公开(公告)号：US20090239795A1

公开(公告)日：2009-09-24

申请号：US11782030

申请日：2007-07-24

申请人： DAVID JAMES BALLANCE ,  Christopher P. Prior ,  Homayoun Sadeghi ,  Andrew J. Turner

发明人： DAVID JAMES BALLANCE ,  Christopher P. Prior ,  Homayoun Sadeghi ,  Andrew J. Turner

IPC分类号： A61K38/16 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N1/19

CPC分类号： C07K14/57563 ,  C07K2319/03

摘要： The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and pharmaceutical compositions. The invention also provides the use of the exendin-4/Tf fusion proteins for treatment of Type II diabetes, obesity, and to reduce body weight.

摘要翻译： 本发明提供融合蛋白，其包含通过多肽接头与转铁蛋白（Tf）融合的毒蜥外泌肽-4以及相应的核酸分子，载体，宿主细胞和药物组合物。 本发明还提供了毒蜥外泌肽-4 / Tf融合蛋白用于治疗II型糖尿病，肥胖症和减轻体重的用途。

公开(公告)号：US07507414B2

公开(公告)日：2009-03-24

申请号：US11078663

申请日：2005-03-14

申请人： Craig A. Rosen ,  Homayoun Sadeghi ,  Christopher P. Prior ,  Andrew J. Turner

发明人： Craig A. Rosen ,  Homayoun Sadeghi ,  Christopher P. Prior ,  Andrew J. Turner

IPC分类号： A61K39/00

CPC分类号： A61K38/4846 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/21 ,  A61K38/212 ,  A61K38/38 ,  A61K47/42 ,  A61K47/65 ,  A61K48/00 ,  A61K2039/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/65 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/76 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/50 ,  C07K2319/75 ,  C12N9/96 ,  C12N15/62 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/412

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20080269128A1

公开(公告)日：2008-10-30

申请号：US11927617

申请日：2007-10-29

申请人： David J. Ballance ,  Darrell Sleep ,  Christopher P. Prior ,  Homayoun Sadeghi ,  Andrew J. Turner

发明人： David J. Ballance ,  Darrell Sleep ,  Christopher P. Prior ,  Homayoun Sadeghi ,  Andrew J. Turner

IPC分类号： A61K38/16 ,  C07K14/775 ,  C07H21/00 ,  A61P43/00

CPC分类号： A61K38/4846 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/21 ,  A61K38/212 ,  A61K38/38 ,  A61K47/42 ,  A61K47/65 ,  A61K48/00 ,  A61K2039/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/65 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/76 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/50 ,  C07K2319/75 ,  C12N9/96 ,  C12N15/62 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/412

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encodings the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the intention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20080261877A1

公开(公告)日：2008-10-23

申请号：US11927593

申请日：2007-10-29

申请人： David J. Ballance ,  Darrell Sleep ,  Christopher P. Prior ,  Homayoun Sadeghi ,  Andrew J. Turner

发明人： David J. Ballance ,  Darrell Sleep ,  Christopher P. Prior ,  Homayoun Sadeghi ,  Andrew J. Turner

IPC分类号： A61K38/16 ,  C07K14/76 ,  C07H21/00 ,  A61P43/00

CPC分类号： A61K38/4846 ,  A01K2217/05 ,  A61K9/0019 ,  A61K38/21 ,  A61K38/212 ,  A61K38/38 ,  A61K47/42 ,  A61K47/65 ,  A61K48/00 ,  A61K2039/54 ,  C07K14/56 ,  C07K14/61 ,  C07K14/62 ,  C07K14/65 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/76 ,  C07K14/765 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/31 ,  C07K2319/50 ,  C07K2319/75 ,  C12N9/96 ,  C12N15/62 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/412

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encodings the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the intention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US5807550A

公开(公告)日：1998-09-15

申请号：US461902

申请日：1995-06-05

申请人： William Robert Baumbach ,  Bosco Shang Wang ,  Homayoun Sadeghi ,  John Steele Logan ,  Ian C. Hart

发明人： William Robert Baumbach ,  Bosco Shang Wang ,  Homayoun Sadeghi ,  John Steele Logan ,  Ian C. Hart

IPC分类号： A61K39/395 ,  A61K38/00 ,  A61K51/00 ,  A61P5/00 ,  C07K1/22 ,  C07K14/00 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  A61K39/00

CPC分类号： C07K16/2869 ,  A61K38/00

摘要： The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may be used alone to enhance the growth of animals, or may be used together with somatotropin to potentiate the effect of somatotropin in animals. The antibodies may also be used to assay the level of somatotropin binding protein of animals.

摘要翻译： 本发明涉及特异性结合动物生长激素结合蛋白但不与相应生长激素受体结合的抗体，特别是单克隆抗体。 抗体可以单独使用以增强动物的生长，或者可以与生长激素一起使用以增强生长激素在动物中的作用。 抗体也可用于测定动物生长激素结合蛋白的水平。

公开(公告)号：US5744318A

公开(公告)日：1998-04-28

申请号：US367507

申请日：1994-12-30

申请人： Henry W. Founds ,  Homayoun Sadeghi

发明人： Henry W. Founds ,  Homayoun Sadeghi

IPC分类号： A61K38/00 ,  C07K16/18 ,  C07K16/44 ,  C12Q1/28 ,  G01N33/53

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K2317/24

摘要： The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularly, the invention is directed to a monoclonal antibody, or an antigen-binding fragment thereof, reactive with in vivo produced advanced glycosylation endproducts (AGEs), which monoclonal antibody or antigen binding fragment thereof demonstrates an immunological binding characteristic of monoclonal antibody 4G9 as produced by hybridoma 4G9, deposited with the American Type Culture Collection (ATCC) and assigned Accession Number CRL 11626. In a specific embodiment, the 4G9 antibody is used in a sandwich ELISA to detect ApoB-AGE, IgG-AGE, collagen-AGE, serum-AGE peptides and proteins and urinary-AGE peptides and proteins.

摘要翻译： 本发明涉及在体内形成的晚期糖基化终产物的单克隆抗体和与体外形成的晚期糖基化终产物交叉反应的单克隆抗体以及基于其的诊断和治疗方法。 更具体地，本发明涉及与体内产生的晚期糖基化终产物（AGE）反应的单克隆抗体或其抗原结合片段，其单克隆抗体或其抗原结合片段表现出单克隆抗体4G9的免疫结合特征， 由保藏在美国典型培养物保藏中心（ATCC）并分配保藏号CRL 11626的杂交瘤4G9产生。在具体实施方案中，将4G9抗体用于夹心ELISA中以检测ApoB-AGE，IgG-AGE，胶原-AGE， 血清AGE肽和蛋白质和尿AGE肽和蛋白质。

公开(公告)号：US5698197A

公开(公告)日：1997-12-16

申请号：US483186

申请日：1995-06-07

申请人： Henry W. Founds ,  Homayoun Sadeghi

发明人： Henry W. Founds ,  Homayoun Sadeghi

IPC分类号： A61K38/00 ,  C07K16/18 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K2317/24

摘要： The present invention relates to monoclonal antibodies to advanced glycosylation endproducts formed in vivo and cross-reactive with advanced glycosylation endproducts formed in vitro, and to methods of diagnosis and therapy based thereon. More particularly, the invention is directed to a monoclonal antibody, or an antigen-binding fragment thereof, reactive with in vivo produced advanced glycosylation endproducts (AGEs), which monoclonal antibody or antigen binding fragment thereof demonstrates an immunological binding characteristic of monoclonal antibody 4G9 as produced by hybridoma 4G9, deposited with the American Type Culture Collection (ATCC) and assigned Accession Number CRL 11626, on Apr. 27, 1994. In a specific embodiment, the 4G9 antibody is used in a sandwich ELISA to detect ApoB-AGE, IgG-AGE, collagen-AGE, serum-AGE peptides and proteins and urinary-AGE peptides and proteins.

摘要翻译： 本发明涉及在体内形成的晚期糖基化终产物的单克隆抗体和与体外形成的晚期糖基化终产物交叉反应的单克隆抗体以及基于其的诊断和治疗方法。 更具体地，本发明涉及与体内产生的晚期糖基化终产物（AGE）反应的单克隆抗体或其抗原结合片段，其单克隆抗体或其抗原结合片段表现出单克隆抗体4G9的免疫结合特征， 由1994年4月27日保藏于美国典型培养物保藏中心（ATCC）并分配保藏号CRL 11626的杂交瘤4G9产生。在具体实施方案中，将4G9抗体用于夹心ELISA中以检测ApoB-AGE，IgG -AGE，胶原蛋白AGE，血清AGE肽和蛋白质以及尿AGE肽和蛋白质。

公开(公告)号：US5439795A

公开(公告)日：1995-08-08

申请号：US473086

申请日：1990-01-31

申请人： William R. Baumbach ,  Bosco S. Wang ,  Homayoun Sadeghi ,  John S. Logan ,  Ian C. Hart

发明人： William R. Baumbach ,  Bosco S. Wang ,  Homayoun Sadeghi ,  John S. Logan ,  Ian C. Hart

IPC分类号： A61K39/395 ,  A61K38/00 ,  A61K51/00 ,  A61P5/00 ,  C07K1/22 ,  C07K14/00 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/577 ,  C07K16/18

CPC分类号： C07K16/2869 ,  A61K38/00

摘要： The present invention is directed to antibodies, in particular monoclonal antibodies, which specifically bind to somatotropin binding proteins of animals, but not with the corresponding somatotropin receptors. The antibodies may also be used to assay the level of somatotropin binding protein of animals.

摘要翻译： 本发明涉及特异性结合动物生长激素结合蛋白但不与相应生长激素受体结合的抗体，特别是单克隆抗体。 抗体也可用于测定动物生长激素结合蛋白的水平。