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83 条记录 (耗时 0.04 秒)

    Prosthetic Heart Valve System
    41.
    发明申请
    Prosthetic Heart Valve System 有权
    假心脏瓣膜系统

    公开(公告)号：US20090198323A1

    公开(公告)日：2009-08-06

    申请号：US12372115

    申请日：2009-02-17

    申请人： Keith M. Johnson ,  Jack D. Lemmon ,  Joseph C. Morrow ,  Timothy R. Ryan

    发明人： Keith M. Johnson ,  Jack D. Lemmon ,  Joseph C. Morrow ,  Timothy R. Ryan

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2439 ,  A61F2/2412 ,  A61F2/2427

    摘要： A prosthetic heart valve system including a prosthetic heart valve and a deflection device. The deflection device includes a line and a connector assembly including a tensioning component. The line interconnects and passes through free ends of stent posts associated with the heart valve, and is further connected to the tensioning component. The tensioning component is transitionable to a tensioning state in which the line is tensioned to inwardly deflect the stent posts. In this regard, the tensioning component is self-locking relative to the line in the tensioning state, and an entirety of the line extending distal the tensioning device does not extend beyond a stent portion of the heart valve opposite the stent posts. In a preferred embodiment, a holder body is further included, coupled to the heart valve apart from the deflection device.

    摘要翻译： 一种假体心脏瓣膜系统，包括假体心脏瓣膜和偏转装置。 偏转装置包括线和包括张紧部件的连接器组件。 线路连接并穿过与心脏瓣膜相关联的支架支柱的自由端，并进一步连接到张紧部件。 张紧部件可转换到张紧状态，其中线被张紧以使支架柱向内偏转。 在这方面，张紧部件相对于处于张紧状态的线是自锁的，并且延伸远离张紧装置的线的整体不延伸超过与支架柱相对的心脏瓣膜的支架部分。 在优选实施例中，进一步包括保持器主体，其与偏转装置相连接到心脏瓣膜。

    Sizing device having two sizers and methods of use
    42.
    发明申请
    Sizing device having two sizers and methods of use 审中-公开
    具有两个筛分机和使用方法的筛分装置

    公开(公告)号：US20090192600A1

    公开(公告)日：2009-07-30

    申请号：US12315950

    申请日：2008-12-08

    申请人： Timothy R. Ryan

    发明人： Timothy R. Ryan

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2496 ,  A61F2/2448

    摘要： A sizing device for measuring a valve annulus, said sizing device comprising: an elongate segment having first and second ends; a first sizer attached to the first end of the elongate segment; and a second sizer attached to the second end of the elongate segment, wherein the first and second sizers have different shapes that correspond to the same size of valve annulus. A method of measuring a valve annulus of a heart. A system for measuring a valve annulus of a heart.

    摘要翻译： 一种用于测量阀环的定径装置，所述定尺寸装置包括：具有第一和第二端的细长段; 附接到细长段的第一端的第一分级器; 以及附接到所述细长段的第二端的第二分级器，其中所述第一和第二筛分器具有对应于相同尺寸的瓣膜环的不同形状。 一种测量心脏瓣膜环的方法。 一种用于测量心脏瓣膜环的系统。

    Multi-layered stents and methods of implanting
    43.
    发明申请
    Multi-layered stents and methods of implanting 审中-公开
    多层支架和植入方法

    公开(公告)号：US20080262593A1

    公开(公告)日：2008-10-23

    申请号：US12070208

    申请日：2008-02-15

    申请人： Timothy R. Ryan ,  Timothy G. Laske ,  Philipp Bonhoeffer ,  Silvia Schievano

    发明人： Timothy R. Ryan ,  Timothy G. Laske ,  Philipp Bonhoeffer ,  Silvia Schievano

    IPC分类号： A61F2/84

    CPC分类号： A61F2/852 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2/90 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2210/0076 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0058 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0015 ,  A61F2250/0018 ,  A61F2250/006 ,  Y10T29/49

    摘要： A method of percutaneously delivering a multi-layered stent assembly to a desired implantation location of a patient including the steps of radially compressing a multi-layered stent assembly to a compressed size for implantation in a patient, the multi-layered stent assembly including a first stent, a second stent coaxially positioned within at least a portion of a length of the first stent, and a valve, wherein the first stent comprises at least one different material property than the second stent. The method further includes delivering the multi-layered stent assembly to the desired implantation location of the patient using a delivery system and substantially simultaneously expanding the first stent and the second stent of the multi-layered stent assembly at the desired implantation location to a radially expanded size that is larger than the compressed size.

    摘要翻译： 一种将多层支架组件经皮递送到患者期望的植入位置的方法，包括将多层支架组件径向压缩至压缩尺寸以便植入患者的步骤，所述多层支架组件包括第一 支架，同轴地定位在第一支架的长度的至少一部分中的第二支架和阀，其中第一支架包括与第二支架相比的至少一种不同的材料特性。 该方法还包括使用递送系统将多层支架组件递送到患者的期望植入位置，并且将所述多层支架组件的第一支架和第二支架基本上同时地扩展到期望的植入位置，以径向扩张 尺寸大于压缩尺寸。

    Annuloplasty Band and Method
    45.
    发明申请
    Annuloplasty Band and Method 有权
    瓣膜成形术和方法

    公开(公告)号：US20080183284A1

    公开(公告)日：2008-07-31

    申请号：US12059495

    申请日：2008-03-31

    申请人： Timothy R. Ryan ,  Joseph C. Morrow

    发明人： Timothy R. Ryan ,  Joseph C. Morrow

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2445 ,  A61F2/2448 ,  A61F2/2466 ,  A61F2/2496

    摘要： An annuloplasty band comprising a sheath, and a generally arcuate stiffening element disposed within the sheath. The stiffening element extends from a first end to a second end, and preferably includes eyelets at its first and second ends adapted to receive sutures to secure the annuloplasty band to a valve annulus. The annuloplasty band preferably has a low profile (e.g., a thickness less than 3 mm). In embodiments intended for mitral valve repair, the eyelets are particularly adapted to receive sutures to secure the annuloplasty band to the antero-lateral trigone and postero-medial trigone. A holder and sizer device useful with the annuloplasty band are also provided.

    摘要翻译： 包括鞘的瓣膜成形带和设置在护套内的大致弓形的加强元件。 加强元件从第一端延伸到第二端，并且优选地包括其第一端和第二端处的孔眼，其适于接收缝合线以将瓣膜成形术带固定到瓣膜环。 瓣膜成形术带优选地具有低轮廓（例如，厚度小于3mm）。 在旨在用于二尖瓣修复的实施例中，孔眼特别适于接收缝合线以将瓣膜成形术带固定到前后三角区和后内侧三角区。 还提供了一种与瓣环成形术带有用的夹持器和分级器装置。

    Process for acylation or alkylation of aromatic compounds in hydrogen fluoride
    47.
    发明授权
    Process for acylation or alkylation of aromatic compounds in hydrogen fluoride 失效
    氟化氢中芳族化合物的酰化或烷基化方法

    公开(公告)号：US5185469A

    公开(公告)日：1993-02-09

    申请号：US748171

    申请日：1991-08-23

    申请人： Daniel D. Lindley ,  Timothy R. Ryan ,  Thomas A. Curtis ,  Edward M. De la Garza ,  Charles R. Hilton ,  Thomas M. Kenesson

    发明人： Daniel D. Lindley ,  Timothy R. Ryan ,  Thomas A. Curtis ,  Edward M. De la Garza ,  Charles R. Hilton ,  Thomas M. Kenesson

    IPC分类号： B01J27/12 ,  C07B61/00 ,  C07C2/70 ,  C07C15/24 ,  C07C45/46 ,  C07C45/85 ,  C07C49/76 ,  C07C51/60

    CPC分类号： C07C45/85 ,  C07C2/70 ,  C07C45/46 ,  C07C51/60 ,  C07C2527/1206

    摘要： A continuous process is disclosed for the acylation or alkylation of aromatic compounds in hydrogen fluoride. The aromatic compound is sufficiently insoluble in hydrogen fluoride that a two phase reaction medium forms. However, surprisingly, the product acylated or alkylated aromatic compound is soluble in hydrogen fluoride. The present invention particularly relates to use of a continuous, multi-stage process for carrying out the acylation or alkylation reaction. In the multi-stage process, the continuous phase can be either the hydrogen-fluoride rich phase or the aromatic compound-rich phase. The movement of the continuous phase relative to the non-continuous (dispersed) phase can be countercurrent or concurrent. The multi-stage process can be operated in a manner such that the aromatic compound feed to the reaction is entirely consumed or such that unreacted aromatic compound is recycled.

    摘要翻译： 公开了在氟化氢中芳族化合物的酰化或烷基化的连续方法。 芳族化合物在形成两相反应介质的氟化氢中是完全不溶的。 然而，令人惊讶的是，产物酰化或烷基化芳族化合物可溶于氟化氢。 本发明特别涉及连续的多级方法用于进行酰化或烷基化反应的用途。 在多级方法中，连续相可以是富氟化氢相或富含芳香族化合物的相。 连续相相对于非连续（分散）相的移动可以是逆流或并行的。 多级方法可以以使得进入反应的芳香族化合物完全消耗或使得未反应的芳族化合物被再循环的方式进行操作。

    Valve holder
    48.
    发明授权
    Valve holder 有权
    阀座

    公开(公告)号：US09421093B2

    公开(公告)日：2016-08-23

    申请号：US13249944

    申请日：2011-09-30

    申请人： Cathy A. Bergin ,  Timothy R. Ryan

    发明人： Cathy A. Bergin ,  Timothy R. Ryan

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2427 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2250/0097

    摘要： Methods and apparatus for holding and maneuvering a valve during preparation and attachment to patient, providing increased visibility of the prosthetic valve and the sewing ring to prevent suture entanglement. A handle attachment is spaced from the valve for improved visibility of the sewing ring and the outlet end of the valve during attachment. Commissure posts are bent inward at the tips while preventing crashing of the commissure posts into each other causing damage. A release force needed to remove the holder and unthread the holder sutures is reduced. The holder and related methods can provide a kink free holder suture path to reduce suture entanglement and prevent damage to the implanted valve during holder removal by reducing the release force needed to remove the holder sutures by up to 30%.

    摘要翻译： 用于在准备和附接到患者期间保持和操纵瓣膜的方法和装置，提供人造瓣膜和缝合环的增加的可视性以防止缝合线缠结。 手柄附件与阀间隔开，以便在连接期间改善缝纫环和阀的出口端的可视性。 小屁股在提示处向内弯曲，同时防止连接柱彼此碰撞造成伤害。 减少保持器和松开保持器缝线所需的释放力减小。 保持器和相关方法可以提供无扭结的缝合线路径，以减少缝合线缠结，并通过将除去夹持器缝合线所需的释放力降低高达30％来防止在保持器移除过程中损伤植入的瓣膜。

    Annuloplasty ring and method
    50.
    发明授权
    Annuloplasty ring and method 有权
    瓣膜成形术环和方法

    公开(公告)号：US09283073B2

    公开(公告)日：2016-03-15

    申请号：US11809194

    申请日：2007-05-31

    申请人： Timothy R. Ryan ,  Cathleen A. Bergin ,  Jerald Redmond

    发明人： Timothy R. Ryan ,  Cathleen A. Bergin ,  Jerald Redmond

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2448 ,  A61F2/2466 ,  A61F2/2496 ,  A61F2250/0018 ,  A61F2250/0029

    摘要： An annuloplasty ring including a sheath, an arcuate stiffening element, and a tensioning member. The stiffening element is disposed within the sheath and defines discrete, first and second ends separated by a lateral spacing. The tensioning member extends between the stiffening element ends. The tensioning member is characterized as being more flexible than the stiffening element and is configured to provide a taut state in which the tensioning member is substantially non-extensible and impedes expansion of the lateral spacing. With this configuration, the stiffening element serves to remodel the valve annulus to a desired shape, while the tensioning member exhibits sufficient flexibility to allow for natural movement of the valve annulus while limiting (in the taut state) the extent of annular dilatation (e.g., overt lateral separation of the first and second ends of the stiffening member) due to in vivo forces.

    摘要翻译： 包括鞘，弓形加强元件和张紧构件的瓣环成形术环。 加强元件设置在护套内并且限定由横向间隔分开的离散的第一和第二端。 张紧构件在加强元件端部之间延伸。 张紧构件的特征在于比加强元件更柔性，并且构造成提供张紧状态，其中张紧构件基本上不可伸长并且阻止横向间隔的膨胀。 通过这种构造，加强元件用于将阀环改造成所需的形状，同时张紧构件表现出足够的柔性以允许阀环的自然运动，同时限制（处于拉紧状态）环形扩张的程度（例如， 由于体内力，加强构件的第一和第二端的突出横向分离）。