公开(公告)号：US08747358B2

公开(公告)日：2014-06-10

申请号：US11238666

申请日：2005-09-29

申请人： Frederick W. Trombley, III ,  Robert M. Schmidt ,  David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Gerald W. Callan ,  Luis A. Pedraza ,  Jennie Kwo ,  Christopher T. Zirps ,  Roderick H. Beaulieu

发明人： Frederick W. Trombley, III ,  Robert M. Schmidt ,  David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Gerald W. Callan ,  Luis A. Pedraza ,  Jennie Kwo ,  Christopher T. Zirps ,  Roderick H. Beaulieu

IPC分类号： A61M1/00

CPC分类号： A61M5/007 ,  A61M5/14546 ,  A61M5/16827 ,  A61M31/005 ,  A61M39/22 ,  A61M2005/1403 ,  A61M2205/582 ,  A61M2209/01 ,  Y10T137/7727

摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injection, a fluid path in fluid communication with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection therewith. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurized the saline, a source of contrast, a contrast valve in fluid connection with the source of contrast, a powered injector in fluid connection with the contrast valve, and a pressure isolation mechanism.

摘要翻译： 注射器系统包括动力注射器，与动力注射操作连接的加压室，与加压室流体连通的流体路径，以及与流体路径流体连接的手动控制。 手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。 致动器通过与其的流体连接提供到操作者的流体路径中的压力的​​触觉反馈。 用于血管造影术的注射系统包括盐水源，与盐水源流体连接的泵以加压盐水，对比源，与对比源流体连接的对比阀，流体中的动力注射器 与对比度阀的连接，以及压力隔离机构。

公开(公告)号：US20080146913A1

公开(公告)日：2008-06-19

申请号：US11612195

申请日：2006-12-18

申请人： Arun Ranchod ,  Page Cedarholm ,  Kevin P. Cowan ,  Adrienne Fazio ,  David M. Griffiths

发明人： Arun Ranchod ,  Page Cedarholm ,  Kevin P. Cowan ,  Adrienne Fazio ,  David M. Griffiths

IPC分类号： A61B5/15

CPC分类号： A61B5/489 ,  A61B5/015

摘要： A device for locating a venous structure of a patient includes a frame having a bottom surface and a top surface, an adhesive disposed on the bottom surface of the frame to allow the frame to be removably attached to skin or a patient, and one or more sections removably attached to the top surface of the frame. The sections are formed of a liquid crystal material that is sensitive to human skin temperature ranges.

摘要翻译： 用于定位患者的静脉结构的装置包括具有底表面和顶表面的框架，设置在框架的底表面上以允许框架可拆卸地附接到皮肤或患者的粘合剂，以及一个或多个 部分可移除地附接到框架的顶表面。 这些部分由对人体皮肤温度范围敏感的液晶材料形成。

公开(公告)号：US20080058758A1

公开(公告)日：2008-03-06

申请号：US11842999

申请日：2007-08-22

申请人： ARUN RANCHOD ,  David M. Griffiths ,  Alan D. Hirschman

发明人： ARUN RANCHOD ,  David M. Griffiths ,  Alan D. Hirschman

IPC分类号： A61M31/00

CPC分类号： A61M25/007 ,  A61F2/013

摘要： In one form, the therapeutic agent delivery apparatus is used for infusing a therapeutic agent into a body lumen and includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a sensing element distal of the infusion ports and adapted to sense the amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen. In another form, the apparatus includes a lumenal body defining a plurality of infusion ports for infusing the therapeutic agent into the body lumen, and a filtration element distal of the infusion ports and adapted to deliver a reaction agent adapted to react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.

摘要翻译： 在一种形式中，治疗剂递送装置用于将治疗剂注入体腔，并且包括界定多个用于将治疗剂注入体腔的输注端口的腔体，以及位于输液端口远端的感测元件 并且适于感测输注的治疗剂或源自体腔内的治疗剂的任何化合物的量。 在另一种形式中，该装置包括限定用于将治疗剂注入体腔内的多个输注端口的腔体，以及位于输注端口远端的过滤元件，并适于递送适于与治疗剂反应的反应剂 体腔。 感测元件可以设置在过滤元件的远侧，用于感测在体腔中输注的治疗剂或其衍生的化合物的量。

公开(公告)号：US07315109B1

公开(公告)日：2008-01-01

申请号：US10916946

申请日：2004-08-12

申请人： David M. Griffiths ,  Amy S. Pomaybo ,  Alan D. Hirschman

发明人： David M. Griffiths ,  Amy S. Pomaybo ,  Alan D. Hirschman

IPC分类号： H01L41/04 ,  H01L41/08

CPC分类号： H01L41/042 ,  F03G7/065 ,  F04B43/043 ,  Y10S310/80

摘要： An actuator includes a non-magnetic, electroactive material that is suitable to impart force upon application of an electric current, a power supply to provide an electric current to the electroactive material and a controller in operative connection with the power supply to control application of electric current to the electroactive material. In one embodiment, the controller is adapted to limit rates at which electric current is applied to or removed from the electroactive material to predefined rates, thereby reducing the potential for high frequency harmonic emissions.

摘要翻译： 致动器包括适于在施加电流时施加力的非磁性电活性材料，用于向电活性材料提供电流的电源以及与电源可操作地连接以控制电力的应用的控制器 电流至电活性材料。 在一个实施例中，控制器适于限制向电活性材料施加电流或从电活性材料移除电流的速率到预定速率，从而降低高频谐波发射的可能性。

公开(公告)号：US07204797B2

公开(公告)日：2007-04-17

申请号：US10893591

申请日：2004-07-16

申请人： David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Currie Crookston

发明人： David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Currie Crookston

IPC分类号： A61N5/00

CPC分类号： A61K51/1282 ,  A61M5/007 ,  A61M5/1407 ,  A61M5/1452 ,  A61M5/14546 ,  A61M5/1785 ,  G06F19/00 ,  G16H20/17

摘要： A method of dispensing a hazardous pharmaceutical comprising the steps of: connecting a source of flushing fluid to a first port of a fluid delivery set; connecting a pressurizing unit of a powered injector system (including a powered injector and the pressurizing unit) to a second port of the fluid delivery set; purging air from the fluid delivery set; and, after purging air from the fluid delivery set, connecting a third port of the fluid delivery set to a source of the hazardous pharmaceutical. The fluid delivery set can, for example, include a valve system or assembly to control flow of fluid through the fluid delivery set. A system for delivery of a hazardous pharmaceutical includes: a syringe in operative connection with a powered injector; a protective container to enclose the syringe during operation thereof; the protective container being adapted to protect personnel from detrimental effects of the pharmaceutical; at least one source of flushing fluid; a fluid path adapted to connect to a patient; at least one source of the pharmaceutical; and a fluid delivery set including a valve assembly to which the syringe, the source of flushing fluid, the fluid path and the source of pharmaceutical are removably connectable. The valve assembly provides flow control through the fluid delivery set such that operator contact with the fluid delivery set is not required after connection of the source of pharmaceutical to the fluid delivery set.

摘要翻译： 一种分配危险药物的方法，包括以下步骤：将冲洗流体源连接到流体输送装置的第一端口; 将动力注射器系统（包括动力注射器和加压单元）的加压单元连接到流体输送组的第二端口; 从流体输送装置吹扫空气; 并且在从流体输送装置吹扫空气之后，将流体输送装置的第三端口连接到危险药物源。 流体输送装置可以例如包括阀系统或组件以控制通过流体输送组的流体的流动。 用于递送危险药物的系统包括：与动力注射器可操作地连接的注射器; 在操作期间包围注射器的保护容器; 保护容器适于保护人员免受药物的不利影响; 至少一个冲洗液源; 适于连接到患者的流体路径; 至少一种药物来源; 以及包括阀组件的流体输送组件，注射器，冲洗流体源，流体路径和药物源可拆卸地连接到该组件。 阀组件通过流体输送组件提供流量控制，使得在将药物源连接到流体输送装置之后，操作者不需要与流体输送装置接触。

公开(公告)号：US20110209764A1

公开(公告)日：2011-09-01

申请号：US12996520

申请日：2009-06-05

申请人： Arthur E. Uber ,  Mark Trocki ,  Marc A. Mabie ,  Larry McCutchan ,  George L. Siddoway ,  Kevin P. Cowan ,  Lisa M. Coates ,  John F. Kalafut ,  Aaron Hughes ,  David M. Griffiths ,  Peter Twichell ,  Julie Gulick

发明人： Arthur E. Uber ,  Mark Trocki ,  Marc A. Mabie ,  Larry McCutchan ,  George L. Siddoway ,  Kevin P. Cowan ,  Lisa M. Coates ,  John F. Kalafut ,  Aaron Hughes ,  David M. Griffiths ,  Peter Twichell ,  Julie Gulick

IPC分类号： F17D3/00 ,  B65D25/02

CPC分类号： A61N5/1007 ,  A61M5/007 ,  A61M5/16827 ,  A61M5/1785 ,  A61M2005/1402 ,  A61M2202/0225 ,  A61M2202/049 ,  A61M2206/11 ,  A61M2206/18 ,  Y10T137/0318

摘要： A hazardous fluid transport container and a hazardous fluid delivery system are disclosed. The hazardous fluid transport container includes a housing enclosing an at least partially shielded enclosure. First and second fluid path elements are disposed within the housing, with the first fluid path element and second fluid path element fluidly coupled together. A pump unit may be provided for dispensing fluid from the first and second fluid path elements optionally into a third fluid path element. Also, methods for priming the hazardous fluid transport container and for mitigating laminar flow injection bolus spreading are disclosed. Additionally, disclosed is a radioactive fluid transport container for a syringe or other container. The radioactive fluid transport container allows the syringe or container to be used in an injection procedure without removal from the container.

摘要翻译： 公开了一种危险的流体输送容器和危险流体输送系统。 危险流体输送容器包括封闭至少部分屏蔽的外壳的壳体。 第一和第二流体通道元件设置在壳体内，第一流体路径元件和第二流体路径元件流体耦合在一起。 可以提供泵单元，用于将流体从第一和第二流体路径元件任选地分配到第三流体路径元件中。 此外，公开了用于引燃危险流体输送容器和减轻层流注射团块扩散的方法。 此外，公开了一种用于注射器或其他容器的放射性流体输送容器。 放射性流体输送容器允许注射器或容器在注射过程中使用而不从容器中取出。

公开(公告)号：US07094216B2

公开(公告)日：2006-08-22

申请号：US09982518

申请日：2001-10-18

申请人： Frederick W. Trombley, III ,  Robert M. Schmidt ,  David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Gerald W. Callan ,  Luis A. Pedraza ,  Jennie Kwo ,  Christopher T. Zirps ,  Roderick H. Beaulieu

发明人： Frederick W. Trombley, III ,  Robert M. Schmidt ,  David M. Reilly ,  Alan D. Hirschman ,  David M. Griffiths ,  Gerald W. Callan ,  Luis A. Pedraza ,  Jennie Kwo ,  Christopher T. Zirps ,  Roderick H. Beaulieu

IPC分类号： A61M31/00

CPC分类号： A61M5/007 ,  A61M5/14546 ,  A61M5/16827 ,  A61M31/005 ,  A61M39/22 ,  A61M2005/1403 ,  A61M2205/582 ,  A61M2209/01 ,  Y10T137/7727

摘要： An injector system includes a powered injector, a pressurizing chamber in operative connection with the powered injector, a fluid path in fluid connection with the pressurizing chamber, and a manual control in fluid connection with the fluid path. The manual control includes at least one actuator for controlling the injector through application of force by an operator. The actuator provides tactile feedback of pressure in the fluid path to the operator via a fluid connection with the fluid path. An injection system for use in angiography includes a source of saline, a pump in fluid connection with the source of saline to pressurize the saline, a saline valve in fluid connection via a first port thereof with an outlet of the pump, a first connector in fluid connection with a second port of the saline valve, a source of contrast, a contrast valve in fluid connection with the source of contrast via a first port of the contrast valve, a powered injector in fluid connection with a second port of the contrast valve, a second connector in fluid connection with a third port of the contrast valve, and a pressure isolation mechanism.

摘要翻译： 注射器系统包括动力注射器，与动力注射器可操作地连接的加压室，与加压室流体连接的流体路径，以及与流体路径流体连接的手动控制。 手动控制包括至少一个执行器，用于通过操作者施加力来控制喷射器。 致动器通过与流体路径的流体连接提供到操作者的流体路径中的压力的​​触觉反馈。 用于血管造影术的注射系统包括盐水源，与盐水源流体连接以对盐水加压的泵，经由其第一端口与泵的出口流体连接的盐水阀，第一连接器 与盐水阀的第二端口的流体连接，对比度源，通过对比度阀的第一端口与对比源流体连接的对比度阀，与对比度阀的第二端口流体连接的动力注射器 与对比度阀的第三端口流体连接的第二连接器和压力隔离机构。

公开(公告)号：US06673033B1

公开(公告)日：2004-01-06

申请号：US09721427

申请日：2000-11-22

申请人： Francis J. Sciulli ,  David M. Griffiths ,  William J. Nolan, Jr. ,  Richard G. Critchlow ,  Salvatore J. Dedola ,  Michael A. Spohn ,  Frank A. Lazzaro ,  Thomas P. Joyce ,  John R. Gardner

发明人： Francis J. Sciulli ,  David M. Griffiths ,  William J. Nolan, Jr. ,  Richard G. Critchlow ,  Salvatore J. Dedola ,  Michael A. Spohn ,  Frank A. Lazzaro ,  Thomas P. Joyce ,  John R. Gardner

IPC分类号： A61M3100

CPC分类号： A61M5/172 ,  A61M5/007 ,  A61M5/1413 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/16854 ,  A61M2205/702

摘要： An injector for use in injecting a fluid in a medical injection procedure includes a drive mechanism to pressurize the fluid; a sensor to measure a variable that is proportional to fluid pressure (that is, a direct or indirect measurement of fluid pressure); and a pressure monitor (for example, including hardwired circuitry and/or software) in communication with the sensor and the drive mechanism to stop the injection procedure when the sensor measures a value of the variable that corresponds to a pressure hazard limit. Preferably, the pressure monitor further limits power input to the drive mechanism to a power limit once the variable reaches a value that corresponds to a power limiting pressure that is below the pressure hazard limit.

摘要翻译： 用于在医疗注射程序中注射流体的注射器包括用于对流体加压的驱动机构; 用于测量与流体压力成比例的变量的传感器（即，直接或间接测量流体压力）; 以及与传感器和驱动机构通信的压力监视器（例如，包括硬连线电路和/或软件），以在传感器测量与压力危险极限对应的变量的值时停止喷射过程。 优选地，一旦变量达到对应于低于压力危险极限的功率限制压力的值，压力监视器进一步将输入到驱动机构的功率限制在功率极限。

公开(公告)号：US08160679B2

公开(公告)日：2012-04-17

申请号：US12477456

申请日：2009-06-03

申请人： Arthur E. Uber ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski ,  Alan Hirschman

发明人： Arthur E. Uber ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski ,  Alan Hirschman

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A method of coordinating an imaging procedure and an injection procedure, the method comprising the steps of providing an injector system having first and second pressurizing units for pressurizing a contrast medium and a diluent for injection into a patient; providing an imaging system for producing an image of an internal region of the patient from a signal resulting from energy applied to the patient; and providing a data interface interconnecting the injector and imaging systems for enabling exchange of digital information therebetween such that the digital information transmitted between the systems is usable to enable closed loop control of at least one of the injection and the imaging procedures during which the contrast medium and the diluent injected into the patient is adjustable so as to achieve a desired level of enhancement within the internal region of the patient of which the images are acquired during the imaging procedure.

摘要翻译： 一种协调成像过程和注射程序的方法，所述方法包括以下步骤：提供具有用于加压造影剂的第一和第二加压单元和用于向患者注射的稀释剂的注射器系统; 提供成像系统，用于从施加到患者的能量产生的信号产生患者的内部区域的图像; 并且提供互连注射器和成像系统的数据接口，以使得能够在其间进行数字信息的交换，使得在系统之间传输的数字信息可用于对注射和成像过程中的至少一个进行闭环控制， 并且注射到患者体内的稀释剂是可调节的，以便在成像过程期间获取图像的患者的内部区域内实现期望的增强水平。

公开(公告)号：US20080228104A1

公开(公告)日：2008-09-18

申请号：US10599366

申请日：2005-03-11

申请人： Arthur E. Uber ,  David M. Griffiths ,  Alan D. Hirschman

发明人： Arthur E. Uber ,  David M. Griffiths ,  Alan D. Hirschman

IPC分类号： A61H1/00 ,  A61B10/02 ,  A61M25/06 ,  A61B5/15

CPC分类号： A61B10/0233 ,  A61B2010/0208

摘要： A device for penetrating tissue and removing a biological sample includes a biological sampling element to remove a biological sample. The biological sampling element includes a passage therethrough. The device further includes a penetrator positioned within the passage. The penetrator is energized in a repetitive manner to assist in penetrating tissue. The biological sample element can be adapted to remove a tissue sample or a biological fluid sample (for example, blood). A device for penetrating tissue and positioning a tissue resident conduit (for example, a catheter), includes a tissue resident conduit (for example, a catheter) including a passage therethrough; and a penetrator in operative connection with the catheter. A device for inserting a tissue resident conduit includes at least one component that is energized during penetration to assist in penetrating tissue. In one embodiment, the tissue resident conduit is flexible and the energized component is positioned or a forward end of the tissue resident conduit. The device can further include a mechanism for directing the penetration of the tissue resident conduit. A needle for penetrating tissue includes a first effector including a surface and at least one actuator in operative connection with the first effector. The actuator is adapted to cause motion of the first effector such that tearing of tissue takes place in regions where there is close proximity of tissue to the surface of the first effector.

摘要翻译： 用于穿透组织并去除生物样品的装置包括用于去除生物样品的生物取样元件。 生物采样元件包括通过其中的通道。 该装置还包括定位在通道内的穿透器。 穿透器以重复的方式通电以辅助穿透组织。 生物样品元件可以适于去除组织样品或生物流体样品（例如血液）。 用于穿透组织并定位组织驻留导管（例如导管）的装置包括组织驻留导管（例如导管），其包括穿过其中的通道; 以及与导管可操作地连接的穿透器。 用于插入组织固定导管的装置包括至少一个在穿透期间被激发以帮助穿透组织的部件。 在一个实施例中，组织驻留导管是柔性的，并且通电部件被定位或组织固定导管的前端。 该装置还可以包括用于引导组织驻留导管穿透的机构。 用于穿透组织的针包括包括表面的第一执行器和与第一执行器可操作地连接的至少一个致动器。 致动器适于引起第一效应器的运动，使得组织的撕裂发生在组织靠近第一效应器的表面的区域中。