公开(公告)号：US20240268958A1

公开(公告)日：2024-08-15

申请号：US18642626

申请日：2024-04-22

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Alon

IPC: A61F2/24 ,  A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/115 ,  A61B17/22

CPC classification number: A61F2/2466 ,  A61B17/068 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2445 ,  A61B2017/00243 ,  A61B2017/00557 ,  A61B2017/00783 ,  A61B2017/0403 ,  A61B2017/0409 ,  A61B2017/0414 ,  A61B2017/0427 ,  A61B2017/0438 ,  A61B2017/0464 ,  A61B2017/0647 ,  A61B17/1155 ,  A61B2017/22068 ,  A61F2/2448 ,  F04C2270/0421

Abstract: A system for use at an annulus of a valve of a heart of a subject comprises an implant and an implant-positioning device. The implant comprises (i) a wire; (ii) multiple anchors, slidably mounted in series along the wire, each of the anchors having: a slot through which the wire is threaded, and a pointy front end; and (iii) multiple tubes, the wire being threaded through each of the tubes such that the multiple tubes are slidably mounted on the wire alternatingly with the multiple anchors. The implant-positioning device is configured to implant the implant in the heart with the wire positioned along the annulus by, for each of the anchors: (i) positioning the anchor at the annulus, and (ii) using a deployment mechanism of the implant-positioning device, driving the pointy front end of the anchor into the annulus. Other embodiments are also described.

公开(公告)号：US11957582B2

公开(公告)日：2024-04-16

申请号：US17468414

申请日：2021-09-07

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0054 ,  A61F2230/0076 ,  A61F2250/0039

Abstract: A delivery assembly includes a prosthetic device, a catheter shaft, a release wire, a first line, and a second line. The prosthetic device has a first arm and a second arm. The release wire extends through the catheter shaft. The first line includes a first loop. The first line extends from the catheter shaft, through the first arm of the prosthetic device, and to the release wire, where the release wire extends through the first loop. The second line includes a second loop. The second line extends from the catheter shaft, through the second arm of the prosthetic device, and to the release wire, where the release wire extends through the second loop.

公开(公告)号：US11839545B2

公开(公告)日：2023-12-12

申请号：US17496649

申请日：2021-10-07

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

CPC classification number: A61F2/246 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2466 ,  A61F2/2412 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016

Abstract: A method of treating a defective heart valve includes inserting a delivery catheter through a small incision in a patient's groin, wherein the delivery catheter has a prosthetic device positioned along a distal end. The prosthetic device includes an insert member and an anchoring member. The insert member self-expands to plug gaps between leaflets of the heart valve. The anchoring member is preferably a stent connected to the insert member by at least one elongate member. The stent is deployed within an adjacent blood vessel for anchoring the insert member. After deployment of the prosthetic device, the leaflets of the heart valve form a tight seal against the insert member for preventing regurgitation when the leaflets are closed and wherein blood passes through the insert member when the leaflets are open.

公开(公告)号：US20230293297A1

公开(公告)日：2023-09-21

申请号：US18203119

申请日：2023-05-30

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/9528

Abstract: Delivery assemblies including a prosthetic heart valve and a delivery apparatus are disclosed. The prosthetic heart valve includes a frame having posts extending from a terminal outflow end of the frame and a valve structure disposed within the frame. The delivery apparatus includes an inner shaft including a valve connection portion having recesses configured to receive the posts of the frame of the prosthetic heart valve, an outer shaft including a valve sheath for retaining the prosthetic valve in a radially compressed state and retaining the posts within the recesses, and a handle including a control knob for moving the valve sheath proximally and distally relative to the handle. The control knob is seated within the handle housing such that the housing partially covers a circumferentially extending outer surface of the control knob.

公开(公告)号：US11737868B2

公开(公告)日：2023-08-29

申请号：US16783005

申请日：2020-02-05

Applicant: Edwards Lifesciences Corporation

Inventor： Michael J. Popp ,  David Alon ,  Jun Liu ,  Luca Pesce ,  Mohammad Jafari

IPC: A61F2/24 ,  A61F2/00 ,  A61F2/915 ,  A61F2/966 ,  A61F2/95 ,  A61M25/00

CPC classification number: A61F2/2427 ,  A61F2/0095 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2/2436 ,  A61F2/915 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9155 ,  A61F2002/9665 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0069 ,  A61M25/0051

Abstract: A handle for a prosthetic heart valve delivery apparatus includes a housing, a motorized mechanism, and a holding mechanism. The housing is configured to be hand-held by a user and includes a distal opening. The motorized mechanism is disposed within the housing and is configured to be releasably coupled to a proximal end portion of a first shaft of the prosthetic heart valve delivery apparatus. When actuated, the motorized mechanism is configured to rotate the first shaft relative to the housing. The holding mechanism is disposed inside the housing and is configured to engage a proximal end portion of a second shaft of the prosthetic heart valve delivery apparatus such that the second shaft is axially and rotationally fixed relative to the housing, and the first shaft extends through the second shaft.

公开(公告)号：US20230172714A1

公开(公告)日：2023-06-08

申请号：US18102024

申请日：2023-01-26

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/9528

Abstract: An assembly for replacement of a native aortic heart valve includes a radially collapsible prosthetic heart valve and a delivery apparatus. The prosthetic heart valve includes an annular frame with attachment posts, wherein each of the posts has an axial post portion and a transverse post portion having a greater circumferential dimension than the axial post portion. The delivery apparatus includes an inner shaft with a valve connection portion for releasably coupling to the attachment posts and an outer shaft having a sheath for maintaining the prosthetic heart valve in a radially compressed state. Rotation of a control knob on a handle causes the sheath to retract for uncovering a portion of the prosthetic heart valve. Further rotation of the control knob allows the posts to decouple from the delivery apparatus such that the prosthetic heart valve self-expands to a fully expanded state.

公开(公告)号：US11116631B2

公开(公告)日：2021-09-14

申请号：US17002636

申请日：2020-08-25

Applicant: Edwards Lifesciences Corporation

Inventor： David Alon ,  Netanel Benichou ,  Oded Meiri

IPC: A61F2/24 ,  A61F2/95

Abstract: A method of delivering a prosthetic heart valve to a native aortic heart valve region of a patient can include introducing a prosthetic heart valve on a transvascular delivery apparatus into an artery of the patient, advancing the delivery apparatus through an aorta of the patient to the native aortic heart valve region, and releasing the prosthetic heart valve from the delivery apparatus. The delivery apparatus can have a shaft with a valve connection portion that is releasably coupled to posts of the prosthetic heart valve. The delivery apparatus can have a delivery sheath positioned around the prosthetic heart valve and the valve connection portion. The releasing the prosthetic valve can include moving the delivery sheath proximally relative to the shaft and the prosthetic heart valve such that the delivery sheath uncovers the prosthetic heart valve and the prosthetic heart valve can self-expand.

公开(公告)号：US20210038385A1

公开(公告)日：2021-02-11

申请号：US17077860

申请日：2020-10-22

Applicant: Edwards Lifesciences Corporation

Inventor： Michael J. Popp ,  David Alon ,  Jun Liu ,  Luca Pesce ,  Mohammad Jafari

IPC: A61F2/24 ,  A61F2/00

Abstract: A prosthetic heart valve delivery system can include a catheter portion having a sheath that can cover and uncover the prosthetic heart valve mounted on an inner shaft, a handle having a sheath actuator operatively coupled to a proximal portion of the sheath, the inner shaft extending through the handle, and a shaft retractor releasably coupled to a proximal portion of the handle and fixedly coupled to a proximal portion of the inner shaft. A sheath actuator can move the sheath axially relative to the inner shaft when the shaft retractor is coupled to the handle, and a proximal movement of the sheath relative to the inner shaft can cause the sheath to uncover the prosthetic heart valve. The shaft retractor can be operable to retract the inner shaft and the nosecone proximally relative to the sheath when the shaft retractor is released from the handle.

公开(公告)号：US10583009B2

公开(公告)日：2020-03-10

申请号：US16593360

申请日：2019-10-04

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A method of treating a defective mitral valve includes percutaneously advancing a prosthetic device into a patient's heart. The prosthetic device includes an insert member and anchoring member. The prosthetic device is contained within a sheath along a distal end of a delivery catheter during advancement. The anchoring member is secured to a muscular wall of the left ventricle and the insert member self-expands between native leaflets of the mitral valve. The insert member preferably includes a biocompatible fabric outer layer, a passageway, and a valve member disposed within the passageway. After deployment, the native leaflets of the mitral valve form a tight seal against the fabric outer layer of the insert member for preventing regurgitation, while blood passes through the passageway of the insert member for allowing blood to pass from the left atrium to the left ventricle.

公开(公告)号：US10441423B2

公开(公告)日：2019-10-15

申请号：US15443289

申请日：2017-02-27

Applicant: Edwards Lifesciences Corporation

Inventor： David L. Hauser ,  Jan Otto Solem ,  David Alon

IPC: A61F2/24

Abstract: A prosthetic device for treating a mitral valve includes a prosthetic insert member insertable between leaflets of mitral valve. The insert member has an elongated cross-sectional profile for conforming to gap between leaflets of a mitral valve. The device also includes an anchoring member for attachment to heart tissue for maintaining the insert member in the mitral valve. The insert member includes a valve that permits one-way blood flow therethrough. An anchoring member secures the prosthetic insert member to a heart wall.