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45 条记录 (耗时 0.041 秒)

    Artificial valve prosthesis having a ring frame
    41.
    发明申请
    Artificial valve prosthesis having a ring frame 审中-公开
    具有环形框架的人造瓣膜假体

    公开(公告)号：US20070038295A1

    公开(公告)日：2007-02-15

    申请号：US11502730

    申请日：2006-08-11

    申请人： Brian Case ,  Jacob Flagle ,  Brian Bates

    发明人： Brian Case ,  Jacob Flagle ,  Brian Bates

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2475 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0026 ,  A61F2230/0054 ,  A61F2230/0095

    摘要： A radially expandable artificial valve prosthesis for regulating fluid flow through a body vessel is provided. The prosthesis includes a radially expandable ring frame, at least one valve leaflet attached to the ring frame forming a valve pocket and a support structure attached to the ring frame and adapted to position the ring frame within the bodily passage. The height of the valve pocket is less than the maximum cross sectional dimension of the lumen defined by the expanded ring frame. The valve leaflet is allows fluid flow in a first, antegrade, direction and restricts flow in a second, retrograde direction.

    摘要翻译： 提供了一种用于调节通过身体容器的流体流动的可径向扩张的人造瓣膜假体。 所述假体包括可径向扩张的环形框架，至少一个安装在所述环形框架上的瓣膜小叶形成一个阀口和一个固定在所述环形框架上并适用于将所述环形框架定位在所述身体通道内的支撑结构。 阀口的高度小于由扩展的环形框架限定的内腔的最大横截面尺寸。 阀瓣允许流体沿第一，顺行方向流动，并限制在第二逆向方向上的流动。

    G-protein coupled receptor and uses therefor
    42.
    发明申请
    G-protein coupled receptor and uses therefor 审中-公开
    G蛋白偶联受体及其用途

    公开(公告)号：US20070031860A1

    公开(公告)日：2007-02-08

    申请号：US11396960

    申请日：2006-04-03

    申请人： Maria Blatcher ,  Brian Bates ,  Janet Paulsen

    发明人： Maria Blatcher ,  Brian Bates ,  Janet Paulsen

    IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/70571 ,  A01K2217/075

    摘要： The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.

    摘要翻译： 本发明基于主要在脑和胎盘中表达的G蛋白偶联受体（GPCR）的鉴定和编码GPCR的核酸分子（分别在本文中称为hCAR蛋白和hCAR基因） 对于人类组成型活性受体）。 基于该鉴定，本发明提供：（1）分离的hCAR蛋白; （2）编码hCAR蛋白的分离的核酸分子; （3）选择性结合hCAR蛋白的抗体; （4）分离hCAR蛋白和基因的等位基因变体的方法; （5）鉴定表达hCAR蛋白/基因的细胞和组织的方法; （6）鉴定与hCAR蛋白结合的试剂和细胞化合物的方法; （7）鉴定调节hCAR基因表达的试剂的方法; 和（8）调节细胞或生物体中hCAR蛋白活性的方法。

    Wire guides having distal anchoring devices
    43.
    发明申请
    Wire guides having distal anchoring devices 审中-公开
    导线器具有远端锚固装置

    公开(公告)号：US20060259063A1

    公开(公告)日：2006-11-16

    申请号：US11410723

    申请日：2006-04-25

    申请人： Brian Bates ,  David Gorky ,  Mark Lorenz

    发明人： Brian Bates ,  David Gorky ,  Mark Lorenz

    IPC分类号： A61M29/00

    CPC分类号： A61M25/09 ,  A61M2025/09125 ,  A61M2025/09175 ,  A61M2025/09183

    摘要： Improved wire guide devices having distal anchoring devices and methods of them percutaneously are provided. One device includes a wire guide having a distal portion operatively coupled to a holding body having a self-expanding end portion having wire members capable of assuming a first radially compressed configuration and a second radially expanded resilient configuration. Another device includes a wire guide distal portion operatively coupled to a distal anchoring device having a distal self-expanding suspension portion having a plurality of stabilizers capable of assuming a first radially compressed configuration when constrained by the outer sheath and a second radially expanded resilient configuration when the sheath is withdrawn proximally. An elongate outer sheath with first and second openings defining a lumen therebetween and slideably constrain the self-expanding portions to the compressed configuration. Expanded configurations help keep the wire guide distal portion at a target site within a body lumen.

    摘要翻译： 提供了具有远端锚固装置的改进的导丝装置及其经皮方法。 一个装置包括线引导件，其具有可操作地联接到保持体的远侧部分，该保持体具有自扩张端部，该自扩张端部具有能够呈现第一径向压缩构造和第二径向扩张的弹性构造的线构件。 另一种装置包括线引导远端部分，其可操作地联接到远侧锚固装置，其具有远端自扩张悬挂部分，该远端自扩张悬挂部分具有多个稳定器，当第二径向压缩构型被外护套约束时能够呈现第一径向压缩构型， 护套在近端被撤回。 细长的外护套，其具有第一和第二开口，在其间限定内腔，并将自膨胀部分滑动地约束到压缩构型。 扩展的构造有助于将导线管远端部分保持在体腔内的目标部位。