公开(公告)号：US07115206B2

公开(公告)日：2006-10-03

申请号：US10684463

申请日：2003-10-15

申请人： Jacques Chevallet ,  Guy Mercier ,  Laurent Simard

发明人： Jacques Chevallet ,  Guy Mercier ,  Laurent Simard

IPC分类号： B01D61/30 ,  B01D61/26 ,  B01D35/12

CPC分类号： A61M1/1656 ,  A61L2/0017 ,  A61M1/1668 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3462 ,  B01D61/142 ,  B01D61/18 ,  C02F1/444

摘要： A method for in-line preparation of liquid for an extracorporeal blood treatment apparatus that makes provision for placing a filter in correspondence with each of two successive filtration stations, for carrying out a liquid preparation cycle, for removing the filter, which operates in correspondence with a first filtration station, for placing in correspondence with the first filtration station the filter that operated in correspondence with the second filtration station, for placing a new filter in correspondence with a second filtration station and for launching a new sterile liquid preparation cycle. The invention also provides a device for implementing the described method and an apparatus for extracorporeal blood treatment, which incorporates this device.

摘要翻译： 一种用于体外血液处理装置的液体的在线制备方法，其用于设置与两个连续的过滤站中的每一个相对应的过滤器，用于进行液体制备循环，用于除去与 第一过滤站，用于与第一过滤站相对应地放置与第二过滤站相对应地操作的过滤器，用于与第二过滤站相对放置新的过滤器，以及发射新的无菌液体制备循环。 本发明还提供了一种用于实现所述方法的装置和用于体外血液处理的装置，其包括该装置。

公开(公告)号：US06649046B2

公开(公告)日：2003-11-18

申请号：US10004858

申请日：2001-12-07

申请人： Jacques Chevallet

发明人： Jacques Chevallet

IPC分类号： B01D6500

CPC分类号： G01L19/0023 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/12

摘要： A device for measuring the pressure of blood in a pipe (44) of an extracoporeal blood cicuit, includes a pressure measurement section (46) having a compartment (58) which is delimited especially by a main wall (64) and by a secondary wall (65) facing it. The two walls (64, 65) have a hole (66, 84) which is closed by a closure element (68, 86) which can be elastically deformed under the effect of the blood pressure, and the compartment (58) has a spacer (94) which transmits the movements from the closure element (86) of the secondary wall (65) to the closure element (68) of the main wall (64), so that a load sensor (56) can measure a force which corresponds to a so-called “negative” blood pressure.

摘要翻译： 一种用于测量血液外科产品的管道（44）中的血液压力的装置，包括一个具有隔室（58）的压力测量部分（46），隔室（58）特别由主壁（64）和第二壁 （65）面向它。 两个壁（64,65）具有孔（66,84），该孔由封闭元件（68,86）封闭，该封闭元件可在血压作用下弹性变形，并且隔室（58）具有间隔件 （94），其将从第二壁（65）的封闭元件（86）的运动传递到主壁（64）的封闭元件（68），使得负载传感器（56）可以测量对应于 到所谓的“负”血压。

公开(公告)号：US5727877A

公开(公告)日：1998-03-17

申请号：US467455

申请日：1995-06-06

申请人： Jacques Chevallet ,  Jacques Burtin ,  Jacques Gauckler

发明人： Jacques Chevallet ,  Jacques Burtin ,  Jacques Gauckler

IPC分类号： A61J3/00 ,  A61M1/14 ,  A61M1/16 ,  B01F1/00 ,  B01F15/02 ,  B01F3/12

CPC分类号： B01F1/00 ,  A61M1/1656 ,  A61M1/1666 ,  B01F1/0038 ,  A61M2206/16 ,  Y10T137/034 ,  Y10T137/2509 ,  Y10T137/3109 ,  Y10T137/4891

摘要： A main line for delivering a medical solution is connected at one end to a source of liquid. A secondary line is connected at two locations to the main line, bypassing a portion of the main line. A reservoir containing a particulate product is located in the secondary line. During a priming step, liquid is pumped to the reservoir in order to pressurize the reservoir and fill the reservoir to sufficiently immerse the particulate product. This priming step prevents the formation of agglomerates and preferential paths through particulate product. After the reservoir is primed, a fraction of liquid flowing through the main line is diverted into the reservoir and then routed back to the main line to introduce a solution of liquid and particulate product into the main line.

摘要翻译： 用于输送医疗溶液的主线在一端连接到液体源。 次级线路连接在主线路的两个位置，绕过主线路的一部分。 含有颗粒产品的储存器位于二次管线中。 在启动步骤期间，将液体泵送到储存器中，以便对储存器加压并填充储存器以充分浸入颗粒产物。 这种起泡步骤防止了聚集体的形成和通过颗粒产物的优先路径。 在储存器被灌注之后，流过主管线的一部分液体被转移到储存器中，然后返回到主管线以将液体和颗粒产物的溶液引入主管线。

公开(公告)号：US5644402A

公开(公告)日：1997-07-01

申请号：US457219

申请日：1995-06-01

申请人： Jacques Chevallet

发明人： Jacques Chevallet

IPC分类号： A61M1/16 ,  G01N21/53 ,  G01N21/85

CPC分类号： G01N21/534 ,  A61M1/1692 ,  G01N21/85 ,  A61M2205/14 ,  A61M2205/3313

摘要： A device for detecting a conduit and for determining at least one characteristic of its content includes a seat for housing at least a portion of the conduit. The seat has first and second zones which are opposite each other with respect to a recess intended to receive the conduit. A light emitter is arranged in the first zone, and has a preferential emission direction oriented towards the recess. A receptor sensitive to the light emitted by the emitter also has a preferential reception direction oriented towards the recess. A first deflector deflects light in the direction of the first zone when a conduit containing a substantially transparent liquid is engaged in the seat. A second deflector deflects in the direction of the second zone at least part of the light deflected by the first deflector so that, when a conduit containing a substantially transparent liquid is engaged in the seat, at least part of the light emitted by the emitter reaches the receptor after having passed through the conduit at least twice obliquely with respect to a longitudinal axis of the recess. The components are arranged so that in the absence of a conduit in the seat, at least part of light from the emitter reaches the receptor after a single deflection.

摘要翻译： 用于检测导管并用于确定其内容的至少一个特征的装置包括用于容纳导管的至少一部分的座。 座椅具有相对于用于容纳导管的凹部彼此相对的第一和第二区域。 光发射器布置在第一区域中，并且具有朝向凹部定向的优先发射方向。 对由发射器发射的光敏感的受体还具有朝向凹部的优先接收方向。 当包含基本上透明的液体的管道接合在座中时，第一偏转器使光沿第一区域的方向偏转。 第二偏转器在第二区域的方向上偏转由第一偏转器偏转的光的至少一部分，使得当包含基本上透明的液体的导管接合在座中时，由发射器发射的光的至少一部分到达 所述受体在相对于所述凹部的纵向轴线倾斜地穿过所述导管至少两次之后。 组件被布置成使得在座椅中不存在导管时，来自发射器的至少一部分光在单次偏转之后到达接收器。

公开(公告)号：US5342527A

公开(公告)日：1994-08-30

申请号：US82928

申请日：1993-06-29

申请人： Jacques Chevallet ,  Bernard Bene

发明人： Jacques Chevallet ,  Bernard Bene

IPC分类号： A61M1/14 ,  A61M1/16 ,  G01F25/00 ,  B01D61/32

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/165 ,  G01F25/0007

摘要： Disclosed is a method for the calibration of a pair of sensors placed in a dialysis circuit. The method includes performing at least one step for determining an auxiliary calibration coefficient for the intake sensor, performing at least one step for determining an auxiliary calibration coefficient for the outlet sensor, and in determining on the basis of at least one auxiliary calibration coefficient, a new calibration coefficient for the two sensors.

摘要翻译： 公开了一种用于校准放置在透析电路中的一对传感器的方法。 该方法包括执行用于确定进气传感器的辅助校准系数的至少一个步骤，执行用于确定出口传感器的辅助校准系数的至少一个步骤，以及基于至少一个辅助校准系数， 两个传感器的新校准系数。

公开(公告)号：US5227049A

公开(公告)日：1993-07-13

申请号：US743037

申请日：1991-08-09

申请人： Jacques Chevallet ,  Jean-Claude Riquier ,  Carl-Henry rndal ,  Allan Petersen

发明人： Jacques Chevallet ,  Jean-Claude Riquier ,  Carl-Henry rndal ,  Allan Petersen

IPC分类号： A61M1/30

CPC分类号： A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M2205/3382 ,  A61M2205/3386

摘要： A blood treatment apparatus having a circuit for circulating blood outside the body and designed to be connected to a patient via a single needle, including a blood treatment device such as a heamodialyzer, pumps for causing blood to flow through the circuit, a first blood expansion chamber located in the circuit upstream of the blood treatment device for temporarily storing a volume of blood to be treated, a second blood expansion chamber located downstream of the blood treatment device for temporarily storing a volume of treated blood, first and second pressure regulators, connected to the first and second blood expansion chambers, for adjusting pressure in the blood expansion chambers, and a controller for interacting with the regulators to maintain a substantially constant pressure in each of the first and second chambers during a treatment session.

公开(公告)号：US5043074A

公开(公告)日：1991-08-27

申请号：US531764

申请日：1990-06-01

申请人： Jacques Chevallet

发明人： Jacques Chevallet

IPC分类号： G01F11/28 ,  A61M1/14 ,  A61M1/16 ,  A61M1/34

CPC分类号： A61M1/16 ,  A61M2205/3396 ,  Y10S210/929

摘要： The invention includes a device for measuring a quantity of liquid extracted from a dialysis liquid circuit, the device having a reservoir means connected to the dialysis liquid circuit for receiving liquid from the dialysis liquid circuit, at least one measurement container for receiving liquid from the reservoir, a flow channel connecting the reservoir with the at least one measurement container for selectively filling the measurement container with liquid from the reservoir, a level detector disposed proximate a predetermined area on the at least one measurement container for detecting the presence of liquid at a predetermined level, and a drain port on the measurement container for receiving a signal from the level detector to empty the contents of the measurement container after the presence of liquid at the predetermined level is detected. The invention also includes a method for measuring a quantity of liquid extracted from an artificial kidney in a dialysis liquid circuit including the steps of successively filling a measurement container to a predetermined level with liquid to be measured, emptying the measurement container, reducing the rate of filling of the measurement container as the predetermined level is approached, and detecting the presence of liquid at the predetermined level.

摘要翻译： 本发明包括一种用于测量从透析液体回路提取的液体量的装置，该装置具有连接到透析液回路的储存装置，用于从透析液回路接收液体;至少一个用于从储存器接收液体的测量容器 连接储存器与至少一个测量容器的流动通道，用于从储存器中选择性地填充测量容器;液位检测器，设置在至少一个测量容器上的预定区域附近，用于检测预定的液体的存在 液位和测量容器上的排水口，用于在检测到存在预定水平的液体之后接收来自液位检测器的信号，以清空测量容器的内容物。 本发明还包括一种用于测量在透析液体回路中从人造肾提取的液体量的方法，包括以下步骤：用待测量的液体将测量容器连续地填充到预定水平，排空测量容器，降低测量容器的速率 接近预定水平的测量容器的填充，并且检测在预定水平的液体的存在。

公开(公告)号：US4599165A

公开(公告)日：1986-07-08

申请号：US691492

申请日：1985-01-14

申请人： Jacques Chevallet

发明人： Jacques Chevallet

IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/30 ,  A61M5/00 ,  A61M7/00 ,  B01D13/00

CPC分类号： A61M1/30 ,  A61M1/1649 ,  A61M1/303 ,  A61M2230/06

摘要： A single-needle artificial kidney comprising a haemodialyser divided by a semi-permeable membrane into first and second compartments, one of which forms part of an extracorporeal blood circuit including a blood circulation pump and a single needle for inserting into the patient and a dialysis liquid circuit including the second chamber and a dialysis liquid pump. The dialysis liquid circuit is provided with means for periodically modulating the flow rate of the dialysis liquid in the haemodialyser between minimum and maximum values, the flow rate of the dialysis liquid being produced by a sensing pulsations of the blood at frequencies less than one hertz and using these pulsations via a servo-control to effect changes in the dialysis liquid flow rate so that it reaches maximum and minimum values simultaneously with maximum and minimum of the blood flow rate.

摘要翻译： 一种单针人造肾，包括由半渗透膜分隔成第一和第二隔室的血液透析器，其中之一形成体外血液回路的一部分，其包括血液循环泵和用于插入患者的单个针头和透析液体 包括第二腔室和透析液体泵。 所述透析液回路设置有用于周期性地调节所述透析器中透析液在最小值和最大值之间的流速的装置，所述透析液体的流速由小于1赫兹的频率的血液的感测脉动产生， 通过伺服控制使用这些脉动来实现透析液体流速的变化，使得其与血液流速的最大值和最小值同时达到最大值和最小值。

公开(公告)号：US07517387B2

公开(公告)日：2009-04-14

申请号：US10518787

申请日：2003-05-26

申请人： Jacques Chevallet ,  Nicolas Semenzato ,  Alain Frugier ,  Francesco Ribolzi

发明人： Jacques Chevallet ,  Nicolas Semenzato ,  Alain Frugier ,  Francesco Ribolzi

IPC分类号： B01D19/00

CPC分类号： B01D19/0057 ,  A61M1/3437 ,  A61M1/3627 ,  A61M1/3639 ,  A61M1/3641 ,  A61M1/3676 ,  A61M2205/3382 ,  A61M2206/16 ,  B01F5/0057 ,  B04C5/103

摘要： A description is given of a gas separation device for a physiological fluid, comprising a containing body (6) having at least a first inlet aperture (7) for a physiological fluid, positioned with a tangential direction of access, at least one outlet aperture (9) for the said fluid, spaced apart from the said inlet aperture, and a guide element (17) housed within the said body. The guide element (17) has a continuous active surface (15) designed to contact and guide the said fluid and delimits, together with the containing body (6), a first annular chamber (20) into which the first inlet aperture (7) opens directly.

摘要翻译： 给出了用于生理流体的气体分离装置的描述，其包括容纳体，其具有至少一个生理流体的第一入口孔，定位在切向方向上，至少一个用于所述流体的出口孔间隔开 和所述入口孔中的引导元件，以及容纳在所述主体内的引导元件。 引导元件具有设计成接触和引导所述流体并且与容纳体一起限定第一入口孔直接打开的第一环形室的连续活性表面。

公开(公告)号：US20090008310A1

公开(公告)日：2009-01-08

申请号：US10595546

申请日：2004-11-05

申请人： Jurgen Dannenmaier ,  Hermann Goehl ,  Thomas Ertl ,  Jacques Chevallet ,  Francesco Ribolzi ,  Bjorn Frederik Seidler ,  Lennart Jonsson ,  Eddie Nilsson

发明人： Jurgen Dannenmaier ,  Hermann Goehl ,  Thomas Ertl ,  Jacques Chevallet ,  Francesco Ribolzi ,  Bjorn Frederik Seidler ,  Lennart Jonsson ,  Eddie Nilsson

IPC分类号： A61M1/16 ,  B01D61/30

CPC分类号： A61M1/3627 ,  A61M1/1008 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/12 ,  B01D61/30 ,  B01D63/02

摘要： An integrated blood treatment module comprises a blood treatment device (1) having a housing (2) and a first end-cap (4) and a second end-cap (5) closing both ends of the housing (2). A pump hose (17) for a peristaltic pump has a first end (18) that is secured to the housing (2) and a second end (16) that is connected to a blood inlet port (15) of the first end-cap (4) so as to form a loop. A degassing device (30) is connected to the second end-cap (5). The degassing device (30), which, in use, is full of liquid, comprises a hydrophobic membrane through which bubbles and micro-bubbles escape the degassing device.

摘要翻译： 集成血液处理模块包括具有壳体（2）和第一端盖（4）的血液处理装置（1）和封闭壳体（2）的两端的第二端盖（5）。 用于蠕动泵的泵管（17）具有固定到壳体（2）的第一端（18）和连接到第一端盖（16）的血液入口（15）的第二端（16） （4）以形成环路。 脱气装置（30）连接到第二端帽（5）。 在使用中充满液体的脱气装置（30）包括疏水膜，气泡和微气泡通过该疏水膜逸出脱气装置。