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公开(公告)号：US07871818B2
公开(公告)日：2011-01-18
申请号：US10765668
申请日：2004-01-27
申请人： David B. Rozema , Darren Wakefield
发明人： David B. Rozema , Darren Wakefield
CPC分类号： A61K47/58
摘要： We describe a class of polymaleic anhydride polymers capable of disrupting cell membranes. Co-delivery of these polymers with biologically active compounds increases cellular cytoplasmic delivery of the compounds.
摘要翻译： 我们描述了一类能够破坏细胞膜的聚马来酸酐聚合物。 这些聚合物与生物活性化合物的共同递送增加化合物的细胞胞质递送。
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公开(公告)号：US07816337B2
公开(公告)日：2010-10-19
申请号：US10780484
申请日：2004-02-17
CPC分类号： C12N15/111 , A61K47/58 , A61K48/00 , A61K48/0041 , C12N15/87 , C12N2310/351 , C12N2320/32
摘要： Described is a process for delivering a biologically active compound to a cell by reversibly linking the compound to a membrane active polymer. In particular, polymer-polynucleotide conjugates are described. Methods for reversibly modifying the polymers to decrease cellular toxicity and improve efficacy are provided.
摘要翻译： 描述了通过可逆地将化合物与膜活性聚合物连接而将生物活性化合物递送至细胞的方法。 特别地，描述了聚合物 - 多核苷酸缀合物。 提供了可逆修饰聚合物以降低细胞毒性并提高功效的方法。
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公开(公告)号：US07442764B2
公开(公告)日：2008-10-28
申请号：US11312319
申请日：2005-12-20
CPC分类号： A61K47/60
摘要： An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo or to alter interactions or activities the compounds. The described modifiers can also be utilized as cross-linkers.
摘要翻译： 描述了含胺化合物的可逆修饰的方法。 化合物的修饰可用于促进分子在体外和体内递送至细胞，或改变化合物的相互作用或活性。 所描述的改性剂也可以用作交联剂。
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公开(公告)号：US20080132689A1
公开(公告)日：2008-06-05
申请号：US12021366
申请日：2008-01-29
申请人： David B. Rozema , Darren Wakefield
发明人： David B. Rozema , Darren Wakefield
IPC分类号： C07H15/203 , C07H21/00 , C07C63/04 , C07C63/15 , C07C63/331
CPC分类号： C07H15/203 , C07H21/00
摘要： Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and have rapid hydrolysis kinetics in conditions which are present in a cell as well as in vivo. Cleavage of the acetal enhances delivery of the biologically active compound.
摘要翻译： 描述的是邻羧基酚衍生的缩醛和含有邻羧基酚衍生的缩醛的组合物，其可用于将生物活性化合物递送到细胞中。 缩醛可以用于可逆地连接三个不同的分子，并且在存在于细胞中以及在体内的条件下具有快速的水解动力学。 缩醛的切割增强了生物活性化合物的递送。
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公开(公告)号：US08217015B2
公开(公告)日：2012-07-10
申请号：US10816081
申请日：2004-04-01
申请人： David B. Rozema , Darren Wakefield
发明人： David B. Rozema , Darren Wakefield
摘要： We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
摘要翻译： 我们描述了pH敏感的内分泌溶解聚合物，包含pH敏感的内分解溶解聚合物的递送颗粒。 所述的颗粒能够将多核苷酸递送至来自外周循环的细胞，随后从内体释放。 内细胞分解的聚合物在细胞外是无活性的，但在暴露于酸化的内体室时破坏膜。
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公开(公告)号：US07348453B2
公开(公告)日：2008-03-25
申请号：US10929707
申请日：2004-08-30
申请人： David B. Rozema , Darren Wakefield
发明人： David B. Rozema , Darren Wakefield
CPC分类号： C12N15/87 , A61K31/192 , A61K48/00
摘要： Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and have rapid hydrolysis kinetics in conditions which are present in a cell as well as in vivo. Cleavage of the acetal enhances delivery of the biologically active compound.
摘要翻译： 描述的是邻羧基酚衍生的缩醛和含有邻羧基酚衍生的缩醛的组合物，其可用于将生物活性化合物递送到细胞中。 缩醛可以用于可逆地连接三个不同的分子，并且在存在于细胞中以及在体内的条件下具有快速的水解动力学。 缩醛的切割增强了生物活性化合物的递送。
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公开(公告)号：US07682626B2
公开(公告)日：2010-03-23
申请号：US10772502
申请日：2004-02-05
申请人： David B. Rozema , Darren Wakefield
发明人： David B. Rozema , Darren Wakefield
CPC分类号： C12N15/87 , A61K9/0019 , A61K47/32 , A61K47/58 , A61K48/0008 , A61K48/0041
摘要： A class of polymers for delivery of polynucleotides to cells in described. More specifically, amphiphilic polyvinylethers and compositions containing amphiphilic polyvinylethers are described.
摘要翻译： 一类用于将多核苷酸递送至所述细胞的聚合物。 更具体地，描述了两亲性聚乙烯醚和含有两亲性聚乙烯醚的组合物。
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公开(公告)号：US07019113B2
公开(公告)日：2006-03-28
申请号：US10444662
申请日：2003-05-23
IPC分类号： C07K1/00
CPC分类号： C12N15/87 , A61K38/00 , A61K47/60 , A61K48/00 , A61K48/0008 , A61K48/0041 , C07H21/00 , C07H21/04 , C07K7/06
摘要： An process for the reversible modification of membrane interaction of a compound is described. Modification of membrane interaction can be used to facilitate delivery of molecules to cells in vitro and in vivo. The described modifiers, which are used to reversibly inactivate the membrane active compounds, can also be utilized as cross-linkers or to reverse the charge of a molecule.
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公开(公告)号：US20070036865A1
公开(公告)日：2007-02-15
申请号：US11533115
申请日：2006-09-19
申请人： David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
发明人： David Rozema , Darren Wakefield , Jon Wolff , Vladimir Budker , Tatyana Budker , Sean Monahan , Vladimir Trubetskoy , James Hagstrom , Aaton Loomis , Paul Slattum
摘要： We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.
摘要翻译： 我们描述了pH敏感的内分泌溶解聚合物，包含pH敏感的内分解溶解聚合物的递送颗粒。 所述的颗粒能够将多核苷酸递送至来自外周循环的细胞，随后从内体释放。 内细胞分解的聚合物在细胞外是无活性的，但在暴露于酸化的内体室时破坏膜。
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公开(公告)号：US20060154867A1
公开(公告)日：2006-07-13
申请号：US11337121
申请日：2006-01-20
申请人： Alexander Sokoloff , So Wong , Jon Wolff , Sean Monahan , James Ludtke , Lori Higgs , Darren Wakefield , Magdolna Sebestyen
发明人： Alexander Sokoloff , So Wong , Jon Wolff , Sean Monahan , James Ludtke , Lori Higgs , Darren Wakefield , Magdolna Sebestyen
IPC分类号： A61K48/00 , A61K38/21 , A61K31/4188 , A61K9/127
CPC分类号： C07K14/005 , A61K41/00 , C12N2795/10222
摘要： We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.
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