating a target gene or other chromosomal DNA. In one aspect, this disclosure relates to methods and compositions for gene targeting with high efficiency in a cell. This disclosure also relates to methods of treating or preventing a genetic disease in an individual in need thereof. Further disclosed are chimeric nucleases and vectors encoding chimeric nucleases.
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公开(公告)号：US09943611B2
公开(公告)日：2018-04-17
申请号：US14067786
申请日：2013-10-30
Applicant: California Institute of Technology
Inventor： Alejandro Benjamin Balazs , David Baltimore
CPC classification number: A61K48/0066 , C12N15/86 , C12N2750/14143 , C12N2800/30 , C12N2800/40 , C12N2830/001 , C12N2830/42 , C12N2840/44
Abstract: According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral vectors encoding a gene product of interest and comprising a plurality of recombinase target sites are provided. In some embodiments, a source of recombinase is provided. In some embodiments, the gene product of interest is expressed, and the recombinase then induces recombination events between the recombinase target sites, thus reducing or eliminating expression of the gene product of interest.
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公开(公告)号：US20180100863A1
公开(公告)日：2018-04-12
申请号：US15729253
申请日：2017-10-10
Applicant: California Institute of Technology
Inventor： Devdoot Majumdar , Anirudh Mathukumilli , David Baltimore
CPC classification number: G01N33/6854 , C12N15/1037 , C12N15/1055 , C12Q1/6876 , G01N33/6878
Abstract: Provided herein are method and kits for elucidation of immunological repertoires (comprising functional pairs of immune cell receptors and antigens). In some embodiments, an immune cell receptor and an antigen that it binds to are isolated, and sequence information is obtained about the immune cell receptor and antigen. In some embodiments, an antigen expressed on a first cell and an immune cell receptor expressed on a second cell can form a synapse, mRNAs can be isolated from the resulting doublet of cells, and sequences of the functional immune cell receptor and its antigen can be obtained from the mRNAs.
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公开(公告)号：US09884075B2
公开(公告)日：2018-02-06
申请号：US14597908
申请日：2015-01-15
Applicant: California Institute of Technology
Inventor： Michael T. Bethune , Marvin H. Gee , David Baltimore
CPC classification number: A61K35/17 , C07K14/7051
Abstract: Disclosed herein are genetically engineered T cell receptors, and methods, vectors, and genetically engineered T cells related to genetically engineered T cell receptors.
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50.发明授权公开(公告)号：US09303072B2
公开(公告)日：2016-04-05
申请号：US14532371
申请日：2014-11-04
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Pin Wang , Lili Yang , David Baltimore
IPC: A01N63/00 , C07K14/005 , A61K31/70 , A61K38/17 , A61K38/19 , A61K38/20 , A61K35/76 , C12N15/86 , A61K39/21 , C12N7/00 , A61K39/00
CPC classification number: C12N15/86 , A61K31/70 , A61K35/76 , A61K38/177 , A61K38/1774 , A61K38/178 , A61K38/1793 , A61K38/191 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/204 , A61K38/2046 , A61K38/2086 , A61K39/21 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/13043 , C12N2740/13045 , C12N2740/15041 , C12N2740/15043 , C12N2740/15045 , C12N2770/36122 , C12N2770/36134 , C12N2810/609 , C12N2810/855 , Y02A50/386 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/466 , Y02A50/475 , Y02A50/48 , Y02A50/481 , Y02A50/492 , A61K2300/00
Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.
Abstract translation: 提供了将编码感兴趣的基因（通常为抗原）的多核苷酸递送至树突状细胞（DC）的方法和组合物。 病毒包膜包含DC-SIGN特异性靶向分子。 方法和相关组合物可用于治疗患有广泛病症的患者，包括感染，例如HIV / AIDS和各种类型的癌症。
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