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公开(公告)号：US20070298459A1
公开(公告)日：2007-12-27
申请号：US11780643
申请日：2007-07-20
申请人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner Gentz
CPC分类号： C07K16/1271 , A61K38/00 , C07K14/4747 , C07K14/70578 , C07K14/7151 , C07K2319/00 , C07K2319/30 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.
摘要翻译： 本发明涉及肿瘤坏死因子受体家族的新成员。 特别地，提供编码人TR9受体的分离的核酸分子。 还提供TR9多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR9受体活性的激动剂和拮抗剂的筛选方法。
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公开(公告)号：US20060142199A1
公开(公告)日：2006-06-29
申请号：US11359509
申请日：2006-02-23
申请人： Jian Ni , Reiner Gentz , Patrick Dillon
发明人： Jian Ni , Reiner Gentz , Patrick Dillon
CPC分类号： C07K14/70585 , A61K38/00 , C12N2799/026
摘要： The present invention concerns a novel CD44-like protein receptor. In particular, isolated nucleic acid molecules are provided encoding the CD44-like protein. CD44-like polypeptides are also provided, as are screening methods for identifying agonists and antagonists capable of enhancing or inhibiting CD44-like protein-mediated signaling. The invention further concerns therapeutic methods for treating diseases associated with processes mediated by CD44-like protein signaling.
摘要翻译： 本发明涉及一种新型的CD44样蛋白受体。 特别地，提供编码CD44样蛋白质的分离的核酸分子。 还提供CD44样多肽，以及用于鉴定能够增强或抑制CD44样蛋白介导的信号传导的激动剂和拮抗剂的筛选方法。 本发明还涉及用于治疗与由CD44样蛋白信号传导介导的过程相关的疾病的治疗方法。
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公开(公告)号：US20050069945A1
公开(公告)日：2005-03-31
申请号：US10994821
申请日：2004-11-23
申请人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
发明人： Jian Ni , Guo-Liang Yu , Pedro Alfonso , Reiner Gentz , Jeffrey Su
摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.
摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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公开(公告)号：US06232291B1
公开(公告)日：2001-05-15
申请号：US09307817
申请日：1999-05-10
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K14435
CPC分类号： C07K14/475 , C07K2319/00
摘要： The invention relates to Cytostatin III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及细胞抑制素III多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06174992B1
公开(公告)日：2001-01-16
申请号：US09263810
申请日：1999-03-08
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz
IPC分类号： C07K1446
CPC分类号： C07K14/4702
摘要： The invention relates to hESF I, II and III polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及hESF I，II和III多肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，以及多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US5985612A
公开(公告)日：1999-11-16
申请号：US467265
申请日：1995-06-06
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
摘要： A human natural killer cell enhancing factor C and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating viral infections, inflammation, neoplasia and damage from superoxide radicals. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
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公开(公告)号：US5238836A
公开(公告)日：1993-08-24
申请号：US167811
申请日：1988-03-14
申请人： Ulrich Certa , Reiner Gentz , Bela Takacs
发明人： Ulrich Certa , Reiner Gentz , Bela Takacs
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/015 , A61P33/02 , A61P37/04 , C07K1/22 , C07K14/00 , C07K14/44 , C07K14/445 , C07K14/76 , C07K16/00 , C07K19/00 , C12N1/21 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/125 , C12R1/19
CPC分类号： C07K14/445 , A61K39/00 , C07K2319/00 , C07K2319/40
摘要： The present invention provides polypeptides having an amino acid sequence derived from the 190 kD precursor to the major merozoite surface antigens of the K1 isolate of Plasmodium falciparum. These polypeptides are capable of eliciting an immune response against different isolates of Plasmodium falciparum. The invention further provides immunogenic compositions and vaccines containing such polypeptides, antibodies raised against the polypeptides. a DNA sequence coding for one of the polypeptides, a replicable microbial vector containing such a DNA sequence and a microorganism transformed with such a vector. The invention also provides processes for the production of the polypeptides, immunogenic compositions, microorganisms and antibodies of the invention and for the use of the polypeptides and immunogenic compositions for the immunization of mammals against malaria.
摘要翻译： 本发明提供具有衍生自恶性疟原虫K1分离株的主要裂殖子表面抗原的190kD前体的氨基酸序列的多肽。 这些多肽能够引发针对恶性疟原虫不同分离株的免疫应答。 本发明还提供了含有这种多肽的免疫原性组合物和疫苗，针对多肽产生的抗体。 编码多肽之一的DNA序列，含有这样的DNA序列的可复制微生物载体和用这种载体转化的微生物。 本发明还提供了生产本发明的多肽，免疫原性组合物，微生物和抗体以及用于免疫哺乳动物免于疟疾的多肽和免疫原性组合物的方法。
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公开(公告)号：US06509170B1
公开(公告)日：2003-01-21
申请号：US08815783
申请日：1997-03-12
申请人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
IPC分类号： C12P2106
CPC分类号： G01N33/6863 , C07K16/2875 , G01N2333/525
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US06506882B2
公开(公告)日：2003-01-14
申请号：US10082260
申请日：2002-02-26
申请人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner Gentz , Patrick J. Dillon
IPC分类号： C07K1600
CPC分类号： G01N33/6863 , C07K16/2875 , G01N2333/525
摘要： The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译： 本发明涉及人TNFδ和TNFε多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。
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公开(公告)号：US5985601A
公开(公告)日：1999-11-16
申请号：US461030
申请日：1995-06-05
申请人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
发明人： Jian Ni , Guo-Liang Yu , Reiner Gentz , Craig A. Rosen
CPC分类号： C07K14/8139 , A61K38/00
摘要： Disclosed is a human CysE polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for treating osteoporosis, tumor metastases, microbial infections, viral infection, septic shock, inflammation, retinal irritation, caries, cachexia and muscle wasting. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
摘要翻译： 公开了编码这种多肽的人CysE多肽和DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽治疗骨质疏松症，肿瘤转移，微生物感染，病毒感染，脓毒性休克，炎症，视网膜刺激，龋齿，恶病质和肌肉消瘦的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。
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