公开(公告)号：US20190046314A1

公开(公告)日：2019-02-14

申请号：US16100601

申请日：2018-08-10

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Giolnara Pinhas ,  Liraz Marom ,  Elena Sherman ,  Noam Mizrahi ,  Delfin Rafael Ruiz ,  Sandip Vasant Pawar ,  Liron Tayeb

IPC: A61F2/24

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame having an inflow end, an outflow end, and a longitudinal axis. A leaflet structure is positioned within the frame and secured thereto, and a sealing element is secured to the frame. The sealing element includes a first woven portion extending circumferentially around the frame. The first woven portion includes a plurality of interwoven filaments. The sealing element further includes a second woven portion extending circumferentially around the frame and spaced apart from the first woven portion along the longitudinal axis of the frame. At least a portion of the filaments exit the weave of the first woven portion and form loops extending radially outwardly from the frame.

公开(公告)号：US20170056163A1

公开(公告)日：2017-03-02

申请号：US15240570

申请日：2016-08-18

Applicant: Edwards Lifesciences Corporation

Inventor： Liron Tayeb ,  Ilan Tamir

IPC: A61F2/24

CPC classification number: A61F2/2409 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2230/0091 ,  A61F2250/006 ,  A61F2250/0069

Abstract: A covering layer for a transcatheter heart valve is in various embodiments configured to prevent or reduce damage to the native valve tissue around the site where the prosthetic valve is implanted. In some cases, prosthetic valves are manufactured with the covering layer attached. Other covering layers are stand-alone accessories that can be mounted onto pre-existing prosthetic valves by an end user. Covering layers that can be mounted by an end user are provided with various features that can facilitate easier attachment of the covering layer to the prosthetic valve, which further reduces the possibility of damage to the covering layer or to the valve. Another covering is provided with two layers in order to insulate and protect the native tissue surrounding the implant from damage due to friction or abrasion, and/or other movement driven wear.

Abstract translation: 用于经导管心脏瓣膜的覆盖层在各种实施例中被配置为防止或减少对植入人造瓣膜的位置附近的天然瓣膜组织的损伤。 在一些情况下，制造具有附着的覆盖层的人造瓣膜。 其他覆盖层是可由最终用户安装到预先存在的人造瓣膜上的独立附件。 可以由终端用户安装的覆盖层具有各种特征，其可以便于将覆盖层更容易地附接到人工瓣膜，这进一步降低了对覆盖层或阀的损害的可能性。 另外的覆盖物设置有两层，以便绝缘和保护植入物周围的天然组织免受摩擦或磨损和/或其他运动驱动的磨损造成的损伤。

公开(公告)号：US12295869B2

公开(公告)日：2025-05-13

申请号：US17660491

申请日：2022-04-25

Applicant: Edwards Lifesciences Corporation

Inventor： John J. Desrosiers ,  Daniel James Murray ,  Michael G. Valdez ,  Liron Tayeb ,  David Maimon ,  Eitan Atias ,  Adi Carmi

IPC: A61F2/966 ,  A61B17/34 ,  A61F2/24 ,  A61B17/12 ,  A61N1/39

Abstract: A system includes a lock and release connector, an implantable medical device, and an outer tube. The lock and release connector includes a connector body defining a recess having planar lateral head portions extending to and intersecting with a cylindrical surface of the connector body, and a longitudinal neck portion extending from the head portion. The implantable medical device has an extension including a neck portion receivable in the longitudinal neck portion of the recess and a head portion receivable in the lateral head portions of the recess. The outer tube extends over the recess to retain the extension in the recess.

公开(公告)号：US20250090315A1

公开(公告)日：2025-03-20

申请号：US18965594

申请日：2024-12-02

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Liron Tayeb ,  Eran Goldberg ,  David Maimon ,  Adi Carmi ,  Arie Tylis ,  Tomer Saar ,  Anatoly Dvorsky

IPC: A61F2/24 ,  A61F2/88 ,  A61F2/90

Abstract: A docking station includes an expandable frame configured to conform to an interior shape of a blood vessel when expanded inside the blood vessel, wherein the frame includes an annular outer wall formed from at least one annular stent segment connected to a plurality of spring elements circumferentially spaced around the at least one annular stent segment.

公开(公告)号：US12245756B2

公开(公告)日：2025-03-11

申请号：US17334479

申请日：2021-05-28

Applicant: Edwards Lifesciences Corporation

Inventor： Boaz Manash ,  Eitan Atias ,  Liron Tayeb ,  Amir Blumenfeld ,  David Maimon ,  Eyal Leiba

IPC: A61B17/00 ,  A61F2/24

Abstract: Valvular implants and blood vessel closure devices herein are configured to be positioned in the heart and to block regurgitant blood flow from the heart into blood vessels supplying blood to the heart. The valvular implants can have a cover, a membrane, a valve, a resilient frame, and/or other features. Some valvular implants can have anchors to be positioned in the blood vessels, such as in pulmonary veins, and can anchor the implant to the heart wall. Various embodiments of covers and/or membranes act as valves contracting and expanding, to alternately permit and block blood flow. The valvular implants can cover one or more blood vessels, such as one, two, three, or four pulmonary veins, and can also be configured and implanted to block an appendage to the heart, such as the left atrial appendage.

公开(公告)号：US20250064581A1

公开(公告)日：2025-02-27

申请号：US18941882

申请日：2024-11-08

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Liron Tayeb ,  Ilan Tamir

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a radially expandable and collapsible frame having an inflow end and an outflow end, the inflow end including a plurality of inflow apices and the outflow end including a plurality of outflow apices. A plurality of valve leaflets is coupled to the frame and configured to control blood flow through the prosthetic heart valve, and a covering is disposed around the frame and includes an inflow end portion and an outflow end portion. The inflow end portion of the covering is disposed over the inflow apices of the frame and covers the inflow apices, and the outflow end portion of the covering is disposed over the outflow apices of the frame and covers the outflow apices. The covering defines narrower end openings than the inflow and outflow ends of the frame.

公开(公告)号：US12201519B2

公开(公告)日：2025-01-21

申请号：US17359964

申请日：2021-06-28

Applicant: Edwards Lifesciences Corporation

Inventor： Liron Tayeb ,  Tamir S. Levi

IPC: A61F2/24

Abstract: A prosthetic valve includes an annular frame and a skirt. The frame is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration. The skirt has a fold around an inflow end of the frame so as to cover at least a portion of an outer surface of the frame and at least a portion of an inner surface of the frame. When the frame is in the radially expanded configuration, an outer portion of the skirt tightly conforms to the outer surface of the frame and the inflow end of the frame is axially spaced from the fold to form an axially extending gap between the frame and the fold. When the frame is in the radially compressed configuration, the inflow end of the frame extends axially so as to at least partially fill the axially extending gap.

公开(公告)号：US12156806B2

公开(公告)日：2024-12-03

申请号：US18352977

申请日：2023-07-14

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Liron Tayeb ,  Ilan Tamir

IPC: A61F2/24

Abstract: A prosthetic heart valve includes a radially expandable and collapsible frame with an inflow end including a plurality of inflow apices and an outflow end including a plurality of outflow apices. A plurality of valve leaflets are positioned in the frame and configured to control blood flow through the prosthetic heart valve. A covering is disposed around the frame. The covering has an inflow end portion having an inflow edge and an outflow end portion having an outflow edge. The inflow end portion of the covering is disposed over the inflow apices of the frame such that the inflow edge of the covering is inside the frame. The outflow end portion of the covering is disposed over the outflow apices of the frame such that the outflow edge of the covering is inside the frame, and the covering covers an entire outer surface of the frame.

公开(公告)号：US12127960B2

公开(公告)日：2024-10-29

申请号：US17673601

申请日：2022-02-16

Applicant: Edwards Lifesciences Corporation

Inventor： Eran Goldberg ,  Noa Axelrod Manela ,  Yair A. Neumann ,  Boaz Manash ,  David Maimon ,  Eyal Leiba ,  Ralph Schneider ,  Liron Tayeb

IPC: A61F2/966 ,  A61F2/24 ,  A61F2/95 ,  A61M25/00 ,  B29D23/00 ,  A61F2/958 ,  A61F2/962 ,  A61M29/00 ,  B29K105/08

CPC classification number: A61F2/966 ,  A61F2/2436 ,  A61F2/9526 ,  A61M25/0012 ,  A61M25/0023 ,  B29D23/00 ,  A61F2/9517 ,  A61F2/9522 ,  A61F2002/9583 ,  A61F2002/9623 ,  A61F2002/9665 ,  A61F2250/001 ,  A61M2025/0024 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0074 ,  A61M29/00 ,  A61M2205/0216 ,  B29K2105/0827

Abstract: An expandable sheath is disclosed herein, which has a first polymeric layer and a braided layer positioned radially outward of the first polymeric layer. The braided layer includes a plurality of filaments braided together. The expandable sheaths further include a resilient elastic layer positioned radially outward of the braided layer. The elastic layer is configured to apply radial force to the braided layer and the first polymeric layer. The expandable sheath further includes a second polymeric layer positioned radially outward of the elastic layer and bonded to the first polymeric layer such that the braided layer and the elastic layer are encapsulated between the first and second polymeric layers. Methods of making and using the devices disclosed herein are also disclosed, as are crimping devices that may be used in methods of making the devices disclosed herein.

公开(公告)号：US12121672B2

公开(公告)日：2024-10-22

申请号：US17078556

申请日：2020-10-23

Applicant: Edwards Lifesciences Corporation

Inventor： Eran Goldberg ,  Liron Tayeb ,  David Maimon

IPC: A61F2/24 ,  A61M25/00 ,  A61F2/962

CPC classification number: A61M25/0023 ,  A61F2/2427 ,  A61F2/962 ,  A61M2025/0024

Abstract: Disclosed herein are reinforced expandable introducer sheaths and methods of using the same. The sheaths minimize trauma to the patient's vasculature by including a reinforcing member to improve the push force of the sheath while reducing the chances of kinking during delivery of a prosthetic device. The sheath can include a plurality of expandable rings aligned along the longitudinal axis of the sheath and coupled together to form an elongated tubular structure. The sheath can also include a plurality of radial members circumferentially arranged to form a tubular support structure. The radial members slidingly interconnected around the circumference of the tubular structure to facilitate radial expansion of the sheath.