公开(公告)号：US20100020099A1

公开(公告)日：2010-01-28

申请号：US12009595

申请日：2008-01-18

Applicant: Suresh Seshadri ,  David Cole ,  Roger M. Smith ,  Bruce R. Hancock

Inventor： Suresh Seshadri ,  David Cole ,  Roger M. Smith ,  Bruce R. Hancock

IPC: G09G5/00

CPC classification number: H04N17/004 ,  G09G3/006 ,  G09G2320/0209 ,  G09G2320/0219 ,  H04N5/2256 ,  H04N5/378

Abstract: The effects of inter pixel capacitance in a pixilated array may be measured by first resetting all pixels in the array to a first voltage, where a first image is read out, followed by resetting only a subset of pixels in the array to a second voltage, where a second image is read out, where the difference in the first and second images provide information about the inter pixel capacitance. Other embodiments are described and claimed.

Abstract translation: 像素化阵列中的像素间电容的影响可以通过首先将阵列中的所有像元复位到第一电压来测量，其中读出第一图像，然后仅将阵列中的像素的子集重置为第二电压， 其中读出第二图像，其中第一和第二图像中的差异提供关于像素间电容的信息。 描述和要求保护其他实施例。

公开(公告)号：US20090236398A1

公开(公告)日：2009-09-24

申请号：US12053199

申请日：2008-03-21

Applicant: David Cole ,  Andrew Smith

Inventor： David Cole ,  Andrew Smith

IPC: A61B17/068

CPC classification number: A61B17/072 ,  A61B17/064 ,  A61B17/115 ,  A61B17/32053 ,  A61B2017/00539 ,  A61B2017/00818 ,  A61B2017/07271 ,  A61B2017/306 ,  A61F5/0013 ,  A61F5/0083

Abstract: Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.

公开(公告)号：US20090171383A1

公开(公告)日：2009-07-02

申请号：US12270607

申请日：2008-11-13

Applicant: David Cole ,  Samuel T. Crews ,  Bretton Swope ,  Andrew Smith ,  John Lunsford ,  Daniel J. Balbierz

Inventor： David Cole ,  Samuel T. Crews ,  Bretton Swope ,  Andrew Smith ,  John Lunsford ,  Daniel J. Balbierz

IPC: A61M29/02

CPC classification number: A61F5/0036 ,  A61F5/003

Abstract: Systems for controlling obesity utilize a number of space occupiers positioned in the stomach to reduce the effective volume of the stomach. Such arrangements provides sufficient stomach volume consumption to induce weight loss, but enable use of space occupiers that are proportioned to minimize the threat of obstruction even if they should migrate into the intestine. In general, numerous small volume space occupiers are placed in the stomach such that the total volume equals or exceeds the single volume of prior art single unit space occupiers. However, each individual space occupier is proportioned so that it will pass without obstruction if it moves into the intestine.

Abstract translation: 用于控制肥胖的系统利用位于胃中的多个空间占用者来减少胃的有效体积。 这种布置提供足够的胃体积消耗以引起体重减轻，但是能够使用成比例的空间占用者，以尽量减少阻塞的威胁，即使它们应该迁移到肠中。 通常，许多小容量空间占用者被放置在胃中，使得总体积等于或超过现有技术的单个单位空间占用者的单个体积。 然而，每个单独的空间占有者是成比例的，以便如果它进入肠道，它将不会阻塞。

公开(公告)号：USD368884S

公开(公告)日：1996-04-16

申请号：US24282

申请日：1994-06-10

Applicant: David Cole

Designer： David Cole

公开(公告)号：US5279243A

公开(公告)日：1994-01-18

申请号：US960823

申请日：1992-10-14

Applicant: David Cole

Inventor： David Cole

IPC: B63B21/06 ,  E02B3/24 ,  B63B21/04

CPC classification number: B63B21/06 ,  E02B3/24

Abstract: For securing a heavy wire rope (hawser), usually to the bow or stern of a large vessel but alternatively to an oil rig or jetty, a bollard comprises(a) a base securable to a deck and having an upstanding cylinder around which is an angled skirt or a plurality of angled brackets;(b) an upper portion having a cylinder which fits rotatably within the base, and on top of which is a round plate on which is fixed a fin, usually a pear-shaped base and the upper portion of which extends at an acute angle to the horizontal and terminates in a narrow peak under which is a notch for retaining the rope, and(c) for retaining the two portions in a desired non-rotating position, corresponding lateral holes in the respective cylinders and at least one locking bar which can be inserted through both cylinders.The upper portion can be rotated manually by inserting a bar in a hole beneath the peak of the fin; or by means of a small motor.The two sections may have respective screw threads.The bollard allows a heavy rope to be secured or released by one man.

Abstract translation: 为了固定一根重的钢丝绳（吊索），通常应用于大型船舶的船首或船尾，或者与石油钻井平台或码头相连，护柱包括（a）可以安装在甲板上的底座，其上有一个直立的缸体 倾斜的裙部或多个倾斜的支架; （b）具有圆筒的上部，该圆筒可旋转地配合在基座内，并且其顶部是圆形板，其上固定有翅片，通常为梨形基部，其上部以锐角延伸至 水平并终止于窄峰，在该峰下方有用于保持绳索的切口，以及（c）用于将两个部分保持在期望的非旋转位置，相应的气缸中的对应的侧孔和至少一个锁定杆 通过两个气瓶插入。 通过将杆插入翅片顶部下方的孔中可以手动旋转上部; 或通过小型电动机。 两个部分可以具有相应的螺纹。 系柱可以让一条绳索固定或释放。

公开(公告)号：US08945167B2

公开(公告)日：2015-02-03

申请号：US13224233

申请日：2011-09-01

Applicant: David Cole ,  Samuel T. Crews ,  Bretton Swope ,  Andrew Smith ,  John Lunsford ,  Daniel J. Balbierz

Inventor： David Cole ,  Samuel T. Crews ,  Bretton Swope ,  Andrew Smith ,  John Lunsford ,  Daniel J. Balbierz

IPC: A61M29/00 ,  A61F5/00

CPC classification number: A61F5/0036 ,  A61F5/003

Abstract: Systems for controlling obesity utilize a number of space occupiers positioned in the stomach to reduce the effective volume of the stomach. Such arrangements provides sufficient stomach volume consumption to induce weight loss, but enable use of space occupiers that are proportioned to minimize the threat of obstruction even if they should migrate into the intestine. In general, numerous small volume space occupiers are placed in the stomach such that the total volume equals or exceeds the single volume of prior art single unit space occupiers. However, each individual space occupier is proportioned so that it will pass without obstruction if it moves into the intestine.

Abstract translation: 用于控制肥胖的系统利用位于胃中的多个空间占用者来减少胃的有效体积。 这种布置提供足够的胃体积消耗以引起体重减轻，但是能够使用成比例的空间占用者，以尽量减少阻塞的威胁，即使它们应该迁移到肠中。 通常，许多小容量空间占用者被放置在胃中，使得总体积等于或超过现有技术的单个单位空间占用者的单个体积。 然而，每个单独的空间占有者是成比例的，以便如果它进入肠道，它将不会阻塞。

公开(公告)号：US08691832B2

公开(公告)日：2014-04-08

申请号：US13990948

申请日：2011-12-01

Applicant: Duane A. Burnett ,  Zhiqiang Zhao ,  David Cole ,  Hubert Josien ,  Dmitri A. Pissarnitski ,  Thavalakulamgar Sasikumar ,  Wen-Lian Wu ,  Martin Domalski

Inventor： Duane A. Burnett ,  Zhiqiang Zhao ,  David Cole ,  Hubert Josien ,  Dmitri A. Pissarnitski ,  Thavalakulamgar Sasikumar ,  Wen-Lian Wu ,  Martin Domalski

IPC: A01N43/54 ,  C07D491/00

CPC classification number: A61K31/519 ,  C07D487/14

Abstract: The present invention is directed to novel tricyclic heterocycles of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Abstract translation: 本发明涉及结构式I的新型三环杂环，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US08024922B2

公开(公告)日：2011-09-27

申请号：US12078252

申请日：2008-03-28

Applicant: Willem Nicolaas van Vuuren ,  Stephen Bugos ,  William Imoehl ,  Michael Hornby ,  Ray Wildeson ,  Olaf Graupner ,  David Cole

Inventor： Willem Nicolaas van Vuuren ,  Stephen Bugos ,  William Imoehl ,  Michael Hornby ,  Ray Wildeson ,  Olaf Graupner ,  David Cole

IPC: F01N3/00

CPC classification number: F01N3/2066 ,  F01N2240/20 ,  F01N2570/14 ,  F01N2610/02 ,  F01N2610/10 ,  F01N2610/1453 ,  F01N2610/1486 ,  Y02A50/2325 ,  Y02T10/24 ,  Y10T137/0486 ,  Y10T137/6606 ,  Y10T137/7833 ,  Y10T137/7886

Abstract: A reductant delivery unit (10) is provided for selective catalytic reduction (SCR) after-treatment for vehicles. The unit includes a solenoid fluid injector (10) constructed and arranged to be associated with an exhaust gas flow path (14) upstream of a SCR catalytic converter (17). The fluid injector has a fluid inlet (13) and a fluid outlet (15) with the fluid inlet being constructed and arranged to receive a source of urea solution and the fluid outlet being constructed and arranged to communicate directly with the exhaust flow path so as to control injection of urea solution into the exhaust gas flow path. An interface (24) is constructed and arranged to couple the fluid injector to the gas flow path. The interface defines a thermal barrier constructed and arranged to decoupled a body of the injector from exposure to heat in the exhaust gas flow path.

Abstract translation: 提供还原剂输送单元（10）用于车辆的选择性催化还原（SCR）后处理。 该单元包括构造和布置为与SCR催化转化器（17）上游的排气流动路径（14）相关联的电磁流体注射器（10）。 流体注射器具有流体入口（13）和流体出口（15），流体入口被构造和布置成接收尿素溶液源，流体出口构造和布置成直接与排气流动路径连通，以便 以控制将尿素溶液注入废气流路。 接口（24）被构造和布置成将流体喷射器耦合到气体流动路径。 界面限定了构造和布置成将喷射器的主体与废气流动路径中的热量相接合的热障。

公开(公告)号：US07934631B2

公开(公告)日：2011-05-03

申请号：US12268404

申请日：2008-11-10

Applicant: Daniel J. Balbierz ,  Pablo R. Hambly ,  Jason S. Stewart ,  David Cole

Inventor： Daniel J. Balbierz ,  Pablo R. Hambly ,  Jason S. Stewart ,  David Cole

IPC: A61B17/068

CPC classification number: A61B17/068 ,  A61B17/072 ,  A61B17/07207 ,  A61B17/115 ,  A61B2017/07214 ,  A61B2017/07228 ,  A61B2017/07271 ,  A61F5/0086

Abstract: A staple housing includes an array of staples each in a staple delivery position or “ready position” ready to be fired into target tissue. A staple driver is advanceable to drive the ready-position staples from the staple head into the tissue using staple pushers. During use, the staples in the ready positions are simultaneously fired into the target tissue using the staple pushers, forming an array of staples in the target tissue. After the array has been fired, one or more feed mechanisms within the staple housing advance a second group of staples from one or more staple storage locations into the ready positions in preparation for firing of the second group of staples.

Abstract translation: 订书钉壳体包括各自位于钉送出位置的订书钉阵列或准备好被烧制到目标组织中的“就绪位置”。 订书钉驱动器可前进，以使用订书钉推动器将订书钉从订书钉驱动到组织中。 在使用期间，准备位置中的订书钉使用订书钉推动器同时被烧制到目标组织中，从而在目标组织中形成一排钉。 在阵列被点火之后，钉仓壳体内的一个或多个进给机构将第二组订书钉从一个或多个订书钉存储位置推进到就绪位置，以准备第二组钉的点火。

公开(公告)号：US07913892B2

公开(公告)日：2011-03-29

申请号：US12053182

申请日：2008-03-21

Applicant: David Cole ,  Andrew Smith

Inventor： David Cole ,  Andrew Smith

IPC: A61B17/068

CPC classification number: A61B17/072 ,  A61B17/064 ,  A61B17/115 ,  A61B17/32053 ,  A61B2017/00539 ,  A61B2017/00818 ,  A61B2017/07271 ,  A61B2017/306 ,  A61F5/0013 ,  A61F5/0083

Abstract: Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.