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41.发明授权公开(公告)号：US07208314B2
公开(公告)日：2007-04-24
申请号：US10083456
申请日：2002-02-26
IPC分类号： C12N5/00
CPC分类号： A61K48/0025 , A61K48/0008 , A61K48/0041 , A61K48/0075 , A61K48/0083
摘要： A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell.
摘要翻译： 关于使用pH敏感递送系统将期望的化合物（例如药物和核酸）递送到细胞中的系统。 该系统提供用于将化合物递送和释放到细胞中的组合物和方法。
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公开(公告)号：US07098032B2
公开(公告)日：2006-08-29
申请号：US11046590
申请日：2005-01-28
申请人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
发明人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K47/60 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US07098030B2
公开(公告)日：2006-08-29
申请号：US10899509
申请日：2004-07-26
申请人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
发明人： David B. Rozema , Vladimir G. Budker , James E. Hagstrom , Vladimir Trubetskoy , Jon A. Wolff , Sean D. Monahan , Paul M. Slattum
IPC分类号： C12N15/88
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/645
摘要： An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US07033607B2
公开(公告)日：2006-04-25
申请号：US10095789
申请日：2002-03-11
申请人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
发明人： Vladimir S. Trubetskoy , James E. Hagstrom , Vladimir G. Budker , Jon A. Wolff , David B. Rozema , Sean D. Monahan
IPC分类号： A61K9/127 , A61K31/713
CPC分类号： C12N15/88 , A61K47/58 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041 , C12N15/87
摘要： A polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extravascular space and may be further delivered to a cell.
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公开(公告)号：US07019113B2
公开(公告)日：2006-03-28
申请号：US10444662
申请日：2003-05-23
IPC分类号： C07K1/00
CPC分类号： C12N15/87 , A61K38/00 , A61K47/60 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07H21/00 , C07H21/04 , C07K7/06
摘要： An process for the reversible modification of membrane interaction of a compound is described. Modification of membrane interaction can be used to facilitate delivery of molecules to cells in vitro and in vivo. The described modifiers, which are used to reversibly inactivate the membrane active compounds, can also be utilized as cross-linkers or to reverse the charge of a molecule.
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46.发明授权公开(公告)号：US07482160B2
公开(公告)日：2009-01-27
申请号：US11322419
申请日：2005-12-30
申请人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
发明人： Sean D. Monahan , David B. Rozema , Vladimir Trubetskoy , Paul M. Slattum , Jon A. Wolff , Vladimir G. Budker , James E. Hagstrom , Lisa J. Hanson
IPC分类号： C12N15/88
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/645 , A61K48/00 , A61K48/0008 , A61K48/0025 , A61K48/0041
摘要： A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
摘要翻译： 使用模板聚合在核酸存在下形成聚合物的方法。 这些方法可用于递送核酸，用于冷凝核酸，用于形成核酸结合聚合物，用于形成含有核酸和聚合物的超分子复合物，并用于形成内聚电解质络合物。
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公开(公告)号：US07138382B2
公开(公告)日：2006-11-21
申请号：US10619778
申请日：2003-07-15
IPC分类号： A61K48/00 , A61K31/711 , A61K31/7105 , A61K38/04 , C12N15/87 , A61K9/127
CPC分类号： C12N15/87 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07H21/00 , C07H21/04 , C07K7/06
摘要： A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell.
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公开(公告)号：US06936729B2
公开(公告)日：2005-08-30
申请号：US09795607
申请日：2001-02-28
IPC分类号： A61K48/00 , C07C323/60 , C07C323/62 , C07D207/46 , C11D1/60 , A61K9/127 , C12N15/88
CPC分类号： C07D207/46 , A61K48/00 , C07C323/60 , C07C323/62
摘要： A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved more rapidly than oxidized glutathione or a disulfide bond constructed from thiols in which one of the constituent thiols has a lower pKa than glutathione or a disulfide bond that is activated by intramolecular attack from a free thiol.
摘要翻译： 在生理条件下的不稳定二硫化物化合物，其包含：具有不稳定二硫键的二硫键化合物，其是比氧化型谷胱甘肽更快地裂解的二硫键或由其中一种组成硫醇组成的硫醇构成的二硫键 具有比谷胱甘肽低的pKa或通过游离硫醇的分子内攻击而活化的二硫键。
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49.发明授权Compounds and methods for reversible modification of biologically active molecules 有权用于可逆修饰生物活性分子的化合物和方法公开(公告)号：US08541548B2
公开(公告)日：2013-09-24
申请号：US12140751
申请日：2008-06-17
申请人： David B. Rozema
发明人： David B. Rozema
CPC分类号： C07D495/04 , A01K2217/058 , A01K2267/0362 , A61K48/0041 , C07C233/21 , C07C233/31 , C07C233/39 , C07D307/60 , C07D475/00 , C12N15/87
摘要： The present invention is directed compounds for reversibly modification of biologically active molecules. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
摘要翻译： 本发明涉及可逆地修饰生物活性分子的化合物。 描述了将靶向，抗调理作用，抗聚集和转染活性结合到小的生物相容性体内递送缀合物中的多偶联体系。 使用可逆修饰提供了生理反应活性调节。
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公开(公告)号：US07871818B2
公开(公告)日：2011-01-18
申请号：US10765668
申请日：2004-01-27
申请人： David B. Rozema , Darren Wakefield
发明人： David B. Rozema , Darren Wakefield
CPC分类号： A61K47/58
摘要： We describe a class of polymaleic anhydride polymers capable of disrupting cell membranes. Co-delivery of these polymers with biologically active compounds increases cellular cytoplasmic delivery of the compounds.
摘要翻译： 我们描述了一类能够破坏细胞膜的聚马来酸酐聚合物。 这些聚合物与生物活性化合物的共同递送增加化合物的细胞胞质递送。
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