公开(公告)号：US07426205B2

公开(公告)日：2008-09-16

申请号：US10688025

申请日：2003-10-16

申请人： Kai Fechner ,  Jürgen Jasperneite ,  Martin Müller

发明人： Kai Fechner ,  Jürgen Jasperneite ,  Martin Müller

IPC分类号： H04L12/66 ,  H04L12/50 ,  H04L12/28 ,  H04L12/56 ,  H04Q11/00

CPC分类号： H04L49/351 ,  H04L49/101 ,  H04Q2213/04

摘要： An Ethernet switch has a header device with a crossbar device and a number of downstream interface modules with a first number of a series of ports and a second number of a series of ports, respectively, such that in each case the same one in the series of the first number of ports is connected to a switching control unit coupled to an interface device, and the further ports in the series of the first number of ports are connected to a port in the second number of the series of ports via respective data lines routed in cascade form.

摘要翻译： 以太网交换机具有标题设备，其具有交叉设备和多个下游接口模块，其分别具有第一数量的一系列端口和第二数量的一系列端口，使得在每种情况下，该系列中的相同的一个端口 所述第一数量的端口连接到耦合到接口设备的交换控制单元，并且所述一系列端口中的另一端口经由相应的数据线连接到所述第二数量的端口中的端口 以级联形式布线。

公开(公告)号：US07354714B2

公开(公告)日：2008-04-08

申请号：US10778936

申请日：2004-02-13

申请人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

发明人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

IPC分类号： C12Q1/68

CPC分类号： C07K16/084 ,  A61K39/12 ,  C12N2710/20034

摘要： A vaccine against disease caused by papilloma viruses is described in certain embodiments, as well as certain vectors, obtainable by the following methods: (a) one or more expression vectors that contain the DNA code for a structural protein of papilloma viruses or a fragment thereof are injected into mammals, whereby in at least some of the expression vectors randomly generated heterologous sequences are inserted into the DNA code (b) serums are obtained from the mammals and these are tested for the presence of antibodies against particles of various papilloma virus types, and (c) using the serums tested, the structural protein gene clones are identified that code for a polyvalent vaccine, and (d) the vaccine is produced from them. Procedures for producing a vaccine is also described, together with its use for vaccination against diseases caused by papilloma viruses.

摘要翻译： 在某些实施方案中描述了针对由乳头瘤病毒引起的疾病的疫苗，以及可通过以下方法获得的某些载体：（a）含有乳头状瘤病毒或其片段的结构蛋白的DNA编码的一种或多种表达载体 注射到哺乳动物中，由此在至少一些表达载体中随机产生的异源序列插入到DNA代码（b）中，从哺乳动物获得血清，并测试这些血清是否存在针对各种乳头状瘤病毒类型的颗粒的抗体， 和（c）使用测试的血清，鉴定编码多价疫苗的结构蛋白质基因克隆，和（d）从它们产生疫苗。 还描述了生产疫苗的程序，以及其用于针对由乳头瘤病毒引起的疾病的疫苗接种的用途。

公开(公告)号：US07270134B2

公开(公告)日：2007-09-18

申请号：US10317944

申请日：2002-12-12

申请人： Alois Müller ,  Martin Müller ,  Dirk Bube ,  Alfred Schneider

发明人： Alois Müller ,  Martin Müller ,  Dirk Bube ,  Alfred Schneider

IPC分类号： B08B3/00 ,  B08B3/06

CPC分类号： B65G49/0459

摘要： A system for treating, in liquids, a mass-production parts contained in transport baskets, comprising at least one tank which contains liquid for submerging the transport baskets, at least one transport vehicle for the transport baskets by which the transport baskets can be moved over the at least one tank, at least one basket carrier which is arranged at the transport vehicle in such a way that its height is adjustable, which is able to grip a transport basket, submerge same in the tank, rotatingly drive same around an axis and lift same out of the tank, as well as a clamp for securing the basket carrier relative to the at least one tank.

摘要翻译： 一种用于在液体中处理包含在运输篮中的批量生产部件的系统，包括至少一个容纳有用于浸没运输篮的液体的罐，用于运输篮的运输篮的至少一个运输车辆，运输篮可以通过该运输车移动 所述至少一个罐，至少一个篮架，其布置在所述运输车辆处，使得其高度是可调节的，其能够夹持运输篮，浸没在所述罐中，相对于所述槽旋转驱动; 将相同的罐从罐中提起，以及用于相对于至少一个罐固定篮架的夹具。

公开(公告)号：US06702121B2

公开(公告)日：2004-03-09

申请号：US10071249

申请日：2002-02-08

申请人： Niels Linge ,  Robert Klein ,  Ernst Kölsch ,  Martin Müller ,  Michael Dietzel

发明人： Niels Linge ,  Robert Klein ,  Ernst Kölsch ,  Martin Müller ,  Michael Dietzel

IPC分类号： B65G4746

CPC分类号： B65G29/00 ,  B07C5/36 ,  B65G37/02 ,  B65G47/648

摘要： A rotating sorting device for sorting packaged goods has one or more linear supply conveyors and a plurality of removal locations arranged circularly about a central axle. One or more linear removal conveyors are positioned between the central axle and the removal locations and are arranged substantially radially. The linear removal conveyor rotates continuously about the central axle. The linear supply conveyor is positioned above or below the linear removal conveyor and has an end portion in a conveying direction of the linear supply conveyor. The end portion has an incline extending downwardly or upwardly toward the linear removal conveyor. A distribution control device controls the linear supply conveyor, the linear removal conveyor, and the removal locations.

摘要翻译： 用于分类包装货物的旋转分拣装置具有一个或多个线性供应输送机和围绕中心轴线循环布置的多个移除位置。 一个或多个线性去除输送机位于中心轴和移除位置之间，并且基本上径向布置。 线性移除输送机围绕中心轴线连续旋转。 线性供给输送机位于线性去除输送机的上方或下方，并且在线性供给输送机的输送方向上具有端部。 端部具有朝向线性移除输送机向下或向上延伸的倾斜。 分配控制装置控制线性供应输送机，线性去除输送机和拆卸位置。

公开(公告)号：US06322794B1

公开(公告)日：2001-11-27

申请号：US08164768

申请日：1993-12-10

申请人： Conrad Bleul ,  Lutz Gissmann ,  Martin Müller

发明人： Conrad Bleul ,  Lutz Gissmann ,  Martin Müller

IPC分类号： A61K3912

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/20022

摘要： The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or in part with the sequences of the seroreactive epitopes, and to vaccines which contain such peptides.

摘要翻译： 本发明涉及人乳头状瘤病毒HPV18蛋白质上的血清反应性表位。此外，本发明涉及具有全部或部分与血清反应性表位的序列重合的氨基酸序列的肽以及含有这些肽的疫苗。

公开(公告)号：US10088443B2

公开(公告)日：2018-10-02

申请号：US14342094

申请日：2012-08-31

申请人： Heidemarie Schmidt ,  Christine Baumgart ,  Ilona Skorupa ,  Manfred Helm ,  Oliver G. Schmidt ,  Martin Müller

发明人： Heidemarie Schmidt ,  Christine Baumgart ,  Ilona Skorupa ,  Manfred Helm ,  Oliver G. Schmidt ,  Martin Müller

IPC分类号： G01N27/26 ,  G01N27/28 ,  G01N27/327 ,  G01N33/543 ,  B01L3/00

摘要： Carriers for biomaterials, for polyelectrolyte materials, for electrically polarizable atoms, ions, molecules are provided wherein the material of the carriers is compatible with materials that are used in microelectronics. The arrangement of the biomaterials or biomolecules and optionally of biomolecules, biomaterials, biological functional units or cells adsorbed thereon can be affected with the carrier in a specific manner. Complex molecular machines can be built and tested by the carriers.

公开(公告)号：US08526480B2

公开(公告)日：2013-09-03

申请号：US12224572

申请日：2007-02-08

申请人： Wolfgang Schmid ,  Martin Müller

发明人： Wolfgang Schmid ,  Martin Müller

IPC分类号： H01S3/091

CPC分类号： H01S5/183 ,  H01S5/026 ,  H01S5/041 ,  H01S5/22 ,  H01S5/4031

摘要： A semiconductor laser device comprising an optically pumped surface emitting vertical emitter which emits in a vertical main radiation direction, and at least one monolithically integrated pump radiation source for optically pumping the vertical emitter, wherein the pump radiation source emits pump radiation in a pump main radiation direction extending transversely with respect to the vertical main radiation direction. In accordance with the invention, suitably dimensioned vertical sections are provided such that modes of the pump radiation are forced completely or at least partly in a vertical direction from this section to reduce absorption losses of the pump radiation at conductive layers.

摘要翻译： 一种半导体激光器件，包括在垂直主辐射方向上发射的垂直发射器的光泵浦表面，以及用于光泵浦垂直发射器的至少一个单片集成泵浦辐射源，其中泵浦辐射源在泵主辐射中发射泵浦辐射 方向相对于垂直主辐射方向横向延伸。 根据本发明，提供适当尺寸的竖直部分，使得泵浦辐射的模式被完全地或者至少部分地沿着该部分的垂直方向强制，以减少在导电层处的泵浦辐射的吸收损失。

公开(公告)号：US20130149696A1

公开(公告)日：2013-06-13

申请号：US13700672

申请日：2011-05-31

申请人： Michael Pawlita ,  Ivonne Rubio ,  Martin Müller ,  Peter Sehr

发明人： Michael Pawlita ,  Ivonne Rubio ,  Martin Müller ,  Peter Sehr

IPC分类号： G01N33/68

CPC分类号： G01N33/6854 ,  C12Q1/66 ,  C12Q1/6813 ,  C12Q1/70

摘要： The present invention relates to a method for the determination of the presence of PV-neutralizing antibodies in a sample, comprising a) contacting said sample with infectious PV particles comprising a reporter gene, wherein the gene product of said reporter gene is secreted into the growth medium, b) contacting the PV particles from a) with host cells, and c) determining PV-neutralizing antibodies based on the amount of gene product from said reporter gene, wherein, preferably, a lower amount of said gene product as compared to a reference amount is indicative of the presence of PV-neutralizing antibodies. It further relates to a host cell strongly adhering to multi-cluster plates for use in a method for diagnosing anti-PV immunity comprising the method of the present invention.

摘要翻译： 本发明涉及一种用于测定样品中PV中和抗体的存在的方法，包括a）使所述样品与包含报道基因的感染性PV颗粒接触，其中所述报告基因的基因产物分泌到生长中 培养基，b）使来自a）的PV颗粒与宿主细胞接触，以及c）基于来自所述报道基因的基因产物的量测定PV中和抗体，其中优选地，较低量的所述基因产物与 参考量表明PV中和抗体的存在。 本发明还涉及一种用于诊断抗PV免疫的方法的多簇板的宿主细胞，其包括本发明的方法。

公开(公告)号：US20120142793A1

公开(公告)日：2012-06-07

申请号：US13130796

申请日：2009-11-24

申请人： Markus Frey ,  Christophe Frossard ,  Katia Studer ,  Karin Powell ,  Jean-Luc Birbaum ,  Martin Müller

发明人： Markus Frey ,  Christophe Frossard ,  Katia Studer ,  Karin Powell ,  Jean-Luc Birbaum ,  Martin Müller

IPC分类号： C08F2/46 ,  C08G77/38 ,  C08J9/00 ,  C09D137/00 ,  C09D11/10 ,  C09J137/00 ,  C08G77/388 ,  C08F224/00

CPC分类号： C07F7/21 ,  B33Y70/00

摘要： Photoinitiator compounds comprising both a photoactive moiety and an amine functionality, bonded to a polyhedral oligomeric silsesquioxane, which photoinitiator is represented by formula (1) or (1′) wherein n is 2m; m is an integer of 2 to 30; the sum of n′+a is an integer 4-60; n′ is an even-numbered integer; a is an even- or uneven-numbered integer; and for example different A C1-C12alkyl, or a photoactive moiety Q1, or a group of formula (2); E for example is a direct bond, L is linear or branched C1-C3alkylene, preferably propylene; R1 and R2 for example are a photoactive moiety Q, or C2-20alkyl; Q is for example a group of formula (4); Z2 is for example C1-C6alkylene which is unsubstituted or substituted by one or more OR6; and R6, R12, R13 and R14 for example are hydrogen; are especially suitable as low-migrating photoinitiators.

摘要翻译： 光引发剂化合物，其包含与多面体低聚倍半硅氧烷结合的光活性部分和胺官能团，该光引发剂由式（1）或（1'）表示，其中n为2m; m为2〜30的整数， n'+ a的和为4-60的整数; n'是偶数整数; a是偶数或不均匀的整数; 例如不同的A C1-C12烷基或光活性部分Q1或式（2）的基团; E例如是直接键合，L是直链或支链C1-C3亚烷基，优选丙烯; R1和R2例如是光活性部分Q或C2-20烷基; Q例如是式（4）的一组; Z2为例如未被取代或被一个或多个OR 6取代的C 1 -C 6亚烷基; R 6，R 12，R 13和R 14例如为氢; 特别适用于低迁移性光引发剂。

公开(公告)号：US08194712B2

公开(公告)日：2012-06-05

申请号：US12217100

申请日：2008-06-30

申请人： Martin Müller ,  Günther Grönninger ,  Alexander Behres

发明人： Martin Müller ,  Günther Grönninger ,  Alexander Behres

IPC分类号： H01S5/00

CPC分类号： H01S5/4043 ,  H01S5/3095 ,  H01S5/3201 ,  H01S5/3211 ,  H01S5/3215 ,  H01S5/4018

摘要： A monolithically integrated laser diode chip having a construction as a multiple beam laser diode, which, on a semiconductor substrate (3) comprised of GaAs, has at least two laser stacks (4a, 4b, 4c) which are arranged one above another and which each contain an active zone (7). The active zone (7) is in each case arranged between waveguide layers (8). The waveguide layers (8) each adjoin a cladding layer (6) at a side remote from the active zone. At least one of the waveguide layers (8) or cladding layers (6) of at least one laser stack (4a, 4b, 4c), comprises AlxGa1-xAs, where 0≦x≦1, and at least one additional material from main group III or V, such that the lattice mismatch between the at least one waveguide layer (8) or cladding layer (6) comprising the at least one additional element and the semiconductor substrate (3) composed of GaAs is reduced. This increases the lifetime of the laser diode chip.

摘要翻译： 具有构造为多光束激光二极管的单片集成激光二极管芯片，其在由GaAs构成的半导体衬底（3）上具有至少两个激光堆叠（4a，4b，4c） 每个都包含活动区域（7）。 有源区（7）分别布置在波导层（8）之间。 每个波导层（8）在远离有源区的一侧与包层（6）相邻。 至少一个激光堆叠（4a，4b，4c）的至少一个波导层（8）或包覆层（6）包括Al x Ga 1-x As，其中0和n 1; x 1和n 1;以及至少一个来自主体的附加材料 III或V族，使得包含至少一个附加元件的至少一个波导层（8）或包层（6）与由GaAs构成的半导体衬底（3）之间的晶格失配减小。 这增加了激光二极管芯片的寿命。